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| 1 | Transarterial chemoembolization using degradable starch microspheres and iodized oil in the treatment of advanced hepatocellular carcinoma: evaluation of tumor response, toxicity, and survival显示文摘BACKGROUND: In a multidisciplinary conference patients with advanced non-resectable hepatocellular carcinoma (HCC) were stratified according to their clinical status and tumor extent to different regional modalities or to best supportive care. The present study evaluated all patients who were stratified to repeated transarterial chemoembolization (TACE) from 1999 until 2003 in terms of tumor response, toxicity, and survival. A moderate embolizing approach was chosen using a combination of degradable starch microspheres (DSM) and iodized oil (Lipiodol) in order to combine anti-tumoral efficiency and low toxicity. METHODS: Fourty-seven patients were followed up prospectively. TACE treatment consisted of cisplatin (50 mg/m2), doxorubicin (50 mg/m2), 450-900 mg DSM, and 5-30 ml Lipiodol. DSM and Lipiodol were administered according to tumor vascularization. Patient characteristics,toxicity, and complications were outlined. In multivariate regression analyses of pre-treatment variables from a prospective database, predictors for tumor response and survival after TACE were determined. RESULTS: 112 TACE courses were performed (2.4±1.5 courses per patient). Mean maximum tumor size was 75 (± 43) mm, in 68% there was bilobar disease. Best response to TACE treatment was: progressive disease (PD) 9%, stable disease (SD) 55%, partial remission (PR) 36%, and complete remission (CR) 0%. Multivariate regression analyses identified tumor size ≤75 mm, tumor number ≤5, and tumor hypervascularization as predictors for PR. The overall 1-, 2-, and 3-year-survival rates were 75%, 59%, and 41%, respectively, and the median survival was 26 months. Low α-fetoprotein levels (<400 ng/ml) (Odds ratio=3.3) and PR as best response to TACE (Odds ratio=6.7) were significantly associated with long term survival (>30 months, R2=36%). Grade 3 toxicity occurred in 7.1% (n=8), and grade 4 toxicity in 3.6% (n=4) of all courses in terms of reversible leukopenia and thrombocytopenia. The incidence of major complications was 5.4% (n=6). All complications were managed conservatively. The mortality within 6 weeks after TACE was 2.1% (one patient). CONCLUSIONS: DSM and Lipiodol were combined successfully in the palliative TACE treatment of advanced HCC resulting in high rates of tumor response and survival at limited toxicity. Favourable tumor response was associated with tumor extent and vascularization. TACE using DSM and Lipiodol can be considered a suitable palliative measure in patients who might not tolerate long acting embolizing agents. | Timm D Kirchhoff Joerg S Bleck Arne Dettmer Ajay Chavan Herbert Rosenthal Sonja Merkesdal Bernd Frericks Lars Zender Nisar P Malek Tim F Greten Stefan Kubicka Michael P Manns Michael Galanski | 2007 | Hepatobiliary & Pancreatic Diseases International2007，6，3： | 15 |
