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| 1 | On the combined effect of soil fertility and topography on tree growth in subtropical forest ecosystems—a study from SE China显示文摘Aims The aim of our research was to understand small-scale effects of topography and soil fertility on tree growth in a forest biodiversity and ecosystem functioning(BEF)experiment in subtropical SE China.Methods Geomorphometric terrain analyses were carried out at a spatial resolution of 5×5 m.Soil samples of different depth increments and data on tree height were collected from a total of 566 plots(667 m2 each).The soils were analyzed for carbon(soil organic carbon[SOC]),nitrogen,acidity,cation exchange capacity(CEC),exchangeable cations and base saturation as soil fertility attributes.All plots were classified into geomorphological units.Analyses of variance and linear regressions were applied to all terrain,soil fertility and tree growth attributes.Important Findings In general,young and shallow soils and relatively small differences in stable soil properties suggest that soil erosion has truncated the soils to a large extent over the whole area of the experiment.This explains the concurrently increasing CEC and SOC stocks downslope,in hollows and in valleys.However,colluvial,carbon-rich sediments are missing widely due to the convexity of the footslopes caused by uplift and removal of eroded sediments by adjacent waterways.The results showed that soil fertility is mainly influenced by topography.Monte-Carlo flow accumulation(MCCA),curvature,slope and aspect significantly affected soil fertility.Furthermore,soil fertility was affected by the different geomorphological positions on the experimental sites with ridge and spur positions showing lower exchangeable base cation contents,especially potassium(K),due to leaching.This geomorphological effect of soil fertility is most pronounced in the topsoil and decreases when considering the subsoil down to 50 cm depth.Few soil fertility attributes affect tree height after 1-2 years of growth,among which C stocks proved to be most important while pH_(KCl)and CEC only played minor roles.Nevertheless,soil acidity and a high proportion of Al on the exchange complex affected tree height even after only 1-2 years growth.Hence,our study showed that forest nutrition is coupled to a recycling of litter nutrients,and does not only depend on subsequent supply of nutrients from the mineral soil.Besides soil fertility,topography affected tree height.We found that especially MCCA as indicator of water availability affected tree growth at small-scale,as well as aspect.Overall,our synthesis on the interrelation between fertility,topography and tree growth in a subtropical forest ecosystem in SE China showed that topographic heterogeneity lead to ecological gradients across geomorphological positions.In this respect,small-scale soil-plant interactions in a young forest can serve as a driver for the future development of vegetation and biodiversity control on soil fertility.In addition,it shows that terrain attributes should be accounted for in ecological research. | Thomas Scholten Philipp Goebes Peter Kühn Steffen Seitz Thorsten Assmann Jürgen Bauhus Helge Bruelheide Francois Buscot Alexandra Erfmeier Markus Fischer Werner Härdtle Jin-Sheng He Keping Ma Pascal A.Niklaus Michael Scherer-Lorenzen Bernhard Schmid Xuezheng Shi Zhengshan Song Goddert von Oheimb Christian Wirth Tesfaye Wubet Karsten Schmidt | 2017 | Journal of Plant Ecology2017，10，1： | 22 |
