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| 1 | Differential effects on apoptosis induction in hepatocyte lines by stable expression of hepatitis B virus X protein显示文摘瞄准:肝炎 B 蛋白质 X (HBx ) 被显示了是弱 oncogenic 在试管内。HBx 的转变活动与肿瘤的功能压制的几的抑制或 p53 被连接了。我们学习了 HBx 是否可以在取决于房间类型的 p53 上有不同效果。方法:我们使用了人的肝细胞瘤房间线 HepG2 和使不朽的鼠科的 hepatocyte 线 AML12 并且稳定地分析了表示了 HBx 的生理的数量的 transfected 克隆。P53 被紫外照耀导致。结果:由紫外照耀的 p53 正式就职由 HBx 的稳定的表示是未受影响的。然而,变得被 p53 激活的 cyclin 激酶禁止者 p21 (waf/cip/sdi ) 的表示在 HBx 被影响转变房间线 AML12-HBx9,然而并非在 HepG2。在 AML-HBx9,房间, p21 (waf/cip/sdi ) 蛋白质表示和 p21 (waf/cip/sdi ) 抄写是 deregulated。而且, apoptosis 的过程在调查的二根房间线以相反的方法被影响。当 HBx 的稳定的表示提高了紫外照耀在 HepG2 房间导致的 apoptosis 时, apoptosis 在 HBx 被减少转变 AML12-HBx9。P53 镇压了从 HBV enhancer 的抄写我,当由紫外照耀从表示向量或在内长的 p53 的正式就职以后表示了时。由内长的 p53 的压抑由在两根房间线的稳定地表示的 HBx 部分是可逆的。结论:HBx 的稳定的表示导致取决于使用的房间线的紫外照耀导致的 apoptosis 的解除管制。而在癌的表示导出 hepatocyte 线 HBx,在一根使不朽的 hepatocyte 线, HBx 扮演了 anti-apoptotic 提高的 apoptosis。 | Nicola Fiedler Ellen Quant Ludger Fink Jianguang Sun Ralph Schuster Wolfram H Gerlich Stephan Schaefer | 2006 | World Journal of Gastroenterology2006，12，29： | 8 |
| 2 | Interfacial bonding mechanism in Al/coated steel dissimilar refill friction stir spot welds显示文摘Defect-free dissimilar Al/zinc coated steel and Al/AlSi coated steel welds were successfully fabricated by refill friction stir spot welding. However, Al alloy and uncoated steel could not be welded under the same welding condition. Al-Zn eutectic layer formed at the Al/zinc coated steel interface showed nonuniformity in thickness and nanoscale intermetallic(IMC) produced was discontinuous. The bonding formation between the Al-Zn layer and the surrounding materials was attributed to a liquid/solid reaction mechanism. Bonding formation at Al alloy and AlSi coated steel interface was attributed to a solid/solid reaction mechanism, as the joining process did not involve with melting of base metals or AlSi coating materials. Kissing bond formed at the weld boundary acted as a crack initiation and propagation site,and the present study showed that weld strength of Al 5754/AlSi coated steel was greatly influenced by properties of original IMC layer. | Z. Shen Y. Ding J. Chen B. Shalch Amirkhiz J.Z. Wen L. Fu A.P. Gerlich | 2019 | Journal of Materials Science & Technology2019，35，6： | 6 |
| 3 | Statements from the Taormina expert meeting on occult hepatitis B virus infection显示文摘 | Giovanni Raimondo Jean-Pierre Allain Maurizia R. Brunetto Marie-Annick Buendia Ding-Shinn Chen Massimo Colombo Antonio Craxì Francesco Donato Carlo Ferrari Giovanni B. Gaeta Wolfram H. Gerlich Massimo Levrero Stephen Locarnini Thomas Michalak Mario U. Mon | 2008 | Journal of Hepatology2008，，4： | 5 |
| 4 | Genotype-dependent activation or repression of HBV enhancer Ⅱ by transcription factor COUP-TF1显示文摘AIM: To study the expression of HBV enhancer Ⅱ by transcription factor COUP-TF1. METHODS: In order to study the regulation of HBV variants in the vicinity of the NRRE we cloned luciferase constructs containing the HBV enhancer Ⅱ from variants and from HBV genotypes A and D and cotransfected them together with expression vectors for COUP-TF1 into HepG2 cells. RESULTS: Our fi ndings show that enhancer Ⅱ of HBV genotype A is also repressed by COUP-TF1. In contrast, two different enhancer Ⅱ constructs of HBV genotype D were activated by COUP-TF1. The activation was independent of the NRRE because