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| 1 | Endoscopic submucosal dissection for colorectal neoplasms:A review显示文摘The introduction of colorectal endoscopic submucosal dissection(ESD)has expanded the application of endoscopic treatment,which can be used for lesions with a low metastatic potential regardless of their size.ESD has the advantage of achieving en bloc resection with a lower local recurrence rate compared with that of piecemeal endoscopic mucosal resection.Moreover,in the past,surgery was indicated in patients with large lesions spreading to almost the entire circumference of the rectum,regardless of the depth of invasion,as endoscopic resection of these lesions was technically difficult.Therefore,a prime benefit of ESD is significant improvement in the quality of life for patients who have large rectal lesions.On the other hand,ESD is not as widely applied in the treatment of colorectal neoplasms as it is in gastric cancers owing to the associated technical difficulty,longer procedural duration,and increased risk of perforation.To diversify the available endoscopic treatment strategies for superficial colorectal neoplasms,endoscopists performing ESD need torecognize its indications,the technical issues involved in its application,and the associated complications.This review outlines the methods and type of devices used for colorectal ESD,and the training required by endoscopists to perform this procedure. | Taku Sakamoto Genki Mori Masayoshi Yamada Yuzuru Kinjo Eriko So Seiichiro Abe Yosuke Otake Takeshi Nakajima Takahisa Matsuda Yutaka Saito | 2014 | World Journal of Gastroenterology2014，20，43： | 13 |
| 2 | Lansoprazole-associated collagenous colitis:Diffuse mucosal cloudiness mimicking ulcerative colitis显示文摘There have only been a few reports on lansoprazole-associated collagenous colitis. Colonic mucosa of collagenous colitis is known to be endoscopically normal. We present a case of collagenous colitis where the mucosa showed diffuse cloudiness mimicking ulcerative colitis. A 70-year-old woman developed watery diarrhea four to nine times a day. She had interstitial pneumonia at 67 and reflux esophagitis at 70 years. Lansoprazole 30 mg/d had been prescribed for reflux esophagitis for nearly 6 mo. Lansoprazole was withdrawn due to its possible side effect of diarrhea. Colonoscopy disclosed diffuse cloudiness of the mucosa which suggested ulcerative colitis. Consequently sulfasalazine 2 g/d was started. The patient's diarrhea dramatically disappeared on the following day. However, biopsy specimens showed subepithelial collagenous thickening and infi ltration of inflammatory cells in the lamina propria, confirming the diagnosis of collagenous colitis. One month after sulfasalazine therapy was initiated, colonoscopic and histological abnormalities resolved completely. Five months later the diarrhea recurred. The findings on colonoscopy and histology were the same as before, confirming a diagnosis of collagenous colitis relapse. We found that the patient had begun to take lansoprazole again 3 mo ahead of the recent diarrhea. Withdrawal of lansoprazole promptly resolved the diarrhea. Endoscopic and histological abnormalities were also completely resolved, similar to the first episode. Retrospectively, the date of commencement of sulfasalazine and discontinuation of lansoprazole in the first episode was found to be the same. We conclude that this patient had lansoprazole-associated collagenous colitis. | Mitsuro Chiba Takeshi Sugawara Haruhiko Tozawa Hidehiko Tsuda Toru Abe Takuo Tokairin Iwao Ono Eriko Ushiyama | 2009 | World Journal of Gastroenterology2009，15，17： | 5 |
