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| 1 | 北京大气颗粒物污染的区域性本质显示文摘颗粒物是北京的首要大气污染物,2006年PM10年均浓度超标60%以上.本研究基于颗粒物质量浓度在线监测和逐日TSP的采样分析,结合地面天气形势,论述了北京大气颗粒物污染的区域性特征.首先,北京大气颗粒物污染过程的形成由以冷锋过境为明显标志的周期性的天气系统决定,天气系统的活动尺度决定了颗粒物污染的区域性.其次,从PM2.5/PM10和Pb/Al比值的变化判别出颗粒物污染过程中随着颗粒物浓度的升高,细颗粒物呈现富集趋势;细颗粒物的富集由粗颗粒物的去除和超细颗粒物的生成(核化过程)、以及二次颗粒物的生成所致;污染过程中颗粒物的老化以及化学组成(Pb/Al)的大幅度变化共同表明了北京大气颗粒物来源的区域性本质. | 贺克斌 贾英韬 马永亮 雷宇 赵晴 TANAKA Shigeru OKUDA Tomoaki | 2009 | 环境科学学报2009，29，3： | 86 |
| 2 | 内蒙古达里湖全新世有机碳氮同位素记录与环境演变显示文摘内蒙古中东部的达里湖为一水文封闭型湖泊,位于现今东亚夏季风的北部边缘区,对区域环境变化十分敏感.本文对达里湖沉积中心提取的岩芯(DL04沉积岩芯)顶部8.5m沉积物进行了有机地球化学分析.15个全岩样品有机质的放射性碳测年结果表明:岩芯顶部8.5m涵盖了过去大约11500年.按约50年分辨率分析的225个总有机碳(TOC)、总氮(TN)含量、总有机碳/总氮(C/N)原子比值数据以及221个有机碳和有机氮稳定同位素(δ13C和δ13C)数据,详细揭示了全新世东亚夏季风边缘区的水文和生态变化历史.在距今11500 ~ 9800日历年(ca1.aB.P.)期间,所有地球化学指标均呈逐渐增大趋势,指示入湖河流逐渐增强,达里湖开始扩张,水生植物生产率逐渐升高;在9800 ~ 7700cal.aB.P.期间,TOC和TN含量以及C/N比值维持稳定高值,δ13C和δ15N值较小,指示湖泊维持高湖面状态,陆源输入和浮游植物生产率较高;在7700~ 5900cal.aB.P.期间,C/N比值和δ15N维持低值,TOC和TN含量呈现更高值,并且波动变化,δ13C值逐渐增大,表明湖面维持高水平,湖水显著变暖,浮游植物生产率显著升高,流域植被大幅度扩张;在5900 ~ 4850cal.aB.P.期间,TOC和TN含量,C/N比值以及δ13C值显著减小,δ15N值显著增大,暗示地表径流显著减弱,达里湖湖面显著下降,湖泊生产率快速下降;从4850cal.a B.P.开始,TOC和TN含量以及C/N比值呈逐渐减小趋势,δ13C和δ15N值呈逐渐增大趋势,表明湖面逐渐下降,湖水盐度、碱度升高,湖水可能变冷,湖泊生产率逐渐下降,流域植被收缩.全新世东亚夏季风边缘区水文和生态环境的变化可能直接或间接受北半球夏季太阳辐射量和区域季风降水强度的共同控制. | 范佳伟 肖举乐 温锐林 翟大有 王旭 崔琳琳 Shigeru Itoh | 2015 | 第四纪研究2015，35，4： | 34 |
| 3 | NAT2*6A, a haplotype of the N-acetyltransferase 2 gene, is an important biomarker for risk of anti-tuberculosis drug-induced hepatotoxicity in Japanese patients with tuberculosis显示文摘AIM: To investigate an association between N -acetyltransferase 2 (NAT2 )-haplotypes/diplotypes and adverse effects in Japanese pulmonary tuberculosis patients. METHODS: We studied 100 patients with pulmonary TB treated with anti-TB drugs including INH. The frequencies and distributions of single nucleotide polymorphisms, haplotypes, and diplotypes of NAT2 were determined by the PCR-restriction fragment length polymorphism method, and the results were compared between TB patients with and without adverse effect, using multivariate logistic regression analysis.RESULTS: Statistical analysis revealed that the frequency of a variant haplotype, NAT2*6A , was signifi cantly increased in TB patients with hepatotoxicity, compared with those without hepatotoxicity [P = 0.001, odds ratio (OR) = 3.535]. By contrast, the frequency of a wild-type (major) haplotype, 'NAT2*4', was signif icantly lower in TB patients with hepatotoxicity than those without hepatotoxicity (P < 0.001, OR = 0.265). There was no association between NAT2-haplotypes and skin rash or eosinophilia. CONCLUSION: The present study shows that NAT2 is one of the determinants of anti-TB drug-induced hepatotoxicity. Moreover, the haplotypes, NAT2*4 and NAT2*6A, are useful new biomarkers for predicting anti- TB drug-induced hepatotoxicity. | Norihide Higuchi Naoko Tahara Katsunori Yanagihara Kiyoyasu Fukushima Naofumi Suyama Yuichi Inoue Yoshitsugu Miyazaki Tsutomu Kobayashi Koh-ichiro Yoshiura Norio Niikawa, Chun-Yang Wen, Hajime Isomoto,Saburou Shikuwa, Katsuhisa Omagari, Yohei Mizuta, Shigeru Kohno, Kazuhiro Tsukamoto Norio Niikawa Chun-Yang Wen Hajime Isomoto Saburou Shikuwa Katsuhisa Omagari Yohei Mizuta Shigeru Kohno Kazuhiro Tsukamoto | 2007 | World Journal of Gastroenterology2007，13，45： | 21 |
