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| 1 | Gallbladder cancer: Clinical and pathological approach显示文摘Gallbladder cancer(GBC) shows a marked geographical variation in its incidence. Middle-aged and elderly women are more commonly affected. Risk factors for its development include the presence of gallstones, chronic infection and pancreaticobiliary maljunction. Controversy remains in regard to the theory of carcinogenesis from adenomyomatosis, porcelain gallbladder and adenoma of the gallbladder. The surgical strategy and prognosis after surgery for GBC differ strikingly according to T-stage. Discrimination of favorable cases, particularly T2 or T3 lesions, is useful for the selection of surgical strategies for individual patients. Although many candidate factors predicting disease progression, such as depth of subserosal invasion, horizontal tumor spread, tumor budding, dedifferentiation, Ki-67 labeling index, p53 nuclear expression, CD8+ tumor-infiltrating lymphocytes, mitotic counts, Laminin-5-gamma-2 chain, hypoxia-inducible factor-1a, cyclooxygenase-2 and the Hedgehog signaling pathway have been investigated,useful prognostic makers or factors have not been established. As GBC is often discovered incidentally after routine cholecystectomy and accurate preoperative diagnosis is difficult, close mutual cooperation between surgeons and pathologists is essential for developing a rational surgical strategy for GBC. | Keita Kai Shinichi Aishima Kohji Miyazaki | 2014 | World Journal of Clinical Cases2014，2，10： | 8 |
| 2 | Granulomatous reaction in hepatic inflammatory angiomyolipoma after chemoembolization and spontaneous rupture显示文摘A 77-year-old Japanese woman was transported to a nearby hospital due to sudden abdominal pain and transient loss of consciousness. Abdominal computed tomography(CT) suggested hemoperitoneum and hepatic nodule. She was conservatively treated. Contrast-enhanced CT two months later revealed an increased mass size, and the enhancement pattern suggested the possibility of hepatocellular carcinoma(HCC). Under a clinical diagnosis of HCC, transcatheter arterial chemoembolization(TACE) was performed. A subsequent imaging study revealed that most of the lipiodol used for the embolization was washed out. Therefore, surgical resection was performed. Histologically, the nodule contained numerous inflammatory cells including small lymphocytes, plasma cells and macrophages. Notably, epithelioid granulomatous features with multinucleated giant cells were observed in both the nodule and background liver. Some of the multinucleated giant cells contained oil lipid. Among the infiltrating inflammatory cells,spindle-shaped, histiocytoid or myoid tumor cells with eosinophilic cytoplasm were found. The tumor cells were positive for Melan A and HMB45. The nodule contained many Ig G4-positive plasma cells; these were counted and found to number 72.6 cells/HPF(range: 61-80). The calculated Ig G4:Ig G ratio was 33.2%. The nodule was finally diagnosed as previously ruptured inflammatory angiomyolipoma modified by granulomatous reaction after TACE. | Keita Kai Atsushi Miyosh Shinichi Aishima Kota Wakiyama Shunya Nakashita Shinji Iwane Shinya Azama Hiroyuki Irie Hirokazu Noshiro | 2015 | World Journal of Gastroenterology2015，21，32： | 4 |
| 3 | Formalin fixation on HER-2 and PD-L1 expression in gastric cancer:A pilot analysis using the same surgical specimens with different fixation times显示文摘BACKGROUND The needs for human epidermal growth factor receptor 2(HER-2) and/or programmed death-ligand 1(PD-L1) evaluations in gastric cancer are dramatically increasing. Although the importance of standardization of sample fixation has been widely recognized, most of the evidence regarding the fixation duration or type of fixing solution are based on breast cancer.AIM To investigate the real effects of fixation conditions on HER-2 testing or PD-L1 testing for gastric cancer using gastrectomy specimens.METHODS Thirty-two patients who underwent gastrectomy for gastric cancer were enrolled.Their resected specimens were each divided into four pieces and fixed in four strictly controlled different durations(6 h, 24 h, and 48 h, and 1 wk) by 10%formalin(n = 22) or 10% neutral buffered formalin(NBF)(n = 10).Immunohistochemistry(IHC) of HER-2 and PD-1 was performed, and a pathology examination was conducted. In the HER-2-immunoreactive