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| 1 | Cyclooxygenase-2 polymorphisms and the risk of esophageal adeno-or squamous cell carcinoma显示文摘AIM:To determine whether-1195 A→G and/or-765 G→C polymorphisms in Cyclooxygenase-2(COX-2 ) may have a risk modifying effect on the development of esophageal carcinoma in a Dutch Caucasian population.METHODS:Two study groups were recruited, 252 patients with esophageal carcinoma and 240 healthy controls, matched for race, age, gender and recruiting area.DNA was isolated from whole blood and used for genotyping.PCR products were digested with restriction enzymes and products were analyzed by agarose gel electrophoresis.Odds ratios(OR) and 95% confldence intervals(CI) were estimated.RESULTS:The distribution of the-1195 A→G polymorphism was signif icantly different in esophageal cancer patients compared to controls.The-1195 GG genotype resulted in a higher risk of developing esophageal adenocarcinoma(OR = 3.85, 95% CI:1.45-10.3) compared with the-1195 AA genotype as a reference.The-765 G→C genotype distribution was not different between the two groups.The GG/ GG haplotype was present more often in esophageal adenocarcinoma patients than in controls(OR = 3.45, 95% CI:1.24-9.58;with AG/AG as a reference).The same trends were observed in patients with squamous cell carcinomas, however, the results did not reach statistical signif icance.CONCLUSION:Presence of the COX-2-1195 GG genotype and of the GG/GG haplotype may result in a higher risk of developing esophageal carcinoma. | Jón O Kristinsson Paul van Westerveld Rene HM te Morsche Hennie MJ Roelofs T Wobbes Ben JM Witteman Adriaan CITL Tan Martijn GH van Oijen Jan BMJ Jansen Wilbert HM Peters | 2009 | World Journal of Gastroenterology2009，15，28： | 11 |
| 2 | Prolonged QTc Interval and Risk of Sudden Cardiac Death in a Population of Older Adults显示文摘 | Sabine M.J.M. Straus Jan A. Kors Marie L. De Bruin Cornelis S. van der Hooft Albert Hofman Jan Heeringa Jaap W. Deckers J. Herre Kingma Miriam C.J.M. Sturkenboom Bruno H. Ch. Stricker Jacqueline C.M. Witteman | 2006 | Journal of the American College of Cardiology2006，，2： | 4 |
| 3 | Early Endoscopic Retrograde Cholangiopancreatography in Predicted Severe Acute Biliary Pancreatitis: A Prospective Multicenter Study显示文摘 | Hjalmar C. van Santvoort Marc G. Besselink Annemarie C. de Vries Marja A. Boermeester Kathelijn Fischer Thomas L. Bollen Geert A. Cirkel Alexander F. Schaapherder Vincent B. Nieuwenhuijs Harry van Goor Cees H. Dejong Casper H. van Eijck Ben J. Witteman Ba | 2009 | Annals of Surgery2009，，1： | 2 |
| 4 | Arterial Stiffness and Risk of Coronary Heart Disease and Stroke: The Rotterdam Study显示文摘 | Francesco U.S. Mattace-Raso Tischa J.M. van der Cammen Albert Hofman Nicole M. van Popele Michiel L. Bos Maarten A.D.H. Schalekamp Roland Asmar Robert S. Reneman Arnold P.G. Hoeks Monique M.B. Breteler Jacqueline C.M. Witteman | 2006 | Circulation2006，，5： | 2 |
| 5 | Early Laparoscopic Cholecystectomy Improves Outcomes After Endoscopic Sphincterotomy for Choledochocystolithiasis显示文摘 | Jan Siert K. Reinders Annemarie Goud Robin Timmer Philip M. Kruyt Ben J.M. Witteman Niels Smakman Ronald Breumelhof Sandra C. Donkervoort Jeroen M. Jansen Joos Heisterkamp Marina Grubben Bert van Ramshorst Djamila Boerma | 2010 | Gastroenterology2010，，7： | 2 |
