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| 1 | Radiation therapy for portal venous invasion by hepatocellular carcinoma显示文摘AIM: To clarify the efficacy and safety of three-dimensional conformal radiotherapy (3-D CRT) for this disease and to specify patient subgroups suitable for this treatment.METHODS: Fifty-two patients with HCC received PVI-targeted radiation therapy from January 1995 through December 2003. Portal venous invasion (PVI) was found in the second or lower order branches of the portal vein in 6 patients, in the first branch in 24 patients and in the main trunk in 22 patients. Child classifications of liver function before radiation therapy were A, B, and C for 19, 24 and 2 patients, respectively. All patients received three-dimensional conformal radiotherapy with a total dose ranging from 39 to 60 Gy (57.0 Gy in average).RESULTS: Overall survival rates at 1, 2, 3, 4, and 5 years were 45.1%, 25.3%, 15.2%, 10.1%, and 5.1%, respectively. Univariate analysis revealed that Child status, the number of tumor foci, tumor type,transcatheter arterial embolization (TAE) after radiation therapy were statistically significant prognostic factors.Multivariate analysis showed that the number of tumor foci and TAE after radiation therapy were statistically significant.CONCLUSION: The results of this study strongly suggest the efficacy of 3-D CRT as treatment for PVI in HCC. 3-D CRT is recommended in combination with postradiation TAE for PVI of HCC with 5 tumor foci or less in the liver and with Child A liver function. | Keiichi Nakagawa Hideomi Yamashita Kenshiro Shiraishi Naoki Nakamura Masao Tago Hiroshi Igaki Yoshio Hosoi Shuichiro Shiina Masao Omata Masatoshi Makuuchi Kuni Ohtomo | 2005 | World Journal of Gastroenterology2005，11，46： | 14 |
| 2 | Acute fatty liver of pregnancy associated with severe acute pancreatitis:A case report显示文摘Acute fatty liver of pregnancy is a rare disease that affects women in the third trimester of pregnancy. Although infrequent, the disease can cause maternal mortality. The diagnosis is not always clear until the pregnancy is terminated, and significant complications, such as acute pancreatitis, can occur. Pancreatic involvement typically only occurs in severe cases after the development of hepatic and renal impairment. To date, little knowledge is available regarding how the disease causes pancreatitis. Treatment involves supportive measures and pregnancy interruption. In this report, we describe a case of a previously healthy 26-year-old woman at a gestational age of 27 wk and 6 d who was admitted with severe abdominal pain and vomiting. This case illustrates the clinical and laboratory overlap between acute fatty liver of pregnancy and pancreatitis, highlighting the difficulties in differentiating each disease. Furthermore, the hypothesis for this overlapping is presented, and the therapeutic options are discussed. | Cássio Vieira de Oliveira Alecsro Moreira Julio P Baima Leticia de C Franzoni Talles B Lima Fabio da S Yamashiro Kunie Yabuki Rabelo Coelho Ligia Y Sassaki Carlos Antonio Caramori Ferno G Romeiro Giovanni F Silva | 2014 | World Journal of Hepatology2014，6，7： | 3 |
| 3 | Digital Geological Mapping of Sinus Iridum Area of the Moon Based on the Chang'E-I Data显示文摘Based on the CCD images,IIM data and DEM data of China’s lunar exploration project(Chang’E-I)and related processed and analytic results,an integrated study of regional geology of Sinus Iridum and its adjacent area was conducted,and a series of relevant researches and analyses were carried out,including analysis of impact craters and their extrusive and accumulative materials,division of stratigraphic and tectonic units and classification of rock types,integrated analysis of chronology and lunar evolution history.In consideration of crater’s shape features,quantity and preserving status of filling materials,the lunar impact craters can be divided into 7 types and 11 subtypes,and the accumulative materials of craters are divided into 6 types and 9 accumulative groups.According