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| 1 | Newly-generated Daliangshan Fault Zone—Shortcutting on the central section of Xianshuihe-Xiaojiang fault system显示文摘The Daliangshan fault zone is the eastern branch in the central section of Xianshuihe-Xiaojiang fault system. It has been neglected for a long time, partly because of no destructive earthquake records along this fault zone. On the other hand, it is located on the remote and inaccessible plateau. So far it was excluded as part of the Xianshuihe-Xiaojiang fault system. Based on the interpretation of aerophotographs and field investigations, we document this fault zone in detail, and give an estimation of strike-slip rate about 3 mm/a in Late Quaternary together with age dating data. The results suggest that the Daliangshan fault zone is a newly-generated fault zone resulted from shortcutting in the central section of Xianshuihe-Xiaojiang fault system because of the clockwise rotation of the Southeastern Tibetan Crustal Block, which is bounded by the Xianshuihe-Xiaojiang fault system. Moreover, the shortcutting may make the Daliangshan fault zone replace the Anninghe and Zemuhe fault zones gradually, and finally, the later two fault zones will probably die out with the continuous clockwise rotation. | IKEDA Yasutaka TOGO Masayoshi TAJIKARA Masayoshi ECHIGO Tomoo OKADA Shinsuke | 2008 | Science China Earth Sciences2008，51，9： | 23 |
| 2 | Propofol sedation during endoscopic treatment for early gastric cancer compared to midazolam显示文摘Endoscopic submucosal dissection(ESD)has been proposed as the gold standard in the treatment of early gastric cancer because it facilitates a more accurate histological assessment and reduces the risk of tumor recurrence.However,the time course of ESD for large gastric tumors is frequently prolonged because of the tumor size and technical difficulties and typically requires higher doses of sedative and pain-controlling drugs.Sedative or anesthetic drugs such as midazolam or propofol are used during the procedure.Therapeutic endoscopy of early gastric cancers can often be performed with only moderate sedation.Compared with midazolam,propofol has a very fast onset of action,short plasma half-life and time to achieve sedation,faster time to recovery and discharge,and results in higher patient satisfaction.For overall success,maintaining safety and stability not only during the procedure but also subsequently in the recovery room and ward is necessary.In obese patients,it is recommended that the injected dose be based on a calculated standard weight.Cooperation between gastroenterologists,surgeons,and anesthesiologists is imperative for a successful ESD procedure. | Shinsuke Kiriyama Hiroshi Naitoh Hiroyuki Kuwano | 2014 | World Journal of Gastroenterology2014，20，34： | 14 |
| 3 | Pancreatic guidewire placement for achieving selective biliary cannulation during endoscopic retrograde cholangio-pancreatography显示文摘AIM: To investigate the frequency and risk factors for acute pancreatitis after pancreatic guidewire placement (P-GW) in achieving cannulation of the bile duct during endoscopic retrograde cholangio-pancreatography (ERCP). METHODS: P-GW was performed in 113 patients in whom cannulation of the bile duct was difficult. The success rate of biliary cannulation, the frequency and risk factors of post-ERCP pancreatitis, and the frequency of spontaneous migration of the pancreatic duct stent were investigated. RESULTS: Selective biliary cannulation with P-GW was achieved in 73% of the patients. Post-ERCP pancreatitis occurred in 12% (14 patients: mild, 13; moderate, 1). Prophylactic pancreatic stenting was attempted in 59% of the patients. Of the 64 patients who successfully underwent stent placement, three developed mild pancreatitis (4.7%). Of the 49 patients without stent placement, 11 developed pancreatitis (22%: mild, 10; moderate, 1). Of the five patients in whom stent placement was unsuccessful, two developed mild pancreatitis. Univariate and