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| 1 | Bile leakage after loop closure vs clip closure of the cystic duct during laparoscopic cholecystectomy:A retrospective analysis of a prospective cohort显示文摘BACKGROUND Laparoscopic cholecystectomy(LC)is one of the most frequently performed surgical procedures.Cystic stump leakage is an underestimated,potentially life threatening complication that occurs in 1%-6%of the patients.With a secure cystic duct occlusion technique during LC,bile leakage becomes a preventable complication.AIM To investigate the effect of polydioxanone(PDS)loop closure of the cystic duct on bile leakage rate in LC patients.METHODS In this retrospective analysis of a prospective cohort,the effect of PDS loop closure of the cystic duct on bile leakage complication was compared to patients with conventional clip closure.Logistic regression analysis was used to develop a risk score to identify bile leakage risk.Leakage rate was assessed for categories of patients with increasing levels of bile leakage risk.RESULTS Of the 4359 patients who underwent LC,136(3%)underwent cystic duct closure by a PDS loop.Preoperatively,loop closure patients had significantly more complicated biliary disease compared to the clipped closure patients.In the loop closure cohort,zero(0%)bile leakage occurred compared to 59 of 4223(1.4%)clip closure patients.For patients at increased bile leakage risk(risk score≥1)rates were 1.6%and up to 13%(4/30)for clip closure patients with a risk score≥4.This risk increase paralleled a stepwise increase of actual bile leakage complication for clip closure patients,which was not observed for loop closure patients.CONCLUSION Cystic duct closure with a PDS loop during LC may reduce bile leakage in patients at increased risk for bile leakage. | Sandra C Donkervoort Lea M Dijksman Aafke H van Dijk Emile A Clous Marja A Boermeester Bert van Ramshorst Djamila Boerma | 2020 | World Journal of Gastrointestinal Surgery2020，12，1： | 4 |
| 2 | Systematic review of cystic duct closure techniques in relation to prevention of bile duct leakage after laparoscopic cholecystectomy显示文摘AIM To study the effect of different techniques of cystic duct closure on bile leakage after laparoscopic cholecystectomy(LC) for biliary disease.METHODS A systematic search of MEDLINE, Cochrane and EMBASE was performed. Rate of cystic duct leakage(CDL) was the primary outcome. Risk of bias was evaluated. Odds ratios were analyzed for comparison of techniques and pooled event rates for non-comparative analyses. Pooled event rates were compared for each of included techniques.RESULTS Out of 1491 articles, 38 studies were included. A total of 47491 patients were included, of which 38683(81.5%)underwent cystic duct closure with non-locking(metal)clips. All studies were of low-moderate methodological quality. Only two studies reported separate data on uncomplicated and complicated gallbladder disease. For overall CDL, an odds ratio of 0.4(95%CI: 0.06-2.48)was found for harmonic energy vs clip closure and an odds ratio of 0.17(95%CI: 0.03-0.93) for locking vs non-locking clips. Pooled CDL rate was around 1% for harmonic energy and metal clips, and 0% for locking clips and ligatures. CONCLUSION Based on available evidence it is not possible to either recommend or discourage any of the techniques for cystic duct closure during LC with respects to CDL,although data point out a slight preference for locking clips and ligatures vs other techniques. No separate recommendation can be made for complicated gallbladder disease. | Aafke H van Dijk Stijn van Roessel Philip R de Reuver Djamila Boerma Marja A Boermeester Sandra C Donkervoort | 2018 | World Journal of Gastrointestinal Surgery2018，10，6： | 3 |
| 3 | Early Endoscopic Retrograde Cholangiopancreatography in Predicted Severe Acute Biliary Pancreatitis: A Prospective Multicenter Study显示文摘 | Hjalmar C. van Santvoort Marc G. Besselink Annemarie C. de Vries Marja A. Boermeester Kathelijn Fischer Thomas L. Bollen Geert A. Cirkel Alexander F. Schaapherder Vincent B. Nieuwenhuijs Harry van Goor Cees H. Dejong Casper H. van Eijck Ben J. Witteman Ba | 2009 | Annals of Surgery2009，，1： | 2 |
