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| 1 | 为十二指肠的胃肠的 stromal 肿瘤的有限切除术:外科的管理和临床的结果显示文摘 AIM:To analyze our experience in patients with duodenal gastrointestinal stromal tumors(GIST) and review the appropriate surgical approach.METHODS:We retrospectively reviewed the medical records of all patients with duodenal GIST surgically treated at our medical institution between 2002 and 2011.Patient files,operative reports,radiological charts and pathology were analyzed.For surgical therapy open and laparoscopic wedge resections and segmental resections were performed for limited resection(LR).For extended resection pancreatoduodenectomy was performed.Age,gender,clinical symptoms of the tumor,anatomical localization,tumor size,mitotic count,type of resection resectional status,neoadjuvant therapy,adjuvant therapy,risk classification and follow-up details were investigated in this retrospective study.RESULTS:Nine patients(5 males/4 females) with a median age of 58 years were surgically treated.The median follow-up period was 45 mo(range 6-111 mo).The initial symptom in 6 of 9 patients was gastrointestinal bleeding(67%).Tumors were found in all four parts of the duodenum,but were predominantly located in the first and second part of the duodenum with each 3 of 9 patients(33%).Two patients received neoadjuvant medical treatment with 400 mg imatinib per day for 12 wk before resection.In one patient,the GIST resection was done by pancreatoduodenectomy.The 8 LRs included a segmental resection of pars 4 of the duodenum,5 wedge resections with primary closure and a wedge resection with luminal closure by Roux-Y duodeno-jejunostomy.One of these LRs was done minimally invasive;seven were done in open fashion.The median diameter of the tumors was 54 mm(14-110 mm).Using the Fletcher classification scheme,3/9(33%) tumors had high risk,1/9(11%) had intermediate risk,4/9(44%) had low risk,and 1/9(11%) had very low risk for aggressive behaviour.Seven resections showed microscopically negative transsection margins(R0),two showed positive margins(R1).No patient developed local recurrence during follow-up.The one patient who underwent pancreatoduodenectomy died due to progressive disease with hepatic metastasis but without evidence of local recurrence.Another patient died in complete remission due to cardiac disease.Seven of the nine patients are alive disease-free.CONCLUSION:In patients with duodenal GIST,limited surgical resection with microscopically negative margins,but also with microscopically positive margins,lead to very good local and systemic disease-free survival. | Jens Hoeppner Birte Kulemann Goran Marjanovic Peter Bronsert Ulrich Theodor Hopt | 2013 | World Journal of Gastrointestinal Surgery2013，5，2： | 11 |
| 2 | Effect of liver regeneration after partial hepatectomy and ischemia-reperfusion on expression of growth factor receptors显示文摘瞄准:在肝新生在四不同生长因素受体的表示的时间功课上调查试验性的部分肝切除术和 normothermic ischemia-reperfusion 损坏的效果。这由于在刺激肝新生的生长因素的潜在的治疗学的使用是相关的。方法:为部分肝切除术(PH ) , 80% 肝质量是在 Sprague Dawley 老鼠的 resected。局部缺血和灌注(I/R ) 被门静脉和肝的动脉的吸藏为 15 min 导致。表皮的生长因素受体,肝的生长因素受体,成纤维细胞生长因素受体和瘤坏死因素 receptor-1 被免疫组织化学在损害以后分析直到 72 h。量的 RT-PCR 在最小的受体表示(24 h ) 的时间点被执行。结果:在免疫组织化学, EGFR, HGFR, FGFR 和 TNFR1 与一座山峰在部分肝切除术以后给双性人看了局面的动力学直到 12 h,在 24 h 以后的一个天底和另一弱增加直到 72 h。在肝新生期间,在局部缺血和灌注以后,受体表示更低;在在灌注以后的 24 h 的天底是一样。评估这个天底是否被 mRNA 抄写的缺乏引起,或由于一根柱子翻译规定, RT-PCR 在 24 h 并且与放松肝相比被执行。在每根探针,为受体有特定的 mRNA。EGFR, FGFR 和 TNFR1 mRNA 表示比在放松肝相等或低,在 I/R 以后的 HGFR 表示比在控制强壮。结论:部分至少由于 post-transcriptional 处理,在分析受体的表达式有一个天底在肝损伤以后的 24 h。因此,到在损坏以后的 stimulate 肝新生 24 h 的生长因素的治疗学的使用可能不是成功的。 | P Baier G Wolf-Vorbeck S Hempel UT Hopt E von Dobschuetz | 2006 | World Journal of Gastroenterology2006，12，24： | 8 |
| 3 | The Lymph Node Ratio is the Strongest Prognostic Factor after Resection of Pancreatic Cancer显示文摘 | Hartwig Riediger Tobias Keck Ulrich Wellner Axel Hausen Ulrich Adam Ulrich T. Hopt Frank Makowiec | 2009 | Journal of Gastrointestinal Surgery2009，，7： | 5 |