a natural variant with a deletion of nt 1763-1770 was still activated by COUP- TF1. CONCLUSION: Regulation of transcription of the HBV genome seems to differ among HBV genomes derived from different genotypes. These differences in transcriptional control among HBV genotypes may be the molecular basis for differences in the clinical course among HBV genotypes. | Silke F Fischer Katja Schmidt Nicola Fiedler Dieter Glebe Christian Schüttler Jianguang Sun Wolfram H Gerlich Reinald Repp Stephan Schaefer | 2006 | World Journal of Gastroenterology2006，12，37： | 2 |
| 5 | Elastic properties of aluminum nitride 显示文摘 | Gerlich D Dole S L Slack G A | 1986 | J Phys Chem Solids1986，47，5： | 1 |
| 6 | Stir zone micro- structure and strain rate during A17075-T6 friction stir spot weld- ing显示文摘 | Gerlich A Avramovic-Cingara G North T | 2006 | Metalurgical and Materials Transaction A2006，37，9： | 1 |
| 7 | Studies on the attachment and penetration of hepatitis B virus显示文摘 | Gerlich WH Lu X Heermann KH | 1993 | J Hepatol1993，17，3： | 1 |
| 8 | Plastic deformation of nanocrystalline aluminum at high temperatures and strain rate显示文摘 | A.P. Gerlich L. Yue P.F. Mendez H. Zhang | 2009 | Acta Materialia2009，，6： | 1 |
| 9 | Hepatitis B virus rtI233V mutation and resistance to adefovir显示文摘 | Geipel A Glebe D Gerlich WH | 2014 | N Engl J Med2014，370，17： | 1 |
| 10 | Peak temperatures and mi-crostructures inaluminium and magnesium alloy friction stir spot welds显示文摘 | Gerlich A Su P North T H | 2005 | Science and Technology of Welding and Joining2005，10，6： | 1 |
| 11 | Effects of using combined transpetrosal surgical approaches to treat petroclival meningiomas显示文摘 | Mathiesen T Gerlich A Kihlstrom L | 2007 | Neurosurgery2007，60，6： | 1 |
| 12 | Strain rates and grain growth in A1 5754 and A1 6061 friction stir spot welds 显示文摘 | GERLICH A YAMAMOTO M NORTH T H | 2007 | Metallurgical and Materials Transactions A2007，38，： | 1 |
| 13 | Synthesis of multiwalled CNT reinforced aluminium alloy composite via friction stir processing显示文摘 | Lim D K Shibayanagi T Gerlich A P | 2009 | Mater Sci Eng A2009，507，12： | 1 |
| 14 | Nature and display of hepatitis B virus envelope proteins and the humoral immune response显示文摘 | Alfredo Alberti Wolfram H. Gerlich Klaus-Hinrich Heermann Patrizia Pontisso | 1990 | Springer Seminars in Immunopathology1990，，1： | 1 |
| 15 | Strainrates and grain growth in Al 5754 and Al 6061 friction stirspot welds显示文摘 | GERLICH A YAMAMOTO M NORTH T H | 2007 | Metallurgical and Materials TransactionsA2007，38，6： | 1 |
| 16 | Strain rates and grain growth in A1 5754 and A1 6061 friction stir spot welds显示文摘 | GERLICH A YAMAMOTO M NORTH T H | 2007 | Metallurgical and Materials Transactions A2007，38，： | 1 |
| 17 | Quantitative detection of hepatitis B virus DNA in two international reference plasma preparations显示文摘 | Heermann KH Gerlich WH Chudy M | 1999 | J Clin Microbiology1999，37，： | 1 |
| 18 | Cytokinetic abscission: cellular dynamics at the midbody显示文摘 | Steigemann P Gerlich DW | 2009 | Trends Cell Biol2009，19，： | 1 |
| 19 | Friction stir spot welding of aluminum and magnesium alloy sheets显示文摘 | Su P Gerlich A North T H | 2005 | Journal of Materials Science2005，40，1： | 1 |
| 20 | Patterns of alcohol consumption and acute myocardial infarction:a case-crossover analysis显示文摘 | Gerlich MG Kramer A Gmel G | | 0，，： | 1 |
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