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| 1 | Long-term survival after resection of pancreatic cancer:A single-center retrospective analysis显示文摘AIM: To retrospectively analyze factors affecting the long-term survival of patients with pancreatic cancer who underwent pancreatic resection.METHODS: From January 2000 to December 2011,195 patients underwent pancreatic resection in our hospital.The prognostic factors after pancreatic resection were analyzed in all 195 patients.After excluding the censored cases within an observational period,the clinicopathological characteristics of 20 patients who survived ≥ 5(n = 20) and < 5(n = 76) years were compared.For this comparison,we analyzed the patients who underwent surgery before June 2008 and were observed for more than 5 years.For statistical analyses,the log-rank test was used to compare the cumulative survival rates,and the χ2 and Mann-Whitney tests were used to compare the two groups.The CoxHazard model was used for a multivariate analysis,and P values less than 0.05 were considered significant.A multivariate analysis was conducted on the factors that were significant in the univariate analysis.RESULTS: The median survival for all patients was 27.1 months,and the 5-year actuarial survival rate was 34.5%.The median observational period was 595 d.With the univariate analysis,the UICC stage was significantly associated with survival time,and the CA19-9 ≤ 200 U/m L,DUPAN-2 ≤ 180 U/m L,t u m o r s i ze ≤ 2 0 m m,R 0 re s e c t i o n,a b s e n c e o f lymph node metastasis,absence of extrapancreatic neural invasion,and absence of portal invasion were favorable prognostic factors.The multivariate analysis showed that tumor size ≤ 20 mm(HR = 0.40; 95%CI: 0.17-0.83,P = 0.012) and negative surgical margins(R0 resection)(HR = 0.48; 95%CI: 0.30-0.77,P = 0.003) were independent favorable prognostic factors.Among the 96 patients,20 patients survived for 5 years or more,and 76 patients died within 5 years after operation.Comparison of the 20 5-year survivors with the 76 non-survivors showed that lower concentrations of DUPAN-2(79.5 vs 312.5 U/mL,P = 0.032),tumor size ≤ 20 mm(35% vs 8%,P = 0.008),R0 resection(95% vs 61%,P = 0.004),and absence of lymph nodemetastases(60% vs 18%,P = 0.036) were significantly associated with the 5-year survival.CONCLUSION: Negative surgical margins and a tumor size ≤ 20 mm were independent favorable prognostic factors.Histologically curative resection and early tumor detection are important factors in achieving long-term survival. | Takehito Yamamoto Shintaro Yagi Hiromitsu Kinoshita Yusuke Sakamoto Kazuyuki Okada Kenji Uryuhara Takeshi Morimoto Satoshi Kaihara Ryo Hosotani | 2015 | World Journal of Gastroenterology2015，21，1： | 18 |
| 2 | Remolded Undrained Strength of Soils显示文摘Extensive data of undrained shear strength for various remolded soils are compiled to normalize the remolded undrained strength. Remolded soils have a wide spectrum of liquid limits ranging from 25% to 412%. It is found that the remolded undrained strength is a function of water content and liquid limit. Furthermore, a simple index designated as normalized water content w * is introduced for normalizing remolded undrained strength for various soils. The normalized water content w * is the ratio of water content to liquid limit. The relationship between the remolded undrained strength and the normalized water content can be expressed by a simple equation. The new simple equation is not only valuable theoretically for helping in assessing the in situ mechanical behavior, but also useful to ocean engineering practice. | 洪振舜 刘汉龙 NEGAMI Takehito | 2003 | 海洋工程:英文版2003，17，1： | 14 |