cases, all four specimens were subjected to dual-color in situ hybridization(DISH). Five cases were assessed as HER-2-positive by IHC and DISH. We used the cut-off values of 1%, 10%, and 50% to assess the IHC findings of PD-L1.RESULTS No significant difference was observed in comparisons between the shorter fixation period groups(6 h, 24 h, and 48 h) and the prolonged fixation period(1 wk) group in the HER-2 and PD-L1 analyses. Although no significant difference was observed between 10% formalin and 10% NBF within 1 wk of fixation, the superiority of 10% NBF was confirmed in a long-term(> 3 mo) fixation in both the HER-2 and PD-L1 analyses.CONCLUSION In this small-numbered pilot study, prolonged fixation within 1 wk showed no inferiority in HER-2 or PD-L1 testing. However, a large-numbered prospective study is needed to obtain conclusive results. | Keita Kai Yukie Yoda Atsushi Kawaguchi Akimichi Minesaki Hironori Iwasaki Shinichi Aishima Hirokazu Noshiro | 2019 | World Journal of Clinical Cases2019，7，4： | 4 |
| 4 | Inverse correlation between CD8^+ inflammatory cells and E-cadherin expression in gallbladder cancer:Tissue microarray and imaging analysis显示文摘AIM To investigated the association between the tumor cells' expression of E-cadherin and the numbers of several types of inflammatory cells infiltrating into the invasive portion of gallbladder cancer(GBC).METHODS We analyzed 50 GBC cases for which a sufficient amount of tumor tissues for tissue microarray(TMA) had been saved. Three tissue cores(3.0 mm) of invasive lesion from each case were used for the TMA. The 4-μm cut sections on slides were immunostained using primary antibodies including E-cadherin for cancer cells, leukocyte common antigen for leukocyte, myeloperoxidase for neutrophils, CD3 for T cells, CD4 for helper T cells, CD8 for killer T cells, CD20 for B cells and CD68 for macrophages. The immunostained slides were digitally analyzed by imaging analysis software.RESULTS A significant inverse correlation between the number of infiltrating CD8^+ cells at invasive areas and the expression of E-cadherin by cancer cells was observed(P = 0.0001), although the degree of this correlation was relatively weak(R = 0.32). The number of CD8^+ cells and the cancer cells' E-cadherin expression were also significantly correlated with tumor differentiation(welldifferentiated vs poorly differentiated)(P = 0.0467 and P = 0.0294, respectively). Inverse correlation of T-stageand the number of CD8^+ cell infiltration was observed with statistical significance in comparison of T2 and T3 cases(P = 0.0324).CONCLUSION Our findings indicate an inverse correlation of CD8^+ T cell infiltration and cancer cells' E-cadherin expression at invasive areas of GBC. Further analyses are essential to test these findings. | Keita Kai Masanori Masuda Shinichi Aishima | 2017 | World Journal of Clinical Cases2017，5，1： | 3 |
| 5 | Occult hepatitis B virus infection and surgical outcomes in non-B, non-C patients with curative resection for hepatocellular carcinoma显示文摘AIM To investigate the prevalence, clinicopathological characteristics and surgical outcomes of occult hepatitis B virus(HBV) infection(OBI) in patients with non-B, non-C(NBNC) hepatocellular carcinoma(HCC).METHODS This study retrospectively examined the cases of 78 NBNC patients with curative resection for HCC for whom DNA could be extracted from formalin-fixed paraffin-embedded tissue. OBI was determined by the HBV-DNA amplification of at least two different sets of primers by TaqM an realtime polymerase chain reaction. Possibly carcinogenetic factors such as alcohol abuse, diabetes mellitus, obesity and non-alcoholic steatohepatitis(NASH) were examined. Surgical outcomes were evaluated according to diseasefree survival(DFS), overall survival(OS) and diseasespecific survival(DSS).RESULTS OBI was found in 27/78 patients(34.6%) with NBNC HCC. The OBI patients were significantly younger than the non-OBI cases at the time of surgery(average age 63.0 vs 68.1, P = 0.0334) and the OBI cases overlapped with other etiologies significantly more frequently compared to the non-OBI cases(P = 0.0057). OBI had no impact on the DFS, OS or DSS. Only tumorrelated factors affected these surgical outcomes.CONCLUSION Our findings indicate that OBI had no impact on surgical outcomes. The surgical outcomes of NBNC HCC depend on early tumor detection; this reconfirms the importance of a periodic medical examination for individuals who have NBNC HCC risk factors. | Hiroki Koga Keita Kai Shinichi Aishima Atsushi Kawaguchi Koutaro Yamaji Takao Ide Junji Ueda Hirokazu Noshiro | 2017 | World Journal of Hepatology2017，9，35： | 2 |
