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| 1 | 患者肠道微生物群失调与肠上皮屏障功能障碍显示文摘最近的证据表明,在动物模型中,肠道病理学和微生物组与高血压之间存在联系。然而,这种关联在人类中是否存在尚不清楚。因此,该研究的目的是检验高血压患者具有明显特异的肠道微生物组以及肠上皮屏障功能标记物和微生物组组成可以预测收缩压变化的假设。研究者通过鸟枪法宏基因组学分析粪便样本显示微生物分类和功能变化,结果显示高血压患者和对照受试者之间丁酸盐产生存在差异。 | Kim S Goel R Kumar A Qi Y Lobaton G Hosaka K Mohammed M Handberg EM Richards EM Pepine CJ Raizada MK 刘青 叶鹏 | 2018 | 中华高血压杂志2018，26，9： | 45 |
| 2 | Hepatitis C virus enhances incidence of idiopathic pulmonary fibrosis显示文摘AIM: To investigate the cumulative development incidence and predictive factors for idiopathic pulmonary fibrosis in hepatitis C virus (HCV) positive patients. METHODS: We studied 6150 HCV infected patients who were between 40-70 years old (HCV-group). Another 2050 patients with hepatitis B virus (HBV) were selected as control (HBV-group). The mean observation period was 8.0 ± 5.9 years in HCV-group and 6.3 ± 5.5 years in HBV-group. The primary goal is the development of idiopathic pulmonary fibrosis (IPF) in both groups. The cumulative appearance rate of IPF and independent factors associated with the incidence rate of IPF were calculated using the Kaplan- Meier method and the Cox proportional hazard model. All of the studies were performed retrospectively by collecting and analyzing data from the patient records in our hospital. RESULTS: Fifteen patients in HCV-group developedIPF. On the other hand, none of the patients developed IPF in HBV-group. In HCV-group, the cumulative rates of IPF development were 0.3% at 10th year and 0.9% at 20th year. The IPF development rate in HCV-group was higher than that in HBV-group (P = 0.021). The IPF development rate in patients with HCV or HBV was high with statistical significance in the following cases: (1) patients ≥ 55 years (P < 0.001); (2) patients who had smoking index (package per day × year) of ≥ 20 (P = 0.002); (3) patients with liver cirrhosis (P = 0.042). CONCLUSION: Our results indicate that age, smoking and liver cirrhosis enhance the development of IPF in HCV positive patients. | Yasuji Arase Fumitaka Suzuki Yoshiyuki Suzuki Norio Akuta Masahiro Kobayashi Yusuke Kawamura Hiromi Yatsuji Hitomi Sezaki Tetsuya Hosaka Miharu Hirakawa Satoshi Saito Kenji Ikeda Hiromitsu Kumada | 2008 | World Journal of Gastroenterology2008，14，38： | 8 |
| 3 | Long‐term entecavir treatment reduces hepatocellular carcinoma incidence in patients with hepatitis B virus infection显示文摘 | Tetsuya Hosaka Fumitaka Suzuki Masahiro Kobayashi Yuya Seko Yusuke Kawamura Hitomi Sezaki Norio Akuta Yoshiyuki Suzuki Satoshi Saitoh Yasuji Arase Kenji Ikeda Mariko Kobayashi Hiromitsu Kumada | 2013 | Hepatology2013，，： | 5 |
| 4 | Long-term continuous entecavir therapy in nucleos(t)ide-na?ve chronic hepatitis B patients显示文摘 | Atsushi Ono Fumitaka Suzuki Yusuke Kawamura Hitomi Sezaki Tetsuya Hosaka Norio Akuta Masahiro Kobayashi Yoshiyuki Suzuki Satoshi Saitou Yasuji Arase Kenji Ikeda Mariko Kobayashi Sachiyo Watahiki Rie Mineta Hiromitsu Kumada | 2012 | Journal of Hepatology2012，，3： | 3 |
| 5 | Addition of docetaxel to S-1 without platinum prolongs survival of patients with advanced gastric cancer: a randomized study (START)显示文摘 | Wasaburo Koizumi Yeul Hong Kim Masashi Fujii Hoon Kyo Kim Hiroshi Imamura Kyung Hee Lee Takuo Hara Hyun Cheol Chung Taroh Satoh Jae Yong Cho Hisashi Hosaka Akihito Tsuji Akinori Takagane Mikito Inokuchi Kazuaki Tanabe Tatsuya Okuno Mariko Ogura Kazuhiro Y | 2014 | Journal of Cancer Research and Clinical Oncology2014，，2： | 2 |
| 6 | Effect of type 2 diabetes on risk for malignancies includes hepatocellular carcinoma in chronic hepatitis C显示文摘 | Yasuji Arase Mariko Kobayashi Fumitaka Suzuki Yoshiyuki Suzuki Yusuke Kawamura Norio Akuta Masahiro Kobayashi Hitomi Sezaki Satoshi Saito Tetsuya Hosaka Kenji Ikeda Hiromitsu Kumada Tetsuro Kobayashi | 2013 | Hepatology2013，，3： | 2 |
