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| 1 | Efficacy and safety of tenofovir in chronic hepatitis B: Australian real world experience显示文摘AIM To evaluate the long-term treatment outcomes of tenofovir therapy in patients in a real world Australian tertiary care setting.METHODS We performed a retrospective analysis of treatment outcomes among treatment-na?ve and treatment-experienced patients receiving a minimum 3 mo tenofovir therapy through St Vincent's Hospital Melbourne, Australia. We included patients receiving tenofovir [tenofovir disoproxil fumarate(TDF)] monotherapy, as well as patients treated with TDF in combination with a second antiviral agent. Patients were excluded if they demonstrated human immune-deficiency virus/hepatitis C virus/hepatitis delta virus coinfection or were less than 18 years of age. We considered virological and biochemicalresponse, as well as safety outcomes. Virological response was determined by measurement of hepatitis B virus(HBV) DNA using sensitive assays; biochemical response was determined via serum liver function tests; histological response was determined from liver biopsy and fibroscan; safety analysis focused on glomerular renal function and bone mineral density. The primary efficacy endpoint was complete virological suppression over time, defined by HBV DNA < 20 IU/m L. Secondary efficacy endpoints included rates of biochemical response, and HB e antigen(HBe Ag)/HB surface antigen loss and seroconversion over time.RESULTS Ninety-two patients were identified who fulfilled the enrolment criteria. Median follow-up was 26 mo(range 3-114). Mean age was 46(24-78) years, 64(70%) were male and 77(84%) were of Asian origin. 55(60%) patients were treatment-na?ve and 62 patients(67%) were HBe Ag-negative. Complete virological suppression was achieved by 45/65(71%) patients at 12 mo, 37/46(80%) at 24 mo and 25/28(89%) at 36 mo. Partial virological response(HBV DNA 20-2000 IU/m L) was achieved by 89/92(96.7%) of patients. Multivariate analysis showed a significant relationship between virological suppression at end of follow-up and baseline HBV DNA level(OR = 0.897, 95%CI: 0.833-0.967, P = 0.0046) and HBe Ag positive status(OR = 0.373, 95%CI: 0.183-0.762, P = 0.0069). There was no difference in response comparing treatment-na?ve and treatment-experienced patients. Three episodes of virological breakthrough occurred in the setting of noncompliance. Tenofovir therapy was well tolerated.CONCLUSION Tenofovir is an efficacious, safe and well-tolerated treatment in an Australian real-world tertiary care setting. Our data are similar to the reported experience from registration trials. | Grace C Lovett Tin Nguyen David M Iser Jacinta A Holmes Robert Chen Barbara Demediuk Gideon Shaw Sally J Bell Paul V Desmond Alexander J Thompson | 2017 | World Journal of Hepatology2017，9，1： | 7 |
| 2 | polyketide and benzopyran compounds of an endophytic fungus isolated from Cinnamomum mollissimum:biological activity and structure显示文摘Objective:To study bioactivity and compounds produced by an endophytic Phoma sp.fungus isolated from the medicinal plant Cinnamomum mollissimum.Methods:Compounds produced by the fungus were extracted from fungal broth culture with ethyl acetate.This was followed by hioaclivity profiling of the crude extract fractions obtained via high performance liquid chromatography.The fractions were tested for cytotoxicity to P388 murine leukemic cells and antimicrobial activity against bacteria and pathogenic fungi.Compounds purified from active fractions which showed antibacterial,antifungal and cytotoxic activities were identified using capillary