| 4 | Association of glypican-3 expression with growth signaling molecules in hepatocellular carcinoma显示文摘AIM:To clarify the association of glypican-3(GPC3)expression with Wnt and other growth signaling molecules in hepatocellular carcinoma(HCC). METHODS:Expression of GPC3,Wnt,matrix metalloproteinases(MMPs),sulfatase(SULF)1,SULF2,and other growth signaling molecules was analyzed in HCC cell lines and tissue samples by real-time reverse transcriptionpolymerase chain reaction,immunoblotting,and/or immunostaining.Expression of various genes in GPC3 siRNA-transfected HCC cells was analyzed. RESULTS:GPC3 was overexpressed in most HCCs at mRNA and protein levels and its serum levels weresignificantly higher in patients with HCC than in non- HCC subjects(P<0.05).Altered expressions of various MMPs and growth signaling molecules,some of which were correlated with GPC3 expression,were observed in HCCs.Down-regulation of GPC3 expression by siRNA in GPC3-overexpressing HCC cell lines resulted in a significant decrease in expressions of MMP2,MMP14,fibroblast growth factor receptor 1,insulin-like growth factor 1 receptor.GPC3 expression was significantly correlated with nuclear/cytoplasmic localization ofβ-catenin. CONCLUSION:These results suggest that GPC3,in conjunction with MMPs and growth signaling molecules, might play an important role in the progression of HCC. | Noriyuki Akutsu Hiroyuki Yamamoto Shigeru Sasaki Hiroaki Taniguchi Yoshiaki Arimura Kohzoh Imai Yasuhisa Shinomura | 2010 | World Journal of Gastroenterology2010，16，28： | 20 |
| 5 | Laparoscopic appendectomy for acute appendicitis: How to discourage surgeons using inadequate therapy显示文摘Acute appendicitis(AA) develops in a progressive and irreversible manner, even if the clinical course of AA can be temporarily modified by intentional medications. Reliable and real-time diagnosis of AA can be made based on findings of the white blood cell count and enhanced computed tomography. Emergent laparoscopic appendectomy(LA) is considered as the first therapeutic choice for AA. Interval/delayed appendectomy at 6-12 wk after disease onset is considered as unsafe with a high recurrent rate during the waiting time. However, this technique may have some advantages for avoiding unnecessary extended resection in patients with an appendiceal mass. Nonoperative management of AA may be tolerated only in children. Postoperative complications increase according to the patient's factors, and temporal avoidance of emergent general anesthesia may be beneficial for high-risk patients. The surgeon's skill and cooperation of the hospital are important for successful LA. Delaying appendectomy for less than 24 h from diagnosis is safe. Additionally, a semi-elective manner(i.e., LA within 24 h after onset of symptoms) may be paradoxically acceptable, according to the factors of the patient, physician, and institution. Prompt LA is mandatory for AA. Fortunately, the Japanese government uses a universal health insurance system, which covers LA. | tomohide hori takafumi machimoto yoshio kadokawa toshiyuki hata tatsuo ito shigeru kato daiki yasukawa yuki aisu yusuke kimura maho sasaki yuichi takamatsu taku kitano shigeo hisamori tsunehiro yoshimura | 2017 | World Journal of Gastroenterology2017，23，32： | 18 |
