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| 1 | Study of Helicobacter pylori genotype status in saliva,dental plaques,stool and gastric biopsy samples显示文摘AIM:To compare genotype of Helicobacter pylori(H.pylori) isolated from saliva,dental plaques,gastric biopsy,and stool of each patient in order to evaluate the mode of transmission of H.pylori infection.METHODS:This cross-sectional descriptive study was performed on 300 antral gastric biopsy,saliva,dental plaque and stool samples which were obtained from patients undergoing upper gastrointestinal tract endoscopy referred to endoscopy centre of Hajar hospital of Shahrekord,Iran from March 2010 to February 2011.Initially,H.pylori strains were identified by rapid urease test(RUT) and polymerase chain reaction(PCR) were applied to determine the presence of H.pylori(ureC) and for genotyping of voculating cytotoxin gene A(vacA) and cytotoxin associated gene A(cagA) genesin each specimen.Finally the data were analyzed by using statistical formulas such as Chi-square and Fisher's exact tests to find any significant relationship between these genes and patient's diseases.P < 0.05 was considered statistically significant,RESULTS:Of 300 gastric biopsy samples,77.66% were confirmed to be H.pylori positive by PCR assay while this bacterium were detected in 10.72% of saliva,71.67% of stool samples.We were not able to find it in dental plaque specimens.The prevalence of H.pylori was 90.47% among patients with peptic ulcer disease(PUD),80% among patients with gastric cancer,and 74.13% among patients with none ulcer dyspepsia(NUD) by PCR assay.The evaluation of vacA and cagA genes showed 6 differences between gastric biopsy and saliva specimens and 11 differences between gastric and stool specimens.94.42% of H.pylori positive specimens were cagA positive and all samples had amplified band both for vacA s and m regions.There was significant relationship between vacA s1a/m1a and PUD diseases(P = 0.04),s2/m2 genotype and NUD diseases(P = 0.05).No statically significant relationship was found between cagA status with clinical outcomes and vacA genotypes(P = 0.65).The evaluation of vacA and cagA genes showed 6 differences between gastric biopsy and saliva specimens and 11 differences between gastric and stool specimens,CONCLUSION:Regard to high similarity in genotype of H.pylori isolates from saliva,stomach and stool,this study support the idea which fecal-oral is the main route of H.pylori transmission and oral cavity may serve as a reservoir for H.pylori,however,remarkable genotype diversity among stomach,saliva and stool samples showed that more than one H.pylori genotype may exist in a same patient. | Hassan Momtaz Negar Souod Hossein Dabiri Meysam Sarshar | 2012 | World Journal of Gastroenterology2012，18，17： | 21 |
| 2 | Sulfuric acid {[3-(3-silicapropyl)sulfanyl]propyl}ester a recyclable catalyst for the synthesis of 2-aryl- 1-arylmethyl- 1H- 1,3-benzimidazole derivatives显示文摘从 o-phenylene-diamine 和芳香的醛的反应的 2-aryl-1-arylmethyl-1H-1,3-benzimidazoles 的高度选择的合成面对硫磺的酸 {[3-(3-silicapropyl ) sulfanyl ] 丙醇 } 水里并且在 80 点的酉旨(SASPSPE ) ? | Nasir Iravani Negar Safikhani Mohammadzade Khodabakhsh Niknam | 2011 | Chinese Chemical Letters2011，22，10： | 4 |
| 3 | Hepatitis B virus genotypes in southwest Iran: Molecular, serological and clinical outcomes显示文摘AIM: To investigate the associations of hepatitis B virus (HBV) genotype with HBeAg and anti-HBe status, alanine aminotransferase (ALT) levels and HBV-DNA detection in different groups of HBV-infected patients in southwest Iran. METHODS: A total of 89 HBsAg-positive serum samples were collected from the same number of patients. All sera were then investigated to determine HBV DNA and serological markers. For all the polymerase chain reaction (PCR)-positive samples, biochemical, histopathological assays and genotyping were also performed. RESULTS: Genotype D was the only type of HBV foundin different clinical forms of acute and chronic infections. There was a high prevalence of HBeAg-negative HBV- infected patients with chronic hepatitis (52.7%). Out of 55 patients with chronic hepatitis, seven (12.7%) were diagnosed with cirrhosis. A significant association between the presence of anti-HBe antibody and an increase in ALT level, among either HBeAg-negative (P = 0.01) or HBeAg-positive (P = 0.026) patients, was demonstrated. No significant differences were observed between the clinical outcomes of HBeAg-positive and -negative