| 3 | Need for pancreatic stenting after sphincterotomy in patients with difficult cannulation显示文摘AIM:To investigate the need for pancreatic stenting after endoscopic sphincterotomy(EST)in patients with difficult biliary cannulation.METHODS:Between April 2008 and August 2013,2136 patients underwent endoscopic retrograde cholangiopancreatography(ERCP)-related procedures.Among them,55 patients with difficult biliary cannulation who underwent EST after bile duct cannulation using the pancreatic duct guidewire placement method(P-GW)were divided into two groups:a stent group(n=24;pancreatic stent placed)and a no-stent group(n=31;no pancreatic stenting).We retrospectively compared the two groups to examine the need for pancreatic stenting to prevent post-ERCP pancreatitis(PEP)in patients undergoing EST after biliary cannulation by P-GW.RESULTS:No differences in patient characteristics or endoscopic procedures were observed between the two groups.The incidence of PEP was 4.2%(1/24)and29.0%(9/31)in the Stent and no-stent groups,respectively,with the no-stent group having a significantly higher incidence(P=0.031).The PEP severity was mild for all the patients in the stent group.In contrast,8 had mild PEP and 1 had moderate PEP in the no-stent group.The mean serum amylase levels(means±SD)3 h after ERCP(183.1±136.7 vs 463.6±510.4 IU/L,P=0.006)and on the day after ERCP(209.5±208.7vs 684.4±759.3 IU/L,P=0.002)were significantly higher in the no-stent group.A multivariate analysis identified the absence of pancreatic stenting(P=0.045;odds ratio,9.7;95%CI:1.1-90)as a significant risk factor for PEP.CONCLUSION:In patients with difficult cannulation in whom the bile duct is cannulated using P-GW,a pancreatic stent should be placed even if EST has been performed. | Kazunari Nakahara Chiaki Okuse Keigo Suetani Yosuke Michikawa Shinjiro Kobayashi Takehito Otsubo Fumio Itoh | 2014 | World Journal of Gastroenterology2014，20，26： | 4 |
| 4 | Right anterior segmental hepatic duct emptying directly into the cystic duct in a living donor显示文摘A 35-year-old mother was scheduled to be the living donor for liver transplantation to her second son,who suffered from biliary atresia complicated with biliary cirrhosis at the age of 2 years.The operative plan was to recover the left lateral segment of the mother's liver for living donor transplantation.With the use of cholangiography at the time of surgery,we found the right anterior segmental duct(RASD) emptying directly into the cystic duct,and the catheter passed into the RASD.After repairing the incision in the cystic duct,transplantation was successfully performed.Her postoperative course was uneventful.Biliary anatomical variations were frequently encountered,however,this variation has very rarely been reported.If the RASD was divided,the repair would be very difficult because the duct will not dilate sufficiently in an otherwise healthy donor.Meticulous preoperative evaluation of the living donor's biliary anatomy,especially using magnetic resonance cholangiography and careful intraoperative techniques,is important to prevent bile duct injury and avoid the risk to the healthy donor. | Yasunao Ishiguro Masanobu Hyodo Takehito Fujiwara Yasunaru Sakuma Nobuyuki Hojo Koichi Mizuta Hideo Kawarasaki Alan T Lefor Yoshikazu Yasuda | 2010 | World Journal of Gastroenterology2010，16，29： | 2 |