| 2 | 1961—2010年松花江流域实际蒸散发时空变化及影响要素分析显示文摘采用1961—2010年松花江流域60个气象站逐日资料,基于平流-干旱模型(AA模型)计算并分析了流域实际蒸散发时空变化特征,采用相关分析方法研究了影响实际蒸散发变化的主要气象要素。结果表明,1961—2010年,松花江流域年均实际蒸散发为420.8 mn,总体呈现增加趋势,增加速率为4.9 mm/10a,呈'减-增-减-增'年代际波动变化。季节上,春、冬两季实际蒸散发增加趋势较明显,夏、秋两季则呈现与年实际蒸散发类似的年代际波动。春、夏、秋三季和年实际蒸散发的空间分布特征基本一致,高值主要出现在流域南部,低值区主要分布在流域西部。冬季绝大部分区域的实际蒸散发呈现微弱上升趋势。1961-2010年,松花江流域年和四季的平均气温、最高气温和最低气温都呈上升趋势,其中平均气温和最低气温上升显著,日照时数和风速大都呈现显著下降趋势。相关分析结果表明,松花江流域实际蒸散发的时空变化是各气象要素共同影响的结果,而且各气象要素在不同时期对实际蒸散发的影响是有差异的。总体上看,松花江流域实际蒸散发的增加主要是由平均气温,特别是最低气温的增加引起,特别在春、冬季体现得较为明显。夏、秋季节,影响实际蒸散发的要素包括气温日较差、实际水汽压、平均风速及降水量等气象要素,但夏、秋季节这些要素的多年变化趋势不明显,导致夏、秋实际蒸散发的总体变化趋势并不明显。 | 温姗姗 姜彤 李修仓 王腾飞 王艳君 Thomas Fischer | 2014 | 气候变化研究进展2014，10，2： | 21 |
| 3 | 1984-2014年影响中国热带气旋的经济损失标准化及其变化特征显示文摘根据1984—2014年中国热带气旋损失数据和社会经济统计资料,采用居民消费者物价指数方法(consumer price index,CPI)、常规标准化方法 (conventional normalization method,CNM)和替代标准化方法(Alternative Normalization Method,ANM)对影响中国的气旋的直接经济损失进行标准化处理,对比研究了原始的和CPI、CNM、ANM等三种标准化的灾害损失时空特征。研究结果表明:(1)原始损失值有利于与同年其他灾种损失进行对比以及数据的逐年延长更新,而标准化后的损失值有利于长时间序列的时空比较研究,其中,CPI方法计算简单,易于推广,可用于中国灾害损失的数据处理与分析汇总,而在人口和财富快速增长的地区,CNM和ANM方法有利于体现人口和财富对损失的影响,在长时间序列的时空比较研究方面更具优势;(2)1984—2014年,共有243个影响气旋影响中国大陆的22个省(区、市),气旋频数多年来没有显著变化趋势,但未登陆的影响气旋和台风(TY)强度及以上等级的影响气旋频数多年来皆呈明显增加趋势;(3)1984—2014年影响气旋所造成的直接经济损失在原始的和经CPI标准化后的序列中均呈显著增加趋势,而经CNM和ANM标准化后的序列则无明显趋势,原始序列中最高损失年是2013年,CPI、CNM和ANM标准化后损失序列在1996年达到最高值后经历了由高到低的突变,原始的以及三种标准化后的损失序列均存在2~3年的周期振荡,浙江、广东和福建省始终是直接经济损失最高的三个省份;(4)在对中国大陆造成最高直接经济损失的十个影响气旋中,1996年的'赫伯'(Herb)始终位居首位,而其他影响气旋的排序位次因标准化与否以及标准化方法的不同而有明显差异。 | 温姗姗 翟建青 THOMAS Fischer 苏布达 姜彤 王艳君 | 2017 | 热带气象学报2017，33，4： | 14 |
| 4 | Hepatitis C virus infection and apoptosis显示文摘Apoptosis is central for the control and elimination of viral infections. In chronic hepatitis C virus (HCV) infection, enhanced hepatocyte apoptosis and upregulation of the death inducing ligands CD95/Fas, TRAIL and TNFα occur. Nevertheless, HCV infection persists in the majority of patients. The impact of apoptosis in chronic HCV infection is not well understood. It may be harmful by triggering liver fibrosis, or essential in interferon (IFN) induced HCV elimination. For virtually all HCV proteins, pro- and anti-apoptotic effects have been described, especially for the core and NS5A protein. To date, it is not known which HCV protein affects apoptosis in vivo and whether the infectious virions act pro- or anti- apoptotic. With the availability of an infectious tissue culture system, we now can address pathophysiologically relevant issues. This review focuses on the effect of HCV infection and different HCV proteins on apoptosis and of the corresponding signaling cascades. | Richard Fischer Thomas Baumert Hubert E Blum | 2007 | World Journal of Gastroenterology2007，13，36： | 10 |
| 5 | Trends in Monthly Temperature and Precipitation Extremes in the Zhujiang River Basin,South China(1961-2007)显示文摘Monthly temperature and precipitation time-series for the Zhujiang River Basin are analyzed in order to identify changes in climate extremes.Daily temperature and precipitation data from 1961 to 2007 of 192 meteorological stations are used.Two temperature indicators(monthly mean and monthly maximum mean) and three precipitation indicators (monthly total,monthly maximum consecutive 5-day precipitation,and monthly dry days) are analyzed.Tendencies in all five indicators can be observed.Many stations show significant positive trends(above the 90%confidence level) for monthly mean temperatures and monthly maximum mean temperatures.For all months,a significant increase in temperature from 1961 to 2007 can be observed in the entire basin with the coastal area in particular.Positive trends of precipitation extremes can be observed from January to March.Negative trends are detected from September to November. The number of dry days in October increased significantly at 40%of all meteorological stations.Stations with changes of monthly precipitation extremes are scattered over the Zhujiang River Basin.An aggregation of heat waves and droughts can be detected which is accompanied by significant increases of temperature extremes and the negative tendencies in precipitation extremes.The detection of tendencies in climate extremes essentially relies on a good data quality and high station density. | Thomas Fischer Marco Gemmer Lliu Liu Buda Su | 2010 | Advances in Climate Change Research2010，1，2： | 6 |