| 6 | Pathophysiology, diagnosis and treatment of intermittent claudication in patients with lumbar canal stenosis显示文摘Spinal nerve roots have a peculiar structure, different from the arrangements in the peripheral nerve. The nerve roots are devoid of lymphatic vessels but are immersed in the cerebrospinal fluid(CSF) within the subarachnoid space. The blood supply of nerve roots depends on the blood flow from both and peripheral direction(ascending) and the spinal cord direction(descending). There is no hypovascular region in the nerve root, although there exists a so-called water-shed of the bloodstream in the radicular artery itself. Increased mechanical compression promotes the disturbance of CSF flow, circulatory disturbance starting from the venous congestion and intraradicular edema formation resulting from the breakdown of the blood-nerve barrier. Although this edema may diffuse into CSF when the subarachnoid space is preserved, the endoneurial fluid pressure may increase when the area is closed by increased compression. On the other hand, the nerve root tissue has already degenerated under the compression and the numerous macrophages releasing various chemical mediators, aggravating radicular symptomsthat appear in the area of Wallerian degeneration. Prostaglandin E1(PGE1) is a potent vasodilator as well as an inhibitor of platelet aggregation and has therefore attracted interest as a therapeutic drug for lumbar canal stenosis. However, investigations in the clinical setting have shown that PGE1 is effective in some patients but not in others, although the reason for this is unclear. | Shigeru Kobayashi | 2014 | World Journal of Orthopedics2014，5，2： | 15 |
| 7 | Correlation between hepatic blood flow and liver function in alcoholic liver cirrhosis显示文摘AIM:To elucidate the correlation between hepatic blood flow and liver function in alcoholic liver cirrhosis(AL-LC).METHODS:The subjects included 35 patients with ALLC(34 men,1 woman;mean age,58.9±10.7 years;median age,61 years;range:37-76 years).All patientswere enrolled in this study after obtaining written informed consent.Liver function was measured with tests measuring albumin(Alb),prothrombin time(PT),brain natriuretic peptide(BNP),branched amino acid and tyrosine ratio(BTR),branched chain amino acid(BCAA),tyrosine,ammonia(NH3),cholinesterase(Ch E),immunoreactive insulin(IRI),total bile acid(TBA),and the retention rate of indocyanine green 15 min after administration(ICG R15).Hepatic blood flow,hepatic arterial tissue blood flow(HATBF),portal venous tissue blood flow(PVTBF),and total hepatic tissue blood flow(THTBF)were simultaneously calculated using xenon computed tomography.RESULTS:PVTBF,HATBF and THTBF were 30.2±10.4,20.0±10.7,and 50.3±14.9 m L/100 m L/min,respectively.Alb,PT,BNP,BTR,BCAA,tyrosine,NH3,Ch E,IRI,TBA,and ICG R15 were 3.50±0.50 g/d L,72.0%±11.5%,63.2±56.7 pg/m L,4.06±1.24,437.5±89.4μmol/L,117.7±32.8μmol/L,59.4±22.7μg/d