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| 1 | Molecular Cloning and Functional Characterization of Porcine MyD88 Essential for TLR Signaling显示文摘We isolated cDNA encoding porcine MyD88 (poMyD88) from Peyer's patches (Pps) of GALT. The complete open reading frame (ORF) of poMyD88 contains 879 bp encoding a deduced 293 aa residues. The amino acid sequence of poMyD88 was characterized by N-terminal death,intermediate and C-terminal Toll/IL-1 receptor (TIR) domains. The putative poMyD88 protein shares a higher level of homology with its human (87.2% amino acid identity) than with its mouse (77.4% amino acid identity) counterpart. Overexpression of poMyD88 participated in the further enhanced activation of NF-κB in human embryonic kidney (HEK) 293 cells expressing porcine TLR2 and porcine TLR4/MD-2,but not porcine RP105/MD-1 after stimulation with the corresponding ligands. The expression levels of MyD88 were highest in the spleen and mesenteric lymph nodes (MLNs),and lower in digestive tissues of newborn swine. In adult swine,the expression levels in the digestive tissues were lower than those in MLNs and the spleen. These results suggest that an MyD88-dependent signaling pathway is present in newborn as well as in adult swine and that it is involved in the innate immune system of these animals. | Masanori Tohno Tomoyuki Shimazu Hisashi Aso Yasushi Kawai Tadao Saito Haruki Kitazawa | 2007 | Cellular & Molecular Immunology2007，4，5： | 20 |
| 2 | Effects of lysedEnterococcus faecalis FK-23 on experimental allergic rhinitis in a murine model显示文摘In the current study,we sought to investigate whether lysed Enterococcus faecalis FK-23(LFK),a heat-killed probiotic preparation,attenuated eosinophil influx into the upper airway and had immunomodulatory activity in a murine allergic rhinitis model.Eighteen BALB/c mice were divided into three groups;the ovalbumin(OVA)-sensitized/challenged group,which received saline orally for 6 weeks(OVA group),the OVA-sensitized/challenged group,which received LFK orally for 6 weeks(LFK-fed group),and the non-sensitized group,which received saline for 6 weeks(saline control group).Nasal rubbing and sneezing were monitored during the study.After the final challenge,interleukin(IL)-4,interferon(IFN)-γ,and OVA-specific IgE levels in the sera and splenocyte culture supernatants were determined,eosinophilic infiltrate into the upper airway was quantified,and splenic CD4+CD25+ regulatory T cells(Tregs) were examined by flow cytometry.We found that nasal rubbing was significantly reduced in LFK-fed mice compared to the OVA group on d 27 and 35,and sneezing was significantly inhibited by LFK administration for 35 d.LFK-fed mice had significantly less eosinophil influx into the nasal mucosa than the OVA group.There were no significant differences between the LFK-fed group and OVA group in the serum and splenocyte culture supernatant levels of IL-4,IFN-γ,and OVA-specific IgE.Interestingly,the LFK-fed mice had a significantly greater percentage of splenic CD4+CD25+ Tregs than OVA group.Our results indicate that oral administration of LFK may alleviate nasal symptoms,reduce nasal eosinophilia,and increase the percentage of CD4+CD25+ Tregs in experimental allergic rhinitis. | Luping Zhu Takashi Shimada Ruoxi Chen Meiping Lu Qingzhao Zhang Wenmin Lu Min Yin Tadao Enomoto Lei Cheng | 2012 | The Journal of Biomedical Research2012，26，3： | 11 |
