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| 1 | Cetuximab plus FOLFOX6 or FOLFIRI in metastatic colorectal cancer: CECOG trial显示文摘AIM: To investigate efficacy and safety of cetuximab combined with two chemotherapy regimens in patients with unresectable metastatic colorectal cancer (mCRC). METHODS: Randomized patients received cetuximab with 5-fluorouracil (5-FU), folinic acid (FA) and oxaliplatin (FOLFOX) 6 (arm A, n = 74) or 5-FU, FA and irinotecan (FOLFIRI) (arm B, n = 77). KRAS mutation status was determined retrospectively in a subset of tumors (n = 117). RESULTS: No significant difference was found between treatment arms A and B in the progression-free survival (PFS) rate at 9 mo, 45% vs 34%; median PFS, 8.6 mo vs 8.3 mo [hazard ratio (HR) = 1.06]; overall response rate (ORR) 43% vs 45% [odds ratio (OR) = 0.93] and median overall survival (OS), 17.4 mo vs 18.9 mo (HR = 0.98). Patients with KRAS wild-type tumors demonstrated improved PFS (HR = 0.55, P = 0.0051), OS, (HR = 0.62, P = 0.0296) and ORR (53% vs 36%) and in arm A, improved PFS (HR = 0.49, P = 0.0196), OS (HR = 0.48, P = 0.0201) and ORR (56%vs 30%), compared with patients with KRAS mutated tumors. In arm B no significant differences were found in efficacy by KRAS mutation status. Treatment in arms A and B was generally well tolerated. CONCLUSION: This study confirms that combinations of cetuximab with FOLFOX6 or FOLFIRI are effective and significantly improve clinical outcome in KRAS wild-type compared with KRAS mutated mCRC. | Janja Ocvirk Thomas Brodowicz Fritz Wrba Tudor E Ciuleanu Galina Kurteva Semir Beslija Ivan Koza Zsuzsanna Pápai Diethelm Messinger Ugur Yilmaz Zsolt Faluhelyi Suayib Yalcin Demetris Papamichael Miklós Wenczl Zrinka Mrsic-Krmpotic Einat Shacham-Shmueli Damir Vrbanec Regina Esser Werner Scheithauer Christoph C Zie-linski | 2010 | World Journal of Gastroenterology2010，16，25： | 17 |
| 2 | The 2007 WHO Classification of Tumours of the Central Nervous System显示文摘 | David N. Louis Hiroko Ohgaki Otmar D. Wiestler Webster K. Cavenee Peter C. Burger Anne Jouvet Bernd W. Scheithauer Paul Kleihues | 2007 | Acta Neuropathologica2007，，2： | 13 |
| 3 | Diagnostic and prognostic value of glycosyltransferase mRNA in glioblastoma multiforme patients.显示文摘 | Oblinger JL Pearl DK Boardman CL Saqr H Prior TW Scheithauer BW Jenkins RB Burger PC Yates AJ | 2006 | 中国神经肿瘤杂志2006，4，2： | 5 |
| 4 | Response to GEMOX plus erlotinib in pancreatic cancer is associated with ERCC 1 overexpression显示文摘 | Thorsten Fuereder Judith Stift Irene Kuehrer Nadja Stranzl Doris Hoeflmayer Gabriela Kornek Werner Scheithauer | 2014 | Eur J Clin Invest2014，，： | 2 |
| 5 | Analysis of proliferation markers and p53 expression in gliomas of astrocytic origin: relationships and prognostic value 显示文摘 | Cunningham JM Kimmel DW Scheithauer BW | 1997 | J Neurosurg1997，86，： | 2 |
| 6 | Mountain Water Tower and Ecological Risk Estimation of the Mesta-Nestos Transboundary River Basin (Bulgaria-Greece)显示文摘The Mesta-Nestos river basin in Bulgaria and Greece is a case study for transboundary decision-making support in south-eastern Europe and a show-case for the development of methodologies and information-gathering for the integrated regional planning of water resources. Land-use conflicts in this water-scarce region cover a wide spectrum of activities like agricultural irrigation,drinking water production,diversions for industrial water,and risk of pollution from mining,to name a few examples. Measurements of the water quality were carried out in the upper basin. Results will be illustrated by the example of the environmental situation in the alpine region of the Pirin National Park as well as in the Razlog Basin with a stronger anthropogenic impact and pollution around a former uranium mine near the village of Ele?nica. The social and economic development of this transboundary region is a recently established priority for the future. It will mean an increase in water usage and more stress for the water resources if regional impacts of global climate change are verified. Problem-focused management of the catchment area as a whole on the basis of proved geo-data sets is needed for the future. | K. Grunewald J. Scheithauer J.