|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | The effects of Spirulina on anemia and immune function in senior citizens显示文摘Anemia and immunological dysfunction(i.e.immunosenescence)are commonly found in older subjects and nutritional approaches are sought to counteract these phenomena.Spirulina is a filamentous and multicellular bule-green alga capable of reducing inflammation and also manifesting antioxidant effects.We hypothesized that Spirulina may ameliorate anemia and immunosenescence in senior citizens with a history of anemia.We enrolled 40 volunteers of both sexes with an age of 50 years or older who had no history of major chronic diseases.Participants took a Spirulina supplementation for 12 weeks and were administered comprehensive dietary questionnaires to determine their nutritional regimen during the study.Complete cell count(CCC)and indoleamine 2,3-dioxygenase(IDO)enzyme activity,as a sign of immune function,were determined at baseline and weeks 6 and 12 of supplementation.Thirty study participants completed the entire study and the data obtained were analyzed.Over the 12-week study period,there was a steady increase in average values of mean corpuscular hemoglobin in subjects of both sexes.In addition,mean corpuscular volume and mean corpuscular hemoglobin concentration also increased in male participants.Older women appeared to benefit more rapidly from Spirulina supplements.Similarly,the majority of subjects manifested increased IDO activity and white blood cell count at 6 and 12 weeks of Spirulina supplementation.Spirulina may ameliorate anemia and immunosenescence in older subjects.We encourage large human studies to determine whether this safe supplement could prove beneficial in randomized clinical trials. | Carlo Selmi Patrick SC Leung Laura Fischer Bruce German Chen-Yen Yang Thomas P Kenny Gerry R Cysewski M Eric Gershwin | 2011 | Cellular & Molecular Immunology2011，8，3： | 2 |
| 2 | P504S: A New Molecular Marker for the Detection of Prostate Carcinoma显示文摘 | Zhong Jiang Bruce A. Woda Kenneth L. Rock Yingdan Xu Lou Savas Ashraf Khan German Pihan Feng Cai John S. Babcook Palaniswami Rathanaswami Steven G. Reed Jiangchun Xu Gary R. Fanger | 2001 | The American Journal of Surgical Pathology2001，，11： | 1 |
| 3 | The Influence of Milk Oligosaccharides on Microbiota of Infants: Opportunities for Formulas显示文摘 | Maciej Chichlowski J. Bruce German Carlito B. Lebrilla David A. Mills | 2011 | Annual Review of Food Science and Technology2011，，： | 1 |
| 4 | Composition, Structure and Absorption of Milk Lipids: A Source of Energy, Fat-Soluble Nutrients and Bioactive Molecules显示文摘 | J. Bruce German Cora J. Dillard | 2006 | Critical Reviews in Food Science and Nutrition2006，，1： | 1 |
| 5 | Bacteroides in the Infant Gut Consume Milk Oligosaccharides via Mucus-Utilization Pathways显示文摘 | Angela Marcobal Mariana Barboza Erica D. Sonnenburg Nicholas Pudlo Eric C. Martens Prerak Desai Carlito B. Lebrilla Bart C. Weimer David A. Mills J. Bruce German Justin L. Sonnenburg | 2011 | Cell Host & Microbe2011，，5： | 1 |
| 6 | Milk fat globule structure and function: nanoscience comes to milk production显示文摘 | Nurit Argov Danielle G. Lemay J. Bruce German | 2008 | Trends in Food Science & Technology2008，，12： | 1 |
| 7 | The health benefits of wine 显示文摘 | Bruce German J | 2000 | Annual Revi Nutr2000，，20： | 1 |
| 8 | Effect of pH and Temperature on Protein Unfolding and Thiol/Disulfide Interchange Reactions during Heat-Induced Gelation of Whey Proteins显示文摘 | Frank J Monahan J Bruce German John E Kinsella | 1995 | Journal of Agricultural and Food Chemistry1995，43，： | 1 |
| 9 | Metabolomics: building on a century of biochemistry to guide human health显示文摘 | J. Bruce German Bruce D. Hammock Steven M. Watkins | 2005 | Metabolomics2005，，1： | 1 |
| 10 | Activities of antioxidants are affected by colloidal properties of oil-in-water and water-in-oil emulsions and bulk oils显示文摘 | KARIN S SHU-WEN H BRUCE GERMAN J | 2000 | Journal of Agricultural and Food Chemistry2000，48，： | 1 |
| 11 | Comprehensive,high-throughput genotyping of human genital papillomaviruses using spectrally addressable liquid bead microarrays显示文摘 | Jan Wallace Bruce A Woda German Pihan Facile | | 0，，01： | 1 |
| 12 | Expression of the Eukaryotic Translation Initiation Factors 4E and 2α in Non-Hodgkin’s Lymphomas显示文摘 | Songtao Wang Igor B. Rosenwald Michael J. Hutzler German A. Pihan Lou Savas Jane-Jane Chen Bruce A. Woda | 1999 | The American Journal of Pathology1999，，： | 1 |
| 13 | The health benefits of wine 显示文摘 | Bruce German J | 2000 | Annual Revi Nutr2000，，20： | 1 |
| 14 | Mechanical properties and water vapor permeability of edible films from whey protein isolate and sodium dodecyl sulfate显示文摘 | PETER FAIRLEY FRANK J MONAHAN J BRUCE GERMAN | 1996 | Agric Food Chem1996，44，2： | 1 |
| 15 | 小胶质细胞耗竭消除了白质缺血预处理的作用显示文摘缺血预处理(ischemic preconditioning,IPC)是通过短暂、无害的缺血性暴露增强对随后发生的缺血障碍耐受性的现象。IPC的机制主要在灰质约占大脑85%的啮齿动物卒中模型中进行研究。人类脑白质占脑容量的50%,是卒中损伤的关键组成部分。我们使用小鼠视神经开发了一种新的中枢神经系统白质IPC模型,并确定了相关的免疫信号通路。我们验证了小胶质细胞对于白质IPC是必需的这一假说。首先用集落刺激因子1受体抑制剂PLX5622处理以耗尽小胶质细胞。视神经在体内暴露于短暂性缺血,72 h后急性分离,并进行氧-葡萄糖剥夺(OGD)以模拟缺血性损伤。通过记录复合动作电位(CAPs)和使用定量体视学的显微镜来评估轴突功能和结构的恢复。结果显示小胶质细胞耗竭消除了IPC介导的保护作用。在对照小鼠中,与非预处理视神经相比,预处理视神经的CAP恢复有所改善。然而在PLX5622处理的小鼠中,预处理和非预处理视神经之间的CAP恢复没有差异。小胶质细胞缺失还消除了IPC对OGD后轴突完整性和成熟(APC+)少突胶质细胞存活的保护作用。IPC介导的保护与视网膜损伤无关,表明它是由白质缺血暴露的固有的机械过程引起的。我们得出结论,预处理的小胶质细胞对白质中的IPC至关重要。'预处理的小胶质细胞'表型可能对其他中枢神经系统病变有保护作用,是值得探索的神经治疗领域。 | Margaret A Hamner Ashley McDonough Davin C Gong Levi J Todd German Rojas Sibylle Hodecker Christopher B Ransom Thomas A Reh Bruce R Ransom Jonathan RWeinstein 杜一星(编译) | 2022 | 神经损伤与功能重建2022，17，2： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员