| 6 | Coexpression of receptor-tyrosine-kinases in gastric adenocarcinoma-a rationale for a molecular targeting strategy?显示文摘AIM: To define the (co-)expression pattern of target receptor-tyrosine-kinases (RTK) in human gastric adenocarcinoma. METHODS: The (co-)expression pattern of VEGFR1-3,PDGFRα/b and EGFR1 was analyzed by RT-PCR in 51 human gastric adenocarcinomas. In addition,IHC staining was applied for confirmation of expression and analysis of RTK localisation. RESULTS: The majority of samples revealed a VEGFR1 (98%),VEGFR2 (80%),VEGFR3 (67%),PDGFRα (82%) and PDGFRβ(82%) expression,whereas only 62% exhibited an EGFR1 expression. 78% of cancers expressed at least four out of six RTKs. While VEGFR1-3 and PDGFRα revealed a predominantly cytoplasmatic staining in tumor cells,accompanied by an additional nuclear staining for VEGFR3 ,EGFR1 was almost exclusively detected on the membrane of tumor cells. PDGFRβ was restricted to stromal pericytes,which also depicted a PDGFRα expression.receptor-tyrosine-kinases coexpression in gastric adenocarcinoma and might therefore encourage an application of multiple-target RTK-inhibitors within a combination therapy. | Daniel Drescher Markus Moehler Ines Gockel Kirsten Frerichs Annett Müller Friedrich Dünschede Thomas Borschitz Stefan Biesterfeld Martin Holtmann Thomas Wehler Andreas Teufel Kerstin Herzer Thomas Fischer Martin R Berger Theodor Junginger Peter R Galle Carl C Schimanski | 2007 | World Journal of Gastroenterology2007，13，26： | 4 |
| 7 | Collaborative innovation in ubiquitous systems显示文摘 | Veronica Serrano Thomas Fischer | 2007 | Journal of Intelligent Manufacturing2007，，5： | 3 |
| 8 | Global, regional, and national causes of child mortality in 2008: a systematic analysis显示文摘 | Robert E Black Simon Cousens Hope L Johnson Joy E Lawn Igor Rudan Diego G Bassani Prabhat Jha Harry Campbell Christa Fischer Walker Richard Cibulskis Thomas Eisele Li Liu Colin Mathers | 2010 | The Lancet2010，，9730： | 3 |
| 9 | Golimumab in real-world practice in patients with ulcerative colitis:Twelve-month results显示文摘BACKGROUND The introduction of biologics has revolutionized the management of the chronic inflammatory bowel disease,ulcerative colitis(UC),with many patients experiencing significant improvements not only in their symptoms but in other outcomes relevant to individuals and society as a whole.In Germany,there are no prospective data>3 mo that assess the work productivity,daily activities and quality of life(QoL)of patients with moderate-to-severe UC treated with golimumab.AIM To assess change in work productivity,capacity for daily activities and QoL in UC patients treated with golimumab in Germany.METHODS The validated Work Productivity Activity Impairment(WPAI)Questionnaire was used to analyze the change in work productivity,the capacity for daily activities after three months(primary endpoint)and disease specific and health related QoL(HRQoL)up to 1 year(secondary endpoints).The changes in work productivity and activity impairment were evaluated every three months until month twelve compared to baseline.Disease-specific and health-related QoL were assessed with the inflammatory bowel disease questionnaire and with the short-form 12 health survey questionnaire(SF-12).RESULTS This prospective