to the content and distribution of TiO2and image characteristics,the basalts are divided into high-TiO2,medium-TiO2and low-TiO2basalts.Discussion was made on division of tectonic units and evolution features in the study area.The geological map of the Sinus Iridum Quadrangle(LQ-4)at a scale of 1:2.5 M was preliminarily compiled with the ArcGIS system,and the spatial database of the map was established.Related technical specification,procedure and method for lunar geological mapping have been worked out,so as to lay a foundation for the forthcoming geological mapping of the global Moon in China by using the data of Chang’E-II and also for comprehensive study and geological mapping of other celestial bodies in the future. | DING Xiaozhong HAN Kunying PANG Jianfeng WANG Liang HAN Tonglin JU Yuanjing DING Weicui | 2013 | Acta Geologica Sinica(English Edition)2013，87，6： | 3 |
| 4 | Selection Criteria for Hepatectomy in Patients with Hepatocellular Carcinoma and Portal Vein Tumor Thrombus显示文摘 | Masami Minagawa Masatoshi Makuuchi Tadatoshi Takayama Kuni Ohtomo | 2001 | Annals of Surgery2001，，3： | 2 |
| 5 | Deep learning for non-parameterized MEMS structural design显示文摘The geometric designs of MEMS devices can profoundly impact their physical properties and eventual performances.However,it is challenging for researchers to rationally consider a large number of possible designs,as it would be very time-and resource-consuming to study all these cases using numerical simulation.In this paper,we report the use of deep learning techniques to accelerate the MEMS design cycle by quickly and accurately predicting the physical properties of numerous design candidates with vastly different geometric features.Design candidates are represented in a nonparameterized,topologically unconstrained form using pixelated black-and-white images.After sufficient training,a deep neural network can quickly calculate the physical properties of interest with good accuracy without using conventional numerical tools such as finite element analysis.As an example,we apply our deep learning approach in the prediction of the modal frequency and quality factor of disk-shaped microscale resonators.With reasonable training,our deep learning neural network becomes a high-speed,high-accuracy calculator:it can identify the flexural mode frequency and the quality factor 4.6×10^(3)times and 2.6×10^(4)times faster,respectively,than conventional numerical simulation packages,with good accuracies of 98.8±1.6%and 96.8±3.1%,respectively.When simultaneously predicting the frequency and the quality factor,up to~96.0%of the total computation time can be saved during the design process.The proposed technique can rapidly screen over thousands of design candidates and promotes experience-free and data-driven MEMS structural designs. | Ruiqi Guo Fanping Sui Wei Yue Zekai Wang Sedat Pala Kunying Li Renxiao Xu Liwei Lin | 2022 | Microsystems & Nanoengineering2022，8，4： | 2 |
| 6 | Single-cell Transcriptomic Analysis Reveals the Cellular Heterogeneity of Mesenchymal Stem Cells显示文摘Ex vivo-expanded mesenchymal stem cells(MSCs)have been demonstrated to be a heterogeneous mixture of cells exhibiting varying proliferative,multipotential,and immunomodulatory capacities.However,the exact characteristics of MSCs remain largely unknown.By singlecell RNA sequencing of 61,296 MSCs derived from bone marrow and Wharton’s jelly,we revealed five distinct subpopulations.The developmental trajectory of these five MSC subpopulations was mapped,revealing a differentiation path from stem-like active proliferative cells(APCs)to multipotent progenitor cells,followed by branching into two paths:1)unipotent preadipocytes or 2)bipotent prechondro-osteoblasts that were subsequently differentiated into unipotent prechondrocytes.The stem-like APCs,expressing the perivascular mesodermal progenitor markers CSPG4/MCAM/NES,uniquely exhibited strong proliferation and stemness signatures.Remarkably,the prechondrocyte subpopulation specifically expressed immunomodulatory genes and was