|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 亚太地区慢性乙型肝炎治疗共识(2012最新版)显示文摘自2008年至今,有大量关于慢性HBV感染的自然史和治疗的最新数据不断涌现。其中包括慢性HBV感染的无症状感染者,以社区为基础的队列研究,HBV基因型的作用,非药物诱导的自然HBV变异型毒株,无创性肝纤维化评估方法的应用,HBsAg定量在临床中的应用,更有效的新治疗药物和新治疗方案等等。来自亚太地区的专家审查和评估了相关数据,并共同商讨了近年来报道的最有意义的发现,基于此,对2008年版的亚太地区慢性乙型肝炎治疗共识进行修订,同时对2008年版治疗指南定义的关键词组进行了修订。修订后的指南包括以下几方面内容:一般治疗,肝纤维化评价适应证,何时开始治疗或停药,初始抗病毒治疗药物的选择,如何监测治疗中和治疗后的患者。关于特殊人群的治疗建议中包括了对妊娠妇女,已发生耐药,合并其他病毒感染,肝功能失代偿,接受免疫抑制治疗、化疗,肝移植或肝细胞癌患者的具体治疗建议。 | 廖运范 Jia-HorngKao Teerha Piratvisuth Henry Lik Yuen Chan Rong-Nan Chien Chun-Jen Liu Ed Gane Stephen Locarnini Seng-Gee Lim Kwang-Hyub Han Deepak Amarapurkar Graham Cooksley Wasim Jafri Rosmawati Mohamed Wan-Long Chuang Laurentius A.Lesmana Jose D.Sollano Dong-Jin Suh Masao Omata 刘颖 徐莹 李芸 黄祖雄 樊蓉 李小溪 吕国涛 周彬 孙剑 侯金林 | 2012 | 临床肝胆病杂志2012，28，8： | 182 |
| 2 | Covalently closed-circular hepatitis B virus DNA reduction with entecavir or lamivudine显示文摘AIM: To investigate the reduction in hepatitis B virus(HBV) covalently closed-circular DNA(ccc DNA) with entecavir(ETV) or lamivudine(LAM). METHODS: This analysis included patients who had participated in the randomized Phase Ⅲ study ETV-022 comparing ETV vs LAM in nucleos(t)ide-naive, HBe Agpositive patients. Patients received ETV(0.5 mg daily) or LAM(100 mg daily) for a minimum of 52 wk. Patients were eligible to participate in this sub-study if they had paired biopsies at baseline and week 48 with evaluable measurements for hepatic HBV ccc DNA and total hepatic HBV DNA. The main objective was to compare changes in hepatic HBV ccc DNA and total hepatic HBV DNA at week 48 of ETV or LAM treatment, which was a secondary endpoint of study ETV-022. Additional post hoc analyses included linear regression analyses to assess associations of baseline levels and on-treatment changes of ccc DNA with other baseline factors [sex,age, serum HBV DNA, alanine aminotransferase(ALT), Knodell necroinflammatory score, Ishak fibrosis score, total hepatic HBV DNA, and HBV genotype], or ontreatment factors(changes from baseline at week 48 in serum HBV DNA, ALT, Knodell necroinflammatory score, Ishak fibrosis score, total hepatic HBV DNA, and HBe Ag loss at week 48).RESULTS: Overall, 305 patients(ETV = 159; LAM = 146) of ETV-022 had paired baseline and week 48 liver biopsies with evaluable measurements for hepatic HBV ccc DNA and total hepatic HBV DNA, and were included in this analysis. Baseline demographics and disease characteristics were comparable between the two arms. After 48 wk, ETV resulted in significantly greater reductions in hepatic HBV ccc DNA [-0.9 log10 copies/human genome equivalent(HGEq) vs-0.7 log10 copies/HGEq; P = 0.0033] and total hepatic DNA levels(-2.1 log10 copies/HGEq vs-1.6 log10 copies/HGEq; P < 0.0001) than LAM. Virologic, biochemical, and histologic response rates at week 48 were also greater with ETV than with LAM. Baseline HBV ccc DNA levels were positively associated with baseline levels of serum HBV DNA and