| 4 | Arguments for an individualized closure of the pancreatic remnant after distal pancreatic resection显示文摘AIM:To analyze risk factors for postoperative pancreatic fistula(POPF) rate after distal pancreatic resection(DPR).METHODS:We performed a retrospective analysis of 126 DPRs during 16 years.The primary endpoint was clinically relevant pancreatic fistula.RESULTS:Over the years,there was an increasing rate of operations in patients with a high-risk pancreas and a significant change in operative techniques.POPF was the most prominent factor for perioperative morbidity.Significant risk factors for pancreatic fistula were high body mass index(BMI) [odds ratio(OR) = 1.2(CI:1.1-1.3),P = 0.001],high-risk pancreatic pathology [OR = 3.0(CI:1.3-7.0),P = 0.011] and direct closure of the pancreas by hand suture [OR = 2.9(CI:1.2-6.7),P = 0.014].Of these,BMI and hand suture closure were independent risk factors in multivariate analysis.While hand suture closure was a risk factor in the low-risk pancreas subgroup,high BMI further increased the fistula rate for a high-risk pancreas.CONCLUSION:We propose a risk-adapted and indication-adapted choice of the closure method for the pancreatic remnant to reduce pancreatic fistula rate. | Ulrich Friedrich Wellner Frank Makowiec Olivia Sick Ulrich Theodor Hopt Tobias Keck | 2012 | World Journal of Gastrointestinal Surgery2012，4，5： | 3 |
| 5 | The Lymph Node Ratio is the Strongest Prognostic Factor after Resection of Pancreatic Cancer显示文摘 | Hartwig Riediger Tobias Keck Ulrich Wellner Axel Hausen Ulrich Adam Ulrich T. Hopt Frank Makowiec | 2009 | Journal of Gastrointestinal Surgery2009，，7： | 2 |
| 6 | Extracellular matrices for gastrointestinal surgery:Ex vivo testing and current applications显示文摘AIM:To assess the effects of bile and pancreatic juice on structural and mechanical resistance of extracellular matrices(ECMs) in vitro.METHODS:Small-intestinal submucosa(SIS),porcine dermal matrix(PDM),porcine pericardial matrix(PPM) and bovine pericardial matrix(BPM) were incubated in human bile and pancreatic juice in vitro.ECMs were examined by macroscopic observation,scanning electron microscopy(SEM) and testing of mechanical resistance.RESULTS:PDM dissolved within 4 d after exposure to bile or pancreatic juice.SIS,PPM and PDM retained their integrity for > 60 d when incubated in either digestive juice.The effect of bile was found to be far more detrimental to mechanical stability than pancreatic juice in all tested materials.In SIS,the loss of mechanical stability after incubation in either of the digestive secretions was less distinct than in PPM and BPM [mFmax 4.01/14.27 N(SIS) vs 2.08/5.23 N(PPM) vs 1.48/7.89 N(BPM)].In SIS,the extent of structural damage revealed by SEM was more evident in bile than in pancreatic juice.In PPM and BPM,structural damage was comparable in both media.CONCLUSION:PDM is less suitable for support of gastrointestinal healing.Besides SIS,PPM and BPM should also be evaluated experimentally for gastrointestinal indications. | Jens Hoeppner Goran Marjanovic Peter Helwig Ulrich Theodor Hopt Tobias Keck | 2010 | World Journal of Gastroenterology2010，16，32： | 2 |
| 7 | Impact of remote ischemic preconditioning on wound healing in small bowel anastomoses显示文摘AIM: To investigate the influence of remote ischemic preconditioning (RIPC) on anastomotic integrity. METHODS: Sixty male Wistar rats were randomized to six groups. The control group (n = 10) had an end-to-end ileal anastomosis without RIPC. The preconditioned groups (n = 34) varied in time of ischemia and time of reperfusion. One group received the amino acid L-arginine before constructing the anastomosis (n = 9). On postoperative day 4, the rats were re-laparotomized, and bursting pressure, hydroxyproline concentration, intra-abdominal adhesions, and a histological score concerning