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| 1 | Radiation therapy for portal venous invasion by hepatocellular carcinoma显示文摘AIM: To clarify the efficacy and safety of three-dimensional conformal radiotherapy (3-D CRT) for this disease and to specify patient subgroups suitable for this treatment.METHODS: Fifty-two patients with HCC received PVI-targeted radiation therapy from January 1995 through December 2003. Portal venous invasion (PVI) was found in the second or lower order branches of the portal vein in 6 patients, in the first branch in 24 patients and in the main trunk in 22 patients. Child classifications of liver function before radiation therapy were A, B, and C for 19, 24 and 2 patients, respectively. All patients received three-dimensional conformal radiotherapy with a total dose ranging from 39 to 60 Gy (57.0 Gy in average).RESULTS: Overall survival rates at 1, 2, 3, 4, and 5 years were 45.1%, 25.3%, 15.2%, 10.1%, and 5.1%, respectively. Univariate analysis revealed that Child status, the number of tumor foci, tumor type,transcatheter arterial embolization (TAE) after radiation therapy were statistically significant prognostic factors.Multivariate analysis showed that the number of tumor foci and TAE after radiation therapy were statistically significant.CONCLUSION: The results of this study strongly suggest the efficacy of 3-D CRT as treatment for PVI in HCC. 3-D CRT is recommended in combination with postradiation TAE for PVI of HCC with 5 tumor foci or less in the liver and with Child A liver function. | Keiichi Nakagawa Hideomi Yamashita Kenshiro Shiraishi Naoki Nakamura Masao Tago Hiroshi Igaki Yoshio Hosoi Shuichiro Shiina Masao Omata Masatoshi Makuuchi Kuni Ohtomo | 2005 | World Journal of Gastroenterology2005，11，46： | 14 |
| 2 | Selection Criteria for Hepatectomy in Patients with Hepatocellular Carcinoma and Portal Vein Tumor Thrombus显示文摘 | Masami Minagawa Masatoshi Makuuchi Tadatoshi Takayama Kuni Ohtomo | 2001 | Annals of Surgery2001，，3： | 2 |
| 3 | Atypical exocrine and endocrine pancreatic tumors (anaplastic, small cell, and giant cell types): CT and pathologic features in 14 patients显示文摘 | T. Ichikawa M. P. Federle S. Ohba K. Ohtomo A. Sugiyama H. Fujimoto H. Haradome T. Araki | 2000 | Abdominal Imaging2000，，4： | 2 |
| 4 | Induction of ischemic tolerance in rat liver via reduced nicotinamide adenine dinucleotide phosphate oxidase in Kupffer cells显示文摘AIM: To elucidate the mechanisms of hepatocyte preconditioning by H2O2 to better understand the pathophysiology of ischemic preconditioning. METHODS: The in vitro effect of H2O2 pretreatment was investigated in rat isolated hepatocytes subjected to anoxia/reoxygenation. Cell viability was assessed with propidium iodide fluorometry. In other experiments, rat livers were excised and subjected to warm ischemia/ reperfusion in an isolated perfused liver system to determine leakage of liver enzymes. Preconditioning was performed by H2O2 perfusion, or by stopping the perfusion for 10 min followed by 10 min of reperfusion. To inhibit Kupffer cell function or reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, gadolinium chloride was injected prior to liver excision, or diphenyleneiodonium, an inhibitor of NADPH oxidase, was added to the perfusate, respectively. Histological detection of oxygen radical formation in Kupffer cells was performed by perfusion with nitro blue tetrazolium. RESULTS: Anoxia/reoxygenation decreased hepatocyte viability compared to the controls. Pretreatment with H2O2 did not improve such hepatocyte injury. In liver perfusion experiments, however, H2O2 preconditioning reduced warm ischemia/reperfusion injury, which wasreversed by inhibition of Kupffer cell function or NADPH oxidase. Histological examination revealed that H2O2 preconditioning induced oxygen radical formation in Kupffer cells. NADPH oxidase inhibition also reversed hepatoprotection by ischemic preconditioning. CONCLUSION: H2O2 preconditioning protects hepato- cytes against warm ischemia/reperfusion injury via NADPH oxidase in Kupffer cells, and not directly. NADPH oxidase also mediates hepatoprotection by ischemic preconditioning. | Kazuaki Tejima Masahiro Arai Hitoshi Ikeda Tomoaki Tomiya Mikio Yanase Yukiko Inoue Takako Nishikawa Naoko Watanabe Natsuko Ohtomo Masao Omata Kenji Fujiwara | 2007 | World Journal of Gastroenterology2007，13，38： | 2 |
| 5 | A multicenter, prospective validation of disseminated intravascular coagulation diagnostic criteria for critically ill patients: Comparing current criteria*显示文摘 | Satoshi Gando Toshiaki Iba Yutaka Eguchi Yasuhiro Ohtomo Kohji Okamoto Kazuhide Koseki Toshihiko Mayumi Atsuo Murata Toshiaki Ikeda Hiroyasu Ishikura Masashi Ueyama Hiroshi Ogura Shigeki Kushimoto Daizoh Saitoh Shigeatsu Endo Shuji Shimazaki | 2006 | Critical Care Medicine2006，，3： | 2 |
