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| 1 | Sitagliptin in patients with non-alcoholic steatohepatitis: A randomized, placebo-controlled trial显示文摘AIM To evaluate the effect of sitagliptin vs placebo on histologic and non-histologic parameters of nonalcoholic steatohepatitis(NASH).METHODS Twelve patients with biopsy-proven NASH were randomized to sitagliptin(100 mg daily)(n=6)or placebo(n=6)for 24 wk.The primary outcome was improvement in liver fibrosis after 24 wk.Secondary outcomes included evaluation of changes in NAFLD activity score(NAS),individual components of NAS(hepatocyte ballooning,lobular inflammation,and steatosis),glycemic control and insulin resistance[including measurements of glycated hemoglobin(Hb A1C)and adipocytokines],lipid profile including free fatty acids,adipose distribution measured using magnetic resonance imaging(MRI),and thrombosis markers(platelet aggregation and plasminogen activator inhibitor 1 levels).We also sought to determine the correlation between changes in hepatic fat fraction(%)[as measured using the Iterative Decomposition of water and fat with Echo Asymmetry and Least-squares estimation(IDEAL)MRI technique]and changes in hepatic steatosis on liver biopsy.RESULTS Sitagliptin was not significantly better than placebo at reducing liver fibrosis score as measured on liver biopsy(mean difference between sitagliptin and placebo arms,0.40,P=0.82).There were no significant improvements evident with the use of sitagliptin vs placebo for the secondary histologic outcomes of NAS total score as well as for the individual components of NAS.Compared to baseline,those patients who received sitagliptin demonstrated improved Hb A1C(6.7%±0.4%vs 7.9%±1.0%,P=0.02),and trended towards improved adiponectin levels(4.7±3.5μg/m L vs 3.9±2.7μg/m L,P=0.06)and triglyceride levels(1.26±0.43 mmol/L vs 2.80±1.64 mmol/L,P=0.08).However,when compared with placebo,sitagliptin did not cause a statistically significant improvement in Hb A1C(mean difference,-0.7%,P=0.19)nor triglyceride levels(mean difference-1.10mmol/L,P=0.19)but did trend towards improved adiponectin levels only(mean difference,0.60μg/m L,P=0.095).No significant changes in anthropometrics,liver enzymes,other adipocytokines,lipid profile,thrombosis parameters,or adipose distribution were demonstrated.The MRI IDEAL procedure correlated well with steatosis scores obtained on liver biopsy in both groups at baseline and post-treatment,and the Spearman correlation coefficients ranged from r=0.819(baseline)to r=0.878(post-treatment),P=0.002.CONCLUSION Sitagliptin does not improve fibrosis score or NAS after 24 wk of therapy.The MRI IDEAL technique may be useful for non-invasive measurement of hepatic steatosis. | Tisha R Joy Charles A McKenzie Rommel G Tirona Kelly Summers Shannon Seney Subrata Chakrabarti Neel Malhotra Melanie D Beaton | 2017 | World Journal of Gastroenterology2017，23，1： | 18 |
| 2 | Diffusion-weighted magnetic resonance imaging to predict response of hepatocellular carcinoma to chemoembolization显示文摘AIM: To investigate whether intra-procedural diffusion- weighted magnetic resonance imaging can predict response of hepatocellular carcinoma (HCC) during trans- catheter arterial chemoembolization (TACE). METHODS: Sixteen patients (15 male), aged 59 ±11 years (range: 42-81 years) underwent a total of 21 separate treatments for unresectable HCC in a hybrid magnetic resonance/interventional radiology suite. Ana- tomical imaging and diffusion-weighted imaging (b = 0, 500 s/mm2) were performed on a 1.5-T unit. Tumor enhancement and apparent diffusion coefficient (ADC, mm2/s) values were assessed immediately before and at 1 and 3 mo after TACE. We calculated the percent change (PC) in ADC values at all time points. We compared follow-up ADC values to baseline values using a paired t test (α = 0.05). RESULTS: The intra-procedural sensitivity, specificity, and positive and negative predictive values (%) for detecting a complete or partial 1-mo tumor response using ADC PC thresholds of ±5%, ±10%, and ±15% were 77, 67, 91, and 40; 54, 67, 88, and 25; and 46, 100, 100, and 30, respectively. There was no clear predictive value for the 3-mo follow-up. Compared to baseline, the immediate post-procedure and 1-mo mean ADC values both increased; the latter obtaining statistical significance (1.48 ± 0.29 mm2/s vs 1.65 ± 0.35 × 10-3 mm2/s, P < 0.014). CONCLUSION: Intra-procedural ADC changes of > 15% predicted 1-mo anatomical HCC response with the greatest accuracy, and can provide valuable feedback at the time of TACE. | Johnathan C Chung Neel K Naik Robert J Lewandowski Mary F Mulcahy Laura M Kulik Kent T Sato Robert K Ryu Riad Salem Andrew C Larson Reed A Omary | 2010 | World Journal of Gastroenterology2010，16，25： | 13 |
