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| 1 | 精子DNA损伤的机制和临床应用显示文摘在男性配子各种不同的DNA异常中,DNA断裂最为常见,尤其是在不育症患者中。目前越来越多的研究表明,DNA断裂并不显著影响精子细胞的存活率、活动率、形态以及与卵细胞的结合能力。研究还证明,卵母细胞在一定程度上可以修复受损的DNA,其修复程度依赖于精子细胞DNA的损伤类型和卵母细胞的质量。因此,研究精子DNA断裂(SDF)在自然分娩或辅助生殖技术助孕中对胚胎发育、胚胎着床、妊娠结果、子代健康的影响变得非常重要。至今,针对SDF对生殖的影响的研究极少,且研究报道的结论很不一致。导致这种不一致的原因可能与检测SDF的手段不同、实验设计不同和精液标本选择标准不同有关。因此,目前还不能确定是否将SDF检测拽术砬用于受精评估和ART技术中。这表明,制定SDF检测技术的标准化方法势在必行,另外关于SDF对ART的影响有必要进行进一步的临床研究。 | Lara Tamburrino Sara Marchiani Margarita Montoya Francesco Elia Marino Ilaria Natali Marta Cambi Gianni Forti Elisabetta Baldi Monica Muratori | 2012 | Asian Journal of Andrology2012，14，1： | 16 |
| 2 | Disruption of the Sugar Transporters AtSWEET11 and AtSWEET12 Affects Vascular Development and Freezing Tolerance in Arabidopsis显示文摘Dear Editor, In plants,the transport of sugars from the site of biosynthesis to the site of utilization or storage relies on sugar transporters located in different subcellular compartments and different vascular cell types.The SWEET sugar transporter family is one such class and is represented by 17 members in Arabidopsis.AtSWEET1 was the first plant SWEET transporter to be characterized;it acts as a glucose uniporter in multiple systems (Chen et al.,2010). | Rozenn Le Hir Lara Spinner Patrick A. W. Klemens Dipankar Chakraborti Federica de Marco Francoise Vilaine Nelly Wolff Remi Lemoine Benoit Porcheron Carine Gery Evelyne Teoule Salem Chabout Gregory Mouille H. Ekkehard Neuhaus Sylvie Dinant Catherine Bellini | 2015 | Molecular Plant2015，8，11： | 16 |
| 3 | 人口普查净误差估计中的三系统估计量研究显示文摘本文针对作为当今人口普查质量评估领域主流方法的双系统估计量因受独立性不满足困扰而有偏估计总体人数的问题,明确提出了用三系统估计量替代双系统估计量的研究目标。三系统估计量指的是依据对同一时点上同一总体的人口普查、人口普查之后的质量评估调查和人口行政记录系统这三个不同途径获得的三份人口登记数据来估计总体人数所使用的估计量。为实现上述目标,采用实地调研、数理模型、抽样估计与实证分析相结合的研究方法,以及借鉴国际相关前沿研究成果的研究思路,研究了人口普查质量评估中三系统估计量的构建、三系统估计量应用操作等问题。通过理论与实证研究,得出如下结论:三系统估计量能够有效地摆脱双系统估计量的独立性约束从而解决估计量偏误的问题;将三系统估计量应用于人口普查质量评估,必须科学合理地解决三个人口登记系统定格在统一的标准时点、人口在三个登记系统等概率分层、用人口普查质量评估调查样本对三系统估计量再估计等实践方面的问题;基于Logistic回归模型的三系统估计量可以较好地实现人口等概率分层目标,但尚有较多的理论与实践问题有待研究解决,在这一问题上有着相当大的研究空间。建议我国在未来人口普查质量评估中应用三系统估计量。 | 胡桂华 Robert McCaa Lara Cleveland | 2017 | 统计研究2017，34，6： | 16 |
| 4 | C-type lectin receptor-induced NF-κB activation in innate immune and inflammatory responses显示文摘C 类型 lectin 受体(CLR ) 属于在他们的细胞外的域上包含糖类识别域(CRD ) 和钙绑定地点的蛋白质的一个大家庭。最近的研究显示许多 CLR 例如 Dectin-1, Dectin-2 和 Mincle,作为从感染的微生物认出糖类 ligands 的模式识别受体(PRR ) 工作。在 ligand 绑定之上,这些 CLR 通过他们的自己的 immunoreceptor 导致多重信号 transduction 串联基于酷氨酸的激活主题(ITAM ) 或与象 FcRγ 那样的包含 ITAM 适配器蛋白质交往;。新兴的证据显示导致 CLR 的发信号串联导致原子因素 kappaB 的激活(NF-κ B ) 通过一条 Syk 依赖、 CARD9 依赖的小径的 transcriptional 因素的家庭。NF-κ 的激活; B 在跟随微生物引起的感染和织物损坏的天生的有免疫力、煽动性的回答的正式就职起一个关键作用。在这评论,我们将在 CLR 导致的信号 transduction 小径上总结最近的进步,并且这些 CLR 怎么激活 NF-κ B 并且贡献天生的有免疫力、煽动性的回答。 | Lara M Kingeter Xin Lin | 2012 | Cellular & Molecular Immunology2012，9，2： | 14 |
| 5 | Multispecies probiotic protects gut barrier function in experimental models显示文摘AIM:To investigate the effect of the probiotic combination Lactibiane Tolerance?(LT)on epithelial barrier function in vitro and in vivo.METHODS:The effect of the multispecies probiotic LT was assessed on several models of epithelial barrier function both in vitro(in basal and inflammatory conditions)and in vivo[visceral hypersensitivity induced by chronic stress or by colonic perfusion of a fecal supernatant(FSN)from patients with irritable bowel syndrome(IBS)].In vitro,we measured the permeability of confluent T84 cell monolayers incubated with or without LT by evaluating the paracellular flux of macromolecules,in basal conditions and after stimulation with lipopolysaccharide(LPS)or with conditioned medium of colonic biopsies from IBS patients(IBS-CM).In vivo,male C57/Bl6 mice received orally NaCl or LT for 15 d and were submitted to water avoidance stress(WAS)before evaluating visceral sensitivity by measuring the myoelectrical activity of the abdominal muscle and the paracellular permeability with 51Cr-EDTA.Permeability and sensitivity were also measured after colonic instillation of FSN.Tight-junctions were assessed by immunoblotting and TLR-4 expression was evaluated by immunohistochemistry RESULTS:Incubation of T84 cell monolayers with LT in basal conditions had no significant effect on permeability(P>0.05 vs culture medium).By contrast,addition of LT