| 3 | ^(85)Sr、^(134)Cs和^(60)Co在浅地层黄土与地下水间的分配系显示文摘本文报道了￣(85)Sr、￣(134)Cs和￣(60)Co在采自本院野外试验场,从地表到地下2m深黄土与地下水间分配系数的测定结果,以及核素浓度、pH和温度对分配系数的影响。黄土采集的深度范围分别为:地表-0.5m,0.5-1m,1-1.5m,1.5-2m,共采集16个样品;地下水取自试验场的井水。实验采用静态法。实验结果表明,16个样品测定的￣(85)Sr、￣(134)Cs和￣(60)Co的分配系数的均值分别为82、7.4×10￣3和5.4×10￣3mL/g;在不同深度的黄土中测得的分配系数基本一致。pH值的变化对￣(134)Cs和￣(85)Sr的分配系数有较大影响,对￣(60)Co则影响不大。 | 李祯堂 王辉 游志均 Tadao Tanaka Hiromichi Ogawa Hidao Kamiyama | 1995 | 辐射防护1995，15，2： | 10 |
| 4 | Selective Mimics of Strigolactone Actions and Their Potential Use for Controlling Damage Caused by Root Parasitic Weeds显示文摘Strigolactones (SL ) 是植物荷尔蒙和根围通讯信号的一个新奇的类,尽管位于他们的活动下面的分子的机制还没是充分坚定的。他们的应用程序也不在很好开发的农业。植物荷尔蒙收缩筋的重要性在基本、适用的研究被表明了,并且模仿 strigolactone 功能的化学药品应该极大地便于 strigolactone 研究。这里,我们报导我们新 phenoxyfuranone 混合物的发现, 4-Br debranone (4BD ) ,那显示出类似的活动到主要 strigolactone (SL ) 的在植物上的生物试金的许多方面的模拟 GR24。4BD 强烈在象 GR24 的一样的集中在 SL 缺乏的米饭异种 d10 禁止了 tiller 芽长出,没有不利效果,甚至在延长耕作期间。这结果也在 Arabidopsis thaliana 被观察 SL 缺乏的异种 max1, max3,和 max4。然而,到 Arabidopsis SL 感觉迟钝的变异的 max2 的 4BD 的应用程序没在它导致词法变化。SL biosynthetic 基因的表示被 4BD 处理也减少,可能经由否定反馈规定。然而在 Striga hermonthica 上的种子萌芽试金,一条根寄生植物, 4BD 远比 GR24 显示出更少的活动。这些结果建议 4BD 是第一植物特定的 strigolactone 模仿。 | Kosuke Fukui Shinsaku Ito Tadao Asami | 2013 | Molecular Plant2013，6，1： | 9 |
| 5 | Multidisciplinary management of acute mesenteric ischemia:Surgery and endovascular intervention显示文摘Acute mesenteric ischemia(AMI)is a rare cause of the“acute abdomen”,characterized by impaired blood flow to the intestine.The principle of treatment is restoration of perfusion to ischemic bowel and resection of any necrotic intestine.Surgery and endovascular intervention are two complementary approaches to mesenteric ischemia.Endovascular intervention is not an alternative to the surgical approach,but it has the potential to improve the prognosis of patients with AMI when judiciously combined with a surgical approach.Due to the need for emergent treatment of patients with acute mesenteric ischemia,the treatment strategy needs to be modified for each facility.This review aims to highlight cutting-edge studies and provide reasonable treatment strategies for patients with acute mesenteric ischemia based on available evidence. | Takashi Sakamoto Tadao Kubota Hiraku Funakoshi Alan Kawarai Lefor | 2021 | World Journal of Gastrointestinal Surgery2021，13，8： | 6 |
| 6 | Chemical Genetic Dissection of Brassinosteroid-Ethylene Interaction显示文摘 | Joshua M. Gendron Asif Haque Nathan Gendron Timothy Chang Tadao Asami Zhi-Yong Wang | 2008 | Molecular Plant2008，1，2： | 6 |