| 3 | Effects of estradiol and progesterone on the proinflammatory cytokine production by mononuclear cells from patients with chronic hepatitis C显示文摘AIM:To investigate the effects of estradiol (E2) and progesterone on the unstimulated and oxidative stressstimulated production of tumor necrosis factor (TNF)-α, interleukin (IL)-1β, IL-8, and macrophage chemotactic protein (MCP)-1 by peripheral blood mononuclear cells (PBMCs) from patients with chronic hepatitis C and healthy controls. METHODS:The PBMCs were separated from agematched 72 males and 71 females with and without chronic hepatitis C, who were divided into two groups based on a mean menopausal age of 50 years. Oxidative stress was induced by hydrogen peroxide in the cells incubated in serum-free media. Cytokines in the culture supernatant were measured by an enzyme-linked immunosorbent assay. RESULTS:The highest levels of the spontaneous production of TNF-α, IL-1β, IL-8, and MCP-1 by the unstimulated PBMCs were in the older male patients with chronic hepatitis C and the lowest levels were in the premenopausal female healthy controls. E2 inhibited the cytokine production by the unstimulated PBMCs from the older male and post-menopausal female patients, which was further stimulated by progesterone. The exposure to hydrogen peroxide in the PBMCs from the younger male and pre-menopausal female healthy subjects induced the production of cytokines. The change rates of the hydrogen peroxide-stimulated cytokine production were suppressed by E2 and enhanced by progesterone. CONCLUSION:These findings suggest that E2 may play a favorable role in the course of persistent liver injury by preventing the accumulation of monocytes-macrophages and by inhibiting proinflammatory cytokine production, whereas progesterone may counteract the favorable E2 effects. | Ying Yuan Ichiro Shimizu Mi Shen Eriko Aoyagi Hidetaka Takenaka Tatuzo Itagaki Mari Urata Katsutaka Sannomiya Nao Kohno Katsuyoshi Tamaki Masayuki Shono Tetsuji Takayama | 2008 | World Journal of Gastroenterology2008，14，14： | 5 |
| 4 | Assessment of disease progression in patients with transfusion-associated chronic hepatitis C using transient elastography显示文摘AIM:To evaluate the relationship between liver stiffness and duration of infection in blood transfusion-associated hepatitis C virus (HCV) patients with or without hepatocellular carcinoma (HCC).METHODS:Between December 2006 and June 2008,a total of 524 transfusion-associated HCV-RNA positive patients with or without HCC were enrolled.Liver stiffness was obtained noninvasively by using Fibroscan (Echosens,Paris,France).The date of blood transfusion was obtained by interview.Duration of infection was derived from the interval between the date of bloodtransfusion and the date of liver stiffness measurement (LSM).Patients were stratified into four groups based on the duration of infection (17-29 years;30-39 years;40-49 years;and 50-70 years).The difference in liver stiffness between patients with and without HCC was assessed in each group.Multiple linear regression analysis was used to determine the factors associated with liver stiffness.RESULTS:A total of 524 patients underwent LSM.Eight patients were excluded because of unsuccessful measurements.Thus 516 patients were included in the current analysis (225 with HCC and 291 without).The patients were 244 men and 272 women,with a mean age of 67.8 ± 9.5 years.The median liver stiffness was 14.3 kPa (25.8 in HCC group and 7.6 in nonHCC group).The patients who developed HCC in short duration of infection were male dominant,having lower platelet count,with a history of heavier alcohol consumption,showing higher liver stiffness,and receiving blood transfusion at an old age.Liver stiffness was positively correlated with duration of infection in patients without HCC (r=0.132,P=0.024) but not in patients with HCC (r=-0.103,P=0.123).Liver stiffness was significantly higher in patients with HCC than in those without in each duration group (P < 0.0001).The factors significantly associated with high liver stiffness in multiple regression were age at blood transfusion (P < 0.0001),duration of infection (P=0.0015),and heavy alcohol consumption (P=0.043) CONCLUSION:Although liver stiffness gradually increases over time,HCC develops in patients with high stiffness value regardless of the duration of infection. | Ryota Masuzaki Ryosuke Tateishi Haruhiko Yoshida Toru Arano Koji Uchino Kenichiro Enooku Eriko Goto Hayato Nakagawa Yoshinari Asaoka Yuji Kondo Tadashi Goto Hitoshi Ikeda Shuichiro Shiina Masao Omata Kazuhiko Koike | 2012 | World Journal of Gastroenterology2012，18，12： | 4 |