able to suppress activated CD3^(+T) cell proliferation in vitro,supporting the role of this population in immunoregulation.In summary,our analysis mapped the heterogeneous subpopulations of MSCs and identified two subpopulations with potential functions in self-renewal and immunoregulation.Our findings advance the definition of MSCs by identifying the specific functions of their heterogeneous cellular composition,allowing for more specific and effective MSC application through the purification of their functional subpopulations. | Chen Zhang Xueshuai Han Jingkun Liu Lei Chen Ying Lei Kunying Chen Jia Si Tian-yi Wang Hui Zhou Xiaoyun Zhao Xiaohui Zhang Yihua An Yueying Li Qian-Fei Wang | 2022 | Genomics, Proteomics & Bioinformatics2022，20，1： | 2 |
| 7 | Model-based iterative reconstruction for reduction of radiation dose in abdominopelvic CT: comparison to adaptive statistical iterative reconstruction显示文摘 | Koichiro Yasaka Masaki Katsura Masaaki Akahane Jiro Sato Izuru Matsuda Kuni Ohtomo | 2013 | SpringerPlus2013，，： | 2 |
| 8 | Ansa pancreatica as a predisposing factor for recurrent acute pancreatitis显示文摘AIM To determine the non-biased prevalence and clinical significance of ansa pancreatica in patients with acute pancreatitis using magnetic resonance imaging(MRI).METHODS Our institutional review board approved this crosssectional study, which consisted of a community-based cohort of 587 consecutive participants in a whole-body health-check program, and 73 subjects with episode of acute pancreatitis(55 patients with a single episode of acute pancreatitis, and 18 patients with recurrent acute pancreatitis). All of the subjects underwent abdominal MRI including magnetic resonance cholangiopancreatography, medical examinations, and blood tests. Two board-certified, diagnostic, abdominal radiologists evaluated the images, and ansa pancreatica was diagnosed based on its characteristic anatomy on MRI.RESULTS Compared with the community group [5/587(0.85%)], patients with recurrent acute pancreatitis had a significantly higher frequency of ansa pancreatica [2/18(11.1%)](P = 0.016; OR = 14.3; 95%CI: 1.27-96.1), but not compared with patients with single-episode acute pancreatitis [1/55(1.8%)](P = 0.42; OR = 2.1; 95%CI: 0.44-19.7). Multiple logistic regression analysis using age, alcohol intake, presence of ansa pancreatica, and presence of autoimmune disease as independent covariates, revealed a significant relationship between the presence of ansa pancreatica and recurrent acute pancreatitis. The presence of autoimmune disease was also significantly associated with the onset of recurrent acute pancreatitis. On the other hand, neither age nor alcohol intake were significantly related to the onset of recurrent acute pancreatitis.CONCLUSION The present study is the first to provide robust evidence that the presence of ansa pancreatica is significantly associated with recurrent acute pancreatitis. | Takana Yamakawa Hayashi Wataru Gonoi Takeharu Yoshikawa Naoto Hayashi Kuni Ohtomo | 2016 | World Journal of Gastroenterology2016，22，40： | 2 |
| 9 | Improvement of machining characteristics of micro-EDM using transistor type isopulse generator and servo feed control显示文摘 | Fuzhu Han Shinya Wachi Masanori Kunied | 2004 | Precision Engineering2004，28，： | 1 |
| 10 | Food-dependent exercise-induced anaphylaxis显示文摘 | Morita E Kunie K Matsuo H | 2007 | J Dermatol Sci2007，47，2： | 1 |
| 11 | FDG-PET is effective in the detection of granulocytic sarcoma in patients with myeloid malignancy显示文摘 | Koki Ueda Motoshi Ichikawa Miwako Takahashi Toshimitsu Momose Kuni Ohtomo Mineo Kurokawa | 2010 | Leukemia Research2010，，9： | 1 |
| 12 | Dietary docosahexaenoic acidsupplementation prevents age-related functional losses and a2eaccumulation in the retina显示文摘 | Domstauder B Suh M Kuny S | 2012 | Invest Ophthalmol Vis Sci2012，53，4： | 1 |
