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| 1 | Hepatitis B virus is degraded by autophagosome-lysosome fusion mediated by Rab7 and related components显示文摘Dear Editor,With an estimated 240 million chronically infected people worldwide,hepatitis B virus(HBV)infection is a major public health problem(Schweitzer et al.,2015).Despite more than 30 years of in tense research,many aspects of the HBV life cycle still remain unknown. | Yong Lin Chunchen Wu Xueyu Wang Thekla Kemper Anthony Squire Matthias Gunzer Jiming Zhang Xinwen Chen Mengji Lu | 2019 | Protein & Cell2019，10，1： | 5 |
| 2 | Big earth data analytics on Sentinel-1 and Landsat imagery in support to global human settlements mapping显示文摘Continuous global-scale mapping of human settlements in the service of international agreements calls for massive volume of multi-source,multi-temporal,and multi-scale earth observation data.In this paper,the latest developments in terms of processing big earth observation data for the purpose of improving the Global Human Settlement Layer(GHSL)data are presented.Two experiments with Sentinel-1 and Landsat data collections were run leveraging on the Joint Research Centre Earth Observation Data and Processing Platform.A comparative analysis of the results of built-up areas extraction from different remote sensing data and processing workflows shows how the information production supported by data-intensive computing infrastructure for optimization and multiple testing can improve the output information reliability and consistency within the GHSL scope.The paper presents the processing workflows and the results of the two main experiments,giving insights into the enhanced mapping capabilities gained by analyzing Sentinel-1 and Landsat data-sets,and the lessons learnt in terms of handling and processing big earth observation data. | Christina Corbane Martino Pesaresi Panagiotis Politis Vasileios Syrris Aneta JFlorczyk Pierre Soille Luca Maffenini Armin Burger Veselin Vasilev Dario Rodriguez Filip Sabo Lewis Dijkstra Thomas Kemper | 2017 | Big Earth Data2017，1，1： | 3 |
| 3 | Automated global delineation of human settlements from 40 years of Landsat satellite data archives显示文摘This paper presents the analysis of Earth Observation data records collected between 1975 and 2014 for assessing the extent and temporal evolution of the built-up surface in the frame of the Global Human Settlement Layer project.The scale of the information produced by the study enables the assessment of the whole continuum of human settlements from rural hamlets to megacities.The study applies enhanced processing methods as compared to the first production of the GHSL baseline data.The major improvements include the use of a more refined learning set on built-up areas derived from Sentinel-1 data which allowed testing the added-value of incremental learning in big data analytics.Herein,the new features of the GHSL built-up grids and the methods are described and compared with the previous ones using a reference set of building footprints for 277 areas of interest.The results show a gradual improvement in the accuracy measures with a gain of 3.6% in the balanced accuracy,between the first production of the GHSL baseline and the latest GHSL multitemporal built-up grids.A validation of the multitemporal component is also conducted at the global scale establishing the reliability of the built-up layer across time. | Christina Corbane Martino Pesaresi Thomas Kemper Panagiotis Politis Aneta J.Florczyk Vasileios Syrris Michele Melchiorri Filip Sabo Pierre Soille | 2019 | Big Earth Data2019，3，2： | 3 |
| 4 | Monoclonal Antibodies Against Lgr5 Identify Human Colorectal Cancer Stem Cells显示文摘 | Kristel Kemper Pramudita R. Prasetyanti Wim De Lau Hans Rodermond Hans Clevers Jan Paul Medema | 2012 | STEM CELLS2012，，11： | 2 |
