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| 1 | Hepatocellular carcinoma in patients with autoimmune hepatitis显示文摘AIM: To evaluate and confirm the low incidence of hepatocellular carcinoma (HCC) in patients with autoimmune hepatitis (AIH). At present only very few cases of HCC in patients with AIH and definite exclusion of chronic viral hepatitis have been published, suggesting that HCC due to AIH is rare. METHODS: In order to further investigate the incidence of HCC in patients with AIH, we reviewed our large cohort of 278 patients with AIH. RESULTS: Eighty-nine patients (32%) were diagnosed with liver cirrhosis, a preneoplastic condition for HCC. We studied a total of 431 patient years of cirrhosis in these patients, an average 4.8 years per patient. During this period none of the patients of our own study cohort developed HCC. However, three patients with HCC due to AIH associated liver cirrhosis were referred to our department for further treatment of HCC. In all three patients chronic viral hepatitis was excluded. CONCLUSION: We conclude that HCC may under rare circumstances develop due to chronic AIH dependent liver cirrhosis. Compared to other causes of liver cirrhosis such as chronic viral hepatitis, alcohol, or hemochromatosis, the incidence of HCC is significantly lower. Pathophysiological differences between AIH and chronic viral hepatitis responsible for differences in the incidence of HCC are yet to be further characterized and may lead to new therapeutic concepts in prevention and treatment of liver cancer. | Andreas Teufel Arndt Weinmann Catherine Centner Anja Piendl Ansgar W Lohse Peter R Galle Stephan Kanzler | 2009 | World Journal of Gastroenterology2009，15，5： | 5 |
| 2 | Toxoplasma gondii : from animals to humans显示文摘 | Astrid M Tenter Anja R Heckeroth Louis M Weiss | 2000 | International Journal for Parasitology2000，，12： | 4 |
| 3 | Infectious, atopic and inflammatory diseases, childhood adversities and familial aggregation are independently associated with the risk for mental disorders: Results from a large Swiss epidemiological study显示文摘AIM To examine the associations between mental disorders and infectious, atopic, inflammatory diseases while adjusting for other risk factors.METHODS We used data from PsyC oL aus, a large Swiss Population Cohort Study(n = 3720; age range 35-66). Lifetime diagnoses of mental disorders were grouped into the following categories: Neurodevelopmental, anxiety(early and late onset), mood and substance disorders. They were regressed on infectious, atopic and other inflammatory diseases adjusting for sex, educational level, familial aggregation, childhood adversities and traumatic experiences in childhood. A multivariate logistic regression was applied to each group of disorders. In a complementary analysis interactions with sex were introduced via nested effects. RESULTS Associations with infectious, atopic and other chronic inflammatory diseases were observable together with consistent effects of childhood adversities and familial aggregation, and less consistent effects of trauma in each group of mental disorders. Streptococcal infections were associated with neurodevelopmental disorders(men), and measles/mumps/rubella-infections with early and late anxiety disorders(women). Gastric inflammatory diseases took effect in mood disorders(both sexes) and in early disorders(men). Similarly, irritable bowel syndrome was prominent in a sex-specific way in mood disorders in women, and, moreover, was associated with early and late anxiety disorders. Atopic diseases were associated with late anxiety disorders. Acne(associations with mood disorders in men) and psoriasis(associations with early anxiety disorders in men and mood disorders in women) contributed sex-specific results. Urinary tract infections were associated with mood disorders and, in addition, in a sex-specific way with late anxiety disorders(men), and neurodevelopmental and early anxiety disorders(women).CONCLUSION Infectious, atopic and inflammatory diseases areimportant risk factors for all groups of mental disorders. The sexual dimorphism of the associations is pronounced. | Vladeta Ajdacic-Gross Aleksandra Aleksandrowicz Stephanie Rodgers Margot Mutsch Anja Tesic Mario Müller Wolfram Kawohl Wulf R?ssler Erich Seifritz Enrique Castelao Marie-Pierre F Strippoli Caroline Vandeleur Roland von K?nel Rosa Paolicelli Markus A Landolt Cornelia Witthauer Roselind Lieb Martin Preisig | 2016 | World Journal of Psychiatry2016，6，4： | 2 |