| 6 | Model-based iterative reconstruction for reduction of radiation dose in abdominopelvic CT: comparison to adaptive statistical iterative reconstruction显示文摘 | Koichiro Yasaka Masaki Katsura Masaaki Akahane Jiro Sato Izuru Matsuda Kuni Ohtomo | 2013 | SpringerPlus2013，，： | 2 |
| 7 | Ultraviolet spontaneous and stimulated emissions from ZnO microcrystallite thin films at room temperature显示文摘 | P. Zu Z.K. Tang G.K.L. Wong M. Kawasaki A. Ohtomo H. Koinuma Y. Segawa | 1997 | Solid State Communications1997，，8： | 2 |
| 8 | Ansa pancreatica as a predisposing factor for recurrent acute pancreatitis显示文摘AIM To determine the non-biased prevalence and clinical significance of ansa pancreatica in patients with acute pancreatitis using magnetic resonance imaging(MRI).METHODS Our institutional review board approved this crosssectional study, which consisted of a community-based cohort of 587 consecutive participants in a whole-body health-check program, and 73 subjects with episode of acute pancreatitis(55 patients with a single episode of acute pancreatitis, and 18 patients with recurrent acute pancreatitis). All of the subjects underwent abdominal MRI including magnetic resonance cholangiopancreatography, medical examinations, and blood tests. Two board-certified, diagnostic, abdominal radiologists evaluated the images, and ansa pancreatica was diagnosed based on its characteristic anatomy on MRI.RESULTS Compared with the community group [5/587(0.85%)], patients with recurrent acute pancreatitis had a significantly higher frequency of ansa pancreatica [2/18(11.1%)](P = 0.016; OR = 14.3; 95%CI: 1.27-96.1), but not compared with patients with single-episode acute pancreatitis [1/55(1.8%)](P = 0.42; OR = 2.1; 95%CI: 0.44-19.7). Multiple logistic regression analysis using age, alcohol intake, presence of ansa pancreatica, and presence of autoimmune disease as independent covariates, revealed a significant relationship between the presence of ansa pancreatica and recurrent acute pancreatitis. The presence of autoimmune disease was also significantly associated with the onset of recurrent acute pancreatitis. On the other hand, neither age nor alcohol intake were significantly related to the onset of recurrent acute pancreatitis.CONCLUSION The present study is the first to provide robust evidence that the presence of ansa pancreatica is significantly associated with recurrent acute pancreatitis. | Takana Yamakawa Hayashi Wataru Gonoi Takeharu Yoshikawa Naoto Hayashi Kuni Ohtomo | 2016 | World Journal of Gastroenterology2016，22，40： | 2 |
| 9 | Molecular cloning and characterization of a surface antigen preferentially overexpressed on multiple myeloma cells显示文摘 | Ohtomo T Sugamata Y Ozaki Y | 1999 | Biochem Biophys Res Commun1999，258，3： | 1 |
| 10 | Attenuation of shock waves propagating over arrayed baffle plates 显示文摘 | Ohtomo E Ohtani K Takayama K | 2005 | Shock Waves2005，14，56： | 1 |
| 11 | Ganglioneuroma:computed tomography and magnetic resonance features 显示文摘 | Ichikawa T Ohtomo K Araki T | 1996 | Br J Radiol1996，69，818： | 1 |
| 12 | Repeated temperature modulation epitaxy for p -type doping and light -emitting diode based on ZnO 显示文摘 | Tsukazaki A Ohtomo A Onuma T | 2005 | Nat Mater2005，4，1： | 1 |
| 13 | FDG-PET is effective in the detection of granulocytic sarcoma in patients with myeloid malignancy显示文摘 | Koki Ueda Motoshi Ichikawa Miwako Takahashi Toshimitsu Momose Kuni Ohtomo Mineo Kurokawa | 2010 | Leukemia Research2010，，9： | 1 |
| 14 | SSJD14073000005013显示文摘 | Karen L. Morris Jonathan D. Tugwood Leila Khoja Matthew Lancashire Robert Sloane Debbie Burt Patrick Shenjere Cong Zhou Clare Hodgson Toshihiko Ohtomo Atsuhiko Katoh Takahiro Ishiguro Juan W. Valle Caroline Dive | 2014 | Cancer Chemotherapy and Pharmacology2014，，2： | 1 |
| 15 | Quantum hall effect in polar oxide heterostructures显示文摘 | Tsukazaki A Ohtomo A Kita T | 2007 | Science2007，315，5817： | 1 |
| 16 | Structure and optical properties of ZnO/MgxZn1-xO super lattices 显示文摘 | OHTOMO A KAWASAKI M OHKUBO I | 1999 | Appl Phys Lett1999，75，： | 1 |
| 17 | Angiotensin converting enzyme gene polymorphism in primary vesicoureteral reflux显示文摘 | Ohtomo Y Nagaoka R Kaneko K | 2001 | Pediatr Nephrol2001，16，8： | 1 |
| 18 | Contrast-enhanced dynamic MRI ofadrenal masses:classification of characteristic enhancement patterns显示文摘 | Ichikawa T Ohtomo K Uchiyama G | 1995 | Clin Radiol1995，50，5： | 1 |
| 19 | Stability analysis and numerical simulation of muhidevice amplifiers 显示文摘 | Ohtomo M | 1993 | IEEE Transactions on Microwave Theory and Techniques1993，41，6： | 1 |
| 20 | Lethal efficacy of extract from Zingiber officinale (traditional Chinese medicine) or [6]-shogaol and [6]-gingerol in Anisakis larvae in vitro显示文摘 | C. Goto S. Kasuya K. Koga H. Ohtomo N. Kagei | 1990 | Parasitology Research1990，，： | 1 |
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