nuclear magnetic resonance analysis,mass spectrometry and admission to AntiMarin database.Results:Three known compounds,namely 4—hydroxymellein,4,8—dihydroxy—6—melhoxy—3—methyl—3,4-dihydro—1H-isochromen-1—one and 1—(2,6-dihydroxyphenyl) ethanone,were isolated from the fungus.The polyketide compound 4—hydroxymellein showed high inhibitory activity against P388 murine leukemic cells(94.6%) and the bacteria Bacillus sublilis(97.3%).Meanwhile.4,8—dihydroxy-6—melhoxy—3—meth) 1—3,4-dihydro—1H—isochromen—1-one,a benzopyran compound,demonstrated moderate inhibitory activity against P388 murine leukemic cells(48.8%)and the fungus Aspergillus niger(56.1%).The second polyketide compound.1(2,6—dihydroxyphenyl)ethanone was inactive against the tested targets.Conclusions:These findings demonstrate the potential of endophytes as producers ol pharmacologically important compounds,including polyketides which are major secondary metabolites in fungi. | Carolina Santiago Lin Sun Murray Herbert Gibson Munro Jacinta Santhanam | 2014 | Asian Pacific Journal of Tropical Biomedicine2014，4，8： | 2 |
| 3 | IL 28 B genotype is not useful for predicting treatment outcome in A sian chronic hepatitis B patients treated with pegylated interferon‐α显示文摘 | Jacinta A Holmes Tin Nguyen Dilip Ratnam Neel M Heerasing Jane V Tehan Sara Bonanzinga Anouk Dev Sally Bell Stephen Pianko Robert Chen Kumar Visvanathan Rachel Hammond David Iser Ferry Rusli William Sievert Paul V Desmond D Scott Bowden Alexander J Thomps | 2013 | J Gastroenterol Hepatol2013，，5： | 2 |
| 4 | Hepatitis C Virus Infects the Endothelial Cells of the Blood-Brain Barrier显示文摘 | Nicola F. Fletcher Garrick K. Wilson Jacinta Murray Ke Hu Andrew Lewis Gary M. Reynolds Zania Stamataki Luke W. Meredith Ian A. Rowe Guangxiang Luo Miguel A. Lopez–Ramirez Thomas F. Baumert Babette Weksler Pierre–Olivier Couraud Kwang Sik Kim Ignacio A. R | 2012 | Gastroenterology2012，，3： | 2 |
| 5 | Traditional knowledge, use and conservation of plants by the communities of Tharaka-Nithi County, Kenya显示文摘Rural communities in Kenya largely depend on plant resources for their livelihood.The utilization of these resources depends on the availability of plant resources and the level of knowledge of the residents.We conducted an ethnobotanical study in Tharaka-Nithi County in Kenya to determine the knowledge and utilization of various plant species by the local communities.The study was conducted in four major administrative regions from June 2018 to February 2019,involving interview schedules using semi-structured open-ended questionnaires and guided field collections with 48 informants.A total of 214 plant species distributed in 73 families and 169 genera with 616 Use Reports(URs)were documented.Fabaceae was the highest family cited by the informants(31 species)followed by Lamiaceae and Euphorbiaceae(each with 11 species).Trees(49%)and shrubs(32%)were the top life forms of the plants frequently utilized by the local residents.The general plant uses reported were medicinal,food,fodder,construction,fuel,pesticidal,religious,live fencing,and making crafts.Zanthoxylum gilletii,Prunus africana,and Solanum incanum were found to be highly valued by the local communities.Plant utilization as food and medicinal uses against snake-bite related problems had the highest Informant Consensus Factor(ICF).Only 29(13.6%)of the species reported had their status assessed by the International Union for Conservation of Nature(IUCN).Conservation measures,alongside awareness creation in this region,are highly recommended for the species endemic to the region,highly depended on by the community,and those threatened according to IUCN standards. | Vivian Kathambi Fredrick Munyao Mutie Peninah Cheptoo Rono Neng Wei Jacinta Ndunge Munyao Peris Kamau Robert Wahiti Gituru Guang-Wan Hu Qing-Feng Wang | 2020 | Plant Diversity2020，42，6： | 2 |