L,161.0±70.8 IU/L,12.8±5.0μg/d L,68.0±51.8μmol/L,and 28.6%±13.5%,respectively.PVTBF showed a significant negative correlation with ICG R15(r=-0.468,P<0.01).No significant correlation was seen between ICG 15R,HATBF and THTBF.There was a significant correlation between PVTBF and Alb(r=0.2499,P<0.05),and NH3 tended to have an inverse correlation with PVTBF(r=-0.2428,P=0.0894).There were also many significant correlations between ICG R15 and liver function parameters,including Alb,NH3,PT,BNP,TBA,BCAA,and tyrosine(r=-0.2156,P<0.05;r=0.4318,P<0.01;r=0.4140,P<0.01;r=0.3610,P<0.05;r=0.5085,P<0.001;r=0.4496,P<0.01;and r=0.4740,P<0.05,respectively).CONCLUSION:Our investigation showed that there is a close correlation between liver function and hepatic blood flow. | Hideaki Takahashi Ryuta Shigefuku Yoshihito Yoshida Hiroki Ikeda Kotaro Matsunaga Nobuyuki Matsumoto Chiaki Okuse Shigeru Sase Fumio Itoh Michihiro Suzuki | 2014 | World Journal of Gastroenterology2014，20，45： | 14 |
| 8 | 远端血管保护装置Guard Wire在急性心肌梗死急诊介入治疗中的应用显示文摘目的 评价GuardWire在急性心肌梗死 (AMI)急诊介入治疗时应用的价值。方法 连续观察 4 8例AMI急诊介入治疗并应用了GuardWire的患者 ,记录术中心电图变化及血流情况等 ,分析该装置的操作、造影和手术成功率 ,以及住院期间和术后 30d内的心血管事件发生率。结果 操作成功率、造影成功率和手术成功率均为 10 0 %。远端球囊阻塞时间平均 (8 1± 6 8)min ,所有患者均能良好耐受。 93 8%的患者吸引出肉眼可见的血栓 /斑块碎片 ,术中未出现因远端血管阻塞而引起的血液动力学或心电图、症状变化 ,未出现远端血管栓塞或无血流现象。住院期间和术后 30d内的心血管事件发生率均为 0。结论 该装置容易操作 ,可安全地应用于冠状动脉系统 ,有效防止AMI急诊介入治疗中可能出现的远端血管栓塞。 | 黄铮 陈红武 Osamu Katoh Shigeru Nakamura | 2003 | 中华心血管病杂志2003，31，11： | 14 |
| 9 | 微通道内超临界二氧化碳的压降与传热特性显示文摘进行了微通道内超临界CO2的局部和平均传热与压降特性实验研究。结果表明,临界点附近物性参数的剧烈变 化使压降增大,但传热被大大强化。同时也发现,系统压力、质量流速及CO2温度对流动与传热特性有重要影响。在大 量实验数据的基础上,得出了冷却条件下水平微通道内超临界CO2强制对流换热关联式。 | 淮秀兰 Shigeru Koyama | 2004 | 工程热物理学报2004，25，5： | 13 |
| 10 | 基于三维人脸成像系统的复数域人脸识别方法显示文摘三维人脸识别是模式识别和人工智能领域的研究热点。提出了一种利用人脸图像的二维灰度信息和三维深度信息进行人脸识别的算法。首先利用相关型图像传感器构成三维实时人脸成像系统,并将获得的三维人脸物理数据用复数形式表达。再将特征脸(Eigenface)方法和Fisherface方法拓展到复数域,提出了复数域特征脸方法和复数域Fisherface方法。改进的复数域人脸识别方法在三维实时成像系统的人脸数据库中进行的人脸识别实验表明,复数域的三维人脸识别方法明显优于传统的人脸识别方法。 | 叶长明 蒋建国 詹曙 Shigeru Ando | 2011 | 电子测量与仪器学报2011，25，5： | 12 |
| 11 | 新疆出血热病毒分子流行病学研究显示文摘目的研究新疆出血热病毒(XHF)分子流行病学,揭示其与相关病毒之间关系,分析XHF的流行来源和分布特点。方法RTPCR检测20012002年XHF患者和蜱标本中XHF病毒S基因,阳性标本直接进行核苷酸序列测定。计算机软件进行S基因部分片段和S全基因序列同源性比较和S基因、M基因的种系发生树分析。结果不同年份人和蜱来源的病毒S基因部分片段核苷酸序列均显示较高同源性(97.3%~100%)。S基因进化树分析将病毒分成了欧洲、非洲和亚洲3组,其中亚洲毒株由中亚分离株和中国分离株组成,中国所有的XHF病毒S基因(同源性93.0%~99.5%)均集中在一个分枝下形成独立的一组,明显区别于世界上其他地区分离株(同源性81.40%~96.4%)。M基因进化树分析表明序列间差异不完全与病毒分离的地理区域相关。结论S基因分析显示XHF病毒蜱分离株与人分离株遗传背景接近,我国XHF病毒有共同的进化途径和基因结构特点,并具明显的地域性。 | 唐青 赵秀芹 王环宇 司马义巴吾东 张玉贞 Masayuki Saijo Shigeru Morikawa 梁国栋 Ichiro Kurane | 2005 | 中华实验和临床病毒学杂志2005，19，4： | 11 |
| 12 | High concentrations of human β-defensin 2 in gastric juice of patients with Helicobacter pylori infection显示文摘AIM: Human β-defensin (HBD)-1 and HBD-2 are endogenous antimicrobial peptides. Unlike HBD-1, the HBD-2 expression is augmented by Helicobacter pylori (H pylori). We sought to determine HBD-1 and HBD-2 concentrations in gastric juice duringH pylori infection.METHODS: HBD-1 and HBD-2 concentrations were measured by radioimmunoassay in plasma and gastric juice of 49 H pylori-infected and 33 uninfected subjects and before and after anti-H pyloritreatment in 13 patients with H pylori-associated