|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Liver insulin-like growth factor 2 methylation in hepatitis C virus cirrhosis and further occurrence of hepatocellular carcinoma显示文摘AIM: To assess the predictive value of the insulinlike growth factor 2 (Igf2) methylation profile for the occurrence of Hepatocellular Carcinoma (HCC) in hepatitis C (HCV) cirrhosis. METHODS: Patients with: (1) biopsy-proven compensated HCV cirrhosis; (2) available baseline frozen liver sample; (3) absence of detectable HCC; (4) regular screening for HCC; (5) informed consent for genetic analysis were studied. After DNA extraction from liver samples and bisulfite treatment, unbiased PCR and DHPLC analysis were performed for methylation analysis at the Igf2 locus. The predictive value of the Igf2 methylation profile for HCC wasassessed by Kaplan-Meier and Cox methods. RESULTS: Among 94 included patients, 20 developed an HCC during follow-up (6.9 ± 3.2 years). The methylation profile was hypomethylated, intermediate and hypermethylated in 13, 64 and 17 cases, respectively. In univariate analysis, two baseline parameters were associated with the occurrence of HCC: age (P = 0.01) and prothrombin (P = 0.04). The test of linear tendency between the three ordered levels of Igf2 methylation and probability of HCC occurrence was significant (Log Rank, P = 0.043; Breslow, P = 0.037; Tarone-Ware, P = 0.039). CONCLUSION: These results suggest that hypomethylation at the Igf2 locus in the liver could be predictive for HCC occurrence in HCV cirrhosis. | Philippe Couvert Alain Carrié Jacques Pariès Jenny Vaysse Audrey Miroglio Antoine Kerjean Pierre Nahon Jamel Chelly Jean-Claude Trinchet Michel Beaugrand Nathalie Ganne-Carrié | 2008 | World Journal of Gastroenterology2008，14，35： | 6 |
| 2 | Impact of Metformin on the Prognosis of Cirrhosis Induced by Viral Hepatitis C in Diabetic Patients显示文摘 | Gisèle Nkontchou Emmanuel Cosson Mounir Aout Amel Mahmoudi Valérie Bourcier Iliass Charif Nathalie Ganne-Carrie Véronique Grando-Lemaire Eric Vicaut Jean-Claude Trinchet Michel Beaugrand | 2011 | The Journal of Clinical Endocrinology & Metabolism2011，，8： | 3 |
| 3 | Effect of sustained virological response on long-term clinical outcome in 113 patients with compensated hepatitis C-related cirrhosis treated by interferon alpha and ribavirin显示文摘AIM:To assess the long-term clinical benefit of sustained virological response(SVR)in patients with hepatitis C virus(HCV)cirrhosis treated by antiviral therapy using mostly ribavirin plus interferon either standard or pegylated.METHODS:One hundred and thirteen patients with uncomplicated HCV biopsy-proven cirrhosis,treated by at least one course of antiviral treatment ≥ 3 mo and followed ≥ 30 mo were included.The occurrence of clinical events hepatocellular carcinoma(HCC),decompensation and death was compared in SVR and non SVR patients.RESULTS:Seventy eight patients received bitherapy and 63 had repeat treatments.SVR was achieved in 37 patients(33%).During a mean follow-up of 7.7 years,clinical events occurred more frequently in non SVR than in SVR patients,with a significant difference for HCC(24/76 vs 1/37,P = 0.01).No SVR patient died while 20/76 non-SVR did(P = 0.002),mainly in relation to HCC(45%).CONCLUSION:In patients with HCV-related cirrhosis,SVR is associated with a significant decrease in the incidence of HCC and mortality during a follow-up period of 7.7 years.This result is a strong argument to perform and repeat antiviral treatments in patients with compensated cirrhosis. | Roland El Braks Nathalie Ganne-Carrié Hélène Fontaine Jacques Paries Véronique Grando-Lemaire Michel Beaugrand Stanislas Pol Jean-Claude Trinchet | 2007 | World Journal of Gastroenterology2007，13，42： | 3 |
| 4 | Risk Factors for Hepatocellular Carcinoma in Patients With Alcoholic or Viral C Cirrhosis显示文摘 | Gisèle N’Kontchou Jacques Paries Myint Tin Tin Htar Nathalie Ganne–Carrie Lydie Costentin Véronique Grando–Lemaire Jean–Claude Trinchet Michel Beaugrand | 2006 | Clinical Gastroenterology and Hepatology2006，，8： | 2 |
| 5 | PNPLA3 rs738409, hepatocellular carcinoma occurrence and risk model prediction in patients with cirrhosis显示文摘 | Erwan Guyot Angela Sutton Pierre Rufat Christelle Laguillier Abdellah Mansouri Richard Moreau Nathalie Ganne-Carrié Michel Beaugrand Nathalie Charnaux Jean-Claude Trinchet Pierre Nahon | 2012 | Journal of Hepatology2012，，： | 2 |
