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| 1 | Liver injury after aluminum potassium sulfate and tannic acid treatment of hemorrhoids显示文摘We are reporting a rare case of acute liver injury that developed after an internal hemorrhoid treatment with the aluminum potassium sulfate and tannic acid(ALTA) regimen. A 41-year-old man developed a fever and liver injury after undergoing internal hemorrhoid treatment with a submucosal injection of ALTA with lidocaine. The acute liver injury was classified clinically as hepatocellular and pathologically as cholestastic. We could not classify the mechanism of injury. High eosinophil and immunoglobulin E levels characterized the injury,and a drug lymphocyte stimulation test was negative on postoperative day 25. Fluid replacement for two weeks after hospitalization improved the liver injury. ALTA therapy involves injecting chemicals into the submucosa,from the rectum to the anus,and this is the first description of a case that developed a severe liver disorder after this treatment; hence,an analysis of future cases as they accumulate is desirable. | Kenichi Yoshikawa Reimi Kawashima Yuki Hirose Keiko Shibata Takafumi Akasu Noriko Hagiwara Takeharu Yokota Nami Imai Akira Iwaku Go Kobayashi Hirohiko Kobayashi Akiyoshi Kinoshita Nao Fushiya Hiroyuki Kijima Kazuhiko Koike Masayuki Saruta | 2017 | World Journal of Gastroenterology2017，23，27： | 5 |
| 2 | Endoscopic submucosal dissection in a patient with esophageal adenoid cystic carcinoma显示文摘We report the first use of endoscopic submucosal dissection(ESD) for the treatment of a patient with adenoid cystic carcinoma of the esophagus(EACC). An 82-year-old woman visited our hospital for evaluation of an esophageal submucosal tumor. Endoscopic examination showed a submucosal tumor in the middle third of the esophagus. The lesion partially stained with Lugol's solution,and narrow band imaging with magnification showed intrapapillary capillary loops with mild dilatation and a divergence of caliber in the center of the lesion. Endoscopic ultrasound imaging revealed a solid 8 mm × 4.2 mm tumor,primarily involving the second and third layers of the esophagus. A preoperative biopsy was non-diagnostic. ESD was performed to resect the lesion,an 8 mm submucosal tumor. Immunohistologically,tumor cells differentiating into ductal epithelium and myoepithelium were observed,and the tissue type was adenoid cystic carcinoma. There was no evidence of esophageal wall,vertical stump or horizontal margin invasion with p T1 b-SM2 staining(1800 μm from the muscularis mucosa). Further studies are needed to assess the use of ESD for the treatment of patients with EACC. | Kenichi Yoshikawa Akiyoshi Kinoshita Yuki Hirose Keiko Shibata Takafumi Akasu Noriko Hagiwara Takeharu Yokota Nami Imai Akira Iwaku Go Kobayashi Hirohiko Kobayashi Nao Fushiya Hiroyuki Kijima Kazuhiko Koike Haruka Kaneyama Keiichi Ikeda Masayuki Saruta | 2017 | World Journal of Gastroenterology2017，23，45： | 3 |
| 3 | Preoperative Neutrophil-to-Lymphocyte Ratio Is a Predictor of Survival After Hepatectomy for Hepatocellular Carcinoma: A Retrospective Analysis显示文摘 | Yohei Mano Ken Shirabe Yo-ichi Yamashita Norifumi Harimoto Eiji Tsujita Kazuki Takeishi Shinichi Aishima Toru Ikegami Tomoharu Yoshizumi Takeharu Yamanaka Yoshihiko Maehara | 2013 | Annals of Surgery2013，，2： | 2 |
| 4 | Rupture of a Small Hepatocellular Carcinoma in a Stable Disease State in a Patient Receiving Sorafenib Treatment显示文摘 | Rumiko Tsuboi Takeharu Asano Katsuhiko Matsuora Shinichi Asabe Hirosato Mashima | 2018 | Chinese Medical Journal2018，，8： | 2 |
| 5 | Ansa pancreatica as a predisposing factor for recurrent acute pancreatitis显示文摘AIM To determine the non-biased prevalence and clinical significance of ansa pancreatica in patients with acute pancreatitis using magnetic resonance imaging(MRI).METHODS Our institutional review board approved this crosssectional study, which consisted of a community-based cohort of 587 consecutive participants in a whole-body health-check program, and 73 subjects with episode of acute pancreatitis(55 patients with a single episode of acute pancreatitis, and 18 patients with recurrent acute pancreatitis). All of the subjects underwent abdominal MRI including magnetic resonance cholangiopancreatography, medical examinations, and blood tests. Two board-certified, diagnostic, abdominal radiologists evaluated the images, and ansa pancreatica was diagnosed based on its characteristic anatomy on MRI.RESULTS Compared with the community group [5/587(0.85%)], patients with recurrent acute pancreatitis had a significantly higher frequency of ansa pancreatica [2/18(11.1%)](P = 