| 3 | Augmented reality assisted surgery: a urologic training tool显示文摘扩充现实广泛地在航空学被使用并且是在外科以内的一个发展中的概念。在这个预研项目,我们在古格尔·格拉斯 ® 上为使用开发了一个应用程序训练在怎么放可膨胀的阴茎修复术的泌尿学居民的光装头的显示。我们使用扩充的短语现实帮助了外科在外科的设置描述扩充现实的这个新奇应用程序。应用程序表明可膨胀的阴茎修复术放置的外科的过程的步。它也包含允许的软件用一个照相机的点从光装头的显示喂使教师能在阴茎修复术的放置期间与居民一起交往的兴趣的察觉。自愿参加学习的泌尿学受训练者和教师被给时间经历技术在起作用或 perioperative 背景并且要求完成反馈调查。从用 10 点规模的 30 个全部的参加者,教育实用性被评估 8.6,航行的容易被评估 7.6,到使用的可能性的被评估 7.4,并且在操作空间的分心被评估 4.9。当在受训练者和教师之间成层时,受训练者发现技术更教育有用,并且少些分散。总的来说, 81% 参加者在他们的住处程序想要这种技术,并且 93% 以后在操作房间里看见这种技术。这种技术的进一步的开发在完整的版本前被保证,并且进一步的研究是必要的更好描绘扩充现实的有效性在泌尿科的外科的训练的帮助外科。 | Ryan M Dickey Neel Srikishen Larry I Lipshultz Philippe E Spiess Rafael E Carrion Tariq S Hakky | 2016 | Asian Journal of Andrology2016，18，5： | 6 |
| 4 | Management of non-alcoholic fatty liver disease in 2015显示文摘There is no single pharmacologic therapy that has been approved to treat nonalcoholic fatty liver disease in the general population. The backbone of therapy currently includes intensive lifestyle modification withestablished targets for diet and weight loss. The use of unsweetened, unfiltered coffee along with limiting high fructose corn syrup have emerged as beneficial dietary recommendations. The use of empiric oral hypoglycemic agents and vitamin E, however, has not been widely accepted. Developing bariatric surgical techniques are promising, but additional studies with long-term follow up are needed before it can be widely recommended. Finally, liver transplantation is an increasingly frequent consideration once complications of endstage disease have developed. The future treatment of those with nonalcoholic fatty liver disease will likely involve a personalized approach. The importance of the gut microbiome in mediating hepatocyte inflammation and intestinal permeability is emerging and may offer avenues for novel treatment. The study of anti-fibrotic agents such as pentoxifylline and FXR agonists hold promise and new pathways, such as hepatocyte cannabinoid receptor antagonists are being studied. With the incidence of obesity and the metabolic syndrome increasing throughout the developed world, the future will continue to focus on finding novel agents and new applications of existing therapies to help prevent and to mediate the progression of nonalcoholic fatty liver disease. | Neel Malhotra Melanie D Beaton | 2015 | World Journal of Hepatology2015，7，30： | 6 |
| 5 | Placental accommodations for transport and metabolism during intra-uterine crowding in pigs显示文摘Litter size and birth weights are limited by uterine capacity, defined as the ability of the uterus to maintain the appropriate development of some number of conceptuses. Uterine capacity is the result of the combined effects of uterine, placental and embryo/fetal function. The number of living conceptuses that the uterus is capable of supporting is greater during early gestation compared to later gestation. Plots of log fetal weight versus log placental weight also indicate that fetal weights are less sensitive to reduced placental weight(and therefore reduced intrauterine space) in early gestation compared to late gestation. However, even in late gestation,mechanisms still exist that maintain fetal growth when the size of the placenta is reduced. One such mechanism is likely to be improved development of the folded placental-epithelial/maternal-epithelial bilayer. Fold depth, and therefore the maternal fetal interactive surface, increases as gestation advances and is greater in placenta from small fetuses. On the fetal side of the placenta, the epithelial bilayer is embedded in stromal tissue. Glycosaminoglycans are major components of stroma, including hyaluronan and heparan sulfate. Hyaluronidases and heparanases are present within placental tissues, and likely play roles in modification of stromal components to facilitate fold development. Glycosaminoglycans are polymers of forms of glucose(glucosamine, glucuronic acid, iduronic acid)suggesting that glycosaminoglycan synthesis may compete with the glucose needs of the developing fetus.Pig conceptuses are fructogenic, such that a substantial portion of glucose transferred from mother to fetus is converted to fructose. Fructose is an intermediate product in the synthesis of glucosamine from glucose, and glucosamine is linked to regulation of trophoblast cell proliferation through regulation of m TOR. These findings suggest a link between glucose, fructose, glucosamine synthesis, GAG production, and placental morphogenesis,but the details of these interactions remain unclear. In addition, recent placental epithelial transcriptome analysis identified several glucose, amino acid, lipid, vitamin, mineral and hormone transporter mechanisms within the placenta. Further elucidation of mechanisms of placental morphogenesis and solute transport could provide clues to improving nutrient transport to the pig fetus, potentially increasing litter size and piglet birth weights. | Jeffrey L Vallet Anthony K Mc Neel Jeremy R Miles Bradley A Freking | 2015 | Journal of Animal Science and Biotechnology2015，6，2： | 5 |