| 5 | OsIDD2, a zinc finger and INDETERMINATE DOMAIN protein, regulates secondary cell wall formation显示文摘Previously, we found 123 transcription factors(TFs) as candidate regulators of secondary cell wall(SCW)formation in rice by using phylogenetic and co-expression network analyses. Among them, we examined in this work the role of OsIDD_2, a zinc finger and indeterminate domain(IDD) family TF. Its overexpressors showed dwarfism, fragile leaves, and decreased lignin content, which are typical phenotypes of plants defective in SCW formation, whereas its knockout plants showed slightly increased lignin content.The RNA-seq and quantitative reverse transcription polymerase chain reaction analyses confirmed that some lignin biosynthetic genes were downregulated in the OsIDD_2-overexpressing plants, and revealed the same case for other genes involved in cellulose synthesis and sucrose metabolism. The transient expression assay using rice protoplasts revealed that OsIDD_2 negatively regulates the transcription of genes involved in lignin biosynthesis, cinnamyl alcohol dehydrogenase 2 and 3(CAD_2 and 3), and sucrose metabolism, sucrose synthase 5(SUS_5), whereas an Alpha Screen assay, which can detect the interaction between TFs and their target DNA sequences, directly confirmed the interaction between OsIDD_2 and the target sequences located in the promoter regions of CAD_2 and CAD_3. Based on these observations, we conclude that OsIDD_2 is negatively involved in SCW formation and other biological events by downregulating its target genes. | Peng Huang Hideki Yoshida Kenji Yano Shunsuke Kinoshita Kyosuke Kawai Eriko Koketsu Masako Hattori Sayaka Takehara Ji Huang Ko Hirano Reynante Lacsamana Ordonio Makoto Matsuoka Miyako Ueguchi-Tanaka | 2018 | Journal of Integrative Plant Biology2018，60，2： | 3 |
| 6 | IgG4-unrelated type 1 autoimmune pancreatitis显示文摘A 50-year-old male was referred to our hospital for the evaluation of hyperproteinemia.Fluorodeoxyglucose positron emission tomography revealed high fluorodeoxyglucose uptake in the pancreas,bilateral lacrimal glands,submandibular glands,parotid glands,bilateral pulmonary hilar lymph nodes,and kidneys.Laboratory data showed an elevation of hepatobiliary enzymes,renal dysfunction,and remarkably high immunoglobulin(Ig) G levels,without elevated serum IgG4.Abdominal computed tomography revealed swelling of the pancreatic head and bilateral kidneys.Endoscopic retrograde cholangiopancreatography showed an irregular narrowing of the main pancreatic duct in the pancreatic head and stricture of the lower common bile duct.Histological examination by endoscopic ultrasonography-guided fine-needle aspiration revealed findings of lymphoplasmacytic sclerosing pancreatitis without IgG4-positive plasma cells.Abnormal laboratory values and the swelling of several organs were improved by the treatment with steroids.The patient was diagnosed as having type 1 autoimmune pancreatitis(AIP) based on the International Consensus Diagnostic Criteria.Therefore,we encountered a case of compatible type 1 AIP without elevated levels of serum IgG4 or IgG4-positive plasma cells.This case suggests that AIP phenotypes are not always associated with IgG4. | Eriko Nakano Atsushi Kanno Atsushi Masamune Naoki Yoshida Seiji Hongo Shin Miura Tetsuya Takikawa Shin Hamada Kiyoshi Kume Kazuhiro Kikuta Morihisa Hirota Keisuke Nakayama Fumiyoshi Fujishima Tooru Shimosegawa | 2015 | World Journal of Gastroenterology2015，21，33： | 3 |
| 7 | Safety and efficacy of lamivudine after radiofrequency ablation in patients with hepatitis B virus-related hepatocellular carcinoma显示文摘 | Hideo Yoshida Haruhiko Yoshida Eriko Goto Takahisa Sato Takamasa Ohki Ryota Masuzaki Ryosuke Tateishi Tadashi Goto Shuichiro Shiina Takao Kawabe Masao Omata | 2008 | Hepatology International2008，，1： | 3 |
