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| 1 | An Update on Abscisic Acid Signaling in Plants and More显示文摘 | Aleksandra Wasilewsk.a Florina Vlad Caroline Sirichandra Yulia Redko Fabien Jammes Christiane Valon Nicolas Frei dit Frey Jeffrey Leung | 2008 | Molecular Plant2008，1，2： | 46 |
| 2 | Altered expression profiles of microRNAs in a stable hepatitis B virus-expressing cell line显示文摘背景 MicroRNAs (miRNAs ) 是调停的 18-25 核苷酸(nt ) 的高度保存的小非编码的 RNA post-transcriptional 基因规定。肝炎 B 病毒(HBV ) 能引起尖锐或长期的肝炎 B,并且是为肝肝硬化和 hepatocellular 癌的一个高风险因素。一些哺乳动物的病毒被显示了调制表示招待细胞的 miRNAs。然而,在 HBV 之间的相互作用和主人细胞的 miRNAs 大部分是未知的。方法 miRNA microarray 和北弄污分析被用来比较稳定的表示 HBV 房间行 HepG2.2.15 和它的父母房间行 HepG2 的细胞的 miRNAs 的表示侧面。mRNA microarray 试金和人权保护的节目被用来预言 miRNA 目标。流动 cytometric 试金进一步被用来调查人的白血球的表示抗原(HLA ) A。结果十八 miRNAs 是在二房间行之间表示的差别。在他们之中,十一是起来调整的,七在 HepG2.2.15 房间是下面调整的。北弄污分析证实 miR-181a, miR-181b, miR-200b 和 miR-146a 的表示是起来调整的, miR-15a 的表示是下面调整的,它在与 microarray 分析的结果一致。而且,一些通常认为的 miRNA 目标被预言并且验证了与 mRNA 表示被连接。HLA 的 3'-UTR -- 基因为 miR-181a 和 miR-181a 力量下面调整有一个部分互补的地点 HLA 的表示 -- 一。结论 HBV 复制调制表达式招待细胞的 miRNAs,它可以在 HBV 相关的肝疾病的致病起一个作用。 | LIU Yan ZHAO Jian-Jun WANG Chun-mei LI Mian-yang HAN Ping WANG Lin CHENG Yong-qian Fabien Zoulim MA Xu XU Dong-ping | 2009 | Chinese Medical Journal2009，，1： | 38 |
| 3 | Update on Anti-Saccharomyces cerevisiae antibodies, anti-nuclear associated anti-neutrophil antibodies and antibodies to exocrine pancreas detected by indirect immunofluorescence as biomarkers in chronic inflammatory bowel diseases: Results of a multicent显示文摘AIM: Anti-Saccharomyces cerevisiae antibodies (ASCA), anti-nuclear associated anti-neutrophil antibodies (NANA) and antibodies to exocrine pancreas (PAB), are serological tools for discriminating Crohn’s disease (CrD) and ulcerative colitis (UC). Like CrD, coeliac disease (CoD) is an inflammatory bowel disease (IBD) associated with (auto) antibodies. Performing a multicenter study we primarily aimed to determine the performance of ASCA, NANA and PAB tests for IBD diagnosis in children and adults, and secondarily to evaluate the prevalence of these markers in CoD. METHODS: Sera of 109 patients with CrD, 78 with UC, 45 with CoD and 50 healthy blood donors were retrospectively included. ASCA, NANA and PAB were detected by indirect immunofluorescence (IIF). RESULTS: ASCA+/NANA- profile displayed a positive predictive value of 94.2% for CrD. Detection of ASCA was correlated with a more severe clinical profile of CrD and treatment of the disease did not influence their serum levels. ASCA positivity was found in 37.9% of active CoD.PAB were found in 36.7% CrD and 13.3% CoD patients and were not correlated with clinical features of CrD, except with an early onset of the disease. Fifteen CrD patients were ASCA negative and PAB positive. CONCLUSION: ASCA and PAB detected by IIF are specific markers for CrD although their presence does not rule out a possible active CoD. The combination of ASCA, NANA and PAB tests improves the sensitivity of immunological markers for CrD. Repeating ASCA, NANA, and PAB testing during the course of CrD has no clinical value. | S Desplat-Jégo C Johanet A Escande J Goetz N Fabien N Olsson E Ballot J Sarles JJ Baudon JC Grimaud M Veyrac P Chamouard RL Humbel | 2007 | World Journal of Gastroenterology2007，13，16： | 24 |
