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| 1 | Toward Cloud Computing QoS Architecture:Analysis of Cloud Systems and Cloud Services显示文摘Cloud can be defined as a new computing paradigm that provides scalable, on-demand, and virtualized resources for users. In this style of computing, users can access a shared pool of computing resources which are provisioned with minimal management efforts of users. Yet there are some obstacles and concerns about the use of clouds. Guaranteeing quality of service(Qo S) by service providers can be regarded as one of the main concerns for companies tending to use it. Service provisioning in clouds is based on service level agreements representing a contract negotiated between users and providers. According to this contract, if a provider cannot satisfy its agreed application requirements, it should pay penalties as compensation. In this paper, we intend to carry out a comprehensive survey on the models proposed in literature with respect to the implementation principles to address the QoS guarantee issue. | Mohammad Hossein Ghahramani MengChu Zhou Chi Tin Hon | 2017 | IEEE/CAA Journal of Automatica Sinica2017，4，1： | 19 |
| 2 | Treatment of functional dyspepsia with sertraline:A double-blind randomized placebo-controlled pilot study显示文摘AIM:To evaluate sertraline,a selective serotonin reuptake inhibitor in the treatment of patients with functional dyspepsia.METHODS:Consecutive tertiary hospital patients with a clinical diagnosis of functional dyspepsia(FD) according to the Rome Ⅱ criteria with a Hong Kong dyspepsia index(HKDI) of greater than 16 were recruited.Patients commenced enrolment prior to the inception of the Rome Ⅲ criteria for functional dyspepsia.All patients were ethnic Chinese,had a normal upper endoscopy and were Helicobacter pylori negative prior to enrolment.Study patients were randomized to receive sertraline 50 mg or placebo daily for 8 wk.HKDI symptom scores,quality of life,hospital anxiety and depression(HAD) scale and global symptom relief were evaluated before,during and after treatment.Adverse effects were monitored during and after treatment.RESULTS:A total of 193 patients were randomized in the intention to treat(ITT),and 150 patients were included in the per protocol(PP) analysis.In both the ITT and PP,there was no difference in the primary outcome of global dyspepsia symptoms between the sertraline and placebo groups at week 8.In the ITT analysis,98 and 95 patients were randomized to the sertraline and placebo groups respectively.A total of 43 patients withdrew from the study(22.3%) by week 8,with 23 of the 24 drop-outs in the sertraline group occurring prior to week 4(95.8%).In contrast,in the placebo arm,11 of 19 patients dropped out by week 4(57.9%).Utilizing the last response carried forward to account for the drop-outs,there were no differences between the sertraline and placebo groups at baseline in terms of the HKDI,HKDI 26.08 ± 6.19 vs 26.70 ± 5.89,P = 0.433;and at week 8,HKDI 22.41 ± 6.36 vs 23.25 ± 7.30,P = 0.352 respectively.In the PP analysis,74 and 76 patients were randomized to the sertraline and placebo groups respectively.At baseline,there were no statistically significant differences between the sertraline and placebo groups,HKDI 25.83 ± 