| 13 | Zircon U–Pb Ages and Lu–Hf Isotope of the Dongchuan Group in Central Yunnan, China, and their Geological Significance显示文摘On the southwestern margin of the Yangtze Block, the Dongchuan Group consists of slightly metamorphosed sedimentary rocks, including silty slate, argillaceous slate, clayey slate, arkose, dolomite, and minor volcanic rocks. To date, it is still a controversy over the depositional age and stratigraphic sequence of the Dongchuan Group. In this study, we analyzed five samples of meta-sedimentary rocks and one sample of meta-tuff from the Yinmin, Luoxue and Etouchang Formations of the Dongchuan Group in the Yuxi region for detrital zircon U-Pb ages and Lu-Hf isotope. The detrital zircon ages of the meta-sediments vary from 3073 to 1703 Ma, mainly clustered at three periods, from 1889 to 1840, 2490 to 2008 and 2878 to 2844 Ma. The youngest age peak of all the samples is ~1859 Ma, with the εHf(t) values of the zircons ranging from-20.3 to +4.3 and more than 90% being negative, indicating that the Paleoproterozoic crustal accretion on the southwestern margin of the Yangtze Block was dominated by reworking of the ancient crustal materials involved in the assembly and breakup of the Columbia supercontinent. Another important age range is between 2490 Ma and 2008 Ma, with εHf(t) values from-14.7 to +8.9 and 70% of them are negative, suggesting that the magmatism in the source area was also dominated by reworking and recycling of the ancient crustal materials, with minor juvenile mantle substances added. The detritus was probably derived from the Paleoproterozoic crystalline basement in the southern Yuxi region. The oldest peak age is ~2847 Ma and the εHf(t) values are from-7.7 to +7.0 with 50% of both positive and negative values, demonstrating a possible ~2.85 Ga ancient continental nucleus on the southwestern margin of the Yangtze Block and substantial growth in juvenile crust materials during this period. Besides, the weighted average age of the zircons from the meta-tuff of the Etouchang Formation is 1677 ± 14 Ma. Combining the previous research data and this study, we can constrain the depositional age of the Dongchuan Group in central Yunnan Province to the period from the late Paleoproterozoic to early Mesoproterozoic, slightly earlier than that of the Dongchuan Group in the Dongchuan area near to the southwestern Sichuan Province. The depositional age of the Dongchuan Group is older than that of the Kunyang Group. | HAN Kunying ZHANG Heng DING Xiaozhong REN Liudong SHI Chenglong PANG Jianfeng | 2020 | Acta Geologica Sinica(English Edition)2020，94，4： | 1 |
| 14 | Delayed induction and longterm effects of mild hypothermia in a focal model of transient cerebral ischemia: neurological outcome and infarct size 显示文摘 | Maier CM Sun GH Kunis D | 2001 | Neurosurg2001，94，1： | 1 |
| 15 | Mild hypothermia increases Bel-2 expression following global cerebral ischemia显示文摘 | Zhang A Yenari MA Kunis DM | 2002 | Mol Brain Res2002，95，： | 1 |
| 16 | Overexpression of the glucose transporter gene with a herpes simplex viral vector protects striatal neurons against stroke显示文摘 | Lawrence MS Sun GH Kunis DM | 1996 | J Cereb Blood Flow Metab1996，16，： | 1 |
| 17 | Delayed induction and long-term effects of mild hypothermia in a focal model of transient cerebral ischemia: neurological outcome and infarct size 显示文摘 | Maier CM Sun GH Kunis D | 2001 | J Neurosurg2001，94，1： | 1 |
| 18 | Messenger RNA of neuronal nitric oxide synthase is expressed and possibly functions in mouse oocytes and embryos during preimplantation development 显示文摘 | KAZUKI A KUNIE M NOBUO I | 1999 | Biomedical Research1999，20，1： | 1 |
| 19 | Gene expression and protein localization of TLR-1, -2, -4 and -6 in amniochorion membranes of pregnancies complicated by histologic chorioamnionitis显示文摘 | Natália P. Mo?o Laura F. Martin Ana Carolina Pereira Jossimara Polettini José C. Pera?oli Kunie I.R. Coelho Márcia G. da Silva | 2013 | European Journal of Obstetrics and Gynecology2013，，： | 1 |
| 20 | Purification and molecular characterization of chitin deaeetylase from Rhizopus nigricans 显示文摘 | Jeraj N Kunie B Lenasi H | 2006 | Enzyme Mierob Tech2006，39，6： | 1 |
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