-M. Monget N. Nikolova | 2007 | Journal of Mountain Science2007，4，3： | 2 |
| 7 | Baseline carcinoembryonic antigen (CEA) serum levels predict bevacizumab‐based treatment response in metastatic colorectal cancer显示文摘 | Gerald W. Prager Kira H. Braemswig Alexandra Martel Matthias Unseld Georg Heinze Thomas Brodowicz Werner Scheithauer Gabriela Kornek Christoph C. Zielinski | 2014 | Cancer Sci2014，，8： | 2 |
| 8 | FOLFIRI plus cetuximab versus FOLFIRI plus bevacizumab as first-line treatment for patients with metastatic colorectal cancer (FIRE-3): a randomised, open-label, phase 3 trial显示文摘 | Volker Heinemann Ludwig Fischer von Weikersthal Thomas Decker Alexander Kiani Ursula Vehling-Kaiser Salah-Eddin Al-Batran Tobias Heintges Christian Lerchenmüller Christoph Kahl Gernot Seipelt Frank Kullmann Martina Stauch Werner Scheithauer J?rg Hielscher | 2014 | Lancet Oncology2014，，10： | 2 |
| 9 | Phase II trial of two-weekly gemcitabine in patients with advanced biliary?tract cancer显示文摘 | M. Penz G. V. Kornek M. Raderer H. Ulrich-Pur W. Fiebiger A. Lenauer D. Depisch G. Krauss B. Schneeweiss W. Scheithauer | 2001 | Annals of Oncology2001，，2： | 2 |
| 10 | Dysemhryoplastie neuroepithelial tumor : a surgically curable tumor of young patients with intractable partial seizures, report of thirtynine cases显示文摘 | Daumas- Duport C Scheithauer BW Chodkiewicz JP | 1988 | Neurosurgery1988，23，： | 1 |
| 11 | Management of recurrent meningeal hemangiopericytoma 显示文摘 | Galanis E Buckner JC Scheithauer BW | 1998 | Cancer1998，82，11： | 1 |
| 12 | Thymoma : a clinicopathologic review 显示文摘 | Lewis JE Wick MR Scheithauer BW | 1987 | Cancer1987，60，： | 1 |
| 13 | p53 expression in pituitary adenomas and carcinomas: correlation with invassiveness and tumor growth fractions显示文摘 | Thapar K Scheithauer BW Kavacs K | 1996 | Neurosurg1996，38，： | 1 |
| 14 | The immunophenotype of pituitary adenomas显示文摘 | Lloyd RV Scheithauer BW Kovacs K | 1996 | Endocr Pathol1996，7，2： | 1 |
| 15 | Immunohisto- chemical expression of pituitary tumor transforming gene (PTTG) in pituitary adenomas: a correlative study of tumor subtypes 显示文摘 | Salehi F Kovacs K Scheithauer BW | 2010 | Int J Surg Pathol2010，18，1： | 1 |
| 16 | Randomized multicenter phase Ⅱ trial of two different schedules of capecitabine plus oxaliplatin as first-line treatment in advanced colorectal cancer显示文摘 | SCHEITHAUER W KORNEK G V RADERER M | 2003 | J Clin Oncol2003，21，7： | 1 |
| 17 | STR loci PentaD and PentaE: Austrian caucasian population data 显示文摘 | Steinlechner M Grubwieser P Scheithauer R | 2002 | Int J Legal Med2002，116，9： | 1 |
| 18 | Olfactory neuroblastoma An immunohis-tochemical, ultrastructural,and flow cytometric study显示文摘 | Scheithauer BW Lopes MB | 1995 | Cancer1995，76，： | 1 |
| 19 | The WHO classification of tumors of the nervous system显示文摘 | Kleihues P Louis DN Scheithauer BW | 2002 | J Nenropathol Exp Neurol2002，61，3： | 1 |
| 20 | Proliferative activity and invasiveness among pituitary adenomas and carcinomas,an analysis using the MIB-1 antibody显示文摘 | Tharpar K Scheithauer BK Kovosk K | 1996 | Neurosurgery1996，38，： | 1 |
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