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| 1 | Risk of recurrence of primary sclerosing cholangitis after liver transplantation is associated with de novo inflammatory bowel disease显示文摘AIM To evaluate risk factors for primary sclerosing cholangitis(PSC) recurrence(rPSC) after orthotopic liver transplantation(OLT) in patients with well-preserved colons. METHODS We retrospectively evaluated the medical records of all patients transplanted for PSC in our center between July 1994 and May 2015 and selected 47 with followup of at least 60 mo for further analysis based on strict inclusion and exclusion criteria. rPSC was confirmed by magnetic resonance or endoscopic retrograde cholangiopancreatography and liver biopsy. All patients were evaluated by protocolary pre-OLT colonoscopy with randomized mucosal biopsies. Colonoscopy was repeated annually after OLT. Both organ donors and recipients were human leukocyte antigen(HLA) typed by serological and/or DNA methods. All input data were thoroughly analyzed employing relevant statistical methods.RESULTS Altogether, 31 men and 16 women with a median(range) age of 36(15-68) years at the time of OLT and a median follow-up of 122(60-249) mo were included. rPSC was confirmed in 21/47(44.7%) of patients, a median 63(12-180) mo after transplantation. De novo colitis [rPSC in 11/12, P ≤ 0.05, hazard ratio(HR): 4.02, 95% confidence interval(CI): 1.58-10.98] and history of acute cellular rejection(rPSC in 14/25, P ≤ 0.05; HR: 2.66, 95%CI: 1.03-7.86) showed strong positive associations with rPSC. According to the univariate analysis, overlapping features of autoimmune hepatitis(r PSC in 5/5, P ≤ 0.05) and HLA-DRB1*07 in the donor(r PSC in 10/15, P ≤ 0.05) represent other potential risk factors for rPSC, while the HLA-DRB1*04(rPSC in 0/6, P ≤ 0.05), HLA-DQB1*03(rPSC in 1/11, P ≤ 0.05), and HLA-DQB1*07(rPSC in 0/7, P ≤ 0.05) recipient alleles may have protective roles.CONCLUSION De novo colitis and acute cellular rejection are clinical conditions significantly predisposed towards recurrence of PSC after liver transplantation. | Lukas Bajer Antonij Slavcev Peter Macinga Eva Sticova Jan Brezina Matej Roder Radim Janousek Pavel Trunecka Julius Spicak Pavel Drastich | 2018 | World Journal of Gastroenterology2018，24，43： | 4 |
| 2 | Brain metastasis in advanced colorectal cancer: results from the South Australian metastatic colorectal cancer (SAmCRC) registry显示文摘Objective:Brain metastasis is considered rare in metastatic colorectal cancer(mCRC);thus,surveillance imaging does not routinely include the brain.The reported incidence of brain metastases ranges from 0.6% to 3.2%.Methods:The South Australian mCRC Registry(SAmCRC)was analyzed to assess the number of patients presenting with brain metastasis during their lifetime.Due to small numbers,a descriptive analysis is presented.Results:Only 59 patients of 4,100 on the registry at the time of analysis had developed brain metastasis(1.4%).The clinical characteristics of those with brain metastasis were as follows:the median age was 65.3 years and 51% were female.Where the V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog(KRAS)mutation status of the tumor was known,the majority harbored a KRAS mutation(55%);31(53%)underwent craniotomy and 55(93%)underwent whole-brain radiotherapy.The median survival time from diagnosis of brain metastasis was 4.2 months(95% confidence interval 2.9–5.5).Patients who underwent craniotomy and radiotherapy had superior survival compared to those who underwent whole-brain radiotherapy(8.5 months vs.2.2 months,respectively).Data from the SAmCRC(a population-based registry)confirm that brain metastases are rare and the median time