| 8 | Pancreatic duct drainage using EUS-guided rendezvous technique for stenotic pancreaticojejunostomy显示文摘The patient was a 30-year-old female who had undergone excision of the extrahepatic bile duct and Rouxen-Y hepaticojejunostomy for congenital biliary dilatation at the age of 7.Thereafter,she suffered from recurrent acute pancreatitis due to pancreaticobiliary maljunction and received subtotal stomach-preserving pancreaticoduodenectomy.She developed a pancreatic fistula and an intra-abdominal abscess after the operation.These complications were improved by percutaneous abscess drainage and antibiotic therapy.How ever,upper abdominal discomfort and the elevation of serum pancreatic enzymes persisted due to stenosis from the pancreaticojejunostomy.Because we could not accomplish dilation of the stenosis by endoscopic retrograde cholangiopancreatography,we tried an endoscopic ultrasonography(EUS) guided rendezvous technique for pancreatic duct drainage.After transgastric puncture of the pancreatic duct using an EUS-fine needle aspiration needle,the guidewire was inserted into the pancreatic duct and finally reached to the jejunum through the stenotic anastomosis.We changed the echoendoscope to an oblique-viewing endoscope,then grasped the guidewire and withdrew it through the scope.The stenosis of the pancreaticojejunostomy was dilated up to 4 mm,and a pancreatic stent was put in place.Though the pancreatic stent was removed after three months,the patient remained symptomfree.Pancreatic duct drainage using an EUS-guided rendezvous technique was useful for the treatment of a stenotic pancreaticojejunostomy after pancreaticoduodenectomy. | Tetsuya Takikawa Atsushi Kanno Atsushi Masamune Shin Hamada Eriko Nakano Shin Miura Hiroyuki Ariga Jun Unno Kiyoshi Kume Kazuhiro Kikuta Morihisa Hirota Hiroshi Yoshida Yu Katayose Michiaki Unno Tooru Shimosegawa | 2013 | World Journal of Gastroenterology2013，19，31： | 3 |
| 9 | The angiotensin II type I receptor blocker olmesartan inhibits the growth of pancreatic cancer by targeting stellate cell activities in mice显示文摘 | Atsushi Masamune Shin Hamada Kazuhiro Kikuta Tetsuya Takikawa Shin Miura Eriko Nakano Tooru Shimosegawa | 2013 | Scandinavian Journal of Gastroenterology2013，，5： | 2 |
| 10 | Colorectal endoscopic submucosal dissection: T echnical advantages compared to endoscopic mucosal resection and minimally invasive surgery显示文摘 | Yutaka Saito Masayoshi Yamada Eriko So Seiichiro Abe Taku Sakamoto Takeshi Nakajima Yosuke Otake Akiko Ono Takahisa Matsuda | 2014 | Digestive Endoscopy2014，，： | 2 |
| 11 | Checkpoint with forkhead-associated and ring finger promoter hypermethylation correlates with microsatellite instability in gastric cancer显示文摘AIM:To examine the methylation status of the promoter region of the checkpoint with forkhead-associated and ring fi nger(CHFR) and microsatellite mutator status in 59 primary gastric cancers.METHODS:We investigated the promoter methylation of CHFR in 59 cases of gastric cancer using methylation-specifi c PCR.Five microsatellite loci were analyzed using high-intensity microsatellite analysis reported previously, and p53 gene mutations were investigated by direct sequencing.RESULTS:Twenty cases(33.9%) showed promoter methylation and no relation was observed with the clinicopathological factors.We found that the promoter methylation of CHFR was frequently accompanied with microsatellite instability(MIN).Seven of 20(35.0%) cases showed MIN in hypermethylation of the CHFR tumor, while three of 39(7.7%) cases showed MIN in the non-methylated CHFR tumor(P < 0.01).However, we failed to fi nd any relationship between CHFR methylation and p53 mutation status.CONCLUSION:The coordinated loss of both the mitotic check point function and mismatch repair system suggests the potential to overcome the cell cycle check point, which may lead to an accumulation of mutations.However, the p53 mutation was not related to hypermethylation of the CHFR promoter and MIN, which indicates that an abnormality in p53 occurs as an independent process from the mismatch repair deficiency in carcinogenesis. | Eiji Oki Yan Zhao Rintaro Yoshida Takanobu Masuda Koji Ando Masahiiko Sugiyama Eriko Tokunaga Masaru Morita Yoshihiro Kakeji Yoshihiko Maehara | 2009 | World Journal of Gastroenterology2009，15，20： | 2 |