| 4 | Lymphocyte subsets and T(h) 1/T(h) 2 immune responses in patients with adenocarcinoma of the oesophagusor oesophagogastric junction relation to pTNM stage and clinical outcome 显示文摘 | Van Sandick J W Boermeester M A Gisbertz S S | 2003 | Cancer hnmunol Immunother2003，52，10： | 1 |
| 5 | Interleukinl blockade attenuates mediator release and dysregulation of the hemostatic mechanism during human Sepsis显示文摘 | Boermeester MA van Leeuwen PA Coyle SM | 1995 | Areh Surg1995，160，： | 1 |
| 6 | Lymphocyte subsets and T (h)1/T (h)2 immune responses in patients with adenocarcinoma of the oesophagusor oesophagogastric junction:relation to pTNM stage and clinical outcome显示文摘 | van Sandick JW Boermeester MA Gisbertz SS | 2003 | Cancer Immunol Immunother2003，52，10： | 1 |
| 7 | Surgical approaches to peritonitis显示文摘 | Boermeester MA | 2007 | Br J Surg2007，94，： | 1 |
| 8 | Evaluation of matrix metalloproteinase 7 in plasma and pancreatic juice as a biomarker for pancreatic cancer显示文摘 | Kuhlmann KF van Till JW Boermeester MA | 2007 | Cancer Epidemiol Biomarkers Prey2007，16，5： | 1 |
| 9 | Differential responses of cellular immunity in patients undergoing neoadjuvant therapy followed by surgery for carcinoma of the oesophagus显示文摘 | Westerterp M Boermeester MA Omloo JM | 2008 | Cancer Immunol Immunother2008，7，12： | 1 |
| 10 | Lymphocyte subsets and T(h)1/T(h)2 immune responses in patients with adenocarcinoma of the oesophagus or oesophagogastric junction:relation to pTNM stage and clinical outcome显示文摘 | Van Sandick JW Boermeester MA Gisbertz SS | 2003 | Cancer Immunol Immunother2003，52，10： | 1 |
| 11 | Interleukin-1blockade attenuates mediator release and dysregulation of the hemostatic mechanism during human sepsis显示文摘 | Boermeester MA van Leeuwen PA Coyle SM | | 0，，07： | 1 |
| 12 | Intestinal Barrier Dysfunction in a Randomized Trial of a Specific Probiotic Composition in Acute Pancreatitis显示文摘 | Marc G. Besselink Hjalmar C. van Santvoort Willem Renooij Martin B. de Smet Marja A. Boermeester Kathelijn Fischer Harro M. Timmerman Usama Ahmed Ali Geert A. Cirkel Thomas L. Bollen Bert van Ramshorst Alexander F. Schaapherder Ben J. Witteman Rutger J. P | 2009 | Annals of Surgery2009，，5： | 1 |
| 13 | Clinical significance of translocation显示文摘 | Van-Leeuween PAM Boermeester MA Houdijk APJ | 1994 | Gut1994，，1： | 1 |
| 14 | Evaluation of matrix metalloproteinase 7 in plasma and pancreatic juice as a bio-marker for pancreatic cancer显示文摘 | Kuhlmann KF van Till JW Boermeester MA | | 0，，05： | 1 |
| 15 | Lymphocyte subsets and T(h)1/T(h)2 immune responses in patients with adenocarcinoma of the oesophagus or oesophagogastric junction:relation to pTNM stage and clinical outcome显示文摘 | VAN SANDICK J W BOERMEESTER M A GISBERTZ S S | 2003 | Cancer Immunol Immunother2003，52，10： | 1 |
| 16 | Pretreatment with enteral cholestyramine prevents suppression of the cellular immune system after partial hepatectomy显示文摘 | Van Leeuwen PA Boermeester MA Houdijk AP et aI | 1995 | Ann Surg1995，221，3： | 1 |
| 17 | Sys- tematic review and recta-analysis of the open abdomen and temporary abdominal closure techniques in non-tramna patients 显示文摘 | Atema J J Gans SL Boermeester MA | 2015 | World J Surg2015，39，4： | 1 |
| 18 | Timing and impact of infections in acute pancreatitis显示文摘 | Besselink MG van Santvoort HC Boermeester MA | 2009 | Br J Surg2009，96，3： | 1 |
| 19 | Systemic and local high mobility group box 1 concentrations during severe infection显示文摘 | Marieke A. D. van Zoelen Pierre-Fran?ois Laterre Suzanne Q. van Veen Jan W. O. van Till Xavier Wittebole Paul Bresser Michael W. Tanck Thierry Dugernier Akitoshi Ishizaka Marja A. Boermeester Tom van der Poll | 2007 | Critical Care Medicine2007，，12： | 1 |
| 20 | Surgical approaches to peritonitis显示文摘 | Boermeester MA | 2007 | Br J Surg2007，94，11： | 1 |
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