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| 1 | 一种特异性识别非小细胞肺癌A549细胞的小分子肽显示文摘应用'一个珠子一个化合物'的组合化学肽库,以期筛选得到特异性识别非小细胞肺癌细胞(A549)的小分子肽.初次筛选共得到29个与A549阳性结合的珠子,经氨基酸序列分析后发现含有-NGXG-肽链结构的序列共有10个.选择cNGQGEQc作进一步的细胞特异性研究,发现cNGQGEQc与非小细胞肺癌A549、Calu-1及H178的粘附特异性明显高于其他细胞系,对cNGQGEQc的结构分析显示,-NGXG-及六肽长度对小分子肽与A549细胞的粘附非常重要.标记FITC的小分子肽cNGQGEQc能与A549细胞发生特异性结合.用抗整合素的抗体(!1~6,'v和#1~5)阻断小分子肽与A549细胞表面的相应受体结合,结果显示,α3与$亚单位的任何组合均对cNGQGEQc与A549细胞的粘附有明显的阻断作用.结果表明,小分子肽cNGQGEQc是通过细胞表面整合素α3与非小细胞肺癌A549发生特异性结合. | 郭琳琅 郭颖 DERICK LAU 许寅超 | 2007 | 生物化学与生物物理进展2007，34，10： | 10 |
| 2 | COVID-19 in cancer patients:risk,clinical features,and management显示文摘A novel coronavirus known as severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has spread across the world,prompting the World Health Organization to declare the coronavirus disease of 2019(COVID-19)a public health emergency of international concern.Cancer patients are regarded as a highly vulnerable population to SARS-CoV-2 infection and development of more severe COVID-19 symptoms,which is possibly due to the systemic immunosuppressive state caused directly by tumor growth and indirectly by effects of anticancer treatment.Currently,much effort has been directed toward studying the pathogenesis and treatment of COVID-19,but the risk profiles,prognoses,and treatment outcomes in cancer patients remain unclear.Based on the current literature,we summarize the risk profiles,clinical and biochemical characteristics,and therapy outcomes of COVID-19 infections in cancer patients.The challenges in the clinical care of cancer patients with COVID-19 are discussed.The goal of this review is to stimulate research to better understand the biological impact and prognoses of COVID-19 infections in cancer patients,thus facilitating improvement of the clinical management of these patients. | Cuiwei Liu Yanxia Zhao Derick Okwan-Duodu Reva Basho Xiaojiang Cui | 2020 | Cancer Biology & Medicine2020，17，3： | 8 |
| 3 | Application of Cydia pomonella expressed sequence tags: Identification and expression of three general odorant binding proteins in codling moth显示文摘幼鳕蛾, Cydia pomonella,是在世界上的梨果水果的最重要的害虫之一,然而,分子的遗传和这个昆虫遗体的生理学糟糕理解。8341 个表示顺序标签的一个联合集会从八个织物特定的 cDNA 图书馆定序的 Roche 454 GS-FLX 被产生。通常认为的化学感应的蛋白质(12 ) 和有气味的东西绑定蛋白质(OBP )(18 ) 被注解,它包括了三通常认为的一般 OBP (GOBP ) ,一个人典型地非常为另外的鳞翅目报导了。为了推进,描绘 CpomGOBPs,我们克隆他们的抄本的 cDNA 拷贝并且在各种各样的纸巾决定了他们的表示模式。为 CpomGOBP1 698nt 抄本克隆并且定序导致了编码区域的 163 氨基酸的预言,并且随后的 RT-PCR 显示抄本主要在天线和 mouthparts 被表示。CpomGOBP3 抄本主要是的 702 nt (169 氨基酸) 在天线, mouthparts,和女腹部表示了的 CpomGOBP2 和小说付小费给的 1289 nt (160 氨基酸) 。这些结果显示定序的那下一代为兴趣的新奇抄本的鉴定是有用的,并且那幼鳕蛾表示为 GOBP 亚科的一个新成员编码的一个抄本。 | Stephen F. Garczynski Brad S. Coates Thomas R. Unruh Scott Schaeffer Derick Jiwan Tyson Koepke Amit Dhingra | 2013 | Insect Science2013，20，5： | 6 |
| 4 | Outlining key inflammation-associated parameters during early phase of an experimental gram-negative sepsis model in rhesus macaques(Macaca mulatta)显示文摘The aim of this study was to identify inflammation-associated markers during the early phase of sepsis in rhesus macaque. Four rhesus macaques were given an intravenous dose of 1010 CFU/kg of E. coli. Blood samples were collected before, or 30 minutes, 2, 4, 6 and 8 hours after E. coli infusion. Physiological parameters, bacteremia, endotoxemia, C-reactive protein(CRP), procalcitonin(PCT), and