6.313 vs 27.19 ± 5.929 respectively,P = 0.233;however by week 8,patients in the sertraline group demonstrated a statistically significant difference in their Hong Kong Dyspepsia Index compared to placebo,HKDI 20.53 ± 6.917 vs 23.34 ± 7.199,P = 0.02,respectively).There was also no statistically significant difference in overall quality of life measures or the HAD scale related to treatment in either the ITT or PP analysis at week 8.CONCLUSION:This pilot study,the first to examine sertraline,a selective serotonin reuptake inhibitor,for the management of FD,did not find that it was superior to placebo. | Victoria PY Tan Tin K Cheung Wai M Wong Roberta Pang Benjamin CY Wong | 2012 | World Journal of Gastroenterology2012，18，42： | 14 |
| 3 | Angiogenesis effect of Astragalus polysaccharide combined with endothelial progenitor cells therapy in diabetic male rat following experimental hind limb ischemia显示文摘 | Tu Sheng Shao Anwen Ren Lihong Chen Tin Yao Dingguo | 2014 | Chinese Medical Journal2014，，11： | 13 |
| 4 | 盐分对广式高盐稀态酱油发酵微生物菌群结构的影响显示文摘随着健康中国计划的推进,酱油的减盐成为一种趋势,然而广式高盐稀态酱油发酵过程中盐分对不同发酵阶段的群落结构影响的基础研究仍较薄弱,难以支撑减盐酱油产品的普及。该研究基于Illumina HiSeq高通量基因序列分析及理化指标监测,研究不同盐分条件下不同发酵阶段微生物群落结构及理化指标变化规律。结果表明,低盐组(120 g/L)pH值最低,发酵后快速积累总酸、氨基酸态氮和还原糖;在细菌菌群结构方面,随着盐浓度降低,葡萄球菌属(Staphylococcus)、乳球菌属(Lactococcus)、乳杆菌属(Lactobacillus)均在低盐酱醪中持续增长;在真菌群落构成方面,假丝酵母属(Candida)和米勒氏酵母属(Millerozyma)含量在低盐组酱醪中明显较高。低盐(120 g/L)酱醪发酵中乳酸菌含量及总酸明显比中盐(150 g/L)及高盐(170 g/L)组较高,并在发酵初期快速形成了更加适合酵母菌目生长的酸性环境,促进酵母菌目在发酵中期形成了明显的优势菌群。该研究结果为减盐发酵提供了理论基础,为进一步开发酱油低盐发酵微生物调控技术提供参考依据。 | TIN Hoe Seng 周斌 侯莎 吴昌正 黄磊 周其洋 | 2022 | 食品与发酵工业2022，48，1： | 11 |
| 5 | A Hybrid Immigrants Scheme for Genetic Algorithms in Dynamic Environments显示文摘动态优化问题是随着时间的过去包含变化的一种优化问题。自从球门不再是寻找一个固定问题的最佳的答案,但是随着时间的过去追踪动人的最佳,他们提出严肃的挑战到传统的优化方法以及常规基因算法。动态优化问题在最近的年里从基因算法社区吸引了成长兴趣。几条途径被开发了在动态环境提高基因算法的表演。一条途径是经由随机的移民维持人口的差异。这篇论文建议联合精英统治,两重性和随机的移民的概念让基因算法处理动态优化问题的一个混合移民计划。在这个混合计划,最好的个人,即,精英,作为底从以前的产生和它的双个人被检索经由传统的变化计划创造移民。和一些随机的移民的这些基于精英统治、基于两重性的移民被代替进当前的人口,代替在人口的最糟的个人。这些三种移民试图分别地探讨细微、中等、重要的度的环境变化并且高效地因此使基因算法适应服从于变化的不同严厉的动态环境。基于一系列系统地构造的动态测试问题,实验被执行与混合移民计划和传统的随机的移民计划调查基因算法的表演。试验性的结果为在动态环境改进基因算法的表演验证建议混合移民计划的效率。关键词基因算法 - 随机的移民 - 基于精英统治的移民 - 两重性 - 动态优化问题这个工作被英国 EPSRC 支持(没有。EP/E060722/01 ) 并且巴西 FAPESP (Proc。04/04289-6 ) 。杨胜祥收到了 B.Sc。并且 M.Sc。在自动控制的学位和在从东北大学设计的系统的博士学位, P. R。在 1993, 1996 和 1999 的中国分别地。他是在计算机科学系的一个博士后的研究伙伴,从 1999 年 10 月的国王鈥檚 学院伦敦到 2000 年 10 月。他当前是在在累斯特的大学的计算机科学系的一个讲师,英国。他在书,杂志和会议出版了超过 50 篇论文。他有 co-guest-edited 为基因编程和可发展的机器的杂志的一期特刊并且共同编辑一本书在动态、不明确的环境的进化计算,在 2007 年 3 月出版了。他的当前的研究兴趣包括进化、基因的算法,为组合优化问题的人工的神经网络,安排问题,动态优化问题,和网络流动问题和算法。杨博士担任区域编辑,伙伴编辑和三本国际杂志的编委的成员。他是在动态、不明确的环境的进化计算上的工作组的一个成员,进化计算技术委员会, IEEE 计算智力社会(CIS ) 。他是 IEEE 和 ACM SIGEVO 的一个成员。Renato 听贸 s 收到了 B.Sc。在从 S 的州立大学的电力工程的度 ? o Paulo (UNESP ) ,在 1994 的巴西,和 M.Sc。并且在来自 S 的大学的电力工程的博士学位 ? 在 S 的 o Paulo (USP )? o 卡洛斯,在 1999 和 2003 的巴西分别地。他然后在 S 加入了 USP 的计算机科学系 ? o 卡洛斯作为一个研究科学家。他当前是在物理的系和在 Ribeir 的 USP 的数学的一个助教 ? o Preto。他的研究兴趣包括进化算法,动态优化,机器人学,容错,和神经网络。 | Shengxiang Yang Renato Tinós | 2007 | International Journal of Automation and computing2007，4，3： | 9 |