| 5 | Gastric submucosa-invasive carcinoma associated with EpsteinBarr virus and endoscopic submucosal dissection: A case report显示文摘BACKGROUND Epstein-Barr virus(EBV)-associated carcinoma is a gastric cancer subtype with a morphology characterized by gastric carcinoma with lymphoid stroma(GCLS).Clinicopathological studies have indicated a better prognosis for GCLS than for common gastric carcinomas.Some previous cases of early gastric cancer associated with EBV had been diagnosed by endoscopic resection.CASE SUMMARY We present two GCLS cases subjected to endoscopic submucosal dissection(ESD)for a definitive diagnosis.A protruded gastric lesion was identified by routine endoscopic examination,but forceps biopsy showed no atypical cells before ESD.The resected specimen showed a poorly differentiated adenocarcinoma with lymphoid cells involving the mucosa and submucosa.The final diagnosis was submucosa-invasive poorly differentiated gastric adenocarcinoma.Accordingly,additional gastrectomy was recommended to obtain a complete cure.One patient underwent additional distal gastrectomy with lymph node dissection,but the other was refused because of cardiovascular complications.Both patients remained in remission for more than half a year.EBV positivity was determined by EBV-encoded RNA in situ hybridization.We also conducted a literature review of cases of early gastric cancer associated with EBV that had been diagnosed by ESD.CONCLUSION Submucosa-invasive GCLS could be dissected using ESD,and EBV positivity should be subsequently assessed to determine whether or not any additional curative surgery is required.Further prospective investigations on the prevalence of lymph node metastasis in EBV-associated carcinoma should be performed to expand the indications for endoscopic resection. | Yu Kobayashi Takehito Kunogi Hiroki Tanabe Yuki Murakami Takuya Iwama Takahiro Sasaki Keitaro Takahashi Katsuyoshi Ando Yoshiki Nomura Nobuhiro Ueno Shin Kashima Kentaro Moriichi Hidehiro Takei Mikihiro Fujiya Toshikatsu Okumura | 2019 | World Journal of Gastrointestinal Oncology2019，11，10： | 2 |
| 6 | Simultaneous augmentation of muscle and bone by locomomimetism through calcium-PGC-1αsignaling显示文摘Impaired locomotion has been extensively studied worldwide because those afflicted with it have a potential risk of becoming bedridden.Physical exercise at times can be an effective remedy for frailty,but exercise therapy cannot be applied in all clinical cases.Medication is safer than exercise,but there are no drugs that reinforce both muscle and bone when administered alone.Multiple medications increase the risk of adverse events;thus,there is a need for individual drugs targeting both tissues.To this end,we established a novel sequential drug screening system and identified an aminoindazole derivative,locamidazole(LAMZ),which promotes both myogenesis and osteoblastogenesis while suppressing osteoclastogenesis.Administration of this drug enhanced locomotor function,with muscle and bone significantly strengthened.Mechanistically,LAMZ induced Mef2c and PGC-1αin a calcium signaling–dependent manner.As this signaling is activated upon physical exercise,LAMZ mimics physical exercise.Thus,LAMZ is a promising therapeutic drug for locomotor diseases,including sarcopenia and osteoporosis. | Takehito Ono Ryosuke Denda Yuta Tsukahara Takashi Nakamura Kazuo Okamoto Hiroshi Takayanagi Tomoki Nakashima | 2022 | Bone Research2022，10，4： | 2 |
| 7 | Stiffness change with temperature in glass fiber reinforced composite laminates embedded with sma wires显示文摘 | Motogi Shinya Tanaka Motohim Fukuda Takehito | | Nippon Kikai Gakkai Ronbunshu C Hen/Transactions of the Japan Society of Mechanical Engineers Part C0，19，： | 1 |