| 4 | Hepatitis B virus in tenofovir-naive Chinese patients with chronic hepatitis B contains no mutation of rtA194T conferring a reduced tenofovir susceptibility显示文摘 | LIU Yan WANG Chun-mei CHENG Jun LIANG Zhao-ling ZHONG Yan-wei REN Xiao-qiang XU Zhi-hui Fabien Zoulim XU Dong-ping | 2009 | Chinese Medical Journal2009，，13： | 13 |
| 5 | Laparoscopic sleeve gastrectomy and gastroesophageal reflux显示文摘Bariatric surgery is the only effective procedure that provides long-term sustained weight loss. Sleeve gastrectomy(SG) has emerged over the last few years to be an ideal bariatric procedure because it has several advantages compared to more complex bariatric procedures,including avoiding an intestinal bypass. However,several published follow-up studies report an increased rate of gastroesophageal reflux(GERD) after a SG. GERD is described as either de novo or as being caused by aggravation of preexisting symptoms. However,the literature on this topic is ambivalent despite the potentially increased rate of GERDs that may occur after this common bariatric procedure. This article reviews the mechanisms responsible for GERD in obese subjects as well as the results after a SG with respect to GERD. Future directions for clinical research are discussed along with the current surgical options for morbidly obese patients with GERD and undergoing bariatric surgery. | Fabien Stenard Antonio Iannelli | 2015 | World Journal of Gastroenterology2015，21，36： | 11 |
| 6 | Biodegradable magnesium barrier membrane used for guided bone regeneration in dental surgery显示文摘Barrier membranes are commonly used as part of the dental surgical technique guided bone regeneration(GBR)and are often made of resorbable collagen or non-resorbable materials such as PTFE.While collagen membranes do not provide sufficient mechanical protection of the covered bone defect,titanium reinforced membranes and non-resorbable membranes need to be removed in a second surgery.Thus,biodegradable GBR membranes made of pure magnesium might be an alternative.In this study a biodegradable pure magnesium(99.95%)membrane has been proven to have all of the necessary requirements for an optimal regenerative outcome from both a mechanical and biological perspective.After implantation,the magnesium membrane separates the regenerating bone from the overlying,faster proliferating soft tissue.During the initial healing period,the membrane maintained a barrier function and space provision,whilst retaining the positioning of the bone graft material within the defect space.As the magnesium metal corroded,it formed a salty corrosion layer and local gas cavities,both of which extended the functional lifespan of the membrane barrier capabilities.During the resorption of the magnesium metal and magnesium salts,it was observed that the membrane became surrounded and then replaced by new bone.After the membrane had completely resorbed,only healthy tissue remained.The in