| 6 | To mask or not to mask:Modeling the potential for face mask use by the general public to curtail the COVID-19 pandemic显示文摘Face mask use by the general public for limiting the spread of the COVID-19 pandemic is controversial,though increasingly recommended,and the potential of this intervention is not well understood.We develop a compartmental model for assessing the communitywide impact of mask use by the general,asymptomatic public,a portion of which may be asymptomatically infectious.Model simulations,using data relevant to COVID-19 dynamics in the US states of New York and Washington,suggest that broad adoption of even relatively ineffective face masks may meaningfully reduce community transmission of COVID-19 and decrease peak hospitalizations and deaths.Moreover,mask use decreases the effective transmission rate in nearly linear proportion to the product of mask effectiveness(as a fraction of potentially infectious contacts blocked)and coverage rate(as a fraction of the general population),while the impact on epidemiologic outcomes(death,hospitalizations)is highly nonlinear,indicating masks could synergize with other nonpharmaceutical measures.Notably,masks are found to be useful with respect to both preventing illness in healthy persons and preventing asymptomatic transmission.Hypothetical mask adoption scenarios,for Washington and New York state,suggest that immediate near universal(80%)adoption of moderately(50%)effective masks could prevent on the order of 17e45%of projected deaths over two months in New York,while decreasing the peak daily death rate by 34e58%,absent other changes in epidemic dynamics.Even very weak masks(20%effective)can still be useful if the underlying transmission rate is relatively low or decreasing:InWashington,where baseline transmission is much less intense,80%adoption of such masks could reduce mortality by 24e65%(and peak deaths 15e69%),compared to 2e9%mortality reduction in New York(peak death reduction 9e18%).Our results suggest use of face masks by the general public is potentially of high value in curtailing community transmission and the burden of the pandemic.The community-wide benefits are likely to be greatest when face masks are used in conjunction with other non-pharmaceutical practices(such as social-distancing),and when adoption is nearly universal(nation-wide)and compliance is high. | Steffen E.Eikenberry Marina Mancuso Enahoro Iboi Tin Phan Keenan Eikenberry Yang Kuang Eric Kostelich Abba B.Gumel | 2020 | Infectious Disease Modelling2020，5，1： | 8 |
| 7 | Hepatitis B surface antigen levels during the natural history of chronic hepatitis B: A perspective on Asia显示文摘 | Tin Nguyen Alexander J.V. Thompson Scott Bowden Catherine Croagh Sally Bell Paul V. Desmond Miriam Levy Stephen A. Locarnini | 2010 | Journal of Hepatology2010，，4： | 7 |
| 8 | Efficacy and safety of tenofovir in chronic hepatitis B: Australian real world experience显示文摘AIM To evaluate the long-term treatment outcomes of tenofovir therapy in patients in a real world Australian tertiary care setting.METHODS We performed a retrospective analysis of treatment outcomes among treatment-na?ve and treatment-experienced patients receiving a minimum 3 mo tenofovir therapy through St Vincent's Hospital Melbourne, Australia. We included patients receiving tenofovir [tenofovir disoproxil fumarate(TDF)] monotherapy, as well as patients treated with TDF in combination with a second antiviral agent. Patients were excluded if they demonstrated human