| 6 | Rapid differen- tial endogenous plasminogen activator expression after acute middle cerebral artery occlusion 显示文摘 | Hosomi N Jacinta Lucero B S Ji Hoe Heo | 2001 | Stroke2001，32，： | 1 |
| 7 | Lead Bioaccessibility in Soil and Mine Wastes After Immobilization with Phosphate显示文摘 | Sérgio T. Bosso Jacinta Enzweiler R?mulo S. Angélica | 2008 | Water, Air, and Soil Pollution . 2008 (1-4)2008，，： | 1 |
| 8 | De-novo mutations of the sodium channel gene SCN1A in alleged vaccine encephalopathy:a retrospective study显示文摘 | Samvel F Berkovic Louise Harkin Jacinta M McMahon | 2006 | Lancet Neurol2006，5，6： | 1 |
| 9 | K SApototic-like cell death pathway is induced in unicellular chlorophyte Cldamydomonas-reinhardtii (Chlorophyceae) cells following UV irradiation:detection and functional analyses显示文摘 | MOHARIK S JACINTAS D ATUL B | 2006 | Journal of Phycology2006，42，： | 1 |
| 10 | Removal of salts from granite by sepiolite显示文摘 | Raquel Trujillano Jacinta Garcia- Talegbn AdolfO C Inigo | 1995 | Appl Clay Sci1995，，9： | 1 |
| 11 | Effect of age on latency and error generation in internally mediated saccades显示文摘 | Larry AA Jacinta D | | 0，，： | 1 |
| 12 | Home visits by community nurses for cancer patients after discharge from hospital: an evaluation study of the continuity visit显示文摘 | Van H Jacinta T M Mistiaen P J | 1997 | Cancer Nurs1997，20，2： | 1 |
| 13 | Correlating Chlamydia trachomatis infectious load with urogenital ecological success and disease pathogenesis显示文摘 | Jo?o P. Gomes Maria J. Borrego Berna Atik Irene Santo Jacinta Azevedo Armando Brito de Sá Paulo Nogueira Deborah Dean | 2005 | Microbes and Infection2005，，1： | 1 |
| 14 | Associations Between Recreational Walking and Attractiveness, Size,and Proximity of Neighborhood Open Spaces显示文摘 | Sugiyama Takemi Francis? Jacinta | 2010 | American Journal of Public Health2010，100，9： | 1 |
| 15 | Monarchs in decline: a collateral landscape-level effect of modern agriculture显示文摘 | Carl Stenoien Kelly R. Nail Jacinta M. Zalucki Hazel Parry Karen S. Oberhauser Myron P. Zalucki | 2018 | Insect Science2018，25，4： | 1 |
| 16 | Determination of platinum group elements and gold in geological materials using an ultraviolet laser ablation high-resolution inductively coupled plasma mass spectrometric technique 显示文摘 | Elisa K S Jorgc E S S Jacinta E | 1998 | Journal of Analytical Atomic Spectrometry1998，13，： | 1 |
| 17 | Measuring perceived communicative ability after traumatic brain injury:Reliability and validity of the La Trobe Communication Questionnaire显示文摘 | Jacinta Christiania Pamela | | 0，，01： | 1 |
| 18 | The Absence of a Mucosal Lesion on Standard Histological Examination Does Not Exclude Diagnosis of Celiac Disease显示文摘 | Bashir M. Mohamed Conleth Feighery Christian Coates Una O’Shea David Delaney Seán O’Briain Jacinta Kelly Mohamed Abuzakouk | 2008 | Digestive Diseases and Sciences2008，，1： | 1 |
| 19 | Global Epigenomic Reconfiguration During Mammalian Brain Development显示文摘 | Ryan Lister Eran A. Mukamel Joseph R. Nery Mark Urich Clare A. Puddifoot Nicholas D. Johnson Jacinta Lucero Yun Huang Andrew J. Dwork Matthew D. Schultz Miao Yu Julian Tonti-Filippini Holger Heyn Shijun Hu Joseph C. Wu Anjana Rao Manel Esteller Chuan He F | 2013 | Science2013，，6146： | 1 |
| 20 | An overview of conflict显示文摘 | Jacinta Kelly | 2006 | Dimensions of Critical Care Nursing2006，25，1： | 1 |
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