gastritis. Interleukin (IL)-1β and IL-8 concentrations in gastric juice were measured by enzyme-linked immunosorbent assay (ELISA). Histological grades of gastritis were determined using two biopsy specimens taken from the antrum and corpus. Reverse phase high performance liquid chromatography (RP-HPLC)was used to identify HBD-2.RESULTS: HBD-2 concentrations in gastric juice, but not in plasma, were significantly higher in H pylori-positive than -negative subjects, albeit the post-treatment levels were unchanged. Immunoreactivity for HBD-2 was exclusively identified in H pylori-infected mucosa by RPHPLC. HBD-2 concentrations in gastric juice correlated with histological degree of neutrophil and mononuclear cell infiltration in the corpus. IL-1β levels correlated with those of IL-8, but not HBD-2. Plasma and gastric juice HBD-1concentrations were similar in H pylori-infected and uninfected subjects.CONCLUSION: Our results place the β-defensins, especially HBD-2, in the front line of innate immune defence.Moreover, HBD-2 may be involved in the pathogenesis of H pylori-associated gastritis, possibly through its function as immune and inflammatory mediator. | Hajime Isomoto Hiroshi Mukae Hiroshi Ishimoto Yoshito Nishi Chun-Yang Wen Akihiro Wad Ken Ohnita Toshiya Hirayama Masamitsu Nakazato Shigeru Kohno | 2005 | World Journal of Gastroenterology2005，11，31： | 10 |
| 13 | 基于Gabor特征核协作表达的三维人脸识别显示文摘为了克服三维人脸识别中光照、表情、姿态等变化带来的识别困难,本文提出了基于Gabor特征的核协作表达三维人脸识别算法.协作表达分类算法利用相似人脸数据共同协作表示测试人脸,通过2范数求解稀疏系数,根据重构误差将测试人脸正确归类.该方法通过Gabor滤波器提取三维人脸深度图的40个不同尺度和方向的Gabor特征,然后选择合适核函数将其映射到高维核空间进行非线性降维和特征选取,最后结合协作表达分类算法完成三维人脸的识别.Kinect人脸库和Texas三维人脸库实验表明,该方法能在较少训练样本的情况下取得足够好的识别效果. | 詹曙 张启祥 蒋建国 Shigeru ANDO | 2013 | 光子学报2013，42，12： | 9 |
| 14 | Advantage of autologous blood transfusion in surgery for hepatocellular carcinoma显示文摘AIM: To evaluate the significance of autologous blood transfusion (AT) in reducing homologous blood transfusion (HT) in surgery for hepatocellular carcinoma (HCC). METHODS: The proportion of patients who received HT was compared between two groups determined by the time of AT introduction; period A (1991-1994, n = 93) and period B (1995-2000, n = 201). Multivariate logistic regression analysis was performed in order to identify independent significant predictors of the need for HT. We also investigated the impact of AT and HT on long-term postoperative outcome after curative surgery for HCC. RESULTS: The proportion of patients with HT was significantly lower in period B than period A (18.9% vs 60.2%, P < 0.0001). Multivariate logistic regression analysis identified AT administration as a significant independent predictor of the need for HT (P < 0.0001). Disease-free survival in patients with AT was comparable to that without any transfusion. Multivariate analysis identified HT administration as an independent significant factor for poorer disease-free survival (P = 0.0380). CONCLUSION: AT administration significantly decreased the need for HT. Considering the postoperative survival disadvantage of HT, AT administration could improve the long-term outcome of HCC patients. | Yoshito Tomimaru Hidetoshi Eguchi Shigeru Marubashi Hiroshi Wada Shogo Kobayashi Masahiro Tanemura Koji Umeshita Yuichiro Doki Masaki Mori Hiroaki Nagano | 2011 | World Journal of Gastroenterology2011，17，32： | 8 |
