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| 1 | Altered expression profiles of microRNAs in a stable hepatitis B virus-expressing cell line显示文摘背景 MicroRNAs (miRNAs ) 是调停的 18-25 核苷酸(nt ) 的高度保存的小非编码的 RNA post-transcriptional 基因规定。肝炎 B 病毒(HBV ) 能引起尖锐或长期的肝炎 B,并且是为肝肝硬化和 hepatocellular 癌的一个高风险因素。一些哺乳动物的病毒被显示了调制表示招待细胞的 miRNAs。然而,在 HBV 之间的相互作用和主人细胞的 miRNAs 大部分是未知的。方法 miRNA microarray 和北弄污分析被用来比较稳定的表示 HBV 房间行 HepG2.2.15 和它的父母房间行 HepG2 的细胞的 miRNAs 的表示侧面。mRNA microarray 试金和人权保护的节目被用来预言 miRNA 目标。流动 cytometric 试金进一步被用来调查人的白血球的表示抗原(HLA ) A。结果十八 miRNAs 是在二房间行之间表示的差别。在他们之中,十一是起来调整的,七在 HepG2.2.15 房间是下面调整的。北弄污分析证实 miR-181a, miR-181b, miR-200b 和 miR-146a 的表示是起来调整的, miR-15a 的表示是下面调整的,它在与 microarray 分析的结果一致。而且,一些通常认为的 miRNA 目标被预言并且验证了与 mRNA 表示被连接。HLA 的 3'-UTR -- 基因为 miR-181a 和 miR-181a 力量下面调整有一个部分互补的地点 HLA 的表示 -- 一。结论 HBV 复制调制表达式招待细胞的 miRNAs,它可以在 HBV 相关的肝疾病的致病起一个作用。 | LIU Yan ZHAO Jian-Jun WANG Chun-mei LI Mian-yang HAN Ping WANG Lin CHENG Yong-qian Fabien Zoulim MA Xu XU Dong-ping | 2009 | Chinese Medical Journal2009，，1： | 38 |
| 2 | Hepatitis B virus in tenofovir-naive Chinese patients with chronic hepatitis B contains no mutation of rtA194T conferring a reduced tenofovir susceptibility显示文摘 | LIU Yan WANG Chun-mei CHENG Jun LIANG Zhao-ling ZHONG Yan-wei REN Xiao-qiang XU Zhi-hui Fabien Zoulim XU Dong-ping | 2009 | Chinese Medical Journal2009，，13： | 13 |
| 3 | Hepatitis B Virus Resistance to Nucleos(t)ide Analogues显示文摘 | Fabien Zoulim Stephen Locarnini | 2009 | Gastroenterology2009，，5： | 6 |
| 4 | Hepatitis B virus genetic variability and evolution显示文摘 | Alan Kay Fabien Zoulim | 2007 | Virus Research2007，，2： | 3 |
| 5 | Management of treatment failure in chronic hepatitis B显示文摘 | Fabien Zoulim Stephen Locarnini | 2012 | Journal of Hepatology2012，，： | 3 |
| 6 | Strategies to Inhibit Entry of HBV and HDV Into Hepatocytes显示文摘 | Stephan Urban Ralf Bartenschlager Ralf Kubitz Fabien Zoulim | 2014 | Gastroenterology2014，，： | 3 |
| 7 | Hepatitis B virus X protein is essential to initiate and maintain virus replication after infection显示文摘 | Julie Lucifora Silke Arzberger David Durantel Laura Belloni Michel Strubin Massimo Levrero Fabien Zoulim Olivier Hantz Ulrike Protzer | 2011 | Journal of Hepatology2011，，5： | 2 |
| 8 | Triple therapy in treatment-experienced patients with HCV-cirrhosis in a multicentre cohort of the French Early Access Programme (ANRS CO20-CUPIC) – NCT01514890<!-- Doctopic: VH -->显示文摘 | Christophe Hézode Hélène Fontaine Céline Dorival Dominique Larrey Fabien Zoulim Valérie Canva Victor de Ledinghen Thierry Poynard Didier Samuel Marc Bourlière Jean-Pierre Zarski Jean-Jacques Raabe Laurent Alric Patrick Marcellin Ghassan Riachi Pierre-Henr | 2013 | Journal of Hepatology2013，，： | 2 |
| 9 | Tenofovir Is Effective Alone or With Emtricitabine in Adefovir-Treated Patients With Chronic-Hepatitis B Virus Infection显示文摘 | Thomas Berg Patrick Marcellin Fabien Zoulim Bernd Moller Huy Trinh Sing Chan Emilio Suarez Fabien Lavocat Andrea Snow–Lampart David Frederick Jeff Sorbel Katyna Borroto–Esoda David Oldach Franck Rousseau | 2010 | Gastroenterology2010，，4： | 2 |
| 10 | Hepatitis B: Reflections on the current approach to antiviral therapy显示文摘 | Fabien Zoulim Robert Perrillo | 2008 | Journal of Hepatology2008，，： | 2 |
| 11 | Entecavir plus tenofovir combination as rescue therapy in pre-treated chronic hepatitis B patients: An international multicenter cohort study显示文摘 | Jorg Petersen Vlad Ratziu Maria Buti Harry L.A. Janssen Ashley Brown Pietro Lampertico Jan Schollmeyer Fabien Zoulim Heiner Wedemeyer Martina Sterneck Thomas Berg Christoph Sarrazin Marc Lutgehetmann Peter Buggisch | 2011 | Journal of Hepatology2011，，3： | 2 |
| 12 | Hepatitis C virus-induced hepatocarcinogenesis显示文摘 | Birke Bartosch Robert Thimme Hubert E. Blum Fabien Zoulim | 2009 | Journal of Hepatology2009，，4： | 2 |
| 13 | Progress in DNA vaccine for prophylaxis and therapy of hepatitis显示文摘 | Thermet A Rollier C Zoulim F | 2003 | B Vaccine2003，21，7： | 1 |
| 14 | Combination therapy in chronic hepatitis B显示文摘 | Fournier C Zoulim F | 2008 | Gastroenterol Clin Biol2008，32，12： | 1 |
| 15 | Animal models for the study of HBV infection and the evaluation of new anti-HBV strategies显示文摘 | Zoulim F Berthillon P Guerhier FL | 2002 | J Gastroenterol Hepatol2002，17，： | 1 |
| 16 | Antiviral drug-resistant HBV: standardization of nomenclature and assays and recommendations for management显示文摘 | Lok AS Zoulim F Locarnini S | 2007 | Hepatology2007，46，1： | 1 |
| 17 | Hepatitis B vires resistance to nucleos (t) ide analogues 显示文摘 | ZOULIM F LOCARNINI S | 2009 | Gastroenterology2009，137，： | 1 |
| 18 | Effects of liver growth factors on hepadnavirus replication in chronically infected duck hepatocytes显示文摘 | Schorr O Borel C Trepo C Zoulim F Hantz O | | Journal of Hepatology0，，： | 1 |
| 19 | Hepatitis C virus-induced hepatocarcinogenesis显示文摘 | Birke Bartosch Robert Thimme Hubert E. Blum Fabien Zoulim | 2009 | Journal of Hepatology2009，，4： | 1 |
| 20 | Management of patients with ecom pensated hepatitis B virus associated cirrhosis 显示文摘 | Zoulim F Radenne S Ducerf C | 2008 | Liver Transpl2008，14，2： | 1 |
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