| 8 | The Rho kinase inhibitor fasudil is involved in p53-mediated apoptosis in human hepatocellular carcinoma cells显示文摘 | Yuko Takeba Naoki Matsumoto Minoru Watanabe Sachiko Takenoshita-Nakaya Yuki Ohta Toshio Kumai Masayuki Takagi Satoshi Koizumi Takeshi Asakura Takehito Otsubo | 2012 | Cancer Chemotherapy and Pharmacology2012，，6： | 1 |
| 9 | Relationship of CD4+CD25+ regulatory T cells to immune status in HIV-infected patients显示文摘 | Sachi Tsunemi Tsuyoshi Iwasaki Takehito Imado Satoshi Higasa Eizo Kakishita Takuma Shirasaka Hajime Sano | 2005 | AIDS2005，，9： | 1 |
| 10 | Pooled analysis of the reports of erlotinib after failure of gefitinib for non-small cell lung cancer显示文摘 | Kyoichi Kaira Tateaki Naito Toshiaki Takahashi Eriko Ayabe Rai Shimoyama Rieko Kaira Akira Ono Satoshi Igawa Takehito Shukuya Haruyasu Murakami Asuka Tsuya Yukiko Nakamura Masahiro Endo Nobuyuki Yamamoto | 2009 | Lung Cancer2009，，1： | 1 |
| 11 | Optimal Ligation Level of the Primary Feeding Artery and Bowel Resection Margin in Colon Cancer Surgery: The Influence of the Site of the Primary Feeding Artery显示文摘 | Jin-ichi Hida M.D. Kiyotaka Okuno M.D. Masayuki Yasutomi M.D. Takehito Yoshifuji M.D. Toshihiro Uchida M.D. Tadao Tokoro M.D. Hitoshi Shiozaki M.D | 2005 | Diseases of the Colon & Rectum2005，，12： | 1 |
| 12 | Localization of osteoprotegerin (OPG) on bone surfaces and cement lines in rat tibia显示文摘 | Hiroaki Nakamura Takehito Tsuji Azumi Hirata | 2002 | J Histochem Cytochem2002，50，7： | 1 |
| 13 | Efficacy of bevacizumab-containing chemotherapy for non-squamous non-small cell lung cancer with bone metastases显示文摘 | Takaaki Tokito Takehito Shukuya Hiroaki Akamatsu Tetsuhiko Taira Akira Ono Hirotsugu Kenmotsu Tateaki Naito Haruyasu Murakami Toshiaki Takahashi Masahiro Endo Nobuyuki Yamamoto | 2013 | Cancer Chemotherapy and Pharmacology2013，，6： | 1 |
| 14 | Effect of titrated mandibular advancement and jaw opening on the upper airway in nonapneic men: a magnetic resonance imaging and cephalometric study显示文摘 | Xuemei Gao Ryo Otsuka Takashi Ono Ei-ichi Honda Takehito Sasaki Takayuki Kuroda | 2003 | American Journal of Orthodontics & Dentofacial Orthopedics2003，，2： | 1 |
| 15 | Serum metabolomics reveals γ-glutamyl dipeptides as biomarkers for discrimination among different forms of liver disease显示文摘 | Tomoyoshi Soga Masahiro Sugimoto Masashi Honma Masayo Mori Kaori Igarashi Kasumi Kashikura Satsuki Ikeda Akiyoshi Hirayama Takehito Yamamoto Haruhiko Yoshida Motoyuki Otsuka Shoji Tsuji Yutaka Yatomi Tadayuki Sakuragawa Hisayoshi Watanabe Kouei Nihei Taka | 2011 | Journal of Hepatology2011，，4： | 1 |
| 16 | Process for recycling waste aluminum with generation of high-pressure hydrogen显示文摘 | Takehito Hiraki Satoru Yamauchi Masayasu Lida | 2007 | Environmental Science Technology2007，41，12： | 1 |
| 17 | What is A Healthy City显示文摘 | Takehito Takano | | 0，，01： | 1 |
| 18 | A case of gastropericardial fistula of a gastric tube after esophagectomy: a case report and review显示文摘 | Takehito Kato Takahiro Mori Koki Niibori | 2010 | World J Emerg Surg2010，5，： | 1 |
| 19 | Covered Metal Stenting for Malignant Lower Biliary Stricture with Pancreatic Duct Obstruction: Is Endoscopic Sphincterotomy Needed?显示文摘 | Kazunari Nakahara Chiaki Okuse Keigo Suetani Yosuke Michikawa Shinjiro Kobayashi Takehito Otsubo Fumio Itoh Peter V. Draganov | 2013 | Gastroenterology Research and Practice2013，，： | 1 |
| 20 | An evidential example of a irborne bacteria in a crowded,underground public concourse in Tokyo显示文摘 | KAORUKO S TAKEHITO T KEIKO N | 2005 | Atmos Environ2005，39，2： | 1 |
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