| 7 | Terahertz imaging based on optical coherence tomography [Invited]显示文摘Three-dimensional(3D)terahertz(THz)imaging or THz tomography has recently proven to be useful for nondestructive testing of industrial materials and structures.In place of previous imaging techniques such as THz pulsed/continuous-wave radar and THz computed tomography,we propose a THz optical coherence tomography using photonics-and electronics-based THz sources,and demonstrate thickness measurement and tomographic imaging in frequency regions from 400 to 800 GHz. | Tadao Nagatsuma Hiroki Nishii Toshiyuki Ikeo | 2014 | Photonics Research2014，2，4： | 5 |
| 8 | Unique microRNA molecular profiles in lung cancer diagnosis and prognosis显示文摘 | Nozomu Yanaihara Natasha Caplen Elise Bowman Masahiro Seike Kensuke Kumamoto Ming Yi Robert M. Stephens Aikou Okamoto Jun Yokota Tadao Tanaka George Adrian Calin Chang-Gong Liu Carlo M. Croce Curtis C. Harris | 2006 | Cancer Cell2006，，3： | 4 |
| 9 | WAVE TRANSMISSION AND REFIECTION DUE TO A THIN VERTICAL BARRIER显示文摘WT5”BZ]A numerical method, the boundary fitted coordinate method (BFC), was used to investigate the transmission and reflection of water waves due to a rigid thin vertical barrier descending from the water surface to a depth, i.e., a curtain-wall type breakwater. A comparison between the present computed results and previous experimental and analytical results was carried out which verifies the prediction of the BFC method. Wave transmission and reflection due to the barrier were computed, and the transmission and refiection coefficients were given in a figure. [WT5”HZ] | Gao Xue-ping Hydraulics Institute, School of Civil Engineering, Tianjin University, Tianjin300072, China Nakamura Takayuki , Inouchi Kunimitsu Ehime University, Matsuyama 790-8577, Japan Kakinuma Tadao Nagasaki Comprehensive University, Nagasaki | 2001 | Journal of Hydrodynamics2001，13，1： | 4 |
| 10 | Verification of the Silica Deficiency Hypothesis Based on Biogeochemical Trends in the Aquatic Continuum of Lake BiwaYodo River-Seto Inland Sea,Japan显示文摘硅酸缺乏假设提出,水力变化引起的静水增加以及高的氮、磷排放都会加快淡水中硅藻的生长,因为硅藻可以吸收天然风化供给的溶解硅酸盐(DSi)。海洋中DSi供给减少的结果对沿海海洋生态系统中鞭毛藻类(非硅质的,且有潜在的害处)而非硅藻类(硅质.良性的)是很有利的。由于缺少相关的数据,尤其是亚洲的数据,这个假设的验证受到了阻碍。我们调查了日本由琵琶湖-淀川-濑户内海组成的流域连续体,那里天然条件使得硅酸缺乏现象很少发生,因为有固有的丰富的DSi供给。研究结果表明,在湖里和河1:2附近都有硅酸滞留的发生。硅藻和鞭毛藻之间的相对优势不能仅仅通过化学计量参数来解释,而是要通过对他们行为特征以及在河1:2附近的过程的差异的讨论来获得有利的支持。河1:2附近是氮、磷的直接输八场所,即使上游水库中的Si/N比值降低了,硅流出物还是会加速硅藻的大量聚集。因而,在湖里和河1:2附近这两个地方易发生DSi滞留,因为那里也是其他形式氮、磷直接载入的地方。DSi滞留造度与社会经济变化有相关关系,如20世纪60年代后期的经济高速增长以及20世纪80年代以后的经济发展减缓。这个连续体对硅过程的敏感程度表明了这个假设对全球具有重要意义。 | Akira Harashima Takashi Kimoto Takashi Wakabayashi Tadao Toshiyasu 李发东(译) | 2006 | AMBIO-人类环境杂志2006，35，1： | 3 |
| 11 | Hepatic osteodystrophy complicated with bone fracture in early infants with biliary atresia显示文摘Biliary atresia(BA) is one of the major hepatobiliary abnormalities in infants and one of the causes of hepatic osteodystrophy.Bone disease may be caused by the malabsorption of calcium and magnesium by vitamin D in hepatobiliary diseases in which bile flow into the intestines is deficient or absent.Bone fracture before Kasai hepatic portoenterostomy or within one month after the procedure in an infant with BA is very rare.We herein report two infants:one infant with BA who initially presented with a bone fracture before Kasai hepatic portoenterostomy,and the other at 4 wk after Kasai hepatic portoenterostomy,and also provide a review of the literature.Moreover,we conclude that clinicians should consider BA in infants with bone fracture during early infancy. | Tadao Okada Shohei Honda Hisayuki Miyagi Masashi Minato Akinobu Taketomi | 2012 | World Journal of Hepatology2012，4，10： | 3 |