| 12 | JNK contributes to temozolomide resistance of stem-like glioblastomacells via regulation of MGMT expression显示文摘 | Masashi Okada Atsushi Sato Keita Shibuya Eriko Watanabe Shizuka Seino Shuhei Suzuki Manabu Seino Yoshitaka Narita Soichiro Shibui Takamasa Kayama Chifumi Kitanaka | 2014 | International Journal of Oncology2014，，2： | 2 |
| 13 | Prospective risk assessment for hepatocellular carcinoma development in patients with chronic hepatitis C by transient elastography显示文摘 | Ryota Masuzaki Ryosuke Tateishi Haruhiko Yoshida Eriko Goto Takahisa Sato Takamasa Ohki Jun Imamura Tadashi Goto Fumihiko Kanai Naoya Kato Hitoshi Ikeda Shuichiro Shiina Takao Kawabe Masao Omata | 2009 | Hepatology2009，，： | 2 |
| 14 | Comparison of EMR and endoscopic submucosal dissection for en bloc resection of early esophageal cancers in Japan显示文摘 | Ryu Ishihara Hiroyasu Iishi Noriya Uedo Yoji Takeuchi Sachiko Yamamoto Takuya Yamada Eriko Masuda Koji Higashino Motohiko Kato Hiroyuki Narahara Masaharu Tatsuta | 2008 | Gastrointestinal Endoscopy2008，，6： | 2 |
| 15 | Therapeutic angiogenesis for patients with limb ischaemia by autologous transplantation of bone marrow cells:a pilot study and a randomized controlled trial显示文摘 | Eriko TY Hiroaki M Toyoaki M | 2002 | Lancet2002，360，9331： | 1 |
| 16 | The expression of PPAR-associated genes is modulated through postnatal development of PPAR subtypes in the small intestine显示文摘 | Kazuki Mochizuki Kazuhito Suruga Eriko Yagi Sachiko Takase Toshinao Goda | 2001 | BBA - Molecular and Cell Biology of Lipids2001，，1： | 1 |
| 17 | Treatment strategy for hepatocellular carcinoma: expanding the indications for radiofrequency ablation显示文摘 | Ryosuke Tateishi Shuichiro Shiina Takamasa Ohki Takahisa Sato Ryota Masuzaki Jun Imamura Eriko Goto Tadashi Goto Hideo Yoshida Shuntaro Obi Shinpei Sato Fumihiko Kanai Haruhiko Yoshida Masao Omata | 2009 | Journal of Gastroenterology2009，，19： | 1 |
| 18 | Therapeutic angiogenesis for patients with limb ischaemia by autologous transplantation of bone-marrow cells: a pilot study and a randomized controlled trial显示文摘 | Eriko TY Hiroaki M Toyoaki M | 2002 | Lancet(S0099-5355)2002，8，： | 1 |
| 19 | Applications of quantum computing for investigations of electronic transitions in phenylsulfonyl-carbazole TADF emitters显示文摘A quantum chemistry study of the first singlet(S_(1))and triplet(T_(1))excited states of phenylsulfonyl-carbazole compounds,proposed as useful thermally activated delayed fluorescence(TADF)emitters for organic light emitting diode(OLED)applications,was performed with the quantum Equation-Of-Motion Variational Quantum Eigensolver(qEOM-VQE)and Variational Quantum Deflation(VQD)algorithms on quantum simulators and devices.These quantum simulations were performed with double zeta quality basis sets on an active space comprising the highest occupied and lowest unoccupied molecular orbitals(HOMO,LUMO)of the TADF molecules.The differences in energy separations between S_(1) and T_(1)(ΔEST)predicted by calculations on quantum simulators were found to be in excellent agreement with experimental data.Differences of 17 and 88 mHa with respect to exact energies were found for excited states by using the qEOM-VQE and VQD algorithms,respectively,to perform simulations on quantum devices without error mitigation.By utilizing state tomography to purify the quantum states and correct energy values,the large errors found for unmitigated results could be improved to differences of,at most,4 mHa with respect to exact values.Consequently,excellent agreement could be found between values ofΔEST predicted by quantum simulations and those found in experiments. | Qi Gao Gavin O.Jones Mario Motta Michihiko Sugawara Hiroshi CWatanabe Takao Kobayashi Eriko Watanabe Yu-ya Ohnishi Hajime Nakamura Naoki Yamamoto | 2021 | npj Computational Materials2021，，1： | 1 |
| 20 | Growth of the 2-in-size Bulk ZnO Single Crystals by the Hydrothermal Method显示文摘 | Eriko O M Hiraku O Ikuo N K Katsumi M Mitsuru S Masumi I Tsuguo F D | 2004 | Journal of Crystal Growth2004，260，： | 1 |
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