| 6 | Predictors of Extrahepatic Recurrence After Curative Hepatectomy for Hepatocellular Carcinoma显示文摘 | Akinobu Taketomi Takeo Toshima Dai Kitagawa Takashi Motomura Kazuki Takeishi Yohei Mano Hiroto Kayashima Keishi Sugimachi Shinichi Aishima Yoichi Yamashita Toru Ikegami Tomonobu Gion Hideaki Uchiyama Yuji Soejima Takashi Maeda Ken Shirabe Yoshihiko Maehar | 2010 | Annals of Surgical Oncology2010，，10： | 2 |
| 7 | Intraductal Papillary Mucinous Neoplasms of the Pancreas With Distinct Pancreatic Ductal Adenocarcinomas Are Frequently of Gastric Subtype显示文摘 | Noboru Ideno Takao Ohtsuka Hiroshi Kono Kenji Fujiwara Yasunori Oda Shinichi Aishima Tetsuhide Ito Kousei Ishigami Shoji Tokunaga Kenoki Ohuchida Shunichi Takahata Masafumi Nakamura Kazuhiro Mizumoto Masao Tanaka | 2013 | Annals of Surgery2013，，1： | 2 |
| 8 | Preoperative Neutrophil-to-Lymphocyte Ratio Is a Predictor of Survival After Hepatectomy for Hepatocellular Carcinoma: A Retrospective Analysis显示文摘 | Yohei Mano Ken Shirabe Yo-ichi Yamashita Norifumi Harimoto Eiji Tsujita Kazuki Takeishi Shinichi Aishima Toru Ikegami Tomoharu Yoshizumi Takeharu Yamanaka Yoshihiko Maehara | 2013 | Annals of Surgery2013，，2： | 2 |
| 9 | Tumor-Associated Macrophage Promotes Tumor Progression via STAT3 Signaling in Hepatocellular Carcinoma显示文摘 | Mano Yohei Aishima Shinichi Fujita Nobuhiro Tanaka Yuki Kubo Yuichiro Motomura Takashi Taketomi Akinobu Shirabe Ken Maehara Yoshihiko Oda Yoshinao | 2013 | Pathobiology2013，，3： | 2 |
| 10 | Extended Indication for Living Donor Liver Transplantation in Patients With Hepatocellular Carcinoma显示文摘 | Yuji Soejima Akinobu Taketomi Tomoharu Yoshizumi Hideaki Uchiyama Shinich Aishima Takahiro Terashi Mitsuo Shimada Yoshihiko Maehara | 2007 | Transplantation2007，，7： | 2 |
| 11 | Prognostic impact of cholangiocellular and sarcomatous components in combined hepatocel- lular and cholangiocarcinoma显示文摘 | Aishima S Kuroda Y Asayama Y | 2006 | Hum Pathol2006，37，3： | 1 |
| 12 | Lymphatic spread is related to VEGF-C expression and D2-40-posotive myofibroblasts in intrahepatic cholangiocarcinoma 显示文摘 | Aishima S Nishihara Y Lguchi T | 2008 | Mod Pathol2008，21，3： | 1 |
| 13 | The mode of tumour progression in combined hepatocellular carcinoma and cholangiocarci- noma: an immunohistochemical analysis of E - cadherin, alpha - catenin and beta - catenin 显示文摘 | Asayama Y Taguchi KK Aishima SS | 2002 | Liver2002，22，1： | 1 |
| 14 | 伴有黏液样变的原发性肝脏肿瘤:形态学罕见的肝脏腺瘤和肝细胞性肝癌显示文摘Sa1aria S N,Graham R P,Aishima S,et al. Primary hepatic tumors with myxoid change:morpho1ogica11y unique hepatic ade-nomas and hepatoce11u1ar carcinomas. Am J Surg Patho1,2015,39(3):318-24。原发性肝脏肿瘤中,如果有黏液产生被认为是向胆道分化最直接的证据。然而,作者观察到在良性和恶性的肝脏肿瘤中,均可有丰富的细胞外黏液产生,而这些肿瘤仅有向肝细胞分化的依据。为进一步描述这种不同寻常的发现,作者发现9例类似的病例并对其进行进一步的研究,其中4例为肝脏腺瘤,5例为肝细胞性肝癌。 | Salaria S N Graham R P Aishima S 魏建国 许春伟 | 2015 | 临床与实验病理学杂志2015，31，6： | 1 |
| 15 | Fascin overexpression is involved in carcinogenesis and prognosis of human intrahepatic cholangiocarcinoma:immunohistochenical and molecular analysis显示文摘 | Iguchi T Aishima S Taketomi A | | 0，，： | 1 |
| 16 | Hepatoid adenocarcinoma of the stomach: histogenesis and progression in association with intestinal phenotype 显示文摘 | Kumashiro Y Yao T Aishima S | 2007 | Hum Pathol2007，38，6： | 1 |
| 17 | Investigating sensory characteristics and volatile components in boiled scallop aroma using chemometric techniques显示文摘 | Morita K Kubota K Aishima T | 2002 | Food Chem2002，78，1： | 1 |
| 18 | Investigating sensory characteristics and volatile componentsin boiled scallop aroma using chemometric techniques显示文摘 | MORITA K KUBOTA K AISHIMA T | 2002 | Food Chemistry2002，78，： | 1 |
| 19 | CD10 + fibroblasts are more involved in the progression of hilar/extrahepatic cholangiocarcinoma than of peripheral intrahepatic cholangiocarcinoma显示文摘 | Nishihara Y Aishima S Hayashi A | 2009 | Histopathology2009，55，4： | 1 |
| 20 | Investigating sensory characteristics and volatile components in boiled scalloparoma using chemometric techniques显示文摘 | Morita K Kubota K Aishima T | 2002 | Food Chemistry2002，78，1： | 1 |
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