| 2 | Combination of repeated single-session percutaneous ethanol injection and transarterial chemoembolisation compared to repeated single-session percutaneous ethanol injection in patients with non-resectable hepatocellular carcinoma显示文摘瞄准:为病人评估经皮的乙醇注射(PEI ) 的治疗效果与先进, non-resectable HCC 与 transarterial chemoembolisation 的联合相比(不作声) 并且重复单个会议的 PEI,独自重复了单个会议的 PEI,重复不作声独自一个,或最好的支持的照顾。方法:在学习时期期间接受了 PEI 治疗的所有病人根据物理地位和肿瘤程度被包括并且成层到下列治疗形式之一:联合不作声并且重复单个会议的 PEI,独自重复了单个会议的 PEI,重复不作声独自一个,或最好的支持的照顾。包括Okuda分类,门静脉血栓的存在,腹水的存在,肿瘤的数字,最大的肿瘤直径,和假胆硷酯酶( CHE )的临床的参数的预示的价值,以及孩子呸上演, alpha-fetoprotein (法新社),发烧,复杂并发症的发生在这些组之间被估计并且比较。幸存用 Kaplan-Meier 被决定,多,变量回归分析。结果:所有病人的 1 年、 3 年的幸存是 73% 和 47% 。在亚群分析,联合不作声, PEI (1 ) 与更长的幸存被联系(1- , 3- , 5 年的幸存:90% , 52% ,和 43%) 与 PEI 治疗相比独自一个(2 )(1- , 3- , 5 年的幸存:65% , 50% ,和 37%) 。(3 ) 在起始的层化以后的第二等的 PEI 产出可比较的结果不作声(1- , 3- , 5 年的幸存:91% , 40% ,和 30%) 当在到最好的支持的照顾(4 ) 的层化以后的 PEI 与减少的幸存被联系时(1- , 3- , 5 年的幸存:50% , 23% , 12%) 。除了选择治疗形式,为更好的幸存的预言者是肿瘤数字(n <
5 ) ,肿瘤尺寸(<
5 厘米) ,在 PEI 前的没有腹水,和在 PEI 以后的稳定的假胆硷酯酶(P <
0.05 ) 。在在 PEI 以后的 2 wk 以内的死亡是 2.8%(n = 3 ) 。有 24 (8.9%) 主修在包括部分肝梗塞,焦点的肝坏死,和肝脓肿的 PEI 以后的复杂并发症。所有复杂并发症能非通过手术被管理。结论:重复单个会议的 PEI 在有以可接受、可管理的复杂并发症率的先进 HCC 的病人是有效的。病人们成层到联合不作声, PEI 能比那些独自成层到重复 PEI 期望更长的幸存。而且,有在好临床的地位的大或多重的肿瘤的病人可以也从联合获利不作声并且为第二等的 PEI 的再考虑。 | Arne Dettmer Timm D Kirchhoff Michael Gebel Lars Zender Nisar P Malek Bernhard Panning Ajay Chavan Herbert Rosenthal Stefan Kubicka Susanne Krusche Sonja Merkesdal Michael Galanski Michael P Manns Joerg S Bleck | 2006 | World Journal of Gastroenterology2006，12，23： | 14 |
| 3 | 形成性评价(Formative Assessment)的本质及其对教与学的影响显示文摘长期以来,很多学者一直倡导指导教学的评价,即通过评估学生需求和监测其学习进展,适当地设计学习顺序,调整教学策略,改良学习计划,以便有效地促进学习目标的完成。本研究调查了形成性评价在美国中学科学课中的实施情况,并分析其对学生学习进步的影响。研究表明,教师都在努力使用形成性评价来指导教学,而学生取得的成绩各不相同。 | Joan L.Herman Ellen Osmundson Carlos Ayala Stephen Schneider Mike Timms 杜承达 | 2010 | 考试研究2010，6，1： | 12 |
| 4 | Transcutaneous perianal sonography:A sensitive method for the detection of perianal inflammatory lesions in Crohn's disease显示文摘AIM: Pelvic magnetic resonance imaging (MRI) and endoanalultrasound which are established imaging methods forperianal inflammatory lesions in patients with Crohn'sdisease require expensive specialized equipments andexpertise. We investigated the feasibility and sensitivity oftranscutaneous perianal ultrasound (PAUS) using regularultrasound probes in the imaging of perianal inflammatorylesions. The sonographic findings were correlated to pelvicMRI-scans.METHODS: We performed PAUS in 25 patients with Crohn'sdisease and clinical signs of perianal inflammatory disease.VCChin a median of 10 d (range 0-75) these patients underwentMRI of the pelvis. Regular convex and linear high resolutionprobes were used for PAUS. The sonographic findings werecorrelated to the MRI findings by blinded investigators.RESULTS: The sonographic investigations were welltolerated by all patients. Fistulae typically presented ashypoechoic tracks. Twenty-nine fistulae were detected in22 patients. Abscesses were detected in 7 patients andpresented as hypo- or anechoic formations. Twenty-six of29 fistulae and 6 of 7 abscesses could be confirmed byMRI. Kappa statistics showed an excellent agreement(kappa>0.83) between the two imaging methods.CONCLUSION: PAUS is a simple, painless, feasible, real-time method that can be performed without specific patientpreparation which is comparable in its sensitivity to pelvicMRI in the detection of perianal fistulae and/or abscesses.PAUS can especially be recommended as a screening toolin acute perianal disorders such as perianal abscess andfor follow-up studies of perianal inflammatory disease. | Jochen Wedemeyer Timm Kirchhoff Gernot Sellge Oliver Bachmann Joachim Lotz Michael Galanski Michael P.Manns Michael J.Gebel Jrg S.Bleck | 2004 | World Journal of Gastroenterology2004，10，19： | 8 |