| 5 | Shot-noise limited, supercontinuum-based optical coherence tomography显示文摘We present the first demonstration of shot-noise limited supercontinuum-based spectral domain optical coherence tomography(SD-OCT)with an axial resolution of 5.9μm at a center wavelength of 1370 nm.Current supercontinuumbased SD-OCT systems cannot be operated in the shot-noise limited detection regime because of severe pulse-topulse relative intensity noise of the supercontinuum source.To overcome this disadvantage,we have developed a low-noise supercontinuum source based on an all-normal dispersion(ANDi)fiber,pumped by a femtosecond laser.The noise performance of our 90 MHz ANDi fiber-based supercontinuum source is compared to that of two commercial sources operating at 80 and 320 MHz repetition rate.We show that the low-noise of the ANDi fiber-based supercontinuum source improves the OCT images significantly in terms of both higher contrast,better sensitivity,and improved penetration.From SD-OCT imaging of skin,retina,and multilayer stacks we conclude that supercontinuumbased SD-OCT can enter the domain of shot-noise limited detection. | Shreesha Rao D.S. Mikkel Jensen Lars Grüner-Nielsen Jesper Toft Olsen Peter Heiduschka Björn Kemper Jürgen Schnekenburger Martin Glud Mette Mogensen Niels Møller Israelsen Ole Bang | 2021 | Light(Science & Applications)2021，10，7： | 2 |
| 6 | Incidence and Morphology of the Posteromedial Fragment in Bicondylar Tibial Plateau Fractures显示文摘 | Thomas F Higgins Dan Kemper Joshua Klatt | 2009 | Journal of Orthopaedic Trauma2009，，1： | 2 |
| 7 | Monoclonal Antibodies Against Lgr5 Identify Human Colorectal Cancer Stem Cells显示文摘 | Kristel Kemper Pramudita R. Prasetyanti Wim De Lau Hans Rodermond Hans Clevers Jan Paul Medema | 2012 | STEM CELLS2012，，11： | 2 |
| 8 | Veterinary antibiotics in the aquatic and terrestrial environment显示文摘 | Nicole Kemper | 2007 | Ecological Indicators2007，，1： | 2 |
| 9 | Parameter-optimized digital holographic microscope for high resolution living-cell analysis显示文摘 | Carl D Kemper B Wernicke G | 2004 | Appl Opt2004，43，6： | 1 |
| 10 | Differential expression of granzymes A and B in human eytotoxie lymphocyte subsets and T regulatory cells 显示文摘 | Grossman WJ Verbsky JW Tollefsen BL Kemper C Atkinson JP Ley TJ | 2004 | Blood2004，104，9： | 1 |
| 11 | Weight-bearing activity during youth is a more important factor for peak bone mass than calcium intake显示文摘 | Welten D C Kemper H C Post G B | 1994 | J Bone Miner Res1994，9，7： | 1 |
| 12 | Differential effects of high-frequency repetitive transcranial magnet- ic stimulation over ipsilesional primary motor cortex in cortical and subcortical middle cerebral artery stroke 显示文摘 | Ameli M Grefkes C Kemper F | 2009 | AnnNeurol2009，66，3： | 1 |
| 13 | Tracking of risk factors for coronary heart disease over a 14-year period:A comparison between lifestyle and biologic risk factors with data from the Amsterdam Growth and Health Study显示文摘 | TWISK JW KEMPER HC VAN MECHELEN W | 1997 | Am J Epidemic1997，14，5： | 1 |
| 14 | Prognosis of antenatally diagnosed oligohydramnios of renal origin显示文摘 | Kemper MJ Mueller-Wiefel DE | 2007 | Eur J Pediatr2007，166，5： | 1 |
| 15 | Diffusion of Salts in Clay-Water Systems 显示文摘 | KEMPER W J VAN SCHAIK | 1966 | Soil Science Society of America Journal1966，30，5： | 1 |
| 16 | Reducing chest in- juries in automobile collisions: rib fracture timing and implica- tions for thoracic injury criteria显示文摘 | Kemper AR Kennedy EA McNally C | 2011 | Ann Biomcd Eng2011，39，8： | 1 |
| 17 | Exploiting early sorting and early partitioning for decision support query processing显示文摘 | Claussen J Kemper A Kossmann D | 2000 | The VLDB Journal2000，9，3： | 1 |
| 18 | The timing of normalization of GA-125 levels during primary chemotherapy is predictive of survival in patients with epithelial ovarian cancer显示文摘 | Rocconi RP Matthews KS Kemper MK | 2009 | Gynecol Oncol2009，114，2： | 1 |
| 19 | Evaluation of the deep venous system in patients with suspected pulmonary em- bolism with multi-detector CT: a prospective study in compari- son to Doppler sonography显示文摘 | Begemann PG Bonaeker M Kemper J | 2003 | J Comput Assist Tomogr2003，27，： | 1 |
| 20 | Systematic review: diagnostic procedures to differentiate unilateral from bilateral adrenal abnormality in primary aldosteronism显示文摘 | Kempers MJ Lenders JW van OL | 2009 | Ann Intern Med2009，151，： | 1 |
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