| 7 | Poor Response to Pegylated Interferon and Ribavirin in Older Women Infected with Hepatitis C Virus of Genotype 1b in High Viral Loads显示文摘 | Hitomi Sezaki Fumitaka Suzuki Yusuke Kawamura Hiromi Yatsuji Tetsuya Hosaka Norio Akuta Masahiro Kobayashi Yoshiyuki Suzuki Satoshi Saitoh Yasuji Arase Kenji Ikeda Yuzo Miyakawa Hiromitsu Kumada | 2009 | Digestive Diseases and Sciences2009，，6： | 2 |
| 8 | Association of two polymorphisms of the IL28B gene with viral factors and treatment response in 1,518 patients infected with hepatitis C virus显示文摘 | Mariko Kobayashi Fumitaka Suzuki Norio Akuta Hitomi Sezaki Yoshiyuki Suzuki Tetsuya Hosaka Yusuke Kawamura Masahiro Kobayashi Satoshi Saitoh Yasuji Arase Kenji Ikeda Kazuaki Chayama Yuzo Miyakawa Hiromitsu Kumada | 2012 | Journal of Gastroenterology2012，，5： | 2 |
| 9 | Cyclosporin A suppresses replication of hepatitis C virus genome in cultured hepatocytes显示文摘 | Koichi Watashi Makoto Hijikata Masahiro Hosaka Masashi Yamaji Kunitada Shimotohno | 2003 | Hepatology2003，，5： | 2 |
| 10 | Selection of a virus strain resistant to entecavir in a nucleoside-naive patient with hepatitis B of genotype H显示文摘 | Fumitaka Suzuki Norio Akuta Yoshiyuki Suzuki Hiromi Yatsuji Hitomi Sezaki Yasuji Arase Yusuke Kawamura Tetsuya Hosaka Masahiro Kobayashi Kenji Ikeda Mariko Kobayashi Sachiyo Watahiki Hiromitsu Kumada | 2007 | Journal of Clinical Virology2007，，2： | 2 |
| 11 | Antibacterial properties of AM-1155, a new 8-methoxy quinolone 显示文摘 | Hosaka M Kinoshita S Toyama A | 1995 | J Antimicrob Chemther1995，36，： | 2 |
| 12 | In vitro and in vivo antibacterial activities of AM-1155, a new 6-fluoro-8-methoxy quinolone 显示文摘 | Hosaka M Yasue T Fukuda H | 1992 | Antimicrob Agents Chenother1992，36，10： | 2 |
| 13 | Prevalence of hepatitis C virus variants resistant to NS3 protease inhibitors or the NS5A inhibitor (BMS-790052) in hepatitis patients with genotype 1b显示文摘 | Fumitaka Suzuki Hitomi Sezaki Norio Akuta Yoshiyuki Suzuki Yuya Seko Yusuke Kawamura Tetsuya Hosaka Masahiro Kobayashi Satoshi Saito Yasuji Arase Kenji Ikeda Mariko Kobayashi Rie Mineta Sachiyo Watahiki Yuzo Miyakawa Hiromitsu Kumada | 2012 | Journal of Clinical Virology2012，，4： | 2 |
| 14 | Antibacterial properties of AM-1155, a new 8-methoxy quinolone 显示文摘 | Hosaka M Kinoshita S Toyama A | 1995 | J Antimicrob Chemother1995，36，： | 2 |
| 15 | Viral Elimination Reduces Incidence of Malignant Lymphoma in Patients with Hepatitis C显示文摘 | Yusuke Kawamura Kenji Ikeda Yasuji Arase Hiromi Yatsuji Hitomi Sezaki Tetsuya Hosaka Norio Akuta Masahiro Kobayashi Fumitaka Suzuki Yoshiyuki Suzuki Hiromitsu Kumada | 2007 | The American Journal of Medicine2007，，12： | 2 |
| 16 | The combined effects of anti - TNFα antibody and IL - 1 receptor antagonist in human rheumatoid arthritis synovial membrane 显示文摘 | Hosaka K Ryu J Saitoh S | 2005 | Cytokine2005，32，6： | 1 |
| 17 | Thymus transplantation , a critical factor for correction of autoimmune disease in aging MRL/+mice显示文摘 | Nose M Kyogoku M | 1996 | Proc Natl Acad Sci U S A1996，93，16： | 1 |
| 18 | An allosteric activator of glucokinase impairs the interaction of glucok- inase and glucokinase regulatory protein and regulates glucose metabolism 显示文摘 | Futamura M Hosaka H Kadotani A | 2006 | J Biol Chem2006，281，37： | 1 |
| 19 | Self-excited vibrations of a flexible disk rotating on an air-film above a flat surface显示文摘 | Hosaka H Crandall S H | 1992 | Acta Mechanica1992，3，1： | 1 |
| 20 | Experiments on concrete filled and reinforced tubular K-joints of truss girder 显示文摘 | Yoshinaga Sakai Tetsuya Hosaka Akira Isoe | 2004 | Journal of Constructional Steel Research2004，60，： | 1 |
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