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| 1 | 胎盘生长因子和色素上皮衍生因子在非小细胞肺癌中的表达及其与预后的关系显示文摘目的探讨胎盘生长因子(PlGF)和色素上皮衍生因子(PEDF)在非小细胞肺癌中的表达特点及与肿瘤新生血管形成的关系,了解这两种因子在判断非小细胞肺癌患者预后中的意义。方法采用超敏过氧化酶免疫组织化学法检测手术切除的81例非小细胞肺癌标本中PlGF和PEDF的表达水平,并利用CD31染色进行微血管计数,统计分析这两个因子与微血管密度(MVD)的关系,及其在非小细胞肺癌患者预后中的意义。结果PlGF和PEDF在81例非小细胞肺癌患者中的阳性率分别为43·2%(35例)和53·1%(43例)。PlGF阳性表达与高值MVD相关;PEDF阳性表达与低值MVD相关;PlGF和PEDF的表达状况存在负相关。单因素和多因素分析均提示PlGF是非小细胞癌患者独立的预后指标。结论PlGF和PEDF均可在非小细胞肺癌组织中表达,二者在血管生成的过程中具有相互拮抗的作用。与PEDF相比,PlGF在非小细胞肺癌发展以及预测患者预后方面具有更大的作用。 | 张力建 陈晋峰 陆爱萍 柯杨 Robert E Mansel Wen G Jiang | 2005 | 中华医学杂志2005，85，47： | 10 |
| 2 | Effects of intermittent fasting on health markers in those with type 2 diabetes:A pilot study显示文摘AIM To determine the short-term biochemical effects and clinical tolerability of intermittent fasting(IF) in adults with type 2 diabetes mellitus(T2DM).METHODS We describe a three-phase observational study(baseline 2 wk, intervention 2 wk, follow-up 2 wk) designed to determine the clinical, biochemical, and tolerability of IF in community-dwelling volunteer adults with T2DM. Biochemical, anthropometric, and physical activity measurements(using the Yale Physical Activity Survey) were taken at the end of each phase. Participants reported morning, afternoon and evening self-monitored blood glucose(SMBG) and fasting duration on a daily basis throughout all study stages, in addition to completing a remote food photography diary three times within each study phase. Fasting blood samples were collected on the final days of each study phase. RESULTS At baseline, the ten participants had a confirmed diagnosis of T2DM and were all taking metformin, and on average were obese [mean body mass index(BMI) 36.90 kg/m^2]. We report here that a short-term periodof IF in a small group of individuals with T2DM led to significant group decreases in weight(-1.395 kg, P = 0.009), BMI(-0.517, P = 0.013), and at-target morning glucose(SMBG). Although not a study requirement, all participants preferentially chose eating hours starting in the midafternoon. There was a significant increase(P < 0.001) in daily hours fasted in the IF phase(+5.22 h), although few attained the 18-20 h fasting goal(mean 16.82 ± 1.18). The increased fasting duration improved at-goal(< 7.0 mmol/L) morning SMBG to 34.1%, from a baseline of 13.8%. Ordinal Logistic Regression models revealed a positive relationship between the increase in hours fasted and fasting glucose reaching target values(χ~2 likelihood ratio = 8.36, P = 0.004) but not for afternoon or evening SMBG(all P > 0.1). Postprandial SMBGs were also improved during the IF phase, with 60.5% readings below 9.05 mmol/L, compared to 52.6% at baseline, and with less glucose variation. Neither insulin resistance(HOMAIR), nor inflammatory markers(C-reactive protein) normalized during the IF phase. IF led to an overall spontaneous decrease in caloric intake as measured by food photography(Remote Food Photography Method). The data demonstrated discernable trends during IF for lower energy, carbohydrate, and fat intake when compared to baseline. Physical activity, collected by a standardized measurement tool(Yale Physical Activity Survey), increased during the intervention phase and subsequently decreased in the follow-up phase. IF was well tolerated in the majority of individuals with 6/10 participants stating they would continue with the IF regimen after the completion of the study, in a full or modified capacity(i.e., every other day or reduced fasting hours).CONCLUSION The results from this pilot study indicate that shortterm daily IF may be a safe, tolerable, dietary intervention in T2DM patients that may improve key outcomes including body weight, fasting glucose and postprandial variability. These findings should be viewed as exploratory, and a larger, longer study is necessary to corroborate these findings. | Terra G Arnason Matthew W Bowen Kerry D Mansell | 2017 | World Journal of Diabetes2017，8，4： | 7 |