total hepatic HBV DNA, and negatively associated with HBV genotype F. On-treatment changes in HBV ccc DNA levels were negatively associated with baseline levels of serum HBV DNA and baseline ALT, and were positively associated with on-treatment changes in the levels of serum HBV DNA, total hepatic HBV DNA levels, and ALT, change in Knodell necroinflammatory score, and HBe Ag loss.CONCLUSION: Forty-eight weeks of ETV resulted in greater reductions in ccc DNA and total hepatic HBV DNA than LAM, but long-term therapy may be needed for ccc DNA elimination. | Scott Bowden Stephen Locarnini Ting-Tsung Chang You-Chen Chao Kwang-Hyub Han Robert G Gish Robert A de Man Miao Yu Cyril Llamoso Hong Tang | 2015 | World Journal of Gastroenterology2015，21，15： | 11 |
| 3 | Asian-Pacific consensus statement on the management of chronic hepatitis B: a 2008 update显示文摘 | Yun-Fan Liaw Nancy Leung Jia-Horng Kao Teerha Piratvisuth Edward Gane Kwang-Hyub Han Richard Guan George K. K. Lau Stephen Locarnini | 2008 | Hepatology International2008，，3： | 10 |
| 4 | Hepatitis B surface antigen levels during the natural history of chronic hepatitis B: A perspective on Asia显示文摘 | Tin Nguyen Alexander J.V. Thompson Scott Bowden Catherine Croagh Sally Bell Paul V. Desmond Miriam Levy Stephen A. Locarnini | 2010 | Journal of Hepatology2010，，4： | 7 |
| 5 | Asian-Pacific consensus statement on the management of chronic hepatitis B: a 2008 update显示文摘 | Yun-Fan Liaw Nancy Leung Jia-Horng Kao Teerha Piratvisuth Edward Gane Kwang-Hyub Han Richard Guan George K. K. Lau Stephen Locarnini | 2008 | Hepatology International2008，，3： | 7 |
| 6 | Asian-Pacific consensus statement on the management of chronic hepatitis B: a 2012 update显示文摘 | Yun-Fan Liaw Jia-Horng Kao Teerha Piratvisuth Henry Chan Rong-Nan Chien Chun-Jen Liu Ed Gane Stephen Locarnini Seng-Gee Lim Kwang-Hyub Han Deepak Amarapurkar Graham Cooksley Wasim Jafri Rosmawati Mohamed Jin-Lin Hou Wan-Long Chuang Laurentius Lesmana Jose | 2012 | Hepatology International2012，，3： | 6 |
| 7 | Hepatitis B Virus Resistance to Nucleos(t)ide Analogues显示文摘 | Fabien Zoulim Stephen Locarnini | 2009 | Gastroenterology2009，，5： | 6 |
| 8 | Hepatitis B surface antigen quantification: Why and how to use it in 2011 – A core group report显示文摘 | Henry Lik-Yuen Chan Alex Thompson Michelle Martinot-Peignoux Teerha Piratvisuth Markus Cornberg Maurizia Rossana Brunetto Hans L. Tillmann Jia-Horng Kao Ji-Dong Jia Heiner Wedemeyer Stephen Locarnini Harry L.A. Janssen Patrick Marcellin | 2011 | Journal of Hepatology2011，，5： | 5 |
| 9 | Statements from the Taormina expert meeting on occult hepatitis B virus infection显示文摘 | Giovanni Raimondo Jean-Pierre Allain Maurizia R. Brunetto Marie-Annick Buendia Ding-Shinn Chen Massimo Colombo Antonio Craxì Francesco Donato Carlo Ferrari Giovanni B. Gaeta Wolfram H. Gerlich Massimo Levrero Stephen Locarnini Thomas Michalak Mario U. Mon | 2008 | Journal of Hepatology2008，，4： | 5 |