individuals (P = 0.24). CONCLUSION: Genotype D has been recognized as the only type of HBV found in different clinical forms of HBV infections, including cirrhosis, among the residents of southwest Iran. Anti-HBe possibly plays a role in disease progression in some patients with chronic hepatitis, at least for a period of disease. | Anahita Mojiri Abbas Behzad-Behbahani Mehdei Saberifirozi Maryam Ardabili Mahmood Beheshti Marjan Rahsaz Mehrdad Banihashemi Negar Azarpira Bita Geramizadeh Baharak Khadang Afsaneh Moaddeb Mojgan Ghaedi Tahereh Heidari Ardeshir Torab Alireza Salah Saeid Amirzadeh Zahra Jowkar Davood Mehrabani Samad Amini-Bavil-Olyaee Mohammad Ali Dehyadegari | 2008 | World Journal of Gastroenterology2008，14，10： | 4 |
| 4 | In vitro differentiation of human umbilical cord Wharton's jelly mesenchymal stromal cells to insulin producing clusters显示文摘AIM: To investigate the differentiation of human Wharton's jelly derived mesenchymal stromal cells(WJMSCs) to insulin producing clusters(IPC) this study was conducted. METHODS: The umbilical cords samples were collected from full term caesarian section mothers and the WJ-MSCS were cultured from tissue explants in High glucose-Dulbecco's Modified Eagle Medium(H-DMEM); H-DMEM supplemented with 10% fetal bovine serum(FBS) and antibiotics. The expression of CD90, CD44, CD105, CD34 and CD133 as well as osteogenic and adipogenic differentiation of cells in appropriate medium were also evaluated. The cells were differentiated toward IPC with changing the culture medium and adding the small molecules such as nicotinic acid, epidermal growth factor, and exendin-4 during 3 wk period. The gene expression of PDX1, NGN3, Glut2, insulin was monitored by reveres transcription polymerase chain reaction method. The differentiated clusters were stained with Dithizone(DTZ) which confirms the presence of insulin granules. The insulin challenge test(low and high glucose concentration in Krebs-Ringer HEPES buffer) was also used to evaluate the functional properties of differentiated clusters.RESULTS: WJ-MSCS were positive for mesenchymal surface markers(CD90, CD44, CD105), and negative for CD34 and CD133. The accumulation of lipid vacuoles and deposition of calcium mineral in cells were considered as adipogenic and osteogenic potential of WJ-MSCS. The cells also expressed the transcriptional factors such as Nanog and OCT4. During this three step differentiation, the WJ-MSCS morphology was gradually changed from spindle shaped cells in to epithelioid cells and eventually to three dimensional clusters. The clusters expressed PDX1, NGN3, Glut2, and insulin. The cells became bright red color when stained with DTZ and the insulin secretion was also confirmed. In glucose challenge test a significant increase in insulin secretion from 0.91 ± 0.04 μIu/mL(2.8 mmol/L glucose) to to 8.34 ± 0.45 μIu/mL(16.7 mmol/L glucose) was recorded(P < 0.05). The insulin secretion of undifferentiated WJ-MSCS was not changed in this challenge test.CONCLUSION: WJ-MSCs have the ability to differentiate in to islet-like cells in vitro. However, this process needs further optimization in order to generate efficient and functional IPCs. | Seideh Masoomeh Nekoei Negar Azarpira Ladan Sadeghi Sulmaz Kamalifar | 2015 | World Journal of Clinical Cases2015，3，7： | 3 |
| 5 | Metformin alleviates cholestasis-associated nephropathy through regulating oxidative stress and mitochondrial function显示文摘Background and aim:Cholestasis-associated renal injury or cholemic nephropathy(CN)is a serious clinical problem.Previous studies mentioned that oxidative stress and mitochondrial impairment play a role in CN.There is no specific pharmacological intervention for CN.Metformin is an anti-diabetic drug administered for decades.On the other hand,novel pharmacological properties have emerged for this drug.The effect of metformin on oxidative stress parameters has been well-recognized in different experimental models.It has also been found that metformin positively affected mitochondrial function.The current study aimed to evaluate the effects of metformin in an animal model of CN.Methods:Rats underwent bile duct ligation(BDL)and were treated with metformin(250 and 500 mg/kg)for 14 consecutive days.Two weeks after the BDL operations,urine,serum,and kidney samples were collected and analyzed.Results:Markers of oxidative stress,including reactive oxygen species(ROS)formation,lipid peroxida-tion,protein carbonylation,depleted