| 3 | Diagnostic tools in male infertility--the question of sperm dysfunction显示文摘精子机能障碍是不孕的最最普通的原因,还是显著的的,是那,没有一个人能服或把 vitro 加在一起到他的精子改进富饶的药。为在这个区域的进步的缺乏的一个原因是我们成熟 spermatazoon 的细胞、分子的活动方式的理解是有限的。然而,在最后几年,在我们的知识库并且在探讨新方法诊断精子机能障碍有可观的进步。我们考察这块地的当前的状态并且为进一步的开发提供卓见。我们结束那:在那里的(i) 是从用一个基本精液评价识别 / 分类人的各种各样的人口的更多的研究要增加的很少,在一个努力在保证分析以一个适当高质量的方法被执行被要求的地方;(ii ) 工艺的开发是可能的带精子功能更近测试到实现进临床的小径的现实。在做这,这些试金一定是柔韧的,便宜(或更适当地称为合算) ,易用、临床上有用;并且(iii ) 临床的必要性,例如,为注射识别高质量的精子的需要向前正在驾驶基本研究。这是一令人激动的时间是 andrologist 并且,多半多产的。 | Christopher LR Barratt Steven Mansell Catherine Beaton Steve Tardif Senga K Oxenham | 2011 | Asian Journal of Andrology2011，13，1： | 5 |
| 4 | Current cancer therapies and their influence on glucose control显示文摘This review focuses on the development of hyperglycemia arising from widely used cancer therapies spanning four drug classes.These groups of medications were selected due to their significant association with new onset hyperglycemia,or of potentially severe clinical consequences when present.These classes include glucocorticoids that are frequently used in addition to chemotherapy treatments,and the antimetabolite class of 5-fluorouracil-related drugs.Both of these classes have been in use in cancer therapy since the 1950s.Also considered are the phosphatidyl inositol-3-kinase(PI3K)/AKT/mammalian target of rapamycin(mTOR)-inhibitors that provide cancer response advantages by disrupting cell growth,proliferation and survival signaling pathways,and have been in clinical use as early as 2007.The final class to be reviewed are the monoclonal antibodies selected to function as immune checkpoint inhibitors(ICIs).These were first used in 2011 for advanced melanoma and are rapidly becoming widely utilized in many solid tumors.For each drug class,the literature has been reviewed to answer relevant questions about these medications related specifically to the characteristics of the hyperglycemia that develops with use.The incidence of new glucose elevations in euglycemic individuals,as well as glycemic changes in those with established diabetes has been considered,as has the expected onset of hyperglycemia from their first use.This comparison emphasizes that some classes exhibit very immediate impacts on glucose levels,whereas other classes can have lengthy delays of up to 1 year.A comparison of the spectrum of severity of hyperglycemic consequences stresses that the appearance of diabetic ketoacidosis is rare for all classes except for the ICIs.There are distinct differences in the reversibility of glucose elevations after treatment is stopped,as the mTOR inhibitors and ICI classes have persistent hyperglycemia long term.These four highlighted drug categories differ in their underlying mechanisms driving hyperglycemia,with clinical presentations ranging from potent yet transient insulin resistant states[type 2 diabetes mellitus(T2DM)-like]to rare permanent insulin-deficient causes of hyperglycemia.Knowledge of the relative incidence of new onset hyperglycemia and the underlying causes are critical to appreciate how and when to best screen and treat patients taking any of these cancer drug therapies. | Carly Yim Kerry Mansell Nassrein Hussein Terra Arnason | 2021 | World Journal of Diabetes2021，12，7： | 5 |