| 12 | Prospective clinical trial of magnetic-anchor–guided endoscopic submucosal dissection for large early gastric cancer (with videos)显示文摘 | Takuji Gotoda Ichiro Oda Katsunori Tamakawa Hirohisa Ueda Toshiaki Kobayashi Tadao Kakizoe | 2009 | Gastrointestinal Endoscopy2009，，1： | 3 |
| 13 | Mortality Risk for Dialysis Patients With Different Levels of Serum Calcium, Phosphorus, and PTH: The Dialysis Outcomes and Practice Patterns Study (DOPPS)显示文摘 | Francesca Tentori Margaret J. Blayney Justin M. Albert Brenda W. Gillespie Peter G. Kerr Jürgen Bommer Eric W. Young Tadao Akizawa Takashi Akiba Ronald L. Pisoni Bruce M. Robinson Friedrich K. Port | 2008 | American Journal of Kidney Diseases2008，，3： | 3 |
| 14 | Unique microRNA molecular profiles in lung cancer diagnosis and prognosis显示文摘 | Nozomu Yanaihara Natasha Caplen Elise Bowman Masahiro Seike Kensuke Kumamoto Ming Yi Robert M. Stephens Aikou Okamoto Jun Yokota Tadao Tanaka George Adrian Calin Chang-Gong Liu Carlo M. Croce Curtis C. Harris | 2006 | Cancer Cell2006，，3： | 2 |
| 15 | Impact of lymphovascular invasion in patients with stage I gastric cancer显示文摘 | Chikara Kunisaki Hirochika Makino Jun Kimura Ryo Takagawa Takashi Kosaka Hidetaka A. Ono Hirotoshi Akiyama Tadao Fukushima Yutaka Nagahori Masazumiu Takahashi | 2010 | Surgery2010，，2： | 2 |
| 16 | Effectiveness of combined anticoagulant therapy for extending portal vein thrombosis in Crohn’s disease显示文摘 | Dr. Tomoyuki Tsujikawa M.D. Ph.D. Takashi Ihara M.D. Masaya Sasaki M.D. Ph.D. Hisayuki Inoue M.D. Ph.D. Yoshihide Fujiyama M.D. Ph.D. Tadao Bamba M.D. Ph.D | 1996 | Diseases of the Colon & Rectum1996，，7： | 2 |
| 17 | Adoptive immunotherapy to lower postsurgical recurrence rates of hepatocellular carcinoma: a randomised trial显示文摘 | Tadatoshi Takayama Teruaki Sekine Masatoshi Makuuchi Susumu Yamasaki Tomoo Kosuge Junji Yamamoto Kazuaki Shimada Michiie Sakamoto Setsuo Hirohashi Yasuo Ohashi Tadao Kakizoe | 2000 | 2000 (9232)2000，，9232： | 2 |
| 18 | Neutralization of interleukin-17 aggravates dextran sulfate sodium-induced colitis in mice显示文摘 | Atsuhiro Ogawa Akira Andoh Yoshio Araki Tadao Bamba Yoshihide Fujiyama | 2003 | Clinical Immunology2003，，： | 2 |
| 19 | Oncoplastic Surgery for Japanese Patients with Centrally Located Breast Cancer: Partial Resection and Reconstruction Using a Local Skin-Glandular Flap显示文摘 | Yuko Kijima Heiji Yoshinaka Munetsugu Hirata Tadao Mizoguchi Sumiya Ishigami Akihiro Nakajo Hideo Arima Youta Kawasaki Shinichi Ueno Shoji Natsugoe | 2011 | Journal of US-China Medical Science2011，8，3： | 2 |
| 20 | Dermal absorption of mucopolysaccharide polysulfate (heparinoid) in human and minipig显示文摘 | Tadao Kumokawa Kazumasa Hirata Keiichi Sato Satoshi Kano | 2011 | Arzneimittelforschung2011，，02： | 2 |
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