antioxidant capacity,and decreased glutathione(GSH)levels were detected in BDL animals.Moreover,mitochondrial indices,including adenosine triphosphate(ATP)level,dehydrogenase activity,mitochondrial membrane potential,and mitochondrial permeability,were impaired in the kidney of cholestatic rats.Renal histopathological alterations in cholestatic animals included tubular degeneration and interstitial inflammation,cast formation,and fibrosis.It was found that metformin significantly alleviated oxidative stress and improved mitochondrial indices in the kidney of cholestatic rats.Tissue histopathological alterations were also mitigated in metformin-treated groups.Conclusions:Metformin could be a candidate for managing CN.The nephroprotective role of metformin is primarily associated with its effects on oxidative stress parameters and mitochondrial function. | Mohammad Mehdi Ommati Hamidreza Mohammadi Khadijeh Mousavi Negar Azarpira Omid Farshad Reyhaneh Dehghani Asma Najibi Sedigheh Kamran Hossein Niknahad Reza Heidari | 2021 | Liver Research2021，5，3： | 3 |
| 6 | 中孔氧化硅负载铬催化剂上苯高选择性生成苯酚:响应曲面分析法用于反应条件优化(英文)显示文摘以硝酸铬为前驱体,中孔氧化硅SBA-16为载体,采用简单浸渍法制备了Cr/SBA-16催化剂,并采用广角和小角X射线衍射、N2吸附-脱附、透射电镜和紫外-可见光谱等技术对其进行了表征.同时将该催化剂用于以H2O2为氧化剂的苯直接羟基化制苯酚反应以考察其催化性能.将中心组合设计与响应曲面分析法(RSM)相结合,对影响反应性能的操作变量如反应温度、反应时间及HO2和催化剂用量进行了优化.结果表明,独立变量和苯酚产率之间的关系可用二阶多项式模型来表达,其相关系数(R22)高达0.985,表明用RSM预测的数值与实验值吻合较好.得到的苯酚选择性较高时的操作条件为:反应温度324 K,反应时间8 h,H2O2和催化剂用量分别为3.28 mL和0.09 g.由此可见,将RSM法用于苯羟基化制苯酚反应条件优化是可靠的. | Milad Jourshabani Alireza Badiei Negar Lashgari Ghodsi Mohammadi Ziarani | 2015 | Chinese Journal of Catalysis2015，36，11： | 3 |
| 7 | Ebola viral disease: a review literature显示文摘Ebola virus is transmitted to people as a result of direct contact with body fluids containing virus of an infected patient. The incubation period usually lasts 5 to 7 d and approximately95% of the patients appear signs within 21 d after exposure. Typical features include fever,profound weakness, diarrhea, abdominal pain, cramping, nausea and vomiting for 3-5days and maybe persisting for up to a week. Laboratory complications including elevated aminotransferase levels, marked lymphocytopenia, and thrombocytopenia may have occurred.Hemorrhagic fever occurs in less than half of patients and it takes place most commonly in the gastrointestinal tract. The symptoms progress over the time and patients suffer from dehydration, stupor, confusion, hypotension, multi-organ failure, leading to fulminant shock and eventually death. The most general assays used for antibody detection are direct IgG and IgM ELISAs and IgM capture ELISA. An IgM or rising IgG titer(four-fold) contributes to strong presumptive diagnosis. Currently neither a licensed vaccine nor an approved treatment is available for human use. Passive transfer of serum collected from survivors of Junin virus or Lassa virus, equine IgG product from horses hypervaccinated with Ebola virus, a 'cocktail'of humanized-mouse antibodies(ZMapp), recombinant inhibitor of factor VIIa/tissue factor,activated protein C, RNA-polymerase inhibitors and small interfering RNA nano particles are among the therapies in development. Preclinical evaluation is also underway for various vaccine candidates. One is a chimpanzee adenovirus vector vaccine; other vaccines involve replication-defective adenovirus serotype 5 and recombinant vesicular stomatitis virus. | Saeed Reza Jamali Moghadam Negar Omidi Samaneh Bayrami Sepideh Jamali Moghadam SeyedAhmad SeyedAlinaghi | 2015 | Asian Pacific Journal of Tropical Biomedicine2015，5，4： | 2 |
| 8 | 氨基功能化的介孔SBA-15分子筛在一锅法合成螺羟吲哚中的应用(英文)显示文摘Amino-functionalized SBA-15(SBA-Pr-NH2) has been used as a new basic nanocatalyst in the one-pot synthesis of spirooxindole derivatives via the three-component condensation reaction of isatins,activated methylene reagents,and dimedone in an aqueous medium.SBA-Pr-NH2 has been established as an efficient heterogeneous nanoporous solid basic catalyst(pore size of 6 nm) that can be easily handled and removed from the reaction mixture by simple filtration,and also recovered and reused without noticeable loss of reactivity. | Ghodsi MOHAMMADI ZIARANI Alireza BADIEI Somayeh MOUSAVI Negar LASHGARI Afsaneh SHAHBAZI | 2012 | 催化学报2012，33，11： | 2 |
| 9 | Endothelial Differentiation of Adipose-Derived Stem Cells: Effects of Endothelial Cell Growth Supplement and Shear Force显示文摘 | Lauren J. Fischer Stephen McIlhenny Thomas Tulenko Negar Golesorkhi Ping Zhang Robert Larson Joseph Lombardi Irving Shapiro Paul J. DiMuzio | 2009 | Journal of Surgical Research2009，，1： | 2 |