| 5 | 基于样方数据的云南松林分生长模型研究——以云南省保山市杨柳白族彝族乡为例显示文摘以云南省保山市杨柳白族彝族乡实地调查的86块云南松样地数据,使用非线性拟合的方法拟合优选常用树木生长方程,建立了包括地位指数、密度指数、平均直径和蓄积量的生长模型。经验生长方程Schumacher的拟合度与其它方程相近,但模型中参数变异系数均比其余方程低,为地位指数、平均直径和蓄积量的最优方程。 | 郎荣 许建初 Timm Tennigkeit 杨雪飞 毕迎凤 | 2011 | 植物分类与资源学报2011，33，3： | 8 |
| 6 | 俯冲板片中微量元素的活动性:西天山榴辉岩相运输脉的制约显示文摘西天山的基性高压变质岩显示互相连接的榴辉岩相脉体网络来源于蓝片岩的进变质脱水作用,通过这些网脉可以洞察在俯冲带高压条件下远程流体流动中的流体一岩石相互作用和元素负载。岩相学证据表明外来流体的渗透作用产生运输脉,而流体持续的沟道式流动导致主岩蓝片岩的淋滤。脉和蓝片岩蚀变带中锂(Li)的含量几乎是蓝片岩主岩中锂的两倍,它支持流体是外部来源的设想。这些流体触发了蓝片岩主岩的榴辉岩化作用而形成蓝片岩蚀变带。由于成脉流体中的微量元素含量低,所以导致与流体发生化学反应的主岩中所有微量元素的强烈淋滤。在此过程中有53%~81%的微量元素被活化,与大离子亲石元素和轻稀土元素的损失相符合,它们的损失量几乎是重稀土元素和高场强元素损失量的两倍。 | 熊贤明 Timm JOHN 高俊 Reiner KLEMD 黄德志 | 2006 | 地质学报2006，80，1： | 6 |
| 7 | Sequence diversity of hepatitis C virus: Implications for immune control and therapy显示文摘With approximately 3% of the world’s population (170 million people) infected with the hepatitis C virus (HCV), the WHO has declared HCV a global health problem. Upon acute infection about 50%-80% of subjects develop chronic hepatitis with viral persistence being at risk to develop liver cirrhosis and hepatocellular carcinoma. One characteristic of HCV is its enormous sequence diversity, which represents a significant hurdle to the development of both effective vaccines as well as to novel therapeutic interventions. Due to a polymerase that lacks a proofreading function HCV presents with a high rate of evolution, which enables rapid adaptation to a new environment including an activated immune system upon acute infection. Similarly, novel drugs designed to specifically inhibit viral proteins will face the potential problem of rapid selection of drug resistance mutations. This review focuses on the sequence diversity of HCV, the driving forces of evolution and the impact on immune control and treatment response. An important feature of any therapeutic or prophylactic intervention will be an efficient attack of a structurally or functionally important region in the viral protein. The understanding of the driving forces, but also the limits of viral evolution, will be fundamental for the design of novel therapies. | Joerg Timm Michael Roggendorf | 2007 | World Journal of Gastroenterology2007，13，36： | 5 |
| 8 | Analysis of the influence of groundwater and the stress regime on bolt behaviour in underground coal mines显示文摘The service failure of rock bolts and cable bolts are frequently reported issues in underground coal mines. Whilst numerous experimental investigations concerned with the service failure of bolts have been conducted, numerical modelling offers an alternative approach in evaluating the factors contributing to service failures of bolts in underground mines. In this study, analysis of the influence of groundwater and tensile stress on bolts in underground coal mines was studied through the numerical modelling of a grouted bolt in the immediate roadway roof. Bolt tensile stress and groundwater dripping rates in the immediate roadway roof were analysed using a package based on finite element method to assess the effect of coal roof thickness and claystone bands, as main contributors of known service failures of bolts in roadways of underground coal mines. Increasing coal roof thickness was found to increase bolt dripping rates. Probable location