plasma cytokines/chemokines were determined for each animal. Bacteremia was present in all animals from 30 minutes to 3 hours after E. coli infusion whereas endotoxin was detected during the full-time course. CRP and PCT levels remained at detectable levels during the whole experimental window suggesting an ongoing inflammatory process. Signature cytokines and chemokines such as TNF-α, MIP-1α, and MIP-1β peaked about 2 hours after E. coli infusion and decreased thereafter. Plasma IL-6, IL-12 p40, IFN-γ, and IL-1 Ra, as well as I-TAC, MIG, IP-10 and MCP-1, remained at detectable levels after 4 hours of E. coli infusion. This nonhuman primate model could be useful for the assessment of new therapeutics aiming to suppress key inflammatory markers throughout sepsis early phases. | Jose J.Rosado-Franco Marcos J.Ramos-Benitez Laura M.Parodi Derick Rosario Nicole Compo Luis D.Giavedoni Ana M.Espino | 2019 | Animal Models and Experimental Medicine2019，2，4： | 5 |
| 5 | 用药管理中的临床安全显示文摘介绍了全球用药管理工作现状,依据差错的危害程度对用药差错进行了科学的分级和分类;总结和分析了用药程序中,诸如药品挑选和采购、储藏、订购和记录、准备和分发、给药和监测等工作环节存在的主要差错和原因,并提出了有效地预防和控制对策。 | Derick P.Pasternak | 2005 | 中国医院2005，9，12： | 5 |
| 6 | Transcriptional activation of endoplasmic reticulum chaperone GRP78 by HCMV IE1-72 protein显示文摘调整葡萄糖的蛋白质 78 (GRP78 ) , endoplasmic 蜂窝胃的一个关键管理者(嗯) 应力,便于癌症细胞生长和病毒的复制。在病毒的感染期间导致 grp78 基因激活的机制大部分是未知的。在这研究,我们证明立即早 1 (IE1-72 ) 人的 cytomegalovirus (HCMV ) 的蛋白质为调停 HCMV 的 GRP78 激活是必要的。取决于 ATP 有约束力的地点,锌手指领域和 IE1-72 的通常认为的白氨酸拉链主题的 IE1-72 upregulated grp78 基因表示,以及 grp78 倡导者上的 ER 压力反应元素(苏格兰之盖尔语) 。净化的 IE1-72 蛋白质在 vitro 在苏格兰之盖尔语以内跳了到 CCAAT 盒子,而在 grp78 倡导者刺激缺乏的 IE1-72 的删除异种没能那么做。而且,对在感染的房间的 grp78 倡导者有约束力的 IE1-72 伴随了 TATA 盒子绑定的招募联系蛋白质的因素 1 (TAF1 ) , histone acetyltransferase,和 acetylated histone H4 的增加的水平,活跃状态的染色质的指示物。这些结果提供 HCMV IE1-72 通过直接倡导者绑定和本地染色质结构的调整激活 grp78 基因表示的证据,显示为病毒的生长感应的细胞的女伴的活跃病毒的机制。 | Derick Shi-Chen Ou Sung-Bau Lee Chi-Shuen Chu Liang-Hao Chang Bon-chu Chung Li-Jung Juan | 2011 | Cell Research2011，21，4： | 3 |
| 7 | Predicting suitability of different scale-dependent dispersivities for reactive solute transport through stratified porous media显示文摘In this paper,the behavior of breakthrough curves(BTCs) for reactive solute transport through stratified porous media is investigated.A physical laboratory model for layered porous media was constructed,in which thin layer of gravel was sandwiched in between two thick layers of natural soil.Gravel layer and natural soil layers were hydraulically connected as single porous continuum.A constant source of tracer was connected through gravel layer and elucidated at different sampling points in the direction of flow.Flexible multiprocess non-equilibrium(MPNE) transport equation with scale-dependent dispersivity function was used to simulate experimental BTCs of reactive solute transport through layered porous media.The values of equilibrium sorption coefficient and other input parameters were obtained experimentally.The simulation of BTC was performed using MPNE model with scale-dependent dispersivity.The simulation of different scale-dependent dispersivities was then compared and it was found that for field scale of estimation of dispersivity,asymptotic and exponential dispersivity functions performed better.In continuation to the comparison of simulated BTCs obtained using different