| 10 | Management of treatment failure in chronic hepatitis B显示文摘 | Fabien Zoulim Stephen Locarnini | 2012 | Journal of Hepatology2012，，： | 3 |
| 11 | The Hepatitis B e antigen (HBeAg) targets and suppresses activation of the Toll-like receptor signaling pathway显示文摘 | Tali Lang Camden Lo Narelle Skinner Stephen Locarnini Kumar Visvanathan Ashley Mansell | 2011 | Journal of Hepatology2011，，4： | 3 |
| 12 | Erratum to: Asian-Pacific consensus statement on the management of chronic hepatitis B: a 2012 update显示文摘 | Yun-Fan Liaw Jia-Horng Kao Teerha Piratvisuth Henry Lik Yuen Chan Rong-Nan Chien Chun-Jen Liu Ed Gane Stephen Locarnini Seng-Gee Lim Kwang-Hyub Han Deepak Amarapurkar Graham Cooksley Wasim Jafri Rosmawati Mohamed Jin-Lin Hou Wan-Long Chuang Laurentius A. | 2012 | Hepatology International2012，，4： | 2 |
| 13 | Intrahepatic Hepatitis B Virus Covalently Closed Circular DNA Can Be a Predictor of Sustained Response to Therapy显示文摘 | Joseph J.Y. Sung May-Ling Wong Scott Bowden Choong-Tsek Liew Alex Y. Hui Vincent W.S. Wong Nancy W.Y. Leung Stephen Locarnini Henry L.Y. Chan | 2005 | Gastroenterology2005，，7： | 2 |
| 14 | Nomenclature for antiviral-resistant human hepatitis B virus mutations in the polymerase region显示文摘 | Lieven J. Stuyver Stephen A. Locarnini Anna Lok Douglas D. Richman William F. Carman Jules L. Dienstag Raymond F. Schinazi | 2001 | Hepatology2001，，： | 2 |
| 15 | Chronic hepatitis B: Virology, natural history, current management and a glimpse at future opportunities显示文摘 | Robert G. Gish Bruce D. Given Ching-Lung Lai Stephen A. Locarnini Johnson Y.N. Lau David L. Lewis Thomas Schluep | 2015 | Antiviral Research2015，，： | 2 |
| 16 | Asian-Pacific consensus statement on the management of chronic hepatitis B: a 2008 update显示文摘 | Yun-Fan Liaw Nancy Leung Jia-Horng Kao Teerha Piratvisuth Edward Gane Kwang-Hyub Han Richard Guan George K. K. Lau Stephen Locarnini | 2008 | Hepatology International2008，，3： | 1 |
| 17 | Hepatitis B surface antigen levels during the natural history of chronic hepatitis B: A perspective on Asia显示文摘 | Tin Nguyen Alexander J.V. Thompson Scott Bowden Catherine Croagh Sally Bell Paul V. Desmond Miriam Levy Stephen A. Locarnini | 2010 | Journal of Hepatology2010，，4： | 1 |
| 18 | Mechanisms of Hepatitis B Virus Resistance Development显示文摘 | Warner Nadia Locarnini Stephen | 2014 | 2014 (3-4)2014，，3： | 1 |
| 19 | Hepatitis B surface antigen quantification: Why and how to use it in 2011 – A core group report显示文摘 | Henry Lik-Yuen Chan Alex Thompson Michelle Martinot-Peignoux Teerha Piratvisuth Markus Cornberg Maurizia Rossana Brunetto Hans L. Tillmann Jia-Horng Kao Ji-Dong Jia Heiner Wedemeyer Stephen Locarnini Harry L.A. Janssen Patrick Marcellin | 2011 | Journal of Hepatology2011，，5： | 1 |
| 20 | Optimal management of chronic hepatitis B patients with treatment failure and antiviral drug resistance显示文摘 | Fabien Zoulim Stephen Locarnini | 2013 | Liver Int2013，，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员