| 4 | Genetic association of autoimmune hepatitis and human leucocyte antigen in German patients显示文摘AIM: To report on our large German collective and updated data of 142 patients with autoimmune hepatitis (AIH) type 1. METHODS: Key investigations performed were liver biopsy, serum autoantibodies as well as serum markers such as IgG and elevated transaminases. Antinuclear antigen (ANA) and smooth muscle antigen (SMA) autoantibodies characterized type 1 AIH. Type 3 (AIH) was solely characterized by the occurrence of soluble liver antigen/liver-pancreas antigen (SLA/LP) autoantibodies either with or without ANA or SMA autoantibodies. RESULTS: Most prevalent HLAs were A2 (68 patients, 48%), B8 (63 patients, 44%), C7 (90 patients, 63%), DR3 (49 patients, 38%), DR4 (49 patients, 38%) and DQ2 (42 patients, 30%). Compared to the Italian and North American patients, we found fewer patients with a DQ2 subtype. Furthermore, the B8-DR3-DQ2 human leucocyte antigen (HLA) was also less prominent compared to the North American patients. However, prevalences of B8, DR3, DR4, DR7, DR11 and DR13 were comparable to the Italian and North American patients. Furthermore, we report on an additional subgroup of patients with SLA/LP positive AIH. Generally, in this subgroup of patients the same HLA subtypes were favoured as the AIH type 1. CONCLUSION: Although HLA subtypes were comparable between these three collectives, the German patients were distinct from the Italian and North American patients with respect to DQ2 and from the North American patients with respect to B8-DR3-DQ2HLA. A clinical correlation, e.g. difference in severity or treatability of AIH type 1, has yet to be determined. | Andreas Teufel Markus Wrns Arndt Weinmann Catherine Centner Anja Piendl Ansgar W Lohse Peter R Galle Stephan Kanzler | 2006 | World Journal of Gastroenterology2006，12，34： | 2 |
| 5 | A Reverse J-Shaped Association Between Serum 25-Hydroxyvitamin D and Cardiovascular Disease Mortality: The CopD Study显示文摘 | Darshana Durup Henrik L?vendahl J?rgensen Jane Christensen Anne Tj?nneland Anja Olsen Jytte Halkj?r Bent Lind Anne-Marie Heegaard Peter Schwarz | 2015 | The Journal of Clinical Endocrinology & Metabolism2015，，6： | 1 |
| 6 | Recent advances in membrane bioreactors ( MBRs ) : Membrane fouling and membrane material 显示文摘 | Meng F G Chae S R Anja D | 2009 | Water Res2009，43，6： | 1 |
| 7 | Usefulness of noninvasive cardiac imaging nsing dual-source computed tomography in an unselected population with high prevalence of coronary artery disease显示文摘 | Martin H Christof B Anja R | 2007 | Am J Cardiol2007，100，4： | 1 |
| 8 | The impact of seP, iceseape on quality percep- tion显示文摘 | Anja R Kuehn R | 2005 | European Journal of Marketing2005，39，78： | 1 |
| 9 | Gas permeability and free volume in poly(amide-b-ethylene oxide)/polyethylene glycol blend membranes显示文摘 | Wilfredo Yave Anja Car Klaus-Viktor Peinemann Muhammed Q. Shaikh Klaus R?tzke Franz Faupel | 2009 | Journal of Membrane Science2009，，1： | 1 |
| 10 | Acquisition of rifabutin resistance by a rifampicin resistant mutant of Mycobacterium tuberculosis involves an unusual spectrum of mutations and elevated frequency 显示文摘 | Richard M A Anja R J Indra L B | 2005 | Annals of Clinical Microbiology and Antimicrobials2005，4，2： | 1 |
| 11 | A globin gene of ancient evolutionary origin in lower vertebrates:evidence for two distinct globin families in animals显示文摘 | Anja R Christine F Thomas H | 2005 | Mol Biol Evol2005，22，1： | 1 |
| 12 | Neonatal outcome in Danish national cohort of 3438 IVF/ICSI and 10362 non-IVF/ICSI twins born between twin 1995 and 2000显示文摘 | Anja P Anne L Steen R | 2004 | Hun Reprod2004，19，2： | 1 |
| 13 | Usefulness of noninvasive car diac imaging using dual-source computed tomography in an unselect ed population with high prevalence of coronary artery disease 显示文摘 | Martin H Christof B Anja R | 2007 | Am J Cardiol2007，100，4： | 1 |
| 14 | A conceptual framework for the definition of the optimal width of riparian forests 显示文摘 | Gerd S Simone B L R Anja G | 2002 | Agriculture Ecosystems and Environment2002，90，2： | 1 |
| 15 | Molecular and immunological characterisatlon of the glucose regulated protein 78 of Leishmania donovani显示文摘 | Anja T R Jensen Joan Curtis Jacqui Montgomery | 2001 | Biochimica et Biophysica Acta2001，1549，： | 1 |
| 16 | Functional characterization of the lectin pathway of complement in human serum显示文摘 | Anja R Lee HB Jeric M | 2003 | Molecular Immunology2003，39，65： | 1 |
| 17 | Effects of long - term use of video - communication technologies on the con- versational process 显示文摘 | VAN DER KLEIJ R PAASHUIS R M ANJA J J L | 2004 | Cognition Technology & Work2004，6，1： | 1 |
| 18 | Dual-source computed tomography : advances of improved temporal resolution in coronary plaque imaging 显示文摘 | Anja JR Daniel R Ayser BA | 2007 | Invest Radiol2007，42，3： | 1 |
| 19 | Neonatal outcome in a danishnational cohort of 3438 IVF/ICSI and 10362 non-IVF/ICSI twins born between 1995 and 2000显示文摘 | Anja P Anne L Steen R | 2004 | Hum Re prod2004，19，2： | 1 |
| 20 | RORγt+ hematopoietic cells are necessary for tumor cell proliferation during colitis‐associated tumorigenesis in mice显示文摘 | Maria Martin Rebecca K. Kesselring Balam Saidou Stefan M. Brunner Gabriela Schiechl Verena F. Mouris Anja K. Wege Petra Rümmele Hans J. Schlitt Edward K. Geissler Stefan Fichtner‐Feigl | 2015 | Eur. J. Immunol2015，，6： | 1 |
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