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| 1 | 核心抗体阳性合格献血者隐匿性乙肝病毒感染分子生物学特性及追踪结果的研究显示文摘目的了解我国核心抗体阳性合格献血者隐匿性乙肝病毒感染(OBI)情况,分析血清学和分子生物性特征。方法对HBs Ag(-)、NAT检测无反应性的合格献血者血浆,进行乙肝两对半检测和anti-HBs定量检测,对核心抗体阳性标本进行病毒核酸提取,和BCP/PC区及S区巢式PCR扩增,对扩增结果阳性产物纯化后进行基因测序及序列分析,同时进行QPCR定量检测。对HBV DNA阳性的献血者进行追踪检测和分析。结果在1 033名合格献血者中,抗-HBc(+)占47.4%,阳性率随年龄的增长而增加(P<0.001),30岁以下年龄组为32.6%而到50岁以上年龄组为为69.8%。777/1033为抗-HBs(+),占75.2%。在抗-HBc(+)人群中共检出14例HBV DNA(+),其中7例抗-HBs滴度在100 IU/L以上,在抗-HBc(+)合格献血者中OBI阳性率为2.86%。8/14例OBI为B型,1例为C型。7/14能追踪的标本中,1例发现抗-HBe血清转换为阳性。所有追踪标本的病毒均变成检不出。5例BCP/PC区序列发生突变,3例S区氨基酸变异。结论经HBs Ag及NAT检测合格的抗-HBc(+)献血者,其血液中仍有一定几率含有HBV DNA,存在经输血传播病毒的威胁,提示在乙肝高流行地区需进一步提高核酸检测方法的灵敏度,必要时可增加抗-HBc的检测。 | 叶贤林 李彤 孙淑君 许晓绚 杜鹏 曾劲峰 朱为刚 杨宝成 黎诚耀 Jean-Pierre Allain | 2016 | 中国输血杂志2016,29,9: | 29 |
| 2 | Statements from the Taormina expert meeting on occult hepatitis B virus infection显示文摘 | Giovanni Raimondo Jean-Pierre Allain Maurizia R. Brunetto Marie-Annick Buendia Ding-Shinn Chen Massimo Colombo Antonio Craxì Francesco Donato Carlo Ferrari Giovanni B. Gaeta Wolfram H. Gerlich Massimo Levrero Stephen Locarnini Thomas Michalak Mario U. Mon | 2008 | Journal of Hepatology2008,,4: | 5 |
| 3 | Transfusion-transmitted hepatitis B virus infection显示文摘 | Daniel Candotti Jean-Pierre Allain | 2009 | Journal of Hepatology2009,,4: | 2 |
| 4 | Structural Flexibility Enables Alternative Maturation, ARGONAUTE Sorting and Activities of miR168, a Global Gene Silencing Regulator in Plants显示文摘在优核质, RNase-III Dicer 经常生产长度 / 顺序 microRNA (miRNA ) 变体,叫的 isomiRs,由于 miRNA 先锋(pre-miRNAs ) 的内在的 structural/sequence 决定因素。在这研究,我们联合了学习 Arabidopsis miR168 的生物物理学,遗传和生物化学途径,中央植物 silencing 受动器蛋白质 ARGONAUTE1 (AGO1 ) 的关键反馈管理者。我们识别了在植物 pre-miR168 orthologs 之中保存的一个主题,它启用灵活内部基础配对的位于 \O 下面至少三种亚稳的结构的配置。这些配置支持与行动的特殊以前排序的性质和模式产生长度和结构的 isomiR168 变体的其他的、精确 Dicer 劈开事件。在这些 isomiR168s 之中,一与 22-nt 指南海滨双为 AGO10 展出惊人地优先的亲密关系,最靠近的 AGO1 paralog。22-nt miR168-AGO10 建筑群反对 AGO1 累积在 ? 经由及物的 RNAi 的部分,一个沉默扩大过程,维持 ? 适当 AGO1 细胞的动态平衡。而且,我们发现 tombusviral P19 silencing-suppressor 蛋白质在它的 isomiR168 货物之中为 22-nt 形式显示显著地更弱的亲密关系,从而支持调停 AGO1 的抗病毒的 silencing 的指导 AGO10 的抑制。一起拿,这些调查结果显示那结构的灵活性, pre-miRNAs 的一个以前俯看的性质,更加增加通用性和单个 MIRNA 基因,和病原体可能发展了的那一些的规章的潜力能力或机制篡夺这个性质。 | Taichiro Iki Antoine Cléry Nicolas G. Bologna Alexis Sarazin Christopher A. Brosnan Nathan Pumplin Frédéric H.T. Allain Olivier Voinnet | 2018 | Molecular Plant2018,11,8: | 2 |
| 5 | High manganese austenitic twinning induced plasticity steels: A review of the microstructure properties relationships显示文摘 | O. Bouaziz S. Allain C.P. Scott P. Cugy D. Barbier | 2011 | Current Opinion in Solid State & Materials Science2011,,4: | 2 |