multivariate analyses revealed no pancreatic stenting to be the only significant risk factor for pancreatitis. Spontaneous migration of the stent was observed within two weeks in 92% of the patients who had undergone pancreatic duct stenting.CONCLUSION: P-GW is useful for achieving selective biliary cannulation. Pancreatic duct stenting after P-GW can reduce the incidence of post-ERCP pancreatitis, which requires evaluation by means of prospective randomized controlled trials. | Kei Ito Naotaka Fujita Yutaka Noda Go Kobayashi Takashi Obana Jun Horaguchi Osamu Takasawa Shinsuke Koshita Yoshihide Kanno | 2008 | World Journal of Gastroenterology2008，14，36： | 14 |
| 4 | Gastric cancer arising from the remnant stomach after distal gastrectomy:A review显示文摘Gastric stump carcinoma was initially reported by Balfore in 1922,and many reports of this disease have since been published. We herein review previous reports of gastric stump carcinoma with respect to epidemiology,carcinogenesis,Helicobacter pylori(H. pylori) infection,Epstein-Barr virus infection,clinicopathologic characteristics and endoscopic treatment. In particular,it is noteworthy that no prognostic differences are observed between gastric stump carcinoma and primary upper third gastric cancer. In addition,endoscopic submucosal dissection has recently been used to treat gastric stump carcinoma in the early stage. In contrast,many issues concerning gastric stump carcinoma remain to be clarified,including molecular biological characteristics and the carcinogenesis of H.pylori infection.We herein review the previous pertinent literature and summarize the characteristics of gastric stump carcinoma reported to date. | Shinsuke Takeno Tatsuya Hashimoto Kenji Maki Ryosuke Shibata Hironari Shiwaku Ippei Yamana Risako Yamashita Yuichi Yamashita | 2014 | World Journal of Gastroenterology2014，20，38： | 13 |
| 5 | Multi-Strategy Dynamic Spectrum Access in Cognitive Radio Networks: Modeling, Analysis and Optimization显示文摘Dynamic spectrum access(DSA) based on cognitive radios(CR) technique is an effective approach to address the 'spectrum scarcity' issue. However, traditional CR-enabled DSA system employs only single DSA strategy, which might not be suited to the dynamic network environment. In this paper, we propose a multi-strategy DSA(MS-DSA) system, where the primary and the secondary system share spectrum resources with multiple DSA strategies simultaneously. To analyze the performance of the proposed MS-DSA system, we model it as a continuous-time Markov chain(CTMC) and derive the expressions to compute the corresponding performance metrics. Based on this, we define a utility function involving the concerns of effective throughput, interference quantity on primary users, and spectrum leasing cost. Two optimization schemes, named as spectrum allocation and false alarm probability selection, are proposed to maximize the utility function. Finally, numerical simulations are provided to validate our analysis and demonstrate that the performance can be significantly improved caused by virtues of the proposed MS-DSA system. | Yi Yang Qinyu Zhang Ye Wang Takahiro Emoto Masatake Akutagawa Shinsuke Konaka | 2019 | China Communications2019，16，3： | 9 |
| 6 | Adaptive Resources Allocation Algorithm Based on Modified PSO for Cognitive Radio System显示文摘Radio spectrum has become a rare resource due to the rapid development of wireless communication technique. Cognitive radio is one of important techniques to deal with this radio spectrum problem. But the resource allocation in cognitive radio also has its own issues, such as the flexibility of the allocation algorithm, the performance of resource allocation, and so on. In order to increase the flexibility of the allocation algorithm for cognitive radio, more and more researches are focusing on the evolutionary algorithms, such as genetic algorithm(GA), particle swarm optimization(PSO). Evolutionary algorithm can greatly improve the flexibility of the allocation algorithm