| 6 | Understanding the influence of petrographic parameters on strength of differently sized shale specimens using XRD and SEM显示文摘Ground failure is a major contributor to fatalities in underground mines in the US.Underground coal mines in the Northern Appalachian have weak roof rock composed of shale,which is prone to failure under high horizontal stress.Understanding the relationship among strength,specimen size and rock petrographic parameters is essential for developing an effective ground control plan.Size effect studies have found that rock strength varies with specimen size.This paper attempts to understand this strength variation using three specimen sizes(254-mm,508-mm,and 762-mm).The specimen strength was measured and the major petrographic parameters affecting the strength,namely grain size,grain shape,quartz content,clay content,etc.were analyzed using X-ray diffraction(XRD)and scanning electron microscopy(SEM).The petrographic parameters were then correlated with the strength of the three differently sized specimens.The results showed that 508-mm specimen had the lowest strength.Quartz content of the 508-mm specimen was lower than that of 254-mm and 762-mm specimens.Clay content and average grain size of the 508-mm specimen were higher than those of 254-mm and 762-mm specimens.These results clearly show that grain size,quartz content and clay content contribute to strength variation observed in differently sized shale specimens. | Debashis Das Brijes Mishra Neel Gupta | 2021 | International Journal of Mining Science and Technology2021，31，5： | 4 |
| 7 | Hydrogen sulfide therapy attenuates the inflammatory response in a porcine model of myocardial ischemia/reperfusion injury显示文摘 | Neel R. Sodha Richard T. Clements Jun Feng Yuhong Liu Cesario Bianchi Eszter M. Horvath Csaba Szabo Gregory L. Stahl Frank W. Sellke | 2009 | The Journal of Thoracic and Cardiovascular Surgery2009，，： | 3 |
| 8 | Clinical spectrum and surgical approach of adult intussusceptions: a multicentric study显示文摘 | M. Barussaud N. Regenet X. Briennon B. Kerviler P. Pessaux N. Kohneh-Sharhi P. A. Lehur A. Hamy J. Leborgne J. C. Neel E. Mirallie | 2006 | International Journal of Colorectal Disease2006，，8： | 3 |
| 9 | Modulation of signal transduction pathways by natural compounds in cancer显示文摘Cancer is generally regarded as the result of abnormal growth of cells. According to World Health Organization, cancer is the leading cause of mortality worldwide. Mother nature provides a large source of bioactive compounds with excellent therapeutic efficacy. Numerous phytochemicals from nature have been investigated for anticancer properties. In this review article, we discuss several natural compounds, which have shown anti-cancer activity. Natural compounds induce cell cycle arrest, activate intrinsic and extrinsic apoptosis pathways, generate Reactive Oxygen Species(ROS), and down-regulate activated signaling pathways, resulting in inhibition of cell proliferation, progression and metastasis of cancer. Several preclinical studies have suggested that natural compounds can also increase the sensitivity of resistant cancers to available chemotherapy agents. Furthermore, combining FDA approved anti-cancer drugs with natural compounds results in improved efficacy. On the basis of these exciting outcomes of natural compounds against several cancer types, several agents have already advanced to clinical trials. In conclusion, preclinical results and clinical outcomes against cancer suggest promising anticancer efficacy of agents from natural sources. | Alok Ranjan Neel M.Fofaria Sung-Hoon Kim Sanjay K.Srivastava | 2015 | Chinese Journal of Natural Medicines2015，13，10： | 2 |