to development is approximately 2 years.Conclusions:Brain metastasis is a rare outcome in advanced CRC.Patients within the registry tended to be female,young in age,and harbored with higher rates of KRAS mutations.Whether routine surveillance brain scanning should be considered remains controversial given the relative rarity of developing brain metastases in mCRC and ultimately,most patients with central nervous system involvement die from their extracranial disease. | Gonzalo Tapia Rico Timothy J. Price Christos Karapetis Cynthia Piantadosi Rob Padbury Amitesh Roy Guy Maddern James Moore Scott Carruthers David Roder Amanda R. Townsend | 2017 | Cancer Biology & Medicine2017，14，4： | 3 |
| 3 | A microsatellite map of wheat显示文摘 | Roder M S KorzunV Wendehake K | 1998 | Genetics1998，149，： | 2 |
| 4 | Epidemiology of neuroendocrine cancers in an Australian population显示文摘 | Colin Luke Timothy Price Amanda Townsend Christos Karapetis Dusan Kotasek Nimit Singhal Elizabeth Tracey David Roder | 2010 | Cancer Causes & Control2010，，6： | 2 |
| 5 | A microsatellite map of wheat显示文摘 | Roder M S Korzun V Wendehake K | 1998 | Genetics1998，149，4： | 2 |
| 6 | The epidemiology of gastric cancer显示文摘 | David M. Roder | 2002 | Gastric Cancer2002，，1： | 2 |
| 7 | Synthesis of oligonucleotide funetionalized magnetic nanoparticles and study on their in vitro cell uptake显示文摘 | Wagner K Kautz A Roder M | 2004 | Appl Organometal Chem2004，18，： | 1 |
| 8 | A microsatellite map of wheat显示文摘 | Roder MS Korzun V Wendehake K | 1998 | Genetics1998，149，： | 1 |
| 9 | Factors predictive of corneal graft survival:report fromo the Australian corneal graft registry显示文摘 | WILLIAMS KA RODER D ESTERMAN A | 1992 | Ophthalmology1992，99，： | 1 |
| 10 | Prognostic Factors in Gastric Carcinoma:Result s of the German Gastric Carcinoma Study 1992显示文摘 | RODER J D BOTTCHER K SIEWERT J R | 1993 | Cancer1993，72，8： | 1 |
| 11 | Acoustic noise source modeling based on microphone array measurement显示文摘 | Brühl S Roder A | 2000 | Journal of Sound and Vibration2000，231，3： | 1 |
| 12 | A microsatellite map of wheat显示文摘 | Roder M S Korzun V Wendehake K | 1998 | Genetic1998，149，： | 1 |
| 13 | Learning and memory in S100-βtransgenic mice:an analysis of impaired and preserved function显示文摘 | Winocur G Roder J Lobaugh N | 2001 | Neurobiol Learn Mem2001，75，2： | 1 |
| 14 | Stented versus non- stented pancreaticojejunostomy after pancreatoduodeneetomy: a prospective study显示文摘 | Roder JD Stein HJ B? ttcher KA | 1999 | Ann Surg1999，229，1： | 1 |
| 15 | Frequencies and sequence charateristics of di-, tri-, and tetranucleo-cide microsatellites in wheat显示文摘 | Ma Z Q Roder M S Sorrells M E | 1996 | Genome1996，39，： | 1 |
| 16 | Vaccination withmage-3A1 peptide-pulsed mature, monocyte-derived dendritic cells expands specific cytotoxic T cells and induces regression of some metastases in advanced stage IV melanoma显示文摘 | Haendle I Roder C | 1999 | J Exp Med1999，190，11： | 1 |
| 17 | MS Detection of genetic diversity in closely elated breed wheat using microsatellite markers显示文摘 | GANAL M W RODER M S | 1995 | Theor Appl Genet1995，91，： | 1 |
| 18 | Reasons for Improved Survival From Ovarian Cancer in New South Wales, Australia, Between 1980 and 2003 Implications for Cancer Control 显示文摘 | Traeey EA Roder DM | 2009 | Int J Gynecol Cancer2009，19，4： | 1 |
| 19 | Construction and analysis of a microsatellite-based database of European wheat varieties显示文摘 | Roder M S Wendehake K Korzun V | 2002 | Theoretical and Applied Genetics2002，，106： | 1 |
| 20 | Disseminated intravascular coagulation: clinical and laboratory aspects显示文摘 | Carey MJ Roders GM | 1998 | Am J Hematol1998，59，1： | 1 |
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