for cognitive radio system in different communication scenarios, but the performances are relatively lower than the original mathematical methods. So in this paper, we proposed an adaptive resource allocation algorithm based on modified PSO for cognitive radio system to solve these problems. Modified particle swarm optimization(Modified PSO) has both genetic algorithm(GA) and particle swarm optimization(PSO)’s updating processes which makes this modified PSO overcame PSO’s own disadvantages and keep advantages. Simulation results showed our proposed algorithm has enough flexibility to meet cognitive radio systems’ requirements, and also has a better performance than original PSO. | Yi Yang Qinyu Zhang Ye Wang Takahiro Emoto Masatake Akutagawa Shinsuke Konaka | 2019 | China Communications2019，16，5： | 9 |
| 7 | A novel animal model for in vivo study of liver cancer metastasis显示文摘AIM:To establish an animal model with human hepatocyte-repopulated liver for the study of liver cancer metastasis.METHODS:Cell transplantation into mouse livers was conducted using alpha-fetoprotein(AFP)-producing hu-man gastric cancer cells(h-GCCs) and h-hepatocytes as donor cells in a transgenic mouse line expressing urokinase-type plasminogen activator(uPA) driven by the albumin enhancer/promoter crossed with a severe combined immunodeficient(SCID) mouse line(uPA/SCID mice).Host mice were divided into two groups(A and B).Group A mice were transplanted with h-GCCs alone,and group B mice were transplanted with h-GCCs and h-hepatocytes together.The replacement index(RI),which is the ratio of transplanted h-GCCs and h-hepatocytes that occupy the examined area of a histological section,was estimated by measuring h-AFP and h-albumin concentrations in sera,respectively,as well as by immunohistochemical analyses of h-AFP and human cytokeratin 18 in histological sections.RESULTS:The h-GCCs successfully engrafted,repopulated,and colonized the livers of mice in group A(RI = 22.0% ± 2.6%).These mice had moderately differentiated adenocarcinomatous lesions with disrupted glandular structures,which is a characteristics feature of gastric cancers.The serum h-AFP level reached 211.0 ± 142.2 g/mL(range,7.1-324.2 g/mL).In group B mice,the h-GCCs and h-hepatocytes independently engrafted,repopulated the host liver,and developed colonies(RI = 12.0% ± 6.8% and 66.0% ± 12.3%,respectively).h-GCC colonies also showed typical adenocarcinomatous glandular structures around the h-hepatocyte-colonies.These mice survived for the full 56 day-study and did not exhibit any metastasis of h-GCCs in the extrahepatic regions during the observational period.The mice with an h-hepatocyte-repopulated liver possessed metastasized h-GCCs and therefore could be a useful humanized liver animal model for studying liver cancer metastasis in vivo.CONCLUSION:A novel animal model of human liver cancer metastasis was established using the uPA/SCID mouse line.This model could be useful for in vivo testing of anti-cancer drugs and for studying the mechanisms of human liver cancer metastasis. | Shinsuke Fujiwara Hikaru Fujioka Chise Tateno Ken Taniguchi Masahiro Ito Hiroshi Ohishi Rie Utoh Hiromi Ishibashi Takashi Kanematsu Katsutoshi Yoshizato | 2012 | World Journal of Gastroenterology2012，18，29： | 6 |
| 8 | Occurrence of emerging flame retardants from e-waste recycling activities in the northern part of Vietnam显示文摘This study investigated the contamination status of 21 emerging flame retardants(FRs)in soils(n=32)and river sediments(n=8)from an e-waste recycling(EWR)site in the northern part of Vietnam.Among analyzed FRs,higher levels of decabromodiphenyl ethane(DBDPE)(NDe4200 ng/g dw),1,2-bis-(2,4,6-tribromophenoxy)ethane(BTBPE)(NDe350 ng/g dw)and Dechlorane Plus isomers(DPs)(NDe65 ng/g dw)were found in soils near EWR workshops and open burning places.The highest concentrations of DBDPE(20 ng/g dw),BTBPE(5.7 ng/g dw)and DPs(6.7 ng/g dw)were also detected in sediments collected from the middle of the EWR site.The