bacterial bodies(LT)completely prevented the LPS-induced increase in paracellular permeability(P<0.01 vs LPS 10 ng/mL(LPS 10);P<0.01 vs LPS 100ng/mL(LPS 100),P>0.05 vs culture medium).The effect was dose dependent as addition of 109 LT bacterial bodies induced a stronger decrease in absorbance than 106 LT(109 LT+LPS 10:-20.1%±13.4,P<0.01vs LPS 10;106 LT+LPS 10:-11.6%±6.2,P<0.01 vs LPS 10;109 LT+LPS 100:-14.4%±5.5,P<0.01 vs LPS 100;106 LT+LPS 100:-11.6%±7.3,P<0.05 vs LPS 100).Moreover,the increase in paracellular permeability induced by culturing T84 cells with conditioned medium of colonic biopsies from IBS patients(IBS-CM)was completely inhibited in the presence of 109 LT(P<0.01 vs IBS-CM).LT also significantly prevented the epithelial disruption induced by intracolonic infusion of fecal supernatant from IBS patients(P<0.01 vs IBS FSN)or water avoidance stress P<0.01 vs WAS)in C57/Bl6 mice and increased the expression of occludin in vitro and in vivo,as assessed by immnunoblotting.The WAS-induced effect on visceral sensitivity was prevented by LT treatment since values obtained for all steps of colorectal distension were significantly(P<0.01)different from the WAS group.Finally,LT downregulated the response mediated through TLR-4 in vitro(decrease in tumor necrosis factorαsecretion in response to LPS:-65.8%for 109 LT and-52.5%for 106LT,P<0.01 vs LPS)and in vivo(inhibition of WAS induced an increase in TLR-4 expression in the LT treated mice colon,P<0.01 vs WAS).CONCLUSION:The probiotic LT mix prevented the disruption to the epithelial barrier induced by LPS,stress or colonic soluble factors from IBS patients and prevented visceral hypersensitivity. | Mylene Nébot-Vivinus Cherryl Harkat Hanene Bzioueche Christel Cartier Raffaella Plichon-Dainese Lara Moussa Helene Eutamene Dorsa Pishvaie Sophie Holowacz Christian Seyrig Thierry Piche Vassilia Theodorou | 2014 | World Journal of Gastroenterology2014，20，22： | 12 |
| 6 | A randomized controlled trial of imipramine in patients with irritable bowel syndrome显示文摘AIM: To study the efficacy of low-dose imipramine in relieving symptoms associated with the irritable bowel syndrome (IBS). METHODS: A randomized, double-blind trial of 25 mg imipramine vs matched placebo for 12 wk was performed. Doubling the dose was allowed once at week 2 in case of an unsatisfactory early response. Primary efficacy variables were subjective global symptom relief and quality of life (QoL) using SF-36 at week 12. RESULTS: One hundred and seven patients were enrolled by advertisement or referral by general practitioners and 56 (31 imipramine: 25 placebo) completed the 16-wk study. Baseline characteristics were comparable. A high overall dropout rate was noted in the imipramine and placebo arms (47.5% vs 47.9%, P > 0.05), a mean of 25.0 and 37.4 d from enrollment, respectively (P < 0.05). At the end of 12 wk, there was a significant difference in global symptom relief with imipramine over placebo (per-protocol: 80.6% vs48.0%, P = 0.01) and a trend on intent-to-treat (ITT) analysis (42.4% vs 25.0%, P = 0.06). This improvement was evident early and persisted to week 16 (P = 0.024 and 0.053 by per-protocol and ITT analyses, respectively). Mean cumulative and componentspecific SF-36 scores improved in the imipramine group only (per-protocol, P < 0.01). Drug-related adverse events leading to patient dropout were more common in the imipramine group (25.4% vs 12.5%, P > 0.05). CONCLUSION: Imipramine may be effective in the treatment of IBS patients and is associated with improved QoL. Careful patient selection, initiation of a low dose with gradual escalation and monitoring for side effects may result in an improved therapeutic response. | Heitham Abdul-Baki Ihab I El Hajj Lara ElZahabi Cecilio Azar Elie Aoun Assaad Skoury Hani Chaar Ala I Sharara | 2009 | World Journal of Gastroenterology2009，15，29： | 11 |
