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| 1 | Cellular and molecular basis of chronic constipation: Taking the functional/idiopathic label out显示文摘In recent years, the improvement of technology and the increase in knowledge have shifted several strongly held paradigms. This is particularly true in gastroenterology, and specifically in the field of the so-called 'functional' or 'idiopathic' disease, where conditions thought for decades to be based mainly on alterations of visceral perception or aberrant psychosomatic mechanisms have, in fact, be reconducted to an organic basis (or, at the very least, have shown one or more demonstrable abnormalities). This is particularly true, for instance, for irritable bowel syndrome, the prototype entity of 'functional' gastrointestinal disorders, where low-grade inflammation of both mucosa and myenteric plexus has been repeatedly demonstrated. Thus, researchers have also investigated other functional/idiopathic gastrointestinal disorders, and found that some organic ground is present, such as abnormal neurotransmission and myenteric plexitis in esophageal achalasia and mucosal immune activation and mild eosinophilia in functional dyspepsia. Here we show evidence, based on our own and other authors' work, that chronic constipation has several abnormalities reconductable to alterations in the enteric nervous system, abnormalities mainly characterized by a constant decrease of enteric glial cells and interstitial cells of Cajal (and, sometimes, of enteric neurons). Thus, we feel that (at least some forms of) chronic constipation should no more be considered as a functional/idiopathic gastrointestinal disorder, but instead as a true enteric neuropathic abnormality. | Gabrio Bassotti Vincenzo Villanacci Dragos Cretoiu Sanda Maria Cretoiu Gabriel Becheanu | 2013 | World Journal of Gastroenterology2013，19，26： | 9 |
| 2 | 支气管的动脉和气管的分叉的大动脉的 ostia : MDCT 分析显示文摘 AIM:To explore the anatomical relationships between bronchial artery and tracheal bifurcation using computed tomography angiography (CTA).METHODS:One hundred consecutive patients (84 men,16 women;aged 46-85 years) who underwent CTA using multi-detector row CT (MDCT) were investigated retrospectively.The distance between sites of bronchial artery ostia and tracheal bifurcation,and dividing directions were explored.The directions of division from the descending aorta were described as on a clock face.RESULTS:We identified ostia of 198 bronchial arteries:95 right bronchial arteries,67 left bronchial arteries,36 common trunk arteries.Of these,172 (87%) divided from the descending aorta,25 (13%) from the aortic arch,and 1 (0.5%) from the left subclavian artery.The right,left,and common trunk bronchial arteries divided at-1 to 2 cm from tracheal bifurcation with frequencies of 77% (73/95),82% (54/66),and 70% (25/36),respectively.The dividing direction of right bronchial arteries from the descending aorta was 9 to 10 o’clock with a frequency of 81% (64/79);that of left and common tract bronchial arteries was 11 to 1 o’clock with frequencies of 70% (43/62) and 77% (24/31),respectively.CONCLUSION:CTA using MDCT provides details of the relation between bronchial artery ostia and tracheal bifurcation. | Julaiti Ziyawudong Nobuyuki Kawai Morio Sato Akira Ikoma Hiroki Sanda Taizo Takeuchi Hiroki Minamiguchi Motoki Nakai Takami Tanaka Tetsuo Sonomura | 2012 | World Journal of Radiology2012，4，1： | 9 |
| 3 | Use of intravascular imaging in managing coronary artery disease显示文摘For many years,coronary angiography has been considered 'the gold standard' for evaluating patients with coronary artery disease. However,angiography only provides a planar two-dimensional silhouette of the lumen and is unsuitable for the precise assessment of atherosclerosis. With the introduction of intravascular imaging,direct visualization of the arterial wall is now feasible. Intravascular imaging modalities extend diagnostic information,thereby enabling more precise evaluation of plaque burden and vessel remodeling. Of all technologies,intravascular ultrasound(IVUS) is the most mature and widely used intravascular imaging technique. Optical coherence tomography(OCT) is an evolving technology that has the highest spatial resolution of existing imaging methods,and it is becoming increasingly widespread. These methods are useful tools for planning interventional strategies and optimizing stent deployment,particularly when stenting complex lesions. We strongly support the mandatory use of IVUS for left main percutaneous coronary intervention(PCI). In addition,it can be used to evaluate vascularresponses,including neointimal growth and strut apposition,during follow-ups. Adequately powered randomized trials are needed to support IVUS or OCT use in routine clinical practice and to answer whether OCT is superior to IVUS in reducing adverse events when used to guide PCI. The current perception and adoption of innovative interventional devices,such as bioabsorbable scaffolds,will increase the need for intravascular imaging in the future. | Sanda Jegere Inga Narbute Andrejs Erglis | 2014 | World Journal of Cardiology2014，6，6： | 6 |