0.016; OR = 14.3; 95%CI: 1.27-96.1), but not compared with patients with single-episode acute pancreatitis [1/55(1.8%)](P = 0.42; OR = 2.1; 95%CI: 0.44-19.7). Multiple logistic regression analysis using age, alcohol intake, presence of ansa pancreatica, and presence of autoimmune disease as independent covariates, revealed a significant relationship between the presence of ansa pancreatica and recurrent acute pancreatitis. The presence of autoimmune disease was also significantly associated with the onset of recurrent acute pancreatitis. On the other hand, neither age nor alcohol intake were significantly related to the onset of recurrent acute pancreatitis.CONCLUSION The present study is the first to provide robust evidence that the presence of ansa pancreatica is significantly associated with recurrent acute pancreatitis. | Takana Yamakawa Hayashi Wataru Gonoi Takeharu Yoshikawa Naoto Hayashi Kuni Ohtomo | 2016 | World Journal of Gastroenterology2016，22，40： | 2 |
| 6 | Thermal conductivity and thermal cycle life of La2 O3 and HfO2 doped ZrO2- Y2O3 coatings produced by EB-PVD 显示文摘 | Mineaki Matsumoto Takeharu Kato Norio Yamaguchi Daisaku Yokoe Hideaki Matsubara | 2009 | Surface and Coatings Technology2009，203，19： | 1 |
| 7 | Development of a flaw evaluation handbook of the high pressure institute of Japan显示文摘 | Hideo Kobayashi Shinsuke Sakai Masayuki Asano Katsumasa Miyazaki Takeharu Nagasaki Yoshiaki Takahashi | 2001 | International Journal of Pressure Vessels and Piping2001，，14： | 1 |
| 8 | Usefulness of new automated cutting needle for tissue-core bisopy of lung nodules under CT fluoroscopic guidence显示文摘 | Takuji Y Shigeharu L Takeharu K | 2003 | Chest2003，124，： | 1 |
| 9 | A neutrophil elastase inhibitor(ONO-5046) reduces neurologic damage after spinalcord injury in rats显示文摘 | Takeharu Tonai Kei-ichiro Shiba Yutaka Taketani | 2001 | Joural of Neurochimistry2001，78，： | 1 |
| 10 | Portal Vein Thrombosis After Hepatectomy显示文摘 | Shohei Yoshiya Ken Shirabe Hidekazu Nakagawara Yuji Soejima Tomoharu Yoshizumi Toru Ikegami Yo-ichi Yamashita Norifumi Harimoto Akihiro Nishie Takeharu Yamanaka Yoshihiko Maehara | 2014 | World Journal of Surgery2014，，： | 1 |
| 11 | A Novel Type of EWS-CHOP Fusion Gene in Two Cases of Myxoid Liposarcoma显示文摘 | Taisuke Hosaka Yasuaki Nakashima Katsuyuki Kusuzaki Hiroaki Murata Tomitaka Nakayama Takeharu Nakamata Tomoki Aoyama Takeshi Okamoto Kohichi Nishijo Nobuhito Araki Tadao Tsuboyama Takashi Nakamura Junya Toguchida | 2002 | The Journal of Molecular Diagnostics2002，，3： | 1 |
| 12 | An Active Muffler for Medium-Duty Diesel Vehicles Considering Acceleration Characteristics 显示文摘 | Tanaka Takeharu Li Keqiang | 2000 | Technical Notes/JSAE Review2000，，21： | 1 |
| 13 | Noise Source Identification on an Operating Vehicle by Acoustic Holography-Part I:Investigation of Noise Source Identification Accuracy by using Mock-Up Tires显示文摘 | Sakamoto Ichiro Tanaka Takeharu Miyake Tatsuya | 1995 | JSAE review1995，16，3： | 1 |
| 14 | The Ef- fectiveness of Latent Semantic Analysis for Building up a Bottom -up Taxonomy from Folksonomy Tags显示文摘 | Eda Takeharu Yoshikawa Masatoshi Uchiyama Toshio | 2009 | World Wide Web- Intemet and Web Information2009，，4： | 1 |
| 15 | Experimental investigation on generated power of amorphous PV module for roof azimuth显示文摘 | Takeharu Yamawaki Seishiro Mizukami Takashi Masui | 2001 | Solar Energy Materials & Solar Cells2001，67，： | 1 |
| 16 | Determination of mustard and lewisite related compounds in abandoned chemical weapons(Yellows shells) from sources in China and Japan 显示文摘 | Shigeyuki H Koji N Takeharu W | 2006 | Journal of Chromatography A2006，1101，： | 1 |
| 17 | Impuluse Generation on Aluminum Tar- get Irradiated with Nd: YAG Laser Pulse in Ambient Gas 显示文摘 | Takeharu Sakai | 2009 | Journal of Propulsion and Power2009，25，2： | 1 |
| 18 | Spectrum of Epstein-Barr virus-related diseases: a pictorial review显示文摘 | Eriko Maeda Masaaki Akahane Shigeru Kiryu Nobuyuki Kato Takeharu Yoshikawa Naoto Hayashi Shigeki Aoki Manabu Minami Hiroshi Uozaki Masashi Fukayama Kuni Ohtomo | 2009 | Japanese Journal of Radiology2009，，1： | 1 |
| 19 | An Active Muffler for mediumDuty Diesel Vehicles Considering Acceleration Characteristics显示文摘 | Tanaka Takeharu Li Keqiang | 2000 | Technical Notes/JSAE Review2000，，21： | 1 |
| 20 | Mixed acinar-endocrine carcinoma of the pancreas with intraductal growth into the main pancreatic duct: Report of a case显示文摘 | Shinjiro Kobayashi Takeshi Asakura Nobuyuki Ohike Takeharu Enomoto Joe Sakurai Satoshi Koizumi Taiji Watanabe Hiroshi Nakano Takehito Otsubo | 2010 | Surgery Today2010，，4： | 1 |
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