levels decreased concomitantly with increasing distance from the EWR site.These results indicate that these FRs were released to the surrounding environment from improper recycling activities,such as manual dismantling of devices and open burning of e-wastes.Moreover,the estimated daily intakes of those FRs via soil ingestion were approximately ten times higher for children than adults.To our knowledge,this is a first comprehensive study on characterization of soil and sediment contamination by a series of emerging FRs at an EWR site in Vietnam. | Masayuki Someya Go Suzuki Alin C.Ionas Nguyen Minh Tue Fuchao Xu Hidenori Matsukami Adrian Covaci Le Huu Tuyen Pham Hung Viet Shin Takahashi Shinsuke Tanabe Hidetaka Takigami | 2016 | Emerging Contaminants2016，2，2： | 5 |
| 9 | Analysis of monomeric and oligomeric organophosphorus flame retardants in fish muscle tissues using liquid chromatographyeelectrospray ionization tandem mass spectrometry:Application to Nile tilapia(Oreochromis niloticus)from an e-waste processing area in northern Vietnam显示文摘Using electrospray ionization tandem mass spectrometry combined with liquid chromatography(LC),a novel analytical method was developed to quantify eight monomeric organophosphorus flame retardants(m-PFRs)and three oligomeric organophosphorus flame retardants(o-PFRs)in fish muscle samples.The optimization and validation experiments indicate that the developed method can determine accurately the concentrations of analytes in fish muscle samples.The recoveries of analytes in fish muscle samples were in the range of 74-105%.The coefficients of variation of the concentrations of analytes in fish muscle samples were 0.6-8.9%.The concentrations of analytes in procedural blanks were below the limit of quantification(LOQ)values.Furthermore,the developed method was applied to the analysis of m-PFRs and o-PFRs in the muscle samples of tilapias collected from an electronic waste(ewaste)processing area in northern Vietnam.The concentrations of m-PFRs such as tris(2-chloroethyl)phosphate(TCEP),tris(2-chloroisopropyl)phosphate(TCIPP),and triphenyl phosphate(TPHP)were dominant among the investigated m-PFRs.The respective concentrations of TCEP,TCIPP,and TPHP were up to 160,300,and 230 ng g^-1 lipid weight,respectively,whereas those of o-PFRs were up to 10 ng g^-1 lipid weight.The results of this study indicate lower accumulation potential of o-PFRs compared with m-PFRs for the first time. | Hidenori Matsukami Go Suzuki Nguyen Minh Tue Le Huu Tuyen Pham Hung Viet Shin Takahashi Shinsuke Tanabe Hidetaka Takigami | 2016 | Emerging Contaminants2016，2，2： | 5 |
| 10 | Nomograms for colorectal cancer:A systematic review显示文摘AIM: To assist in the selection of suitable nomograms for obtaining desired predictions in daily clinicalpractice.METHODS: We conducted electronic searches for journal articles on colorectal cancer(CRC)-associated nomograms using the search terms colon/rectal/colorectal/nomogram. Of 174 articles initially found, we retrieved 28 studies in which a nomogram for CRC was developed.RESULTS: We discuss the currently available CRCassociated nomograms, including those that predict the oncological prognosis, the short-term outcome of treatments, such as surgery or neoadjuvant chemoradiotherapy, and the future development of CRC. Developing nomograms always presents a dilemma. On the one hand, the desire to cover as wide a patient range as possible tends to produce nomograms that are too complex and yet have C-indexes that are not sufficiently high. Conversely, confining the target patients might impair the clinical applicability of constructed nomograms.CONCLUSION: The information provided in this review should be of use in selecting a nomogram suitable for obtaining desired predictions in daily clinical practice. | Kazushige Kawai Eiji Sunami Hironori Yamaguchi Soichiro Ishihara Shinsuke Kazama Hiroaki Nozawa Keisuke Hata Tomomichi Kiyomatsu Junichiro Tanaka Toshiaki Tanaka Takeshi Nishikawa Joji Kitayama Toshiaki Watanabe | 2015 | World Journal of Gastroenterology2015，21，41： | 5 |