| 4 | Three benefits of microcatheters for retrograde transvenous obliteration of gastric varices显示文摘AIM:To evaluate the usefulness of the microcatheter techniques in balloon-occluded retrograde transvenous obliteration (BRTO) of gastric varices.METHODS:Fifty-six patients with gastric varices underwent BRTOs using microcatheters.A balloon catheter was inserted into gastrorenal or gastrocaval shunts.A microcatheter was navigated close to the varices,and sclerosant was injected into the varices through the microcatheter during balloon occlusion.The next morning,thrombosis of the varices was evaluated by contrast enhanced computed tomography (CE-CT).In patients with incomplete thrombosis of the varices,a second BRTO was performed the following day.Patients were followed up with CE-CT and endoscopy.RESULTS:In all 56 patients,sclerosant was selectively injected through the microcatheter close to the varices.In 9 patients,microcoil embolization of collateral veinswas performed using a microcatheter.In 12 patients with incomplete thrombosis of the varices,additional injection of sclerosant was performed through the microcatheter that remained inserted overnight.Complete thrombosis of the varices was achieved in 51 of 56 patients,and the remaining 5 patients showed incomplete thrombosis of the varices.No recurrence of the varices was found in the successful 51 patients after a median follow up time of 10.5 mo.We experienced one case of liver necrosis,and the other complications were transient.CONCLUSION:The microcatheter techniques are very effective methods for achieving a higher success rate of BRTO procedures. | Tetsuo Sonomura Wataru Ono Morio Sato Shinya Sahara Kouhei Nakata Hiroki Sanda Nobuyuki Kawai Hiroki Minamiguchi Motoki Nakai Kazushi Kishi | 2012 | World Journal of Gastroenterology2012，18，12： | 5 |
| 5 | Basket pattern blood flow signals discovered in a case of splenic hamartoma by power Doppler ultrasonography显示文摘We present the gray-scale ultrasonography (GSUS), power Doppler ultrasonography (PDUS), abdominal computed tomography (CT), and magnetic resonance imaging (MRI) findings for a case of splenic hamartoma in a 27-year-old man, showing a ψ 50 mm homogeneous, iso- and hypo-echoic splenic mass with evidence of a small plural cystic lesion.This splenic hamartoma showed increased vascularity on power Doppler sonograms. PDUS showed multiple circular blood flow signals inside the mass (i.e. a basket pattern),which was consistent with the small plural cystic lesion shown by GSUS. Spectral analysis also confirmed arterial and venous flow. CT scans showed that the mass had lowdensity relative to the normal spleen and MRI showed that the mass was isodense, relative to the normal spleen.Therefore, CT and MRI are not useful for the diagnosis of splenic hamartoma. Ultrasonography can be used to diagnose splenic hamartoma without administration of a contrast material and therefore is an indispensable method for the diagnosis of splenic hamartoma. | Shigeo Nakanishi Katsuya Shiraki Kouji Yamamoto Takeshi Nakano Mutsumi Koyama Takatsugu Yano Takayuki Sanda Hisao Tamaki Tadanori Hirano Kazuo Fukudome Akinori Ishihara | 2005 | World Journal of Gastroenterology2005，11，33： | 4 |
| 6 | Differential hepatoprotective mechanisms of rutin and quercetin in CCl_(4)-intoxicated BALB/cN mice显示文摘 | Rbert DOMITROVIC Hrvoje JAKOVAC Vanja VASILJEV MARCHESI Sanda VLADIMIR-KNEZEVIC Olga CVIJANOVIC Zarko TADIC Zeljko ROMIC Dario RAHELIC | 2012 | Acta Pharmacologica Sinica2012，33，10： | 4 |
| 7 | Generalized two-dimensional correlation spectroscopy——Theory and applications in analytical field显示文摘Since the theory of generalized two-dimensional (2-D) correlation spectroscopy was proposed, it has been keenly concerned in scientific research and its analytical method has been widely applied in various analytical fields. The mathematical process to construct generalized 2-D correlation spectroscopy and the physical meaning of 2-D correlation spectral map are described, and three examples in the fields of chemical analysis and molecular biology are provided, such as the component analysis of organic solvent, the analysis of biological molecules in the solvent with different pH values and structural analysis of protein. The theory and analytical method of generalized 2-D correlation spectroscopy are also detailedly commented. | DOU Xiaoming1, YUAN Bo1, ZHAO Haiying1, YIN Guangzhong2 & Yukihiro Ozaki3 1. Molecular and Photonics Laboratory, Physical Department, Shanghai Jiao Tong University, Shanghai 200030, China 2. Suzhou No.2 People抯 Hospital, Suzhou 215000, China 3. Chemical Department, School of Science and Technology, Kwansei-Gakuin University, Sanda 669-1337, Japan | 2004 | Science China Chemistry2004，47，3： | 2 |