models,spatial moment analysis of each aforesaid scale-dependent dispersivity model was also done.Spatial moment analysis provides the information related to mean solute mass,rate of mass travel,and mean plume dispersion.Linear and constant dispersivities showed higher variance as compared to asymptotic and exponential dispersion functions.This supports the field applicability of asymptotic and exponential dispersivity functions.The BTCs were also found to elucidate a nonzero concentration with time,which was clearly affected by physical non-equilibrium.In natural condition,such information is required in effective aquifer remediation process. | Deepak Swami Abhimanyu Sharma Pramod Kumar Sharma Dericks P.Shukla | 2016 | Journal of Rock Mechanics and Geotechnical Engineering2016，8，6： | 2 |
| 8 | Regulation of drug-induced liver injury by signal transduction pathways: critical role of mitochondria显示文摘 | Derick Han Lily Dara Sanda Win Tin Aung Than Liyun Yuan Sadeea Q. Abbasi Zhang-Xu Liu Neil Kaplowitz | 2013 | Trends in Pharmacological Sciences2013，，4： | 2 |
| 9 | 一种特异性识别小细胞肺癌细胞的小分子肽显示文摘应用“一个珠子一个化合物”的组合化学肽库技术,筛选得到特异性识别小细胞肺癌细胞(DMS53)的小分子肽.初次筛选共得到32个与DMS53阳性结合的珠子,经氨基酸序列分析后发现,含有cNGRXXXc或cXNGRXXc肽链结构的序列共有10个.再次合成三种有代表性的小分子肽,发现cFNGRQQc与DMS53的结合率明显高于其他小分子肽.选择cFNGRQQc作进一步的细胞特异性研究,发现cFNGRQQc与DMS53的粘附特异性明显高于其他细胞系,对cFNGRQQc的结构分析显示,-NGR-及六肽长度对小分子肽与DMS53细胞的粘附非常重要.用抗整合素、E-cadherin、NCAM及ICAM的抗体或多肽阻断小分子肽与DMS53细胞表面的相应受体结合,未见明显的阻断效应.小分子肽与DMS53细胞表面的结合位点有待于进一步证实. | 郭琳琅 郭颖 DERICK LAU 肖莎 许寅超 申洪 | 2006 | 生物化学与生物物理进展2006，33，6： | 2 |
| 10 | Rapid improvement of rubeosis iridis from a single bevacizumab (Avastin) injection显示文摘 | Davidorf FH Mouser JG Derick RJ | 2006 | Retina2006，26，3： | 1 |
| 11 | Dynamic specification in the measurement of the impact of exchange rate adjustment on output:Jamaica 1960-90 显示文摘 | Derick Boyd | 1996 | Applied Econo- mics Letters1996，，3： | 1 |
| 12 | Community rehabilitation, or rehabilitation in the community?显示文摘 | DERICK WADE | 2003 | Disability & Rehabilitation2003，，15： | 1 |
| 13 | Pierre Robin Sequence显示文摘 | Noopur Gangopadhyay Derick Mendonca Albert Woo | 2012 | Seminars in Plastic Surgery2012，，02： | 1 |
| 14 | Fat crystals and water- in-oil emulsion stability显示文摘 | Ghosh Supratim Rousseau Derick | 2011 | Current Opinion in Colloid & Interface Science2011，16，5： | 1 |
| 15 | Dysphagia in Acute stroke显示文摘 | Caroline Gordon Richard Langton Uewer Derick T Ward | 1987 | British Medical Journal1987，295，15： | 1 |
| 16 | Financial Mechanisms for Enewable Energy 显示文摘 | A Derick | 1998 | Renewable Energy1998，15，14： | 1 |
| 17 | Rapid improvement of rubeosis iridis from a single bevacizumab(Avastiu) injection显示文摘 | Davidorf FH Mouser JG Derick RJ | 2006 | Retina2006，26，3： | 1 |
| 18 | Dysphagia in acute stroked显示文摘 | Caroline Gordon Richard Langton newer Derick Twade | 1987 | British Medical Journal1987，295，15： | 1 |
| 19 | Concurrent carboplatin,etopsid and thoracic radiation for poor-riskstage non-small-cell lung cancer:a pilot study显示文摘 | Lu P Derick H Janice K | 1997 | Int J Radiat Oncol Biol Phys1997，38，： | 1 |
| 20 | An evaluation of optic disc and nerve fiber layer examinations in monitoring progression of early glaucoma damage 显示文摘 | QU1GLEY H A KATZ J DERICK U | 1992 | Ophthalmology1992，99，1： | 1 |
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