non-interventional study included 287 patients.The analysis population was comprised of 282 patients who had completed at least two visits.At baseline,61%of patients had moderate UC and 18%had severe UC.Furthermore,75%of patients worked full-time or part-time at baseline.A total of 212 patients who were employed at the start of the study(employed population)were evaluated for the primary endpoint.Golimumab significantly reduced all WPAI sub-scores compared to baseline after three,six,nine and twelve months after the start of treatment(P<0.0001).In addition,disease-specific QoL and HRQoL,as measured by the SF-12 questionnaire,improved significantly with golimumab at all evaluation times(P<0.0001 in each case vs baseline).CONCLUSION Treatment of moderate-to-severe UC with golimumab leads to significant improvements in patient´s work productivity,daily activity and QoL over twelve months. | Niels Teich Harald Grümmer Eric Jorgensen Thomas Liceni Frank Holtkamp-Endemann Tim Fischer Susanne Hohenberger | 2020 | World Journal of Gastroenterology2020，26，21： | 3 |
| 10 | A phylogeographic break and bioacoustic intraspecific differentiation in the Buff-barred Warbler(Phylloscopus pulcher)(Aves:Passeriformes,Phylloscopidae)显示文摘Background: According to current taxonomy only three out of 27 Sinohimalayan leaf warbler species(Phylloscopidae) are considered genetically uniform across their entire breeding range along the Southeastern margin of the Qinghai-Tibetan Plateau, the Buff-barred Warbler(Phylloscopus pulcher) being one of them. Because marked differentiation among Himalayan and Chinese populations has been recently demonstrated for a number of Phylloscopus species(or sister species) we investigated the intraspecific variation of a mitochondrial gene, songs and morphology of P. pulcher in a phylogeographic approach.Methods: We sequenced a fragment of the mitochondrial cytochrome b, reconstructed haplotype networks and analyzed DNA polymorphism among Himalayan and Chinese populations. We measured time and frequency parameters of two distinct song types and analyzed among population-differentiation in a principal component analysis and a discriminant analysis. We also compared measurements of body size dimensions taken from museum specimens.Results: The mitochondrial haplotype network(cytb) was divided into two distinct clusters corresponding to geographic origin of samples. Pairwise genetic distances among Himalayan and Chinese mt DNA lineages account for 1.3% which coincides with Pleistocene lineage separation at roughly 650,000 years ago. Genetic diversity is slightly higher in the Chinese part of the species' range with respect to haplotype and nucleotide diversity while the less diversified Himalayan population lineage shows signs of recent range expansion. The vocal repertoire of P. pulcher comprises two distinct verse types that are combined with short interspersed click notes to long continuous song displays. Trill verse types showed significant differences among regions in almost all measured frequency and time parameters: Chinese males displayed more rapid and more broad-banded trills at a lower pitch. In contrast,warbling verse types showed a distinctively different structure among regions: Himalayan songs consisted of repeated syllables while Chinese songs comprised repetitions of single, long and strongly modulated elements.Subtle morphological differences among specimens from the two study regions could only be confirmed for plumage coloration but not for metric characters.Conclusions: Based on the genetic and bioacoustic distinctiveness of Chinese Buff-barred Warbler populations,we recommend that the name Phylloscopus pulcher vegetus Bangs, 1913 should be re-validated for this taxon. | Martin Packert Yue-Hua Sun Balduin S Fischer Dieter Thomas Tietze Jochen Martens | 2014 | Chinese Birds2014，，1： | 2 |