| 8 | Emergency balloon-occluded retrograde transvenous obliteration of ruptured gastric varices显示文摘AIM: To evaluate the effectiveness and safety of emergency balloon-occluded retrograde transvenous obliteration(BRTO) for ruptured gastric varices.METHODS: Emergency BRTO was performed in 17 patients with gastric varices and gastrorenal or gastrocaval shunts within 24 h of hematemesis and/or tarry stool.The gastric varices were confirmed by endoscopy,and the gastrorenal or gastrocaval shunts were identified by contrast-enhanced computed tomography(CE-CT).A 6-Fr balloon catheter(Cobra type) was inserted into the gastrorenal shunt via the right internal jugular vein,or into the gastrocaval shunt via the right femoral vein,depending on the varices drainage route.The sclerosant,5% ethanolamine oleate iopamidol,was injected into the gastric varices through the catheter during balloon occlusion.In patients with incom plete thrombosis of the varices after the first BRTO,a second BRTO was performed the following day.Patients were followed up by endoscopy and CE-CT at 1 d,1 wk,and 1,3 and 6 mo after the procedure,and every 6 mo thereafter.RESULTS: Complete thrombosis of the gastric varices was not achieved with the first BRTO in 7/17 patients because of large gastric varices.These patients underwent a second BRTO on the next day,and additional sclerosant was injected through the catheter.Complete thrombosis which led to disappearance of the varices was achieved in 16/17 patients,while the remaining patient had incomplete thrombosis of the varices.None of the patients experienced rebleeding or recurrence of the gastric varices after a median follow-up of 1130 d(range 8-2739 d).No major complications occurred after the procedure.However,esophageal varices worsened in 5/17 patients after a mean follow-up of 8.6 mo.CONCLUSION: Emergency BRTO is an effective and safe treatment for ruptured gastric varices. | Tetsuo Sonomura Wataru Ono Morio Sato Shinya Sahara Kouhei Nakata Hiroki Sanda Nobuyuki Kawai Hiroki Minamiguchi Motoki Nakai Kazushi Kishi | 2013 | World Journal of Gastroenterology2013，19，31： | 2 |
| 9 | Regulation of drug-induced liver injury by signal transduction pathways: critical role of mitochondria显示文摘 | Derick Han Lily Dara Sanda Win Tin Aung Than Liyun Yuan Sadeea Q. Abbasi Zhang-Xu Liu Neil Kaplowitz | 2013 | Trends in Pharmacological Sciences2013，，4： | 2 |
| 10 | Foraging and Pollination Behaviour of Apis mellifera adansonii Latreille (Hymenoptera, Apidae) on Gossypium hirsutum (Malvaceae) Flowers at Dang (Ngaoundere, Cameroon)显示文摘 | Mazi Sanda Tchuenguem Fohouo Femand-Nestor Briackner Dorothea | 2013 | Journal of Agricultural Science and Technology(A)2013，3，4： | 2 |
| 11 | Induction of cell death in adult T-cell leukemia cells by a novel IκB kinase inhibitor显示文摘 | Sanda T Asamitsu K Qgura H | 2006 | Leukemia2006，20，4： | 1 |
| 12 | Contemporary diagnosis and management of renal angiomyolipoma 显示文摘 | Nelson CP Sanda MG | 2002 | J Urol2002，168，4： | 1 |
| 13 | An internet intervention for management of uncertainty during active surveillance for prostate cancer显示文摘 | Kazer MW Bailey DE Sanda M | | 0，，05： | 1 |
| 14 | Contemporary diagnosis and managemeat of renal angiomyolipoma显示文摘 | Nelson CP Sanda MG | 2002 | J Urol2002，168，41： | 1 |
| 15 | Syntheses and functions of polymers based on aminoacids显示文摘 | Sanda F Endo T | 1999 | Macromol Chem Phys1999，200，： | 1 |
| 16 | Quality of life and satisfaction with outcome among prostate-cancer survivors显示文摘 | Sanda MG Dunn RL Michalski J | | 0，，12： | 1 |
| 17 | Binding of APC to the human homolog of the drosophila discs large tumor suppressor protein 显示文摘 | Matsumine A Ogai A Sanda T | 2006 | Science2006，272，5264： | 1 |
| 18 | Contemporary diagnosis and management of renal angiomyolipomas显示文摘 | Nelson C P Sanda M G | 2002 | J Urol2002，168，41： | 1 |
| 19 | Prostate cancer involving survival and implications for A- JCC staging modification显示文摘 | DASH A SANDA MG YU M the bladder neck:recurrence-free | 2002 | American Joint Committee on Cancer J Urol2002，60，2： | 1 |
| 20 | Reaction of carbon dioxide with glycidol: The synthesis of a novel hyperbranched oligomer with a carbonate main chain with a hydroxyl terminal显示文摘 | MOTOKUCHO S SUDO A SANDA F | 2004 | J Polym Sci A: Polym Chem2004，42，： | 1 |
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