immune-deficiency virus/hepatitis C virus/hepatitis delta virus coinfection or were less than 18 years of age. We considered virological and biochemicalresponse, as well as safety outcomes. Virological response was determined by measurement of hepatitis B virus(HBV) DNA using sensitive assays; biochemical response was determined via serum liver function tests; histological response was determined from liver biopsy and fibroscan; safety analysis focused on glomerular renal function and bone mineral density. The primary efficacy endpoint was complete virological suppression over time, defined by HBV DNA < 20 IU/m L. Secondary efficacy endpoints included rates of biochemical response, and HB e antigen(HBe Ag)/HB surface antigen loss and seroconversion over time.RESULTS Ninety-two patients were identified who fulfilled the enrolment criteria. Median follow-up was 26 mo(range 3-114). Mean age was 46(24-78) years, 64(70%) were male and 77(84%) were of Asian origin. 55(60%) patients were treatment-na?ve and 62 patients(67%) were HBe Ag-negative. Complete virological suppression was achieved by 45/65(71%) patients at 12 mo, 37/46(80%) at 24 mo and 25/28(89%) at 36 mo. Partial virological response(HBV DNA 20-2000 IU/m L) was achieved by 89/92(96.7%) of patients. Multivariate analysis showed a significant relationship between virological suppression at end of follow-up and baseline HBV DNA level(OR = 0.897, 95%CI: 0.833-0.967, P = 0.0046) and HBe Ag positive status(OR = 0.373, 95%CI: 0.183-0.762, P = 0.0069). There was no difference in response comparing treatment-na?ve and treatment-experienced patients. Three episodes of virological breakthrough occurred in the setting of noncompliance. Tenofovir therapy was well tolerated.CONCLUSION Tenofovir is an efficacious, safe and well-tolerated treatment in an Australian real-world tertiary care setting. Our data are similar to the reported experience from registration trials. | Grace C Lovett Tin Nguyen David M Iser Jacinta A Holmes Robert Chen Barbara Demediuk Gideon Shaw Sally J Bell Paul V Desmond Alexander J Thompson | 2017 | World Journal of Hepatology2017，9，1： | 7 |
| 9 | A simple,water-soluble,Fe^(3+)-selective fluorescent probe and its application in bioimaging显示文摘A simple,water-soluble,Fe^(3+)-selective fluorescent probe,derived from rhodamine B,was synthesized and characterized.The probe exhibits a fluorescence response toward Fe^(3+) with acceptable sensitivity and selectivity and even facilitates visual or naked-eye detection of Fe^(3+).The experiment results show that the response of the probe to Fe^(3+) is pH-independent over a wide range of 4.0-10.0.In addition,fluorescence microscopic imaging experiments have proven that the probe is cell permeable and can be used for monitoring intracellular Fe^(3+) in living cells. | Xiao-Hang Yang Shu Li Zhi-Shu Tang Xi-Di Yu Tin Huang Yong Gao | 2015 | Chinese Chemical Letters2015，26，1： | 5 |
