|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Intestinal barrier in inflammatory bowel disease显示文摘A complex mucosal barrier protects as the first line of defense the surface of the healthy intestinal tract from adhesion and invasion by luminal microorganisms.In this review,we provide an overview about the major components of this protective system as for example an intact epithelium,the synthesis of various antimicrobial peptides(AMPs)and the formation of the mucus layer.We highlight the crucial importance of their correct functioning for the maintenance of a proper intestinal function and the prevention of dysbiosis and disease.Barrier disturbances including a defective production of AMPs,alterations in thickness or composition of the intestinal mucus layer,alterations of pattern-recognition receptors,defects in the process of autophagy as well as unresolved endoplasmic reticulum stress result in an inadequate host protection and are thought to play a crucial role in the pathogenesis of the inflammatory bowel diseases Crohn’s disease and ulcerative colitis. | Lena Antoni Sabine Nuding Jan Wehkamp Eduard F Stange | 2014 | World Journal of Gastroenterology2014，20，5： | 33 |
| 2 | Extraintestinal manifestations and complications in inflammatory bowel diseases显示文摘Crohn 的疾病(CD ) 和 ulcerative (UC ) 是经常包含胃肠道的除那些以外的机关的长期的煽动性的肠疾病(IBD ) 。这些非肠的爱被称为额外的肠的症状。把煽动性的肠疾病的真额外的肠的表明区分开来与第二等的额外的肠的复杂并发症,由治疗的营养不良,慢性炎或副作用引起了,可能困难。这评论在煽动性的肠疾病专注于频率,临床的演讲和额外的肠的症状的治疗学的含意。如果可能,肠的表明被区分开来与额外的肠的复杂并发症。特殊注意被给参与的更最近描述的地点;即中枢神经系统的 thromboembolic 事件,骨质疏松症,肺的参与和爱。 | Katja S Rothfuss Eduard F Stange Klaus R Herrlinger | 2006 | World Journal of Gastroenterology2006，12，30： | 26 |
| 3 | From intestinal stem cells to inflammatory bowel diseases显示文摘The pathogenesis of both entities of inflammatory bowel disease (IBD), namely Crohn's disease (CD) and ulcerative colitis (UC), is still complex and under investigation. The importance of the microbial flora in developing IBD is beyond debate. In the last few years, the focus has changed from adaptive towards innate immunity. Crohn's ileitis is associated with a deficiency of the antimicrobial shield, as shown by a reduced expression and secretion of the Paneth cell defensin HD5 and HD6, which is related to a Paneth cell differentiation defect mediated by a diminished expression of the Wnt transcription factor TCF4. In UC, the protective mucus layer, acting as a physical and chemical barrier between the gut epithelium and the luminal microbes, is thin- ner and in part denuded as compared to controls. This could be caused by a missing induction of the goblet cell differentiation factors Hath1 and KLF4 leading to immature goblet cells. This defective Paneth and goblet cell differentiation in Crohn's ileitis and UC may enablethe luminal microbes to invade the mucosa and trigger the inflammation. The exact molecular mechanisms behind ileal CD and also UC must be further clarified, but these observations could give rise to new therapeutic strategies based on a stimulation of the protective innate immune system. | Michael Gersemann Eduard Friedrich Stange Jan Wehkamp | 2011 | World Journal of Gastroenterology2011，17，27： | 19 |
| 4 | Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses显示文摘 | Andreas Stang | 2010 | European Journal of Epidemiology2010，，9： | 14 |
| 5 | The second European evidence-based Consensus on the diagnosis and management of Crohn’s disease: Definitions and diagnosis显示文摘 | Gert Van Assche Axel Dignass Julian Panes Laurent Beaugerie John Karagiannis Mathieu Allez Thomas Ochsenkühn Tim Orchard Gerhard Rogler Edouard Louis Limas Kupcinskas Gerassimos Mantzaris Simon Travis Eduard Stange | 2009 | Journal of Crohn’s and Colitis2009，，1： | 10 |
| 6 | 应用烧结金属过滤介质的过滤技术进展显示文摘介绍了使用烧结金属过滤介质的过滤技术的进展情况。内容涉及过滤器的设计及其性能测试,介质选择以及烧结金属过滤介质过滤器的应用实例。 | Kenneth L.Rubow Louise Stange Billy Huang | 2005 | 产业用纺织品2005，23，9： | 8 |