| 15 | 米仓山楔入冲断构造模型低温热年代学证据及其意义显示文摘基于低温热年代学特征的构造重建(或解译)与浅部地表过程模型在诠释盆-山结构与演化过程中受到越来越广泛的重视与应用.青藏高原东缘米仓山一川北前陆盆山系统楔人冲断构造模型与浅部地貌建造(非)耦合的检验校正为米仓山造山带构造变形及其动力学模型研究提供了契机.基于稳态楔入冲断构造低温热年代学模型研究表明,米仓山-川北前陆盆-山结构带盆山地貌的建造和低温热年代学(磷灰石裂变径迹和(U-Th)/He)特征具有明显的耦合性,二者统一于(盆地向)具~4°古地貌斜坡的楔入冲断构造模型.现今米仓山地区低温热年代学不具有明显的海拔高程和年龄线性关系,但当古地貌具有~4。坡度时低温热年代学与古地貌具有明显的线性相关性,揭示晚白垩世米仓山东西段具有一致(或相似)的稳态抬升剥露特征,东西段剥露速率分别为0.05mm/a和0.03mm/a.古地貌坡度与古地温梯度具有较好的相关性(R2=5%~98%),相关古地温梯度(25~35℃/km)符合米仓山稳态剥露地质结构特征.米仓山造山带楔人冲断构造模型的发育可能受控于多套滑脱层系(尤其是深部和浅部滑脱层系)和扬子板块能干性基底对造山带盆地向扩展变形过程的阻挡作用. | 邓宾 SUEOKA Shigeru 刘树根 李智武 李金玺 | 2014 | 地球物理学报2014，57，4： | 8 |
| 16 | Short-term effects of di-(2-ethylhexyl) phthalate on testes,liver, kidneys and pancreas in mice显示文摘瞄准:决定 di-(2-ethylhexyl ) 的生物化学的效果在生精的上皮的退化的过程的白天 10 上的睾丸,肝,肾和胰上的 phthalate (DEHP ) 。方法:包含 2% DEHP 的食谱被给男 Crlj : CD1 (ICR ) 老鼠 for10 天。DEHP 的剂量是 0.90 ± 0.52 mg/mouse/day。他们的睾丸,肝,肾 andpancreata 为察觉被检验单音 --(2-ethylhexyl ) phthalate (MEHP ) ,氮氧化物(NOx ) 生产了由每氮的氧化物的氧化(没有) 与自由激进分子,和类脂化合物一起每自由激进分子的链反应导致的氧化。结果:组织学的观察和浆液分析显示出严重 spermatogenic 骚乱, Leydig 房间机能障碍,肝机能障碍和脱水的存在。出人意料地,在睾丸的 MEHP 的集中在肝与那相比是极其低的。然而,在睾丸的 NOx 的集中象肝的集中一样高。而且,免费导致激进分子的类脂化合物组织化学地在睾丸然而并非在肝每氧化被检测。结论:结果显示阴囊的纸巾的高敏感引起到传播 MEHP 的 MEHP 而非特定的累积或举起进睾丸的那导致 DEHP 的 aspermatogenesisis。 | Yumi Miura Munekazu Naito Maira Ablake Hayato Terayama Shuang-Qin Yi Ning Qu Lin-Xian Cheng Shigeru Suna Fumihiko Jitsunari Masahiro Itoh | 2007 | Asian Journal of Andrology2007，9，2： | 6 |
| 17 | Gastrointestinal polyposis with esophageal polyposis is useful for early diagnosis of Cowden's disease显示文摘Cowden's disease, one of the several hamartoma syndromes, is characterized by hyperplastic lesions and hamartomas distributed in the whole body. About thirty percent of patients with Cowden's disease have been reported to be complicated by malignant tumors. Based on the criteria of the International Cowden Consortium, this disease is mainly diagnosed as trichilemmoma of the face and oral mucosal papillomatosis. However, Cowden's disease patients themselves often do not recognize trichilemmoma of the face and oral mucosal papillomatosis. We report a case of Cowden's disease in a 33-year-old female patient who was diagnosed based on the characteristic findings at gastrointestinal endoscopy. Clinically, the patient was aware of having bloody stools. Multiple polyps found endoscopically in the esophagus, stomach, ileum, colon and rectum showed histopathologically hamartomatous changes and epithelial hyperplasia. Physical examination revealed oral papillomatosis and facial trichilemmomas. A germline mutation in exon 8 of the phosphatase and tensin homolog deleted on chromosome ten (PTEN) gene was found in this case. It was a point mutation of C to T at codon 1003 (CGA→TGA, arginine→stop codon). The characteristic findings on gastrointestinal endoscopy led us to a diagnosis of Cowden's disease. It has been reported that gastrointestinal polyposis with esophageal polyposis is found in about 85.7% of Japanese patients with Cowden's disease. The characteristic findings on gastrointestinal endoscopy can be a useful diagnostic clue to Cowden's disease. | Ken Umemura Sho Takagi Yasushi Ishigaki Masahiro Iwabuchi Shigeru Kuroki Yoshitaka Kinouchi Tooru Shimosegawa | 2008 | World Journal of Gastroenterology2008，14，37： | 6 |
