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| 1 | Expression of the tumor suppressor gene maspin and its significance in intraductal papillary mucinous neoplasms of the pancreas显示文摘BACKGROUND: Maspin is a member of the serpin family of protease inhibitors and is thought to inhibit carcinoma invasion, metastasis, and angiogenesis and induce apoptosis. We examined maspin expression immunohistochemically and assessed its significance in intraductal papillary mucinous neoplasm (IPMN) of the pancreas. METHODS: We examined 39 surgically resected specimens of IPMN that included 17 adenomas (IPMAs), 5 borderline tumors (IPMBs), 4 non-invasive carcinomas (non-invasive IPMCs), and 13 invasive carcinomas (invasive IPMCs). Immunostaining was performed according to the EnVision ChemMate method. The degree of maspin expression was scored and assessed according to the percentage and staining intensity of positive cells. RESULTS: Maspin expression was minimal in normal pancreatic duct epithelium, whereas in IPMNs, maspin was expressed in neoplasms of all stages. Maspin expression increased with increasing grade from IPMAs, IPMBs, to non-invasive IPMCs but decreased significantly in invasive IPMCs. No specific association between maspin expression and mucin type was found. Analysis of maspin expression with respect to clinicopathologic factors in cases of invasive IPMC revealed a greater extent of invasion in cases of low maspin expression and significantly fewer apoptotic cells in the tumor.CONCLUSIONS: Maspin was expressed at high levels in IPMNs at various stages from adenoma to invasive carcinoma, and our results suggest that maspin may be involved in the occurrence and progression of IPMN. In addition, our data suggest that the apoptosis-inducing action of maspin suppresses invasion and progression of IPMN. | Kyoko Kashima Nobuyuki Ohike Seishiro Mukai Masashi Sato Manabu Takahashi Toshio Morohoshi | 2008 | Hepatobiliary & Pancreatic Diseases International2008，7，1： | 9 |
| 2 | Spontaneous regression of gastric gastrinoma after resection of metastases to the lesser omentum:A case report and review of literature显示文摘BACKGROUND Gastric gastrinoma and spontaneous tumor regression are both very rarely encountered.We report the first case of spontaneous regression of gastric gastrinoma.CASE SUMMARY A 37-year-old man with a 9-year history of chronic abdominal pain was referred for evaluation of an 8 cm mass in the lesser omentum discovered incidentally on abdominal computed tomography.The tumor was diagnosed as grade 2 neuroendocrine neoplasm(NEN)on endoscopic ultrasound-guided fine-needle aspiration.Screening esophagogastroduodenoscopy revealed a 7 mm red polypoid lesion with central depression in the gastric antrum,also confirmed to be a grade 2 NEN.Laparoscopic removal of the abdominal mass confirmed it to be a metastatic gastrinoma lesion.The gastric lesion was subsequently diagnosed as primary gastric gastrinoma.Three months later,the gastric lesion had disappeared without treatment.The patient remains symptom-free with normal fasting serum gastrin and no recurrence of gastrinoma during 36 mo of follow-up.CONCLUSION Gastric gastrinoma may arise as a polypoid lesion in the gastric antrum.Spontaneous regression can rarely occur after biopsy. | Takeshi Okamoto Takaaki Yoshimoto Nobuyuki Ohike Aoi Fujikawa Takayoshi Kanie Katsuyuki Fukuda | 2021 | World Journal of Gastroenterology2021，27，1： | 2 |
| 3 | Factors affecting membrane-controlled drug release for an osmotic pump tablet (OPT) utilizing (SBE) 7 m -β-CD as both a solubilizer and osmotic agent显示文摘 | Kazuto Okimoto Atsuo Ohike Rinta Ibuki Osamu Aoki Norio Ohnishi Roger A. Rajewski Valentino J. Stella Tetsumi Irie Kaneto Uekama | 1999 | Journal of Controlled Release1999，，2： | 2 |