| 11 | Searching for a treatment for Alport syndrome using mouse models显示文摘Alport syndrome(AS) is a hereditary nephritis caused by mutations in COL4A3,COL4A4 or COL4A5 encoding the type IV collagen α3,α4,and α5 chains,which are major components of the glomerular basement membrane.About 20 years have passed since COL4A3,COL4A4,and COL4A5 were identified and the first Alport mouse model was developed using a knockout approach.The phenotype of Alport mice is similar to that of Alport patients,including characteristic thickening and splitting of the glomerular basement membrane.Alport mice have been widely used to study the pathogenesis of AS and to develop effective therapies.In this review,the newer therapies for AS,such as pharmacological interventions,genetic approaches and stem cell therapies,are discussed.Although some stem cel therapies have been demonstrated to slow the rena disease progression in Alport mice,these therapies demand continual refinement as research advances.In terms of the pharmacological drugs,angiotensin-converting enzyme inhibitors have been shown to be effective in Alport mice.Novel therapies that can provide a better outcome or lead to a cure are still awaited. | Kan Katayama Shinsuke Nomura Karl Tryggvason Masaaki Ito | 2014 | World Journal of Nephrology2014，3，4： | 5 |
| 12 | 非稳态风边界条件下的自然通风机理及效率显示文摘研究动态自然风风向情况下的自然通风效果,对自然风基础数据进行长期实测,并分析自然风风向动态变化的特征。设计风向动态变化的风洞试验及CFD数值模拟分析,对非稳态自然风条件下的自然通风进行定量化研究,并定性解释不同建筑条件下的非稳态自然通风机理。结果表明:自然风风向在主导风向两侧±45°范围内随机振动,客观动态变化的自然风相对于假定的稳态自然风而言,打破了通风短路的情况,根据建筑条件不同,通风效果提高10%~50%。 | 谭洪卫 季亮 KATO Shinsuke 卜震 | 2012 | 中南大学学报(自然科学版)2012，43，6： | 5 |
| 13 | Breakthrough therapy for peritoneal carcinomatosis of gastric cancer:Intraperitoneal chemotherapy with taxanes显示文摘The effect of chemotherapy on peritoneal carcinomatosis(PC) of gastric cancer remains unclear.Recently,the intraperitoneal(IP) administration of taxanes [e.g.,paclitaxel(PTX) and docetaxel(DOC)] during the perioperative period has shown promising results.Herein,we summarized the rationale and methodology for using IP chemotherapy with taxanes and reviewed the clinical results.IP administered taxanes remain in the IP space at an extremely high concentration for 48-72 h.The drug directly infiltrates peritoneal metastatic nodules from the surface and then produces antitumor effects,making it ideal for IP chemotherapy.There are two types of perioperative IP chemotherapy with taxanes: neoadjuvant intraperitoneal and systemic chemotherapy and sequential perioperative intraperitoneal chemotherapy(SPIC).In SPIC,patients receive neoadjuvant IP chemotherapy and the same regimen of IP chemotherapy after cytoreductive surgery(CRS) until disease progression.Usually,a taxane dissolved in 500-1000 m L of saline at ordinary temperature is administered through an IP access port on an outpatient basis.According to phase Ⅰ?studies,the recommended doses(RD) are as follows: IP DOC,45-60 mg/m2; IP PTX [without intravenous(IV) PTX],80 mg/m2; and IP PTX(with IV PTX),20 mg/m2.Phase Ⅱ studies have reported a median survival time of 14.4-24.6 mo with a 1-year overall survival of 67%-78%.A phase Ⅲ study comparing S-1 in combination with IP and IV PTX to S-1 with IV cisplatin started in 2011.The prognosis of patients who underwent CRS was better than that of those who did not; however,this was partly due to selection bias.Although several phase Ⅱ studies have shown promising results,a randomized controlled study is needed to validate the effectiveness of IP chemotherapy with taxanes for PC of gastric cancer. | Hironori Yamaguchi Joji Kitayama Hironori Ishigami Shinsuke Kazama Hiroaki Nozawa Kazushige Kawai Keisuke Hata Tomomichi Kiyomatsu Toshiaki Tanaka Junichiro Tanaka Takeshi Nishikawa Kensuke Otani Koji Yasuda Soichiro Ishihara Eiji Sunami Toshiaki Watanabe | 2015 | World Journal of Gastrointestinal Oncology2015，7，11： | 3 |