| 18 | A Computational Study of Thrust Vectoring Control Using Dual Throat Nozzle显示文摘Dual throat nozzle (DTN) is fast becoming a popular technique for thrust vectoring. The DTN is designed with two throats, an upstream minimum and a downstream minimum at the nozzle exit, with a cavity in between the upstream throat and exit. In the present study, a computational work has been carried out to analyze the performance of a dual throat nozzle at various mass flow rates of secondary flow and nozzle pressure ratios (NPR). Two-dimensional, steady, compressible Navier-Stokes equations were solved using a fully implicit finite volume scheme. The present computational results were validated with available experimental data. Based on the present results, the control effectiveness of thrust-vectoring is discussed in terms of the thrust coefficient and the coefficient of discharge. | Choon Sik Shin Heuy Dong Kim Toshiaki Setoguchi Shigeru Matsuo | 2010 | Journal of Thermal Science2010，19，6： | 6 |
| 19 | Endoscopic papillary large balloon dilation for removal of bile duct stones显示文摘AIM:To investigate the efficacy and outcomes of endoscopic papillary large balloon dilation(EPLBD)for bile duct stones in a multicenter prospective study.METHODS:Lithotomy by EPLBD was conducted in 124patients with bile duct stones≥13 mm in size or with three or more bile duct stones≥10 mm.After endoscopic sphincterotomy,the papilla was dilated using balloons 12-20 mm in diameter fitting the bile duct diameter.RESULTS:The success rate of first-time lithotomy was 86.3%(107/124)and the final lithotomy success rate was 100%(124/124).Lithotripsy was needed in10 of the 124(13.6%)patients.Adverse events due to the treatment procedure occurred in 6(4.8%)patients,all of which were mild.Performing large balloon dilation after endoscopic sphincterotomy in patients with large stones or multiple stones in the bile duct is considered to ensure the safety of treatment and to reduce the need for lithotripsy.CONCLUSION:It is suggested that treatment by EPLBD for large bile duct stones may be safe and useful. | Yuji Sakai Toshio Tsuyuguchi Yoshiaki Kawaguchi Nobuto Hirata So Nakaji Katsuya Kitamura Shigeru Mikami Tatsuya Fujimoto Masashi Ijima Eishin Kurihara Shuhei Oana Takayoshi Nishino Ryo Tamura Dai Sakamoto Masato Nakamura Takao Nishikawa Harutoshi Sugiyama Hitoshi Yoshida Tetsuya Mine Osamu Yokosuka | 2014 | World Journal of Gastroenterology2014，20，45： | 6 |
| 20 | 爆炸焊接Ti/SUS 304与Ti/SUS 821L1的对比显示文摘将商业纯钛分别与SUS 304奥氏体不锈钢和SUS 821L1双相不锈钢进行焊接。得到的Ti/SUS 821L1的波状界面小于Ti/SUS 304的。从纵向和横向均可观察到涡旋区域,并对涡旋区域的成分进行分析。Ti/SUS 821L1的界面可以承受401~431 MPa的剪切载荷,Ti/SUS 304的界面可以承受352~387 MPa的剪切载荷。使用爆炸焊接窗口来解释实验现象。使用光滑粒子动力学对波状界面进行数值模拟,模拟得出的波长与波幅随不锈钢强度与炸高的变化趋势与实验结果相符合。 | 陈翔 Daisuke INAO Shigeru TANAKA 李晓杰 I.A.BATAEV Kazuyuki HOKAMOTO | 2021 | Transactions of Nonferrous Metals Society of China2021，31，9： | 6 |
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