| 6 | Long-Term Follow-Up After Fractional Flow Reserve–Guided Treatment Strategy in Patients With an Isolated Proximal Left Anterior Descending Coronary Artery Stenosis显示文摘 | Olivier Muller Fabio Mangiacapra Argyrios Ntalianis Katia M.C. Verhamme Catalina Trana Michalis Hamilos Jozef Bartunek Marc Vanderheyden Eric Wyffels Guy R. Heyndrickx Frank J.A. van Rooij Jacqueline C.M. Witteman Albert Hofman William Wijns Emanuele Barb | 2011 | JACC: Cardiovascular Interventions2011，，11： | 2 |
| 7 | Lipoprotein-Associated Phospholipase A2 Activity Is Associated With Risk of Coronary Heart Disease and Ischemic Stroke: The Rotterdam Study显示文摘 | Hok-Hay S. Oei Irene M. van der Meer Albert Hofman Peter J. Koudstaal Theo Stijnen Monique M.B. Breteler Jacqueline C.M. Witteman | 2005 | Circulation2005，，5： | 2 |
| 8 | Diagnostic performance of rapid tests for dection of fecal calprotectin and lactoferrin and their a- bility to discriminate inflammatory from irritable bowel syndrome 显示文摘 | Otten CM Kok L Witteman BJ | 2008 | Clin Chem Lab Med2008，46，9： | 1 |
| 9 | Man-agement of Severe acute pancreatitis:it's all about timing显示文摘 | Besselink MG Van Santoort HC Witteman BJ | 2007 | Curr Opin Crit Care2007，13，2： | 1 |
| 10 | Sodium and potassium intake and risk of cardiovascular events and all-cause mortality: the Rotterdam study显示文摘 | GELEIJNSE J M WITTEMAN C M | 2007 | European Journal of Epidemiology2007，22，5： | 1 |
| 11 | Alcohol consumption and risk of dementia:the Rotterdam Study显示文摘 | Ruitenberg A van Swieten JC Witteman JC | 2002 | Lancet2002，359，9303： | 1 |
| 12 | Smoking - dependent effects of the angiotensin - converting enzyme gene in- sertion/deletion polymorphism on blood pressure显示文摘 | Schut AF Sayed - Tabatabaei FA Witteman JC | 2004 | J Hyper- tens2004，22，2： | 1 |
| 13 | Alcohol consumption and risk of dementia:the Rotterdam Study显示文摘 | RUITENBERG A VAN SWIETEN JC WITTEMAN JC | 2002 | Lancet2002，359，9303： | 1 |
| 14 | Dietary folate, vita- min B12, and vitamin B6 and the risk of Parkinson disease 显示文摘 | De Lau LM Koudstaal PJ Witteman JC | 2006 | Neurology2006，67，2： | 1 |
| 15 | Insulin-resistance and metabolic syndrome are related to executive function in women in a large family-based study显示文摘 | M. Schuur P. Henneman J. C. Swieten M. C. Zillikens I. Koning A. C. J. W. Janssens J. C. M. Witteman Y. S. Aulchenko R. R. Frants B. A. Oostra K. Willems Dijk C. M. Duijn | 2010 | European Journal of Epidemiology2010，，8： | 1 |
| 16 | Tytgal GN1 Functional dyspepsia显示文摘 | Witteman EM | 1995 | Neth J Med1995，205，： | 1 |
| 17 | Diagnostic performance of rapid tests for dection of fecal calprotectin and lactoferrin and their ability to discriminate inflammatory from irritable bowel syndrome显示文摘 | Otten CM Koh L Witteman BJ | | 0，，09： | 1 |
| 18 | Improvement of gastric inflammation and resolution of epithelial damage one year after eradication of Helicobacter pylori显示文摘 | Witteman EM Mravunac M Becx MJ | | 0，，： | 1 |
| 19 | High dietary menaquinone intake is associated with reduced coronary calcification显示文摘 | Joline W.J. Beulens Michiel L. Bots Femke Atsma Marie-Louise E.L. Bartelink Matthias Prokop Johanna M. Geleijnse Jacqueline C.M. Witteman Diederick E. Grobbee Yvonne T. van der Schouw | 2008 | Atherosclerosis2008，，2： | 1 |
| 20 | Diuretic-gene interaction and the risk of myocardial infarction and stroke 显示文摘 | Schelleman H Klungel OH Witteman JC | 2007 | Pharmacog- enomics J2007，7，5： | 1 |
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