| 10 | Mitigation of cholestasis-associated hepatic and renal injury by edaravone treatment: Evaluation of its effects on oxidative stress and mitochondrial function显示文摘Background and aim:The liver is the primary organ affected by cholestasis,and complications such as renal injury,renal failure,and the need for renal transplantation are associated with cholestatic liver disease.There is substantial evidence indicating that reactive oxygen species(ROS)and mitochondrial impairment are fundamental mechanisms underlying cholestasis-induced hepatic and renal injury.Edaravone(EDV)is a potent radical scavenger and antioxidant that may prevent oxidative stress and improve impaired mitochondrial function in various diseases.This study was performed to evaluate the effects and mechanisms of action of EDV on hepatic and renal injury in an animal model of cholestasis.Methods:Rats subjected to bile duct ligation(BDL)were treated with EDV 1 or 10 mg/kg/day intraper-itoneally for 14 consecutive days.Biomarkers of oxidative stress and mitochondrial impairment in the liver and kidney were assessed in EDV-treated and untreated rats with cholestasis.Results:Significant increases in tissue ROS level,lipid peroxidation,protein carbonylation,and oxidized glutathione level were detected in rats subjected to BDL.Additionally,significant decreases in tissue glutathione level and antioxidant capacity were observed in the hepatic and renal tissues of rats with cholestasis.Markers of mitochondrial impairment,including mitochondrial depolarization,lipid perox-idation,mitochondrial permeabilization,depleted adenosine triphosphate content,and decreased de-hydrogenase activity,were also detected in rats subjected to BDL.Furthermore,portal inflammation,necrosis,and tissue fibrosis were detected in the liver and significant tubular atrophy and interstitial inflammation,as well as fibrotic lesions,were detected in the kidneys of rats with cholestasis.EDV treatment significantly mitigated cholestasis-associated hepatic and renal injury.Conclusions:The antioxidative properties of EDV and its positive effects on the indices of mitochondrial function may be critical factors contributing to protection against cholestasis-associated hepatic and renal injury. | Mohammad Mehdi Ommati Hanie Attari Asma Siavashpour Marzieh Shafaghat Negar Azarpira Hasti Ghaffari Leila Moezi Reza Heidari | 2021 | Liver Research2021，5，3： | 2 |
| 11 | A quantitative method for the evaluation of the soft tissue facial profile显示文摘 | Negar M | 1959 | Am J Orthod1959，45，6： | 1 |
| 12 | Electrospinning of 100% carboxymethyl chitosan nanofibers显示文摘 | Negar Sohofi Hossein Tavanai Mohammad Morshed | 2014 | Journal of Engineered Fibers and Fabrics2014，9，1： | 1 |
| 13 | An application of multi-criteria decision aidsmodels for Case-Based Reasoning 显示文摘 | Negar A Jean R | 2012 | Information Sciences2012，210，22： | 1 |
| 14 | The re--emergence in Canada of meningovascular syphilis: 2 patients with headache and stroke显示文摘 | Negar A Taim M James S | 2007 | CMAJ2007，176，12： | 1 |
| 15 | Structural and Physical Characterization of Transparent Conducting Pulsed Laser Deposited In2O3–Zn O Thin Films显示文摘 | Negar N Marcel C | 2000 | Journal of Materials Chemistry2000，10，： | 1 |
| 16 | Tert-butylhydrocluinone is a novel aryl hydrocarbon receptor ligand显示文摘 | NEGAR G AYMAN O S EL-KADI | 2005 | Drug Metabo lism and Disposition2005，33，3： | 1 |
| 17 | Expression of Ki67 and P53 in primary squamous cellcarcinoma of the larynx 显示文摘 | MOHAMAD J A MARYAM M NEGAR A | 2010 | Indian J PatholMicrobiol2010，53，： | 1 |
| 18 | Effects of dietary selenium supplementation on serum and liver selenium, serum malondialdehyde and liver glutathione peroxidase activity in rats consuming thermally oxidized sunflower oil显示文摘 | Negar Tabatabaei Jalal Jamalian Ali Akbar Owji | 2008 | Food and Chemical Toxicology2008，46，： | 1 |
| 19 | Autonomous Robots for Agricultural Tasks and Farm Assignment and Future Trends in Agro Robots 显示文摘 | Sajjad Yaghoubi Negar Ali Akbarzadeh Shadi Sadeghi Ba- zargani | 2013 | International Journal of Mechanical & Mechatronics Engi- neering2013，13，3： | 1 |
| 20 | Response of soil mesofauna to different afforested types in the North of Iran 显示文摘 | Negar M Hashem H Yahya K | 2013 | Journal of Applied Environ- mental Biological Science2013，3，4： | 1 |
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