of stress corrosion cracking (SCC) occurrence was established through examining the shift and increase in maximum bolt tensile stress that was exhibited along the bolt length with increasing coal roof thickness. Claystone bands situated at the top and centre horizon of a grouted bolt produced lower bolt dripping rates compared with scenarios with no claystone bands. Intersecting claystone bands at the centre horizon of a bolt for a fully grouted bolt could increase the likelihood of SCC corrosion and bolt failure by contributing to microbial corrosion processes and grout fracturing by tensile stress. This study improves the understanding the bolt failure associated with the presence of groundwater and changing stress environments, which in turn is imperative in formulating strategies to mitigate support element failures and improve the ground support viability. | Jack A.Smith Hamed Lamei Ramandi Chengguo Zhang Wendy Timms | 2019 | International Journal of Coal Science & Technology2019，6，2： | 5 |
| 9 | Osteoprotegerin Ligand Is a Cytokine that Regulates Osteoclast Differentiation and Activation显示文摘 | D.L Lacey E Timms H.-L Tan M.J Kelley C.R Dunstan T Burgess R Elliott A Colombero G Elliott S Scully H Hsu J Sullivan N Hawkins E Davy C Capparelli A Eli Y.-X Qian S Kaufman I Sarosi V Shalhoub G Senaldi J Guo J Delaney W.J Boyle | 1998 | Cell1998，，2： | 4 |
| 10 | Is There a Metabolic Requirement for Photorespiratory Enzyme Activities in Heterotrophic Tissues?显示文摘Dear Editor, Photorespiration is an essential metabolic process in leaves that facilitates recovery of carbon lost by the oxygenase reaction of Rubisco and avoids the accumulation of the toxic product,2-phosphoglycolate (2PG) of this reaction (Bauwe et al.,2012).However,there is also evidence to suggest that photorespiration has a more complex role during normal growth than the mere detoxification of 2PG and the recovery of 3-phosphoglycerate (3PGA) (Bauwe et al.,2012).The current view is that photorespiration is an essential mechanism to maintain optimal photosynthesis,normal growth,and development of oxygenic photosynthetic organisms in an oxygen-containing environment (Bauwe et al.,2012). | Adriano Nunes-Nesi Alexandra Florian Andrew Howden Kathrin Jahnke Stefan Timm Hermann Bauwe Lee Sweetlove Alisdair R. Fernie | 2014 | Molecular Plant2014，7，1： | 3 |
| 11 | Initial experience from a combination of systemic and regional chemotherapy in the treatment of patients with nonresectable cholangiocellular carcinoma in the liver显示文摘AIM: In nonresectable cholangiocellular carcinoma (CCC)therapeutic options are limited. Recently, systemic chemotherapy has shown response rates of up to 30%.Additional regional therapy of the arterially hyper vascularized hepatic tumors might represent a rational approach in an attempt to further improve response and palliation. Hence, a protocol combining transarterial chemoembolization and systemic chemotherapy was applied in patients with CCC limited to the liver.METHODS: Eight patients (6 women, 2 men, mean age 62 years) with nonresectable CCC received systemic chemotherapy (gemcitabine 1 000 mg/m2) and additional transarterial chemoembolization procedures (50 mg/m2cisplatin, 50 mg/m2 doxorubicin, up to 600 mg degradable starch microspheres). Clinical follow-up of patients, tumor markers, CT and ultrasound were performed to evaluate maximum