| 10 | Setting kinetics and mechanical properties of flax fibre reinforced glass ionomer restorative materials显示文摘Regardless of the excellent properties of glass ionomer cements,their poor mechanical properties limit their applications to non-load bearing areas.This study aimed to investigate the effect of incorporated short,chopped and randomly distributed flax fibers(0,0.5,1,2.5,5 and 25 wt%) on setting reaction kinetics,and mechanical and morphological properties of glass ionomer cements.Addition of flax fibers did not significantly affect the setting reaction extent.According to their content,flax fibers increased the compressive(from 148 to 250 MPa) and flexure strength(from 20 to 42 MPa).They also changed the brittle behavior of glass ionomer cements to a plastic one.They significantly reduced the compressive(from 3 to 1.3 GPa) and flexure modulus(from 19 to 14 GPa).Accordingly,flax fiber-modified glass ionomer cements could be potentially used in high-stress bearing areas. | Ensanya Ali Abou Neel Anne M.Young | 2017 | The Journal of Biomedical Research2017，31，3： | 2 |
| 11 | Outcomes of submucosal(T1b) esophageal adenocarcinomas removed by endoscopic mucosal resection显示文摘AIM To investigate the outcomes and recurrences of p T1 b esophageal adenocarcinoma(EAC) following endoscopic mucosal resection(EMR) and associated treatments.METHODS Patients undergoing EMR with pathologically confirmed T1 b EAC at two academic referral centers were retrospectively identified.Patients were divided into 4 groups based on treatment following EMR:Endoscopic therapy alone(group A),endoscopic therapy with either chemotherapy,radiation or both(group B),surgicalresection(group C) or no further treatment/lost to follow-up(<12 mo)(group D).Pathology specimens were reviewed by a central pathologist.Follow-up data was obtained from the academic centers,primary care physicians and/or referring physicians.Univariate analysis was performed to identify factors predicting recurrence of EAC.RESULTS Fifty-three patients with T1 b EAC underwent EMR,of which 32(60%) had adequate follow-up ≥ 12 mo(median 34 mo,range 12-103).There were 16 patients in group A,9 in group B,7 in group C and 21 in group D.Median follow-up in groups A to C was 34 mo(range 12-103).Recurrent EAC developed overall in 9 patients(28%) including 6(38%) in group A(median:21 mo,range:6-73),1(11%) in group B(median:30 mo,range:30-30) and 2(29%) in group C(median 21 mo,range:7-35.Six of 9 recurrences were local;of the 6 recurrences,5 were treated with endoscopy alone.No predictors of recurrence of EAC were identified.CONCLUSION Endoscopic therapy of T1 b EAC may be a reasonable strategy for a subset of patients including those either refusing or medically unfit for esophagectomy. | Darren D Ballard Neel Choksi Jingmei Lin Eun-Young Choi B Joseph Elmunzer Henry Appelman Douglas K Rex Hala Fatima William Kessler John M DeWitt | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，20： | 2 |
| 12 | IL 28 B genotype is not useful for predicting treatment outcome in A sian chronic hepatitis B patients treated with pegylated interferon‐α显示文摘 | Jacinta A Holmes Tin Nguyen Dilip Ratnam Neel M Heerasing Jane V Tehan Sara Bonanzinga Anouk Dev Sally Bell Stephen Pianko Robert Chen Kumar Visvanathan Rachel Hammond David Iser Ferry Rusli William Sievert Paul V Desmond D Scott Bowden Alexander J Thomps | 2013 | J Gastroenterol Hepatol2013，，5： | 2 |
| 13 | An evidence-based medicine review of lymphadenectomy extent for gastric cancer显示文摘 | Sun Hu Yang You Cheng Zhang Ke Hu Yang You Ping Li Xiao Dong He Jin Hui Tian Ting Hong Lv Ying Hua Hui Neel Sharma | 2009 | The American Journal of Surgery2009，，2： | 2 |
| 14 | Multidrug-resistant and extensively drug-resistant tuberculosis: a threat to global control of tuberculosis显示文摘 | Neel R Gandhi Paul Nunn Keertan Dheda H Simon Schaaf Matteo Zignol Dick van Soolingen Paul Jensen Jaime Bayona | 2010 | The Lancet2010，，9728： | 2 |
| 15 | Pefrormance of an NIDDM screening questionnaire based on symptoms and risk factors显示文摘 | Ruige JB Neeling JN Kostense PJ | 1997 | Diabetes Care1997，20，4： | 1 |
| 16 | The 'thrifty 8enotype' in 1998显示文摘 | Neel JV | 1999 | Nutr Rev1999，57，52： | 1 |
| 17 | Effcieney of boundary evaluation for a cellular model显示文摘 | Bidarra R Madeira J Neels W | 2005 | Computer- Aided Design2005，37，12： | 1 |
| 18 | Solubilization and purification of enzymatically active glutathione S - transferase ( pGEX ) fusion protein显示文摘 | FRANGIONI J V NEEL B G | 1993 | Anal Biochem1993，210，1： | 1 |
| 19 | New insight into tumor suppression:PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway显示文摘 | Cantley LC Neel BG | 1999 | Proc Natl Acad Sci USA1999，96，： | 1 |
| 20 | Cytology of bone marrow显示文摘 | Grindem C B Neel J A Juopperi T A | | 0，，： | 1 |
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