| 5 | lux基因发光菌的研究及其在食品科学中的应用显示文摘本文论述了细菌发光lux基因的研究及其在食品科学,特别是在乳品科学研究和食品工业中的应用,详细探讨了生物发光的化学机理、遗传基础及研究进展。同时,还重点探讨了lux基因发光乳球菌及影响其发光亮度(RLU)的主要因素和最新研究结果。另外,还探讨了带有lux基因噬菌体的构建原理和方法及在食品科学中的应用。 | 蒋爱民 魏素红 Wang Haifeng Griffiths Mansel W 杨公明 李元瑞 | 2003 | 中国食品学报2003，3，2： | 5 |
| 6 | 荧光实时定量PCR检测NSCLC中PEDF基因表达状态的研究显示文摘背景与目的SYBRGreenⅠ是一种较为常用的非探针类定量PCR的方法,其主要优点在于操作过程简单,结果具有一定特异性。本研究的目的是建立检测色素上皮衍生因子(pigmentepitheliumderivedfactor,PEDF)mRNA的SYBRGreenⅠ实时定量PCR的方法,了解肺癌组织及其远癌肺组织中PEDF的表达水平,研究肺癌组织中PEDF的表达水平与各种临床病理特征之间的关系。方法利用RTPCR的方法扩增并纯化PEDF以及内对照GAPDHmRNA的目的片段,倍比稀释后作为定量模板。利用相对定量的方法,检测21例肺癌及相应远癌肺组织中PEDFmRNA相对于GAPDHmRNA的表达量,进行相对定量分析。结果21例肺癌组织及相应的远癌肺组织中均可检出PEDF的表达,肺癌组织中PEDF的相对表达量为0.5505±0.3590(0.11~1.11),远癌肺组织中为0.7219±0.2582(0.29~1.31)(P=0.024)。早期(Ⅰ~Ⅱ期)肺癌患者和肿瘤较小时(T1)PEDF的表达量显著高于晚期(Ⅲ~Ⅳ期,P=0.010)和肿瘤较大者(T2~4,P=0.007)。结论所建立的SYBRGreenⅠ实时定量PCR方法可以成功地检测PEDF基因的表达量。初步检测结果显示PEDF可能是一种肺癌发生发展过程中的保护因素。 | 张力建 陈晋峰 柯杨 Robert E Mansel Wen G Jiang | 2006 | 中国肺癌杂志2006，9，2： | 4 |
| 7 | Differential expression of the CCN family member WISP-1, WISP-2 andWISP-3 in human colorectal cancer and the prognostic implications显示文摘 | Simon Davies Mansel Davies Andrew Sanders Chris Parr Jared Torkington Wen Jiang | 2010 | International Journal of Oncology2010，，5： | 3 |
| 8 | The Hepatitis B e antigen (HBeAg) targets and suppresses activation of the Toll-like receptor signaling pathway显示文摘 | Tali Lang Camden Lo Narelle Skinner Stephen Locarnini Kumar Visvanathan Ashley Mansell | 2011 | Journal of Hepatology2011，，4： | 3 |
| 9 | Suppressor of cytokine signaling 1 negatively regulates Toll-like receptor signaling by mediating Mal degradation显示文摘 | Mansell A Smith R Doyle S L | 2006 | Nat Immunol2006，7，2： | 1 |
| 10 | European studies on breast lymphatic mapping显示文摘 | Mansel RE Goyal A | 2004 | Semin Oncol2004，31，3： | 1 |
| 11 | How mammillary fistulas should be managed显示文摘 | Hanavadi S Pereira G Mansel R E | 2005 | Breast J2005，11，2： | 1 |
| 12 | Mutiplex polymerase chain reaction assay for simultaneous detection of Staphylococcus aureus and Streptococcal causes of bovine mastitis 显示文摘 | PHUEKTES P MANSELL P D BROWING G F | 2001 | Journal of Dairy Science2001，84，5： | 1 |
| 13 | Benign breast disorders 显示文摘 | Santen RJ Mansel R | 2005 | N Engl J Med2005，353，3： | 1 |
| 14 | Hepatocyte growth factor disrupts tight junctions in human breast cancer cells显示文摘 | Martin TA Watkins G Mansel RE | 2004 | Cell Biol Int2004，28，5： | 1 |
| 15 | External fixation or arteriogram in bleeding pelvic fracture: initial therapy guided by markers of arterial hemorrhage 显示文摘 | Miller PR Moore PS Mansell E | 2003 | J Trauma2003，54，3： | 1 |
| 16 | The effects of interleukin-7 on the lymphangiogenic properties of human endothelial cells显示文摘 | Al-Rawi M A Watkins G Mansel R E | 2005 | Int J Oncol2005，27，3： | 1 |
| 17 | Phosphate movement in columns of sandy soil from a wastewaterirrigated site显示文摘 | MANSELL R S MCKENNA P J FLAIG E | 1985 | Soil Science1985，140，1： | 1 |
| 18 | Hepatocyte growth factor modulates vascular endothelial cadherin expression in human endothelial cells显示文摘 | MARTIN T A MANSEL R JIANG W G | 2001 | Clin Cancer Res2001，7，： | 1 |
| 19 | Suppressor of cytokine signaling 1 negatively regulates Toll-like receptor signaling by mediating Mal degradation显示文摘 | Mansell A Smith R Doyle SL | 2006 | Nat Immunol2006，7，2： | 1 |
| 20 | Molecular and cellular mechanisms of lymphangiogenesis 显示文摘 | J AI Rawi MA Mansel RE Jiang WG | 2005 | Euro J Surg Oncol2005，31，2： | 1 |
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