vivo performance study demonstrated that the magnesium membrane has a comparable healing response and tissue regeneration to that of a resorbable collagen membrane.Overall,the magnesium membrane demonstrated all of the ideal qualities for a barrier membrane used in GBR treatment. | Patrick Rider Zeljka Peric Kacarevic Akiva Elad Drazen Tadic Daniel Rothamel Gerrit Sauer Fabien Bornert Peter Windisch David Botond Hangyasi Balint Molnar Emely Bortel Bernhard Hesse Frank Witte | 2022 | Bioactive Materials2022，7，8： | 7 |
| 7 | Multidisciplinary management of Mirizzi syndrome with cholecystobiliary fistula: the value of minimally invasive endoscopic surgery显示文摘Mirizzi syndrome, a rare complication of gallstones, is defined by obstruction of the main bile duct. This obstruction may worsen and thus result in cholecystobiliary fistula. Surgical management of Mirizzi syndrome is complicated by the presence of inflamed tissue around the hepatic pedicle, making it impossible to distinguish between the main bile duct and the gallbladder. The surgeon's first task is to perform subtotal cholecystotomy(from the fundus of the gallbladder to the neck) without trying to locate the cystic duct. In a second step, the gallstones are extracted and the main bile duct is then repaired. In most cases, a T-tube is used to drain the main bile duct, and abdominal drainage is left in place(in case a bile fistula forms). This study concluded that preoperative drainage of the main bile duct in the treatment of Mirizzi syndrome types II and III is feasible and might help to decrease the postoperative complication rate. | Fabien Le Roux Charles Sabbagh Brice Robert Thierry Yzet Laurent Dugue Jean-Paul Joly Jean-Marc Regimbeau | 2015 | Hepatobiliary & Pancreatic Diseases International2015，14，5： | 6 |
| 8 | Temporomandibular joint damage in K/BxN arthritic mice显示文摘Rheumatoid arthritis(RA) is an autoimmune disease affecting 1% of the world population and is characterized by chronic inflammation of the joints sometimes accompanied by extra-articular manifestations. K/Bx N mice, originally described in 1996 as a model of polyarthritis, exhibit knee joint alterations. The aim of this study was to describe temporomandibular joint(TMJ)inflammation and damage in these mice. We used relevant imaging modalities, such as micro-magnetic resonance imaging(μMRI)and micro-computed tomography(μCT), as well as histology and immunofluorescence techniques to detect TMJ alterations in this mouse model. Histology and immunofluorescence for Col-I, Col-II, and aggrecan showed cartilage damage in the TMJ of K/Bx N animals, which was also evidenced by μCT but was less pronounced than that seen in the knee joints. μMRI observations suggested an increased volume of the upper articular cavity, an indicator of an inflammatory process. Fibroblast-like synoviocytes(FLSs)isolated from the TMJ of K/Bx N mice secreted inflammatory cytokines(IL-6 and IL-1β) and expressed degradative mediators such as matrix metalloproteinases(MMPs). K/Bx N mice represent an attractive model for describing and investigating spontaneous damage to the TMJ, a painful disorder in humans with an etiology that is still poorly understood. | Sabine Kuchler-Bopp Alexandre Mariotte Marion Strub Chrystelle Po Aurore De Cauwer Georg Schulz Xavier Van Bellinghen Florence Fioretti Francois Clauss Philippe Georgel Nadia Benkirane-Jessel Fabien Bornert | 2020 | International Journal of Oral Science2020，12，1： | 6 |