the mucosal ischemic injury were collected. The data are given as median (range).RESULTS: On postoperative day 4, median bursting pressure was 124 mmHg (60-146 mmHg) in the control group. The experimental groups did not show a statistically significant difference (P > 0.05). Regarding the hydroxyproline concentration, we did not find any significant variation in the experimental groups. We detected significantly less mucosal injury in the RIPC groups. Furthermore, we assessed more extensive intra-abdominal adhesions in the preconditioned groups than in the control group. CONCLUSION: RIPC directly before performing small bowel anastomosis does not affect anastomotic stability in the early period, as seen in ischemic preconditioning. | Philipp Anton Holzner Birte Kulemann Simon Kuesters Sylvia Timme Jens Hoeppner Ulrich Theodor Hopt Goran Marjanovic | 2011 | World Journal of Gastroenterology2011，17，10： | 2 |
| 8 | Long-Term Outcome after 92 Duodenum-Preserving Pancreatic Head Resections for Chronic Pancreatitis: Comparison of Beger and Frey Procedures显示文摘 | Tobias Keck Ulrich Friedrich Wellner Hartwig Riediger Ulrich Adam Olivia Sick Ulrich Theodor Hopt Frank Makowiec | 2010 | Journal of Gastrointestinal Surgery2010，，3： | 2 |
| 9 | Postoperative morbidity and long-term survival after pancreaticoduodenectomy with superior mesenterico-portal vein resection显示文摘 | Hartwig Riediger M.D. Frank Makowiec M.D. Eva Fischer Ulrich Adam M.D. Ulrich T. Hopt M.D | 2006 | Journal of Gastrointestinal Surgery2006，，8： | 1 |
| 10 | Postoperative Morbidity and Long-term Survival After Pancreaticoduodenectomy With Superior Mesenterico?Portal Vein Resection显示文摘 | Hartwig Riediger Frank Makowiec Eva Fischer Ulrich Adam Ulrich T. Hopt | 2006 | Journal of Gastrointestinal Surgery2006，，8： | 1 |
| 11 | A novel approach for reliable microarray analysis of microdissected tumor cells from formalin-fixed and paraffin-embedded colorectal cancer resection specimens显示文摘 | Silke Lassmann Clemens Kreutz Anja Schoepflin Ulrich Hopt Jens Timmer Martin Werner | 2009 | Journal of Molecular Medicine2009，，2： | 1 |
| 12 | Morphological studies of graft pancreatitis following pancreas transplantation显示文摘 | Biising M Hopt UT Qnacken M | 1993 | Br J Surg1993，80，： | 1 |
| 13 | Tumour stem cells and metastasis显示文摘 | Wellner UF Hopt UT Brabletz T | 2010 | Zentralbl Chir2010，135，4： | 1 |
| 14 | Long-term Outcome After Resection for Chronic Pancreatitis in 224 Patients显示文摘 | Hartwig Riediger Ulrich Adam Eva Fischer Tobias Keck Frank Pfeffer Ulrich T. Hopt Frank Makowiec | 2007 | Journal of Gastrointestinal Surgery2007，，8： | 1 |
| 15 | Current practice patterns in pancreatic surgery: Results of a multi-institutional analysis of seven large surgical departments in germany with 1454 pancreatic head resections, 1999 to 2004 (german advanced surgical treatment study group)显示文摘 | Frank Makowiec M.D. Stefan Post M.D. Hans-Detlev Saeger M.D. Norbert Senninger M.D. F.A.C.S. Heinz Becker M.D. F.A.C.S. Michael Betzler M.D. Heinz J. Buhr M.D. F.A.C.S. Ulrich T. Hopt M.D | 2005 | Journal of Gastrointestinal Surgery2005，，8： | 1 |
| 16 | Systemic differential gene regulation of the inter-α-trypsin inhibitor family in acute necrotizing pancreatitis in mice显示文摘 | Gabriel Seifert Rolf-Pascal Kurzinger Ulrich T. Hopt Uwe A. Wittel | 2012 | Journal of Surgical Research2012，，： | 1 |
| 17 | Comparison of various methods of surgical hernia repair显示文摘 | Benz S Hopt UT | 2005 | MMW Fortschr Med2005，147，31： | 1 |
| 18 | 查看详情显示文摘 | Hopt UT Drognitz O | | 0，，： | 1 |
| 19 | Comparison of various methods of surgical hernia repair显示文摘 | Benz S Hopt UT | 2005 | MMW Fortschr Med2005，147，： | 1 |
| 20 | White-matter integrity predicts stroop performance in pa-tients with geriatric depression显示文摘 | Murphy CF Gunning-Dixon FM Hopt man MJ | 2007 | Biol Psychiatry2007，61，： | 1 |
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