| 11 | Early Endoscopic Retrograde Cholangiopancreatography in Predicted Severe Acute Biliary Pancreatitis: A Prospective Multicenter Study显示文摘 | Hjalmar C. van Santvoort Marc G. Besselink Annemarie C. de Vries Marja A. Boermeester Kathelijn Fischer Thomas L. Bollen Geert A. Cirkel Alexander F. Schaapherder Vincent B. Nieuwenhuijs Harry van Goor Cees H. Dejong Casper H. van Eijck Ben J. Witteman Ba | 2009 | Annals of Surgery2009，，1： | 2 |
| 12 | National Forest Inventories capture the multifunctionality of managed forests in Germany显示文摘Background:Forests perform various important ecosystem functions that contribute to ecosystem services.In many parts of the world,forest management has shifted from a focus on timber production to multi-purpose forestry,combining timber production with the supply of other forest ecosystem services.However,it is unclear which forest types provide which ecosystem services and to what extent forests primarily managed for timber already supply multiple ecosystem services.Based on a comprehensive dataset collected across 150 forest plots in three regions differing in management intensity and species composition,we develop models to predict the potential supply of 13 ecosystem services.We use those models to assess the level of multifunctionality of managed forests at the national level using national forest inventory data.Results:Looking at the potential supply of ecosystem services,we found trade-offs(e.g.between both bark beetle control or dung decomposition and both productivity or soil carbon stocks)as well as synergies(e.g.for temperature regulation,carbon storage and culturally interesting plants)across the 53 most dominant forest types in Germany.No single forest type provided all ecosystem services equally.Some ecosystem services showed comparable levels across forest types(e.g.decomposition or richness of saprotrophs),while others varied strongly,depending on forest structural attributes(e.g.phosphorous availability or cover of edible plants)or tree species composition(e.g.potential nitrification activity).Variability in potential supply of ecosystem services was only to a lesser extent driven by environmental conditions.However,the geographic variation in ecosystem function supply across Germany was closely linked with the distribution of main tree species.Conclusions:Our results show that forest multifunctionality is limited to subsets of ecosystem services.The importance of tree species composition highlights that a lack of multifunctionality at the stand level can be compensated by managing forests at the landscape level,when stands of complementary forest types are combined.These results imply that multi-purpose forestry should be based on a variety of forest types requiring coordinated planning across larger spatial scales. | Nadja K.Simons María R.Felipe-Lucia Peter Schall Christian Ammer Jürgen Bauhus Nico Blüthgen Steffen Boch François Buscot Markus Fischer Kezia Goldmann Martin M.Gossner Falk Hänsel Kirsten Jung Peter Manning Thomas Nauss Yvonne Oelmann Rodica Pena Andrea Polle Swen C.Renner Michael Schloter Ingo Schöning Ernst-Detlef Schulze Emily F.Solly Elisabeth Sorkau Barbara Stempfhuber Tesfaye Wubet Jörg Müller Sebastian Seibold Wolfgang W.Weisser | 2021 | Forest Ecosystems2021，8，1： | 2 |
| 13 | Global, regional, and national causes of child mortality in 2008: a systematic analysis显示文摘 | Robert E Black Simon Cousens Hope L Johnson Joy E Lawn Igor Rudan Diego G Bassani Prabhat Jha Harry Campbell Christa Fischer Walker Richard Cibulskis Thomas Eisele Li Liu Colin Mathers | 2010 | The Lancet . 2010 (9730)2010，，： | 2 |