| 9 | Hepatitis B Virus Resistance to Nucleos(t)ide Analogues显示文摘 | Fabien Zoulim Stephen Locarnini | 2009 | Gastroenterology2009，，5： | 6 |
| 10 | 活性染料竭染染色的配伍性研究显示文摘活性染料的拼色染色以其可靠的染色结果而得到广泛应用。本文给出了一种直观、简便的可视化新方法 ,为活性染料的应用提供了可靠的参考依据。选用MCT MCT双活性基染料 ,按一定的工艺处方染纯棉织物 ,作其上染和固色曲线 ,并测试具有代表性的染色特征值使其可视化 ,以选择理想的三原色组合进行拼色染色 ,并与染料生产厂家推荐的其他类型三原色进行比较。 | 姜秀增 朱泉 Fabien Roland | 2003 | 印染2003，29，2： | 6 |
| 11 | Branched alkanes with quaternary carbon atoms in Chinese soils: Potential environmental implications显示文摘Lipids extracted from 26 modern soils collected from different climate zones in China and Mongolia are analyzed using gas chromatography- mass spectrometry. These extracts contain pseudo- homologous families of 5,5-diethylalkanes (5,5- DEAs), 6,6-diethylalkanes, 5-butyl-5-ethylalkanes and 6-butyl-6-ethylalkanes, which are first detected in modern soils. All these pseudohomologous series display exclusively odd or exclusively even carbon numbers, clearly indicating a biosynthetic origin, and their carbon number distributions generally covary. The distributions of 5,5-DEAs exhibit strong regional variations, correlated with the spatial distributions of climate and vegetation. The lower molecular weight 5,5-DEAs, maximizing at C21 or C23, dominate in southeast and southwest China samples, while the higher molecular weight 5,5-DEAs with a mode at C29 dominate in cold, arid northwest China and Mongolia. The results demonstrate that the distribution of 5,5-DEAs can serve as a new independent proxy, indicating variations in soil ecosystems and climates, just like the well-known proxy of n-C15—21/n-C22—33 ratios. | BAI Yan FANG Xiaomin WANG Yongli Fabien Kenig CHEN Xiuling WANG Youxiao | 2006 | Chinese Science Bulletin2006，51，9： | 6 |
| 12 | Exchange-correlation functionals for band gaps of solids:benchmark,reparametrization and machine learning显示文摘We conducted a large-scale density-functional theory study on the influence of the exchange-correlation functional in the calculation of electronic band gaps of solids.First,we use the large materials data set that we have recently proposed to benchmark 21 different functionals,with a particular focus on approximations of the meta-generalized-gradient family.Combining these data with the results for 12 functionals in our previous work,we can analyze in detail the characteristics of each approximation and identify its strong and/or weak points.Beside confirming that mBJ,HLE16 and HSE06 are the most accurate functionals for band gap calculations,we reveal several other interesting functionals,chief among which are the local Slater potential approximation,the GGA AK13LDA,and the meta-GGAs HLE17 and TASK.We also compare the computational efficiency of these different approximations.Relying on these data,we investigate