| 6 | Challenges in hepatitis B detection among blood donors显示文摘 | Jean-Pierre Allain Laura Cox | 2011 | Current Opinion in Hematology2011,,6: | 2 |
| 7 | 中国献血者隐匿性乙型肝炎病毒感染分子生物学特性分析显示文摘 | 郑欣 叶贤林 张玲 王文敬 王安琪 曾劲峰 Daniel Candotti Jean-Pierre Allain 黎诚耀 | 2010 | 中国输血杂志2010,23,S1: | 2 |
| 8 | Increase in thyrotoxieosis associated With iodine supplement in Zimbabwe 显示文摘 | Todd CH Allain T Gomo ZA | 1995 | Lancet1995,346,: | 1 |
| 9 | Effects of non-genetic factors on production traits of Inner Mongolia cashmere goats in China显示文摘 | Zhou H M Allain D Li J Q | 2003 | Small Rumin Res2003,47,: | 1 |
| 10 | The RNA reeognition mo- tif, a plastic RNA-binding platform to regulate post-transcription- al gene expression显示文摘 | Maris C Domingue Z C Allain F H | 2005 | FEBS J2005,272,9: | 1 |
| 11 | Crown ether-doped sol-gel materiaIs for strontium( 1I ) separation显示文摘 | YOST T L Jr FAGAN B C ALLAIN L R | 2000 | Analytical Chemis- try2000,72,21: | 1 |
| 12 | Transfusion - transmitted infectious diseases 显示文摘 | Allain JP Stramer SL Carneiro - Proietti AB | 2009 | Biologicals2009,2,: | 1 |
| 13 | Analysis of the tensile behavior of a TWIP steel based on the texture and microstructure evolutions显示文摘 | D. Barbier N. Gey S. Allain N. Bozzolo M. Humbert | 2008 | Materials Science & Engineering A2008,,1: | 1 |
| 14 | Determination of iodine and bromine in plasma and urine by inductively coupled plasma mass spectrometry显示文摘 | Allain P Mauras Y Douge C | 1990 | Analyst1990,115,6: | 1 |
| 15 | The risk of hepatitis B virus infection by transfusion in Kumasi,Ghana显示文摘 | Allain JP Candotti D Soldan K | 2003 | Blood2003,101,5: | 1 |
| 16 | Resistance of human muhidrug resistance - associated protein 1 - overexpressing lung tumor cells to the anticancer drug arsenic trioxide显示文摘 | Vernhet L Allain N Payen L | 2001 | Biochem Pharmacol2001,61,11: | 1 |
| 17 | Microplate fluorescence assay for the quantification of double stranded DNA using SYBR Green I dye显示文摘 | Leggate J Allain R Isaac L | 2006 | Biotechnol Lett2006,28,: | 1 |
| 18 | Coronary angiography through the radial or the femoral approach: the CARAFE study显示文摘 | Louvard Y Lfevre T Allain A | 2001 | Cathet Cardiovasc Intervent2001,52,2: | 1 |
| 19 | Arsenic induces expression of the multidrug resistance-associated protein 2 (MRP2) gene in primary rat and human hepatocytes 显示文摘 | Vernhet L Seite MP Allain N | 2001 | J Pharmacol Exp Ther2001,298,1: | 1 |
| 20 | Pharmacological treatment of stable chronic obstructive pulmonary disease 显示文摘 | Allain YM Giraud F Huchon G | 2009 | Presse Med2009,38,3: | 1 |