| 7 | Crohn’s disease-Defect in innate defence显示文摘Crohn’s disease may prinicipally involve the whole gastrointestinal tract. Most commonly, the inflammation occurs in the small intestine and/or in the colon with stable disease location over the years. The pathogenesis of both disease phenotypes is complex, the likely primary defect lies in the innate rather than adaptive immunity, particularly in the chemical antimicrobial barrier of the mucosa. Crohn’s ileitis is associated with a reduced expression of the Wnt signalling pathway transcription factor T-cell factor 4 (TCF4), which is regulating Paneth cell differentiation. As a result, the alpha-defensins and principal Paneth cell products HD5 and HD6 are deficiently expressed in ileal disease, independent of current inflammation. In contrast, Crohn’s colitis is typically associated with an impaired induction of the beta-defensins HBD2 and HBD3 caused by fewer gene copy numbers in the gene locus of the beta-defensins on chromosome 8. This ileal and colonic defect in innate defence mediated by a deficiency of the protective alpha- and beta- defensins may enable the luminal microbes to invade the mucosa and trigger the inflammation. A better understanding of the exact molecular mechanisms behind ileal and colonic Crohn’s disease may give rise to new therapeutic strategies based on a stimulation of the protective innate immune system. | Michael Gersemann Jan Wehkamp Klaus Fellermann Eduard Friedrich Stange | 2008 | World Journal of Gastroenterology2008，14，36： | 7 |
| 8 | Second European evidence-based consensus on the diagnosis and management of ulcerative colitis Part 2: Current management显示文摘 | Axel Dignass James O. Lindsay Andreas Sturm Alastair Windsor Jean-Frederic Colombel Mathieu Allez Gert D’Haens André D’Hoore Gerassimos Mantzaris Gottfried Novacek Tom ?resland Walter Reinisch Miquel Sans Eduard Stange Severine Vermeire Simon Travis Gert | 2012 | Journal of Crohn’s and Colitis2012，，10： | 4 |
| 9 | Resection of colorectal liver metastases显示文摘 | Johannes Scheele M.D. Richard Stang M.D. Annelore Altendorf-Hofmann M.D. Martin Paul M.D | 1995 | World Journal of Surgery1995，，1： | 4 |
| 10 | European evidence-based Consensus on the prevention, diagnosis and management of opportunistic infections in inflammatory bowel disease显示文摘 | J.F. Rahier S. Ben-Horin Y. Chowers C. Conlon P. De Munter G. D’Haens E. Domènech R. Eliakim A. Eser J. Frater M. Gassull M. Giladi A. Kaser M. Lémann T. Moreels A. Moschen R. Pollok W. Reinisch M. Schunter E.F. Stange H. Tilg G. Van Assche N. Viget B. Vu | 2009 | Journal of Crohn’s and Colitis2009，，2： | 3 |
| 11 | 一种新型的基于四电极结构的生物电阻测量方法显示文摘提出了一种成本低而且精度高的人体阻抗测量系统。测量电路采用四电极结构,使每个电极模拟人体皮肤电阻,分别与人体的赤足接触,利用单片机产生50 kHz的正弦波信号,经过四电极以及与其接触的人体后形成电压降,再经过信号放大电路处理,最终实现人体阻抗的测量。系统有效降低了产品的成本,克服了接触阻抗以及空间电磁波的干扰,试验结果与理论值证明了测量方法具有高精度、高稳定性和准确性。 | 王家海 张志征 Pedro Stange | 2010 | 机电一体化2010，16，7： | 3 |
| 12 | Detection of Circulating Pancreas Epithelial Cells in Patients with Pancreatic Cystic Lesions显示文摘 | Andrew D. Rhim Fredrik I. Thege Steven M. Santana Timothy B. Lannin Trisha N. Saha Shannon Tsai Lara R. Maggs Michael L. Kochman Gregory G. Ginsberg John G. Lieb Vinay Chandrasekhara Jeffrey A. Drebin Nuzhat Ahmad Yu- Xiao Yang Brian J. Kirby Ben Z. Stang | 2013 | Gastroenterology2013，，： | 3 |
| 13 | Lgr5 +ve Stem Cells Drive Self-Renewal in the Stomach and Build Long-Lived Gastric Units In Vitro显示文摘 | Nick Barker Meritxell Huch Pekka Kujala Marc van de Wetering Hugo J. Snippert Johan H. van Es Toshiro Sato Daniel E. Stange Harry Begthel Maaike van den Born Esther Danenberg Stieneke van den Brink Jeroen Korving Arie Abo Peter J. Peters Nick Wright Richa | 2010 | Cell Stem Cell2010，，1： | 2 |
| 14 | The second European evidence-based Consensus on the diagnosis and management of Crohn’s disease: Current management显示文摘 | A. Dignass G. Van Assche J.O. Lindsay M. Lémann J. S?derholm J.F. Colombel S. Danese A. D’Hoore M. Gassull F. Gomollón D.W. Hommes P. Michetti C. O’Morain T. ?resland A. Windsor E.F. Stange S.P.L. Travis | 2010 | Journal of Crohn’s and Colitis2010，，1： | 2 |