| 10 | A modified θ projection model for constant load creep curves-I.Introduction of the model显示文摘Estimating long-term creep deformation and life of materials is an effective way to ensure the service safety and to reduce the cost of long-term integrity evaluation of high temperature structural materials.Since the 1980 s, the θ projection model has been widely used for predicting creep lives due to its ability to capture the characteristic transitions observed in creep curves obtained under constant true stress conditions. However, the creep rupture behavior under constant load or engineering stress conditions cannot be simulated accurately using this model because of the different stress states. In this paper, creep curves obtained under constant load conditions were analyzed using a modified θ projection model by considering the increase in true stress with creep deformation during the creep tests. This model is expressed as ε = θ_1(1-e^(-θ_2t)) + θ3 e^(θ_4e^θ5^εt)-1, and was validated using the creep curves of K465 and DZ125 superalloys tested at a range of temperatures and engineering stresses. Moreover, it was shown that the predictive capability of the modified θ projection model was significantly improved over the original one, as it reduces the prediction uncertainty from a range of 10% to 20% to below 5%. Meanwhile,it was shown that the model can be reasonably used for predicting constant stress creep conditions, when appropriate parameters are used. The prediction performance of the modified model will be discussed in another paper. The results of this study show great potential for the evaluation and assessment of the service safety of structural materials used in applications where designs are limited by creep deformation. | Chao Fu Yadong Chen Xiaofei Yuan Sammy Tin Stoichko Antonov Koichi Yagi Qiang Feng | 2019 | Journal of Materials Science & Technology2019，35，1： | 4 |
| 11 | Toll-like receptor 2-mediated NF-kappa B pathway activation in ocular surface epithelial cells显示文摘Background:Gram-positive bacteria stimulate Toll-like receptor(TLR)2 and then activate the pro-inflammatory nuclear factor-kappa B(NF-κB)pathway.As the human ocular surface is heavily colonised by gram-positive cocci bacteria,a balance of activation/repression of NF-κB target genes is essential to avoid uncontrolled infection or autoimmune-related inflammation.It is advantageous to test NF-κB targeting molecules in an ocular surface culture system that allows assessment of temporal NF-κB activation in a longitudinal fashion without destruction of cells.Such initial testing under standardised conditions should reduce the number of molecules that progress to further evaluation in animal models.This study aims to establish an in-vitro cell culture system to assess NF-κB activation in the context of ocular surface cells.Methods:NF-κB activity was evaluated through a secretory alkaline phosphatase reporter assay(SEAP).Immunoblots and immunofluorescence were used to examine IκBαphosphorylation and p65/p50 nuclear localization.Monocyte chemoattractant protein-1(MCP-1)transcripts were evaluated by real time PCR and protein levels were measured by ELISA.Results:NF-κB activity in HCE-T cells treated with TLR2 activator Pam3CSK4 was higher than control cells at both 6 and 24 h.Pam3CSK4-stimulated NF-κB activation was inhibited by IκK inhibitors,Wedelolactone and BMS-345541.In Pam3CSK4 treated cells,active NF-κB subunits p50 and p65 increased in cell nuclear fractions as early as 1.5 h.Although the level of total IκB-αremained constant,phospho-IκB-αincreased with treatment over time.In the culture media of Pam3CSK4-stimulated cells,MCP-1 protein level was increased,which was suppressed in the presence of IκK inhibitors.Conclusion:NF-κB pathway can be activated by the TLR2 ligand and inhibited by IκK inhibitors in the ocular surface cell culture system.This cell culture system may be used to evaluate TLR-related innate defences in ocular surface diseases. | Aihua Hou Min Qi Tin Louis Tong | 2017 | Eye and Vision2017，4，1： | 4 |