response and toxicity.RESULTS: Both systemic and regional therapies were tolerated well; no severe toxicity (WHO Ⅲ/Ⅳ) was encountered. Nausea and fever were the most commonly observed side effects. A progressive rarefication of the intrahepatic arteries limited the maximum number of chemoembolization procedures in 4 patients. A median of 2 chemoembolization cycles (range, 1-3) and a median of 6.5 gemcitabine cycles (range, 4-11) were administered.Complete responses were not achieved. As maximum response, partial responses were achieved in 3 cases,stable diseases in 5 cases. Two patients died from progressive disease after 9 and 10 mo. Six patients are still alive. The current median survival is 12 mo (range, 9-18); the median time to tumor progression is 7 mo (range, 3-18). Seven patients suffered from tumor-related symptoms prior to therapy, 3 of these experienced a treatment-related clinical relief. In one patient the tumor became resectable under therapy and was successfully removed after 10 mo.CONCLUSION: The present results indicate that a combination of systemic gemcitabine therapy and repeated regional chemoembolizations is well tolerated and may enhance the effect of palliation in a selected group of patients with intrahepatic nonresectable CCC. | Timm Kirchhoff Lars Zender Sonja Merkesdal Bernd Frericks Nisar Malek Joerg Bleck Stefan Kubicka Stefan Baus Ajay Chavan Michael P.Manns Michael Galanski | 2005 | World Journal of Gastroenterology2005，11，8： | 3 |
| 12 | Perioperative treatment options in resectable pancreatic cancer-how to improve long-term survival显示文摘Surgery remains the only chance of cure for pancreatic cancer, but only 15%-25% of patients present with resectable disease at the time of primary diagnosis. Important goals in clinical research must therefore be to allow early detection with suitable diagnostic procedures, to further broaden operation techniques and to determine the most effective perioperative treatment of either chemotherapy and/or radiation therapy. More extensive operations involving extended pancreatectomy, portal vein resection and pancreatic resection in resectable pancreatic cancer with limited liver metastasis, performed in specialized centers seem to be the surgical procedures with a possible impact on survival. After many years of stagnation in pharmacological clinical research on advanced pancreatic ductal adenocarcinomas(PDAC)- since the approval of gemcitabine in 1997- more effective cytotoxic substances(nab-paclitaxel) and combinations(FOLFIRINOX) are now available for perioperative treatment. Additionally, therapies with a broader mechanism of action are emerging(stroma depletion, immunotherapy, antiinflammation), raising hopes for more effective adjuvant and neoadjuvant treatment concepts, especially in the context of 'borderline resectability'. Only multidisciplinary approaches including radiology, surgery, medical and radiation oncology as the backbones of the treatment of potentially resectable PDAC may be able to further improve the rate of cure in the future. | Marianne Sinn Marcus Bahra Timm Denecke Sue Travis Uwe Pelzer Hanno Riess | 2016 | World Journal of Gastrointestinal Oncology2016，8，3： | 3 |
| 13 | Osteoprotegerin (OPG) ligand is a cytokine that regulates osteoclast differentiation and activation显示文摘 | Lacey DL Timms E Tan HL | | 0，，： | 3 |