| 15 | 【原创论文】德国东西部睾丸癌后发生第二原发癌的风险关注对侧睾丸癌显示文摘上世纪70年代起以顺铂为基础的化疗使睾丸癌的存活率显著提高。然而,化疗和放疗具有潜在的致癌性。本研究的目的是评估德国睾丸癌存活者患第二原发癌(包括原发组织学类型精原细胞瘤和非精原细胞瘤)的风险。我们确认了德国东部地区(1961-1989年和1996-2008年)癌症登记的16990例睾丸癌和德国西部地区萨尔州(1970.2008年)癌症登记的1401例睾丸癌。我们用标准化发病率(SIRs)和95%N信区间(95%CI)估计第二原发癌的风险。我们将估计的年标准化发病率绘制成图以显示趋势。德国东部1961.1989年观察到301例第二原发癌(SIR:1.9;95%CI:1.7-2.1),1996—2008年观察到159例第二原发癌(SIR:1.7:95%CI:1.4~2.0)。两地癌症登记的对侧睾丸癌增加(SIR:萨尔6.0,德国东部13.9)。与其它地区相比,德国东部精原细胞瘤的SIR增加更为显著。数据分析显示对侧睾丸癌的SIR有稳定的趋势。大多数其它癌症(包括组织学特异性肿瘤)的SIRs的估计精度低,可能与样本量较小有关。睾丸癌患者患第二原发癌尤其是对侧睾丸癌的风险增加,因此应进行严密随访。 | Carsten Rusner Brigitte Streller Christa Stegmaier Pietro Trocchi Oliver Kuss Katherine A McGlynn Britton Traberts Andreas Stang | 2014 | Asian Journal of Andrology2014，16，2： | 2 |
| 16 | Intestinal bacterial translocation in rats with cirrhosis is related to compromised paneth cell antimicrobial host defense显示文摘 | Zora Teltschik Reiner Wiest Julia Beisner Sabine Nuding Claudia Hofmann Juergen Schoelmerich Charles L. Bevins Eduard F. Stange Jan Wehkamp | 2012 | Hepatology2012，，： | 2 |
| 17 | 药物流行病学与电子健康档案数据库显示文摘1前言
自发不良事件报告已成为上市后药品安全信息的主要来源之一。对于通过自发报告鉴别出的具体事件,经常会开展一些有选择的研究以便更加严格地评估药物与事件之问的相互关系。在过去的20年里,通过采用书面或电子形式的数据库等已有的健康档案,大部分这样的研究变得具有可观察性(流行病学)。健康数据库数量的增长致使此类研究不断增加;另外,人们对于电子数据库应用于系统的药物安全警戒活动方面的兴趣也大增。 | Paul E. Stang Hong Qiu Jesse A. Berlin 无 | 2009 | 中国药物警戒2009，6，9： | 2 |
| 18 | European evidence-based Consensus on the management of ulcerative colitis: Current management显示文摘 | S.P.L. Travis E.F. Stange M. Lémann T. ?resland W.A. Bemelman Y. Chowers J.F. Colombel G. D'Haens S. Ghosh P. Marteau W. Kruis N.J.McC. Mortensen F. Penninckx M. Gassull | 2008 | Journal of Crohn’s and Colitis2008，，1： | 2 |
| 19 | Herpes simplex virus colitis complicating ulcerative colitis: A case report and brief review on superinfections显示文摘 | Marco Oliver Schunter Thorsten Walles Peter Fritz Uta Meyding-Lamadé Klaus-Peter Thon Klaus Fellermann Eduard Friedrich Stange Wolfram Lamadé | 2007 | Journal of Crohn’s and Colitis2007，，： | 2 |
| 20 | Comparative transcriptome analysis during early fruit development between three seedy citrus genotypes and their seedless mutants显示文摘Identification of genes with differential transcript abundance(GDTA)in seedless mutants may enhance understanding of seedless citrus development.Transcriptome analysis was conducted at three time points during early fruit development(Phase 1)of three seedy citrus genotypes:Fallglo(Bower citrus hybrid(Citrus reticulata×C.reticulata×C.paradisi)×Temple(C.reticulata×C.sinensis)),grapefruit(C.paradisi),Pineapple sweet orange(C.sinensis),and their seedless mutants.Seed abortion in seedless mutants was observed at 26 days post anthesis(Time point 2).Affymetrix transcriptomic analysis revealed 359 to 1077 probe sets with differential transcript abundance in the comparison of seedless versus seedy fruits for each citrus genotypes and time points.The GDTA identified by 18 microarray probe sets were validated by qPCR.Hierarchical clustering analysis revealed a range of GDTA associated with development,hormone and protein metabolism,all of which may reflect genes associated with seedless fruit development.There were 14,9 and 12 genes found exhibiting similar abundance ratios in all three seedless versus seedy genotype comparisons at time point 1,2 and 3,respectively.Among those genes were genes coding for an aspartic protease and a cysteine protease,which may play important roles in seedless fruit development.New insights into seedless citrus fruit development may contribute to biotech approaches to create seedless cultivars. | Shujian Zhang Qingchun Shi Ute Albrecht Robert G Shatters Jr Ric Stange Greg McCollum Shuo Zhang Chengming Fan Ed Stover | 2017 | Horticulture Research2017，4，1： | 2 |
您所在的机构暂未开通此部分的功能，请联系管理员