the potential for improvement of a promising subset of functionals by varying their internal parameters.The identified optimal parameters yield a family of functionals fitted for the calculation of band gaps.Finally,we demonstrate how to train machine learning models for accurate band gap prediction,using as input structural and composition data,as well as approximate band gaps obtained from density-functional theory. | Pedro Borlido Jonathan Schmidt Ahmad W.Huran Fabien Tran Miguel A.L.Marques Silvana Botti | 2020 | npj Computational Materials2020，，1： | 6 |
| 13 | 镧助剂对模拟生物沼气重整制备合成气中Ni/SBA-15催化剂结构和性能的影响显示文摘以介孔分子筛SBA-15为载体,采用浸渍法制备了镍质量分数(w)为12.5%,并且分别添加质量分数(w)为2.5%的镧、铈、镁、钙、锶等助剂的系列Ni基催化剂.以CH4/CO2体积比为2∶1的模拟生物沼气和适量氧气作为原料气,在常压固定床反应器上评价了催化剂对模拟生物沼气重整制合成气的反应性能.采用X射线粉末衍射(XRD)、N2吸附/脱附、透射电子显微镜(TEM)、X射线光电子能谱(XPS)及H2程序升温还原(H2-TPR)等对催化剂的结构进行了表征.催化活性评价显示,添加镧助剂的2.5%La/12.5%Ni/SBA-15催化剂比添加铈、镁、钙、锶等助剂的催化剂具有更高的催化活性,并且具有很好的稳定性.因此,文中着重研究了镧助剂对催化剂结构和模拟生物沼气重整制合成气的反应性能的影响.结果表明,镧能明显提高Ni/SBA-15催化剂的表面镍含量,同时还具有很好的抗积炭作用,在850℃的温度下反应820h没有发现积炭生成,这些可能是提高催化剂性能和稳定性的重要因素. | 郎宝 李秀金 季生福 FABIEN Habimana 李成岳 | 2009 | 物理化学学报2009，25，8： | 5 |
| 14 | 用于GNSS的SpT星载原子钟及时间系统介绍显示文摘研究了空间铷钟和被动型氢钟的地面批量和寿命试验测试结果,以及卫星在轨试验所达到的最新性能结果。基于这些星载钟的试验结果,对全球卫星导航系统的地面时间站的关键设备及其相关算法作了简要描述,并介绍了一种新颖的在轨技术,即从星载原子钟组(ONCLE)直接产生高度稳健的时间频率信号。 | 王庆华 Droz Fabien Rochat Pascal | 2011 | 武汉大学学报(信息科学版)2011，36，10： | 5 |
| 15 | 现代土壤中含季碳支链烷烃的分布特征及环境意义显示文摘利用色谱质谱(GC-MS)技术对中国及蒙古国不同气候区的26个深约20cm表层土壤中的类脂物进行了系统分析.讨论了在现代土壤中首次发现的含季碳的支链烷烃系列化合物,如5,5-二乙基烷烃、6,6-二乙基烷烃、5-丁基,5-乙基烷烃和6-丁基,6-乙基烷烃等.它们每个系列都只有奇碳或偶碳分布,明显指示生物来源,其碳数分布具有协变性.其中5,5-二乙基烷烃的分布同正构烷烃一样具有规律性的空间变化趋势,与气候和植被的空间分布有很好的一致关系.在湿热的东南和西南地区其低碳数组分占优势,主峰基本上为C21或C23;而在寒冷干旱的西北地区及蒙古国高碳数组分丰度较高,主峰基本上为C29.研究结果证明:和正构烷烃的ΣC?21/ΣC+21一样,5,5-二乙基烷烃的高低碳数分布优势作为一个新的独立指标,可以敏感地指示土壤生态和气候的变化. | 白艳 方小敏 王永莉 Fabien Kenig 陈秀玲 王有孝 | 2006 | 科学通报2006，51，4： | 5 |
| 16 | Effect of Cu promoter on Ni-based SBA-15 catalysts for partial oxidation of methane to syngas显示文摘A series of Ni/SBA-15 catalysts with 5wt% to 15wt% Ni content as well as a series of 12.5%Ni/Cu/SBA-15 catalysts with 1% to 10% copper content were prepared by the impregnation method. The catalytic performance for partial oxidation of methane was investigated in a continuous flow microreactor under atmospheric pressure. The textural and chemical properties of the catalysts were characterized by XRD,TEM,BET and H 2-TPR techniques. The results indicated that the catalysts modified with Cu promoter showed better performance than those without modification. For the 12.5%Ni/2.5%/Cu/SBA-15 catalyst,at 850 C the conversion of CH 4 reached 97.9% and the selectivity of CO and H 2 reached 98.0% and 96.0%,respectively. In XRD patterns of the Ni/Cu/SBA-15 catalyst with 7.5 to 10% Cu contents there were CuO characteristic peaks beside NiO characteristic peaks. The mesoporous structure of SBA-15 was retained in all of the catalysts. TPR analysis of the catalysts revealed that a strong interaction between Ni,Cu promoter and SBA-15 support may be existed. This interaction enhanced significantly the redox properties of the catalysts resulting in the higher catalytic activity. | Fabien Habimana Xiujin Li Shengfu Ji Bao Lang Daoan Sun Chengyue Li | 2009 | Journal of Natural Gas Chemistry2009，18，4： | 4 |