| 14 | 日本三陆沿岸白胸拟鼠海豚体内铁的蓄积(英文)显示文摘根据22头日本三陆沿岸白胸拟鼠海豚的检测结果,研究了必需元素铁在13种组织和器官中的蓄积特征。肺、肝脏和脾脏中铁的浓度显著高于其它脏器,铁在皮肤和鲸脂中的浓度却非常低。研究发现,鲸类肝脏中铁的平均浓度与其最大潜水持续时间有着极其显著的正相关(y=285.17x0.5267;r2=0.92;y:a肝脏中铁的平均浓度,单位为μg·g-1干重;x:最大潜水持续时间,单位为min)。利用该关系式,首次推测白胸拟鼠海豚的最大潜水持续时间为11.85min。 | 杨健 KUNITO Takashi TANABE Shinsuke MIYAZAKI Nobuyuki | 2003 | 水产学报2003，27，5： | 3 |
| 15 | Endoscopic treatment of biliary complications after right-lobe living-donor liver transplantation with duct-to-duct biliary anastomosis显示文摘 | Shujiro Yazumi Takanobu Yoshimoto Hiroshi Hisatsune Kazunori Hasegawa Masaya Kida Shinsuke Tada Yoshito Uenoyama Junichi Yamauchi Seiji Shio Mureo Kasahara Kohei Ogawa Hiroto Egawa Koichi Tanaka Tsutomu Chiba | 2006 | Journal of Hepato-Biliary-Pancreatic Surgery2006，，6： | 2 |
| 16 | Efficacy of a newly developed dilator for endoscopic ultrasound-guided biliary drainage显示文摘AIM To evaluate the efficacy of a newly developed dilator for endoscopic ultrasound(EUS)-guided drainage(ES Dilator).METHODS Fourteen consecutive patients who had undergone EUSguided choledochoduodenostomy(EUS-CDS) with the ES Dilator were identified from a prospectively maintained database and enrolled in the study group.Fourteen other patients who had undergone EUS-CDS without the dilator just prior to its introduction were analyzed as the control group.A historical cohort study was carried out comparing the two groups.The main outcome measurement was the procedure time.The technical success rate and early AE rate were also compared between the two groups.RESULTS There were no significant differences in age,sex and etiology of biliary obstruction.The utilization rate of a plastic stent was higher in the control group(36% vs 0%).The technical success rate was 100% in both groups.The mean procedure time was significantly shorter in the study group than in the control group(27 ± 7 min vs 44 ± 26 min,P = 0.026).Additionally,there were no patients who required more than 40 min for the procedure in the study group.Early adverse events occurred in 29%(4/14) of the control group whereas none in the study group.The adverse events in all 4 patients was bile peritonitis,including pan-peritonitis in one patient.All patientsrecovered with conservative treatment by medication.CONCLUSION The newly developed dilator was found to be useful for shortening procedure time and would prevent adverse events related to bile leakage in EUS-CDS. | Yoshihide Kanno Kei Ito Shinsuke Koshita Takahisa Ogawa Kaori Masu Yoshiharu Masaki Yutaka Noda | 2017 | World Journal of Gastrointestinal Endoscopy2017，9，7： | 2 |
| 17 | Cervical spondylosis: Evaluation of microstructural changes in spinal cord white matter and gray matter by diffusional kurtosis imaging显示文摘 | Masaaki Hori Satoshi Tsutsumi Yukimasa Yasumoto Masanori Ito Michimasa Suzuki Fumine S. Tanaka Shinsuke Kyogoku Masanobu Nakamura Takashi Tabuchi Issei Fukunaga Yuriko Suzuki Koji Kamagata Yoshitaka Masutani Shigeki Aoki | 2014 | Magnetic Resonance Imaging2014，，： | 2 |
| 18 | Function of RNA-binding protein Musashi-1 in stem cells显示文摘 | Hideyuki Okano Hironori Kawahara Masako Toriya Keio Nakao Shinsuke Shibata Takao Imai | 2005 | Experimental Cell Research2005，，2： | 2 |
| 19 | Can pancreatic duct stenting prevent post-ERCP pancreatitis in patients who undergo pancreatic duct guidewire placement for achieving selective biliary cannulation? A prospective randomized controlled trial显示文摘 | Kei Ito Naotaka Fujita Yutaka Noda Go Kobayashi Takashi Obana Jun Horaguchi Osamu Takasawa Shinsuke Koshita Yoshihide Kanno Takahisa Ogawa | 2010 | Journal of Gastroenterology2010，，11： | 2 |
| 20 | Induction of human cardiomyocyte-like cells from fibroblasts by defined factors显示文摘 | Rie Wada Naoto Muraoka Kohei Inagawa Hiroyuki Yamakawa Kazutaka Miyamoto Taketaro Sadahiro Tomohiko Umei Ruri Kaneda Tomoyuki Suzuki Kaichiro Kamiya Shugo Tohyama Shinsuke Yuasa Kiyokazu Kokaji Ryo Aeba Ryohei Yozu Hiroyuki Yamagishi Toshio Kitamura Keiic | 2013 | Proceedings of the National Academy of Sciences2013，，31： | 2 |
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