| 14 | The effects of Spirulina on anemia and immune function in senior citizens显示文摘Anemia and immunological dysfunction(i.e.immunosenescence)are commonly found in older subjects and nutritional approaches are sought to counteract these phenomena.Spirulina is a filamentous and multicellular bule-green alga capable of reducing inflammation and also manifesting antioxidant effects.We hypothesized that Spirulina may ameliorate anemia and immunosenescence in senior citizens with a history of anemia.We enrolled 40 volunteers of both sexes with an age of 50 years or older who had no history of major chronic diseases.Participants took a Spirulina supplementation for 12 weeks and were administered comprehensive dietary questionnaires to determine their nutritional regimen during the study.Complete cell count(CCC)and indoleamine 2,3-dioxygenase(IDO)enzyme activity,as a sign of immune function,were determined at baseline and weeks 6 and 12 of supplementation.Thirty study participants completed the entire study and the data obtained were analyzed.Over the 12-week study period,there was a steady increase in average values of mean corpuscular hemoglobin in subjects of both sexes.In addition,mean corpuscular volume and mean corpuscular hemoglobin concentration also increased in male participants.Older women appeared to benefit more rapidly from Spirulina supplements.Similarly,the majority of subjects manifested increased IDO activity and white blood cell count at 6 and 12 weeks of Spirulina supplementation.Spirulina may ameliorate anemia and immunosenescence in older subjects.We encourage large human studies to determine whether this safe supplement could prove beneficial in randomized clinical trials. | Carlo Selmi Patrick SC Leung Laura Fischer Bruce German Chen-Yen Yang Thomas P Kenny Gerry R Cysewski M Eric Gershwin | 2011 | Cellular & Molecular Immunology2011，8，3： | 2 |
| 15 | Gastric Bypass Leads to Improvement of Diabetic Neuropathy Independent of Glucose Normalization—Results of a Prospective Cohort Study (DiaSurg 1 Study)显示文摘 | Beat P. Müller-Stich Lars Fischer Hannes G. Kenngott Matthias Gondan Jonas Senft Gabriella Clemens Felix Nickel Thomas Fleming Peter P. Nawroth Markus W. Büchler | 2013 | Annals of Surgery2013，，5： | 2 |
| 16 | FOLFIRI plus cetuximab versus FOLFIRI plus bevacizumab as first-line treatment for patients with metastatic colorectal cancer (FIRE-3): a randomised, open-label, phase 3 trial显示文摘 | Volker Heinemann Ludwig Fischer von Weikersthal Thomas Decker Alexander Kiani Ursula Vehling-Kaiser Salah-Eddin Al-Batran Tobias Heintges Christian Lerchenmüller Christoph Kahl Gernot Seipelt Frank Kullmann Martina Stauch Werner Scheithauer J?rg Hielscher | 2014 | Lancet Oncology2014，，10： | 2 |
| 17 | Endothelial Differentiation of Adipose-Derived Stem Cells: Effects of Endothelial Cell Growth Supplement and Shear Force显示文摘 | Lauren J. Fischer Stephen McIlhenny Thomas Tulenko Negar Golesorkhi Ping Zhang Robert Larson Joseph Lombardi Irving Shapiro Paul J. DiMuzio | 2009 | Journal of Surgical Research2009，，1： | 2 |
| 18 | Ionic liquids for extraction of metals and metal containing compounds from communal and industrial waste water显示文摘 | Lisa Fischer Thomas Falta Gunda Koellensperger Anja Stojanovic Daniel Kogelnig Markus Galanski Regina Krachler Bernhard K. Keppler Stephan Hann | 2011 | Water Research2011，，15： | 2 |
| 19 | Budget Balance Booklet 显示文摘 | Thomas B Fischer | 2008 | (3) :15 - 162008，19，： | 1 |
| 20 | Collabora-tive innovation in ubiquitous systems显示文摘 | VERONICASERRANO THOMAS FISCHER | 2007 | International man-ufacturing2007，，18： | 1 |
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