| 17 | 蛋鸡营养对鸡蛋品质的影响显示文摘鸡蛋品质是影响鸡蛋产业内所有环节收益的重要因素。孵化场、鸡蛋生产者和鸡蛋加工厂对鸡蛋品质下的定义不尽相同,但鸡蛋品质的重要因素包括蛋壳品质(强度和清洁度)、鸡蛋的营养成分、鸡蛋大小以及卵黄膜强度。所有鸡蛋品质成分都涉及营养因素。已有报道,许多营养因素会影响蛋壳品质。 | 毛慧 Fabien Galea | 2014 | 国外畜牧学(猪与禽)2014，0，5： | 4 |
| 18 | Focus on intracytoplasmic morphologically selected sperm injection (IMSI). a mini-review显示文摘Intracytoplasmic 精子注射(ICSI ) 是在坏分子不孕的许多情况中的推荐治疗。几研究表明了在最佳的精子形态学和积极 ICSI 结果之间的积极关联。事实上,有头的严重畸形的精子很好被记录与低使肥沃,培植和怀孕率被联系。然而,作为 ‘ 被分类的一个精子;由在低放大的显微镜的观察的 normal' 能包含损害使肥沃过程和胚胎的开发的 ultrastructural 缺点。intracytoplasmic 词法上选择了注射(IMSI ) 过程改变了的精子对注射合适的一个精子应该显得怎么样的感觉。精子选择在 × 被执行; 6000 放大,允许改进了对精子原子核的评价。当前,标准化了临床的指示因为 IMSI 正在缺乏,候选人在他们的病历或精子暂停的小心的分析的根据上被选择。进一步未来的使随机化的研究被需要在病人的特定的组证实 IMSI 的优点。除了提供 IMSI 过程的简短概述,这研究试图考察文学,它解释理论基础和这种技术的临床的结果。IMSI 与改进培植和临床的怀孕被联系的几报告表演象更低的流产率一样评价什么时候与 ICSI 相比。尽管在精子的反常原子核形状,增加的 DNA 破碎和否定实验室和临床的结果之间的可能的关联长被调查了,结果正在冲突。 | Giuseppe Lo Monte Fabien Murisier Isabella Piva Marc Germond Roberto Marci | 2013 | Asian Journal of Andrology2013，15，5： | 3 |
| 19 | Hepatitis B virus genetic variability and evolution显示文摘 | Alan Kay Fabien Zoulim | 2007 | Virus Research2007，，2： | 3 |
| 20 | Effect of MgO promoter on Ni-based SBA-15 catalysts for combined steam and carbon dioxide reforming of methane显示文摘A series of Ni/SBA-15 catalysts with Ni contents ranging from 5 wt% to 15 wt%, as well as another series of 10%Ni/MgO/SBA-15 catalysts, in which the range of the MgO content was from 1 wt% to 7 wt%, were prepared, and their catalytic performances for the reaction of combined steam and carbon dioxide reforming of methane were investigated in a continuous flow microreactor. The structures of the catalysts were characterized using the XRD, H2-TPR and CO2-TPD techniques. The results indicated that the CO selectivity for this reaction was very close to 100%, and the H2/CO ratio of the product gas could be controlled by changing the H2O/CO2 molar ratio of the feed gas. The simultaneous and plentiful existing of steam and CO2 had a significant influence on the catalytic performance of the 10%Ni/SBA-15 catalyst without modification. After reacting at 850 °C for 120 h over this catalyst, the CH4 conversion dropped from 98% to 85%, and the CO2 conversion decreased from 86% to 53%. However, the 10%Ni/3%MgO/SBA-15 catalyst exhibited a much better catalytic performance, and after reacting for 620 h, the CO2 conversion over this catalyst dropped from 92% to around 77%, while the CH4 conversion was not decreased. Oxidation of the Ni0 species as well as carbon deposition during the reaction were the main reasons for the deactivation of the catalyst without modification. On the other hand, modification by the MgO promoter improved the dispersion of the Ni0 species, and enhanced the CO2 adsorption affinity which in turn depressed the occurring of carbon deposition, and thus retarded the deactivation process. | Bingyao Huang Xiujin Li Shengfu Ji Bao Lang Fabien Habimana Chengyue Li | 2008 | Journal of Natural Gas Chemistry2008，17，3： | 3 |
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