| 12 | Immediate Changes in Intraocular Pressure after Laser Peripheral Iridotomy in Primary Angle-Closure Suspects显示文摘 | Yuzhen Jiang Dolly S. Chang Paul J. Foster Mingguang He Shengsong Huang Tin Aung David S. Friedman | 2012 | Ophthalmology2012，，2： | 2 |
| 13 | Angle closure glaucoma: a mechanistic review显示文摘 | Monisha E Nongpiur Judy YF Ku Tin Aung | 2011 | Current Opinion in Ophthalmology2011，，2： | 2 |
| 14 | 缅甸饮用水安全保障显示文摘缅甸现有5400万人口,其中近1700万人的饮用水安全存在隐患。目前,缅甸全国的集中供水率仅有20%左右,这一数字在世界范围内相当低,特别是在偏远的山区或农村,集中供水更加无保障。近年来,缅甸政府开始解决居民的饮用水安全保障问题,并拟于2030年实现全面集中供水。 | 王为东 栾富波 Tin Mar Aung | 2019 | 人与生物圈2019，0，3： | 2 |
| 15 | Risk Factors for Hepatocellular Carcinoma in Patients With Alcoholic or Viral C Cirrhosis显示文摘 | Gisèle N’Kontchou Jacques Paries Myint Tin Tin Htar Nathalie Ganne–Carrie Lydie Costentin Véronique Grando–Lemaire Jean–Claude Trinchet Michel Beaugrand | 2006 | Clinical Gastroenterology and Hepatology2006，，8： | 2 |
| 16 | Immune regulation by CD52-expressing CD4 T cells显示文摘由表示 CD52 CD4 T 房间的 T 房间规定看起来操作由二不同并且可能 synergistic 机制。第一由它从表示那然后绑在由损害 T 房间受体的 phosphorylation 稀释受动器 T 房间激活的酸绑定的像免疫球蛋白的 lectins-10 (Siglec-10 ) 受体联系了的禁止的 sialic 的 CD52 的高水平的 CD4 T 房间的房间表面的版本 lck 和 zap-70。第二机制看起来由由被导致他们的扩大的二原子价的 anti-CD52 抗体模仿的迄今为止未辩别出的内长的 ligand 的 CD52 分子的 crosslinkage。 | Ban-Hock Toh Tin Kyaw Peter Tipping Alex Bobik | 2013 | Cellular & Molecular Immunology2013，10，5： | 2 |
| 17 | IL 28 B genotype is not useful for predicting treatment outcome in A sian chronic hepatitis B patients treated with pegylated interferon‐α显示文摘 | Jacinta A Holmes Tin Nguyen Dilip Ratnam Neel M Heerasing Jane V Tehan Sara Bonanzinga Anouk Dev Sally Bell Stephen Pianko Robert Chen Kumar Visvanathan Rachel Hammond David Iser Ferry Rusli William Sievert Paul V Desmond D Scott Bowden Alexander J Thomps | 2013 | J Gastroenterol Hepatol2013，，5： | 2 |
| 18 | Regulation of drug-induced liver injury by signal transduction pathways: critical role of mitochondria显示文摘 | Derick Han Lily Dara Sanda Win Tin Aung Than Liyun Yuan Sadeea Q. Abbasi Zhang-Xu Liu Neil Kaplowitz | 2013 | Trends in Pharmacological Sciences2013，，4： | 2 |
| 19 | 一种便捷剪式摘果器显示文摘目前,我国大部分地区的采果主要依靠人工进行,出现的各式各样的采摘机和摘果平台,虽可提高采摘效率,但基于果树种植密度较大、果实生长高度不一及大小各异的特性,使用此类采摘机和摘果平台容易造成果实损伤而影响外观品质,且采摘系统制造成本较高。也设计出各种果实机械采摘器,虽然成本得以降低,但存在携带不便、操作复杂、只局限对果树一定高度范围内的果实采摘或对果实保护度不够等问题,导致果实采摘操作不便、效率较低且采摘质量较差。笔者发明了一种便捷剪式摘果器,通过铰接杆带动摘果碗剪切刀片闭合剪断果蒂,从而实现果实的快速且安全采摘。该摘果器属纯机械设计,设计巧妙,结构简单,便携性好,操作方便快捷,成本较低,很适合在我国果实采摘领域内大面积推广应用。 | 化延斌 权丽春 LEE Chew Tin 张乃儒 白忠全 杨建刚 袁信 乔云兰 赵利英 赵宏博 屈亚妮 魏建科 齐荣 王艳 | 2018 | 中国南方果树2018，47，2： | 2 |
| 20 | Prevalence of Plateau Iris in Primary Angle Closure Suspects显示文摘 | Rajesh S. Kumar Mani Baskaran Paul T.K. Chew David S. Friedman Swati Handa Raghavan Lavanya Lisandro M. Sakata Hon-Tym Wong Tin Aung | 2008 | Ophthalmology2008，，3： | 2 |
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