| 4 | Effect of mulberry leaf extract with enriched 1-deoxynojirimycin content on postprandial glycemic control in subjects with impaired glucose metabolism显示文摘 | Akira A Kjyotaka N Ohik H | 2011 | J Diabetes Investig2011，2，4： | 1 |
| 5 | Immunohistochemical analysis of nestin and c-kit and their significance in pancreatic tumors 显示文摘 | Ohike N Sato M Hisayuki T | 2007 | Pathol Int2007，57，9： | 1 |
| 6 | Low testosterone level as a predictor of cardiovascular events in Japanese men with coronary risk factors显示文摘 | AKISHITA M HASHIMOTO M OHIKE Y | 2010 | Atherosclerosis2010，210，： | 1 |
| 7 | Prognostic significance of the maspin tumor suppressor gene in pulmonary adenocarcinoma显示文摘 | Masanao Nakashima Nobuyuki Ohike Koichi Nagasaki Mitsuru Adachi Toshio Morohoshi | 2004 | Journal of Cancer Research and Clinical Oncology2004，，8： | 1 |
| 8 | Enoxaparin and fondaparinux attenuates endothelial damage in endotox- emic rats 显示文摘 | Iba T Okamoto K Ohike T | 2012 | J Trauma Acute Care Surg2012，72，1： | 1 |
| 9 | Relation of E -cadherin and beta-catenin expression to pig pattern in colorectal cancer显示文摘 | Kojima M Shiokawa A Ohike N | 2004 | Oncol Rep2004，12，3： | 1 |
| 10 | Comparative analysis ofdifferent counting methodologies for Ki-67 in pancreatic neuroendocrine tumors显示文摘 | Bagci P Ohike N Dursun N | 2012 | Mod Pathol2012，25，2： | 1 |
| 11 | Low testosterone level as a predictor of cardiovascular events in Japanese men with coronary risk factors 显示文摘 | Akishita M Hashimoto M Ohike Y et M | 2010 | Atherosclerosis2010，210，1： | 1 |
| 12 | Factors affecting membrane-controlled drug release for an osmotic pump tablet (OPT) utilizing(SBE)7m-β-CD as both a solubilier and osmotic agent 显示文摘 | Okimoto K Ohike A Ibuki R | 1999 | J Controlled Release1999，60，： | 1 |
| 13 | Clinicopathological signi-ficance and molecular regulation of maspin expression in ductal adenocarcinoma of the pancreas显示文摘 | Ohike N Maass N Mundhenke C | 2003 | Cancer Lett2003，199，2： | 1 |
| 14 | Factors affecting membrane - controlled drug release for an osmotic pump tablet (OPT) utilizing (SBE)7m - β - CD as both a solubilizer and osmotic agent 显示文摘 | Okimoto K Ohike A Ibuki R | 1999 | J Control Release1999，60，： | 1 |
| 15 | Design and evaluation of an osmotic pump tablet(OPT)forChlorpromazine using (SBE)7m-β-CD显示文摘 | Okimoto K Ohike A Ibuke R etc al | 1999 | PharmRes1999，16，4： | 1 |
| 16 | Factors affecting membrane controlled drug release for an osmotictable(OPT),utilizing (SBE)7m-β-CD as both a solubilizer and osmotic agent显示文摘 | Okimoto K Ohike A Ibuke R etc al | 1999 | J ControlledRelease1999，60，23： | 1 |
| 17 | Mixed acinar-endocrine carcinoma of the pancreas with intraductal growth into the main pancreatic duct: Report of a case显示文摘 | Shinjiro Kobayashi Takeshi Asakura Nobuyuki Ohike Takeharu Enomoto Joe Sakurai Satoshi Koizumi Taiji Watanabe Hiroshi Nakano Takehito Otsubo | 2010 | Surgery Today2010，，4： | 1 |
| 18 | Clinicopathological significance and molecular regulation of maspin expression in ductal adenocareinoma of the pancreas 显示文摘 | OHIKE N MAASS N MUNDHENKE C | 2003 | Cancer Lett2003，199，2： | 1 |
| 19 | Low testosterone level is an independent determinant of endothelial dysfunc- tion in men显示文摘 | Akishita M Hashimoto M Ohike Y | 2007 | Hypertens Res2007，30，11： | 1 |
| 20 | Prognostic significance of the maspin tumor suppressor gene in pulmonary adenocacinoma 显示文摘 | NAKASHIMA M OHIKE N NAGASAKI K | 2004 | J Cancer Res Clin Oncol2004，130，8： | 1 |
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