| 6 | A new prognostic classification for predicting survival in patients with hepatocellular carcinoma显示文摘 | Sylvie Chevret Jean-Claude Trinchet Didier Mathieu Antoine Abou Rached Michel Beaugrand Claude Chastang | 1999 | Journal of Hepatology1999，，1： | 2 |
| 7 | Assessment of liver fibrosis using transient elastography in patients with alcoholic liver disease显示文摘 | Pierre Nahon Adrien Kettaneh Iulia Tengher-Barna Marianne Ziol Victor de Lédinghen Catherine Douvin Patrick Marcellin Nathalie Ganne-Carrié Jean-Claude Trinchet Michel Beaugrand | 2008 | Journal of Hepatology2008，，6： | 1 |
| 8 | Treatment of hepatocellular carcinoma in patients with cirrhosis显示文摘 | Trinchet JC Beaugrand M | 1997 | J Hepatol1997，27，4： | 1 |
| 9 | Hepatic iron over- load and risk of hepatocellular carcinoma in cirrhosis显示文摘 | Nahon P Ganne-Carri N Trinchet JC | 2010 | Gastro- enterol Clin Biol2010，34，1： | 1 |
| 10 | Prospective study of screening for hepatocellular carcinoma in Caucasian patients with cirrhosis显示文摘 | Pateron D Ganne N Trinchet JC | 1994 | J Hepatol1994，20，： | 1 |
| 11 | Systemic treatment of hepatocellular carcinoma 显示文摘 | Ganne-Carrie N Trinchet JC | 2004 | Eur J Gastroenterol Hepatol2004，16，3： | 1 |
| 12 | Insulin resistance is associated with a higher risk of hepatocellular carcinoma in cirrhotic HIV/HCV-co-infected patients: Results from ANRS CO13 HEPAVIH显示文摘 | Dominique Salmon Firouzé Bani-Sadr Marc-Arthur Loko Hind Stitou Anne Gervais Jacques Durant Eric Rosenthal Yann Quertainmont Karl Barange Daniel Vittecoq Michka Shoai-Tehrani Muriel Alvarez Maria Winnock Jean Claude Trinchet Fran?ois Dabis Philippe Sogni | 2011 | Journal of Hepatology2011，，4： | 1 |
| 13 | Pathological modifications following sub-chronic exposure of medaka fish(Oryzias latipes) to microcystin-LR显示文摘 | Trinchet I Djediat C Huet H | 2011 | Reproductive Toxicology2011，32，3： | 1 |
| 14 | Systemic treatment of hepatocellular carcinoma显示文摘 | Ganne-Carrie N Trinchet JC | 2004 | Eur J Gastroenterol Hepatol2004，16，3： | 1 |
| 15 | Genetic risk markers for hepatocellular carcinoma in patients with alcoholic liver disease显示文摘 | Pierre Nahon Angela Sutton Marianne Ziol Jessica Zucman-Rossi Jean-Claude Trinchet Nathalie Ganne-Carrié | 2015 | Hepat. Oncol2015，，1： | 1 |
| 16 | Hepatocellular carcinoma in patients with hepatitis C virus-related chronic liver disease显示文摘Hepatitis C virus (HCV) is a major cause of hepatocellular carcinoma (HCC) worldwide due to the high prevalence of HCV infection and the high rate of HCC occurrence in patients with HCV cirrhosis. A striking increase in HCC incidence has been observed during the past decades in most industrialized countries, partly related to the growing number of patients infected by HCV. HCC is currently the main cause of death in patients with HCV-related cirrhosis, a fact that justifies screening as far as curative treatments apply only in patients with small tumors. As a whole, treatment options are similar in patients with cirrhosis whatever the cause. Chemoprevention could be also helpful in the near future. It is strongly suggested that antiviral treatment of HCV infection could prevent HCC occurrence, even in cirrhotic patients, mainly when a sustained virological response is obtained. | Jean-Claude Trinchet Nathalie Ganne-Carrié Pierre Nahon Gisèle N’kontchou Michel Beaugrand | 2007 | World Journal of Gastroenterology2007，13，17： | 1 |
| 17 | Systemic antibiotic therapy prevents bacteria infection in cirrhotic patients with gastrointestinal hemorrhage显示文摘 | Blaise M Pateron D Trinchet JC | 1994 | Hepatology1994，20，1： | 1 |
| 18 | Prospective study of screening for hepatocellular carcinoma in Caucasion patients with cirrhosis显示文摘 | PATERON D GANNE N TRINCHET J C | 1994 | J Hepatol1994，20，1： | 1 |
| 19 | Prospective study of screening for hepatocellular carcinoma in Cauca- sian patients with cirrhosis显示文摘 | Pateron D Ganne N Trinchet J C | 1994 | J Hepatol1994，20，1： | 1 |
| 20 | Risk Factors for Hepatocellular Carcinoma in Patients With Alcoholic or Viral C Cirrhosis显示文摘 | Gisèle N’Kontchou Jacques Paries Myint Tin Tin Htar Nathalie Ganne–Carrie Lydie Costentin Véronique Grando–Lemaire Jean–Claude Trinchet Michel Beaugrand | 2006 | Clinical Gastroenterology and Hepatology2006，，8： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员