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| 1 | Natural history of chronic hepatitis B:Phases in a complex relationship显示文摘Chronic hepatitis B(CHB)is a condition of globalprevalence and its sequelae include cirrhosis and hepatocellular carcinoma.The natural history of CHB isa complex interplay of virological,environmental andhost factors.The dynamic relationship between thevirus and host evolves over the duration of the infection and different phases of the disease have been observed and described.These have been conceptualizedin terms of the state of balance between the host immune system and the hepatitis B virus and have beengiven the labels immune tolerant,immune clearance,immune control and immune escape although othernomenclature is also used.Host factors,such as age atinfection,determine progression to chronicity.Virological factors including hepatitis B viral load,mutationsand genotype also have an impact on the adverseoutcomes of the infection,as do hepatotoxic cofactorssuch as alcohol.Our understanding of the natural history of CHB has evolved significantly over the past fewdecades and characterizing the phase of disease ofCHB remains an integral part of managing this virus in the clinic. | Catherine MN Croagh John S Lubel | 2014 | World Journal of Gastroenterology2014，20，30： | 32 |
| 2 | Genotypes and viral variants in chronic hepatitis B: A review of epidemiology and clinical relevance显示文摘The Hepatitis B Virus(HBV) has a worldwide distribu-tion and is endemic in many populations. It is constantly evolving and 10 genotypic strains have been identified with varying prevalences in different geographic regions. Numerous stable mutations in the core gene and in the su-rface gene of the HBV have also been identified in untreated HBV populations. The genotypes and viral variants have been associated with certain clinical featu-res of HBV related liver disease and Hepatocellu-lar carcinoma. For example Genotype C is associated withlater hepatitis B e antigen(HBe Ag) seroconversion, and more advanced liver disease. Genotype A is associated with a greater risk of progression to chronicity in adu-lt acqu-ired HBV infections. Genotype D is particu-larly associated with the precore mu-tation and HBe Ag negative chronic hepatitis B(CHB). The genotypes prevalent in parts of West Africa, Central and Sou-th America, E, F and H respectively, are less well stu-died. Viral variants especially the Basal Core Promotor mutation is associated with increased risk of fibrosis and cancer of the liver. Althou-gh not cu-rrently part of rou-tine clinical care, evalu-ation of genotype and viral variants may provide u-sefu-l adju-nctive information in predicting risk abou-t liver related morbidity in patients with CHB. | Catherine MN Croagh Paul V Desmond Sally J Bell | 2015 | World Journal of Hepatology2015，7，3： | 24 |
| 3 | Hepatitis B surface antigen levels during the natural history of chronic hepatitis B: A perspective on Asia显示文摘 | Tin Nguyen Alexander J.V. Thompson Scott Bowden Catherine Croagh Sally Bell Paul V. Desmond Miriam Levy Stephen A. Locarnini | 2010 | Journal of Hepatology2010，，4： | 7 |
| 4 | Acute chylous ascites mimicking acute appendicitis in a patient with pancreatitis显示文摘We report a case of acute chylous peritonitis mimicking acute appendicitis in a man with acute on chronic pancreatitis. Pancreatitis, both acute and chronic, causing the development of acute chylous ascites and peritonitis has rarely been reported in the English literature. This is the fourth published case of acute chylous ascites mimicking acute appendicitis in the literature. | Emily K Smith Edmund Ek Daniel Croagh Lavinia A Spain Stephen Farrell | 2009 | World Journal of Gastroenterology2009，15，38： | 7 |
| 5 | Hepatitis B surface antigen levels during the natural history of chronic hepatitis B: A perspective on Asia显示文摘 | Tin Nguyen Alexander J.V. Thompson Scott Bowden Catherine Croagh Sally Bell Paul V. Desmond Miriam Levy Stephen A. Locarnini | 2010 | Journal of Hepatology2010，，4： | 1 |
| 6 | Identifi- cation of candidate murine esophageal stem cells using a combi- nation of cell kinetic studies and cell surface markers显示文摘 | Croagh D Phillips WA Redvers R Thomas R J Kaur P | 2007 | Stem Cells2007，25，2： | 1 |
| 7 | Increasing hepatitis B viral load is associated with risk of signiecant liver fibrosis in HBeAg-negative but not HBeAg-positive chronic hepatitis B 显示文摘 | Croagh CMN Bell S J Slavin J | 2010 | Liver Int2010，30，8： | 1 |
| 8 | Increasing hepatitis B viral load is associated with risk of significant liver fibrosis in HBeAg-negative but not HBeAg-positive chronic hepatitis B 显示文摘 | Croagh CM Bell SJ Slavin J | 2010 | Liver lnt2010，30，8： | 1 |
| 9 | Esophageal stem cellsa review of their identification and characterization 显示文摘 | Daniel Croagh | 2008 | Stem Cell Rev2008，10，4： | 1 |
| 10 | Increasing hepatitis B viral load is associated with risk of significant liver fibrosis in HBeAg- negative but not HBeAg-positive chronic hepatitis B显示文摘 | Croagh CMN Bell S J Slavin J | 2010 | Liver Int2010，30，8： | 1 |
| 11 | Identification of candidate murine esophageal stem cells using combination of cell kinetic studies and ceil surface markers 显示文摘 | Croagh D Phillips W A Redvers R | 2007 | Stem Cells2007，25，2： | 1 |
| 12 | Acute chylous ascltes mim- icking acute appendicitis in a patient with pancreatitis 显示文摘 | Smith EK Edmund EK Croagh D | 2009 | World Gastroenterol2009，15，38： | 1 |
| 13 | Hepatitis B surface antigen levels during the natural history of chronic hepatitis B:a perspective on Asia显示文摘 | Nguyen T Thompson AJ Bowden S Croagh C Bell S Desmond PV Levy M Locarnini SA | | 0，，： | 1 |
| 14 | Hepatitis B surface antigen levels during the natural history of chronic hepatitis B: a perspective on Asia 显示文摘 | Nguyen T Thompson AJ Bowden S Croagh C Bell S Desmond PV Levy M Locarnini SA | 2010 | J Hepatol2010，52，4： | 1 |
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