| 14 | Oncological Superiority of Hilar En Bloc Resection for the Treatment of Hilar Cholangiocarcinoma显示文摘 | Peter Neuhaus Armin Thelen Sven Jonas Gero Puhl Timm Denecke Wilfried Veltzke-Schlieker Daniel Seehofer | 2012 | Annals of Surgical Oncology2012，，5： | 2 |
| 15 | Performance, structure, and mechanism of CeO 2 in HCl oxidation to Cl 2显示文摘 | Amol P. Amrute Cecilia Mondelli Maximilian Moser Gerard Novell-Leruth Núria López Dirk Rosenthal Ramzi Farra Manfred E. Schuster Detre Teschner Timm Schmidt Javier Pérez-Ramírez | 2011 | Journal of Catalysis2011，，： | 2 |
| 16 | A study of the salt lakes and salt springs of Eyre Peninsula, South Australia显示文摘 | Brian V. Timms | 2009 | Hydrobiologia2009，，1： | 2 |
| 17 | Salt Lakes in Australia: Present Problems and Prognosis for the Future显示文摘 | Brian V. Timms | 2005 | Hydrobiologia2005，，1： | 2 |
| 18 | Paediatric coblation tonsillectomy显示文摘 | R.H. Temple M.S. Timms | 2001 | International Journal of Pediatric Otorhinolaryngology2001，，3： | 2 |
| 19 | Analysis of Short-Term Metabolic Alterations in Arabidopsis Following Changes in the Prevailing Environmental Conditions显示文摘尽管我们有关到相反的 growthconditions 的新陈代谢的调整的重要性的知识的可观的增加最近被提供了,相对,很少对响应 fluctuationin 发生的调整被知道环境因素。评估发生在这样改变环境条件下面的新陈代谢的调整增加我们在是影响 bysuch 的主要小径之间的串音的当前的理解的好机会调节的 offersa。到这个目的,在正常条件下面成长的植物被转移到不同的光,温度 conditionswhich 被期望影响(在另外的过程之中) 光合作用和 photorespiration 和 characterizedat 的率跟随这转变的生理、分子、新陈代谢的层次。我们的结果揭示了类似的行为 inresponse 到处理并且与植物 metabolism.They 的小径进一步加亮的专业一起暗示 photorespiration 的一个紧密的连接这些小径的规定的多数没在叶新陈代谢是的 transcriptionbut 的水平被调停,这相当预先平衡在这些输入 parameters.Key 适应变化词: | Alexandra Florian Zoran Nikoloski Ronan Sulpice Stefan Timm Wagner L. Araujo Takayuki Tohge Hermann Bauwe Alisdair R. Fernie | 2014 | Molecular Plant2014，7，5： | 2 |
| 20 | Impact of remote ischemic preconditioning on wound healing in small bowel anastomoses显示文摘AIM: To investigate the influence of remote ischemic preconditioning (RIPC) on anastomotic integrity. METHODS: Sixty male Wistar rats were randomized to six groups. The control group (n = 10) had an end-to-end ileal anastomosis without RIPC. The preconditioned groups (n = 34) varied in time of ischemia and time of reperfusion. One group received the amino acid L-arginine before constructing the anastomosis (n = 9). On postoperative day 4, the rats were re-laparotomized, and bursting pressure, hydroxyproline concentration, intra-abdominal adhesions, and a histological score concerning the mucosal ischemic injury were collected. The data are given as median (range).RESULTS: On postoperative day 4, median bursting pressure was 124 mmHg (60-146 mmHg) in the control group. The experimental groups did not show a statistically significant difference (P > 0.05). Regarding the hydroxyproline concentration, we did not find any significant variation in the experimental groups. We detected significantly less mucosal injury in the RIPC groups. Furthermore, we assessed more extensive intra-abdominal adhesions in the preconditioned groups than in the control group. CONCLUSION: RIPC directly before performing small bowel anastomosis does not affect anastomotic stability in the early period, as seen in ischemic preconditioning. | Philipp Anton Holzner Birte Kulemann Simon Kuesters Sylvia Timme Jens Hoeppner Ulrich Theodor Hopt Goran Marjanovic | 2011 | World Journal of Gastroenterology2011，17，10： | 2 |
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