| 7 | Differential effects of two dominant plant species on community structure and invasibility in an old-field ecosystem显示文摘Aims In this study,we examined the effects of Solidago altissima(hereafter Solidago)and two species in the genus Verbesina,Verbesina virginica and Verbesina occidentalis(hereafter Verbesina),on the structure of an old-field plant community and establishment by an invasive plant species,Lespedeza cuneata(hereafter Lespedeza).Methods We removed Solidago,Verbesina and both Solidago and Verbesina from 4m^(-2)plots in an intact old-field community during two growing seasons.We then quantified the effects of these removals on richness,evenness,diversity and composition of the subdominant plant community.We also measured the total aboveground biomass and the aboveground biomass of the subdominant community.To assess how these removals affected establishment by Lespedeza,we planted 20 seeds in each plot and tracked seedling emergence and survival for one growing season.Important Findings Subdominant community evenness and Shannon diversity were higher in plots from which Solidago and Verbesina were removed relative to control plots.However,there were no effects of dominant species removal on species richness or composition of the subdominant community.Total aboveground biomass was not affected by dominant species removal,suggesting that the community of subdominant species exhibited compensation.In fact,subdominant community biomass was greater when Solidago,but not Verbesina,was removed.Light availability was also greater in plots where Solidago was removed relative to control plots throughout the growing season.In addition,removal of dominant species,in particular Solidago,indirectly reduced the emergence,but not survival,of Lespedeza seedlings by directly promoting subdominant community biomass.Taken together,our results suggest that dominant old-field plant species affect subdominant community structure and indirectly promote establishment by Lespedeza. | Lara Souza Jake F.Weltzin Nathan J.Sanders | 2011 | Journal of Plant Ecology2011，4，3： | 8 |
| 8 | Metastatic colorectal cancer-past,progress and future显示文摘The clinical management of metastatic (stage Ⅳ) colorectal cancer (CRC) is a common challenge faced by surgeons and physicians. The last decade has seen exciting developments in the management of CRC, with significant improvements in prognosis for patients diagnosed with stage Ⅳ disease. Treatment options have expanded from 5-fluorouracil alone to a range of pharmaceutical and interventional therapies, improving survival, and providing a cure in selected cases. Enhanced understanding of the biologic pathways most important in colorectal carcinogenesis has led to a new generation of drugs showing promise in advanced disease. It is hoped that in the near future the treatment paradigm of metastatic CRC will be analogous to that of a chronic illness, rather than a rapidly terminal condition. This overview discusses the epidemiology of advanced CRC and currently available therapeutic options including medical, surgical, ablative and novel modalities in the management of metastatic colorectal cancer. | Kathryn Field Lara Lipton | 2007 | World Journal of Gastroenterology2007，13，28： | 8 |
| 9 | Molecular genetics and genomics of the Rosoideae: state of theart and future perspectives显示文摘The Rosoideae is a subfamily of the Rosaceae that contains a number of species of economic importance,including the soft fruit species strawberry(Fragaria 3ananassa),red(Rubus idaeus)and black(Rubus occidentalis)raspberries,blackberries(Rubus spp.)and one of the most economically important cut flower genera,the roses(Rosa spp.).Molecular genetics and genomics resources for the Rosoideae have developed rapidly over the past two decades,beginning with the development and application of a number of molecular marker types including restriction fragment length polymorphisms,amplified fragment length polymorphisms and microsatellites,and culminating in the recent publication of the genome sequence of the woodland strawberry,Fragaria vesca,and the development of high throughput single nucleotide polymorphism(SNP)-genotyping resources for Fragaria,Rosa and Rubus.These tools have been used to identify genes and other functional elements that control traits of economic importance,to study the evolution of plant genome structure within the subfamily,and are beginning to facilitate genomic-assisted breeding through the development and deployment of markers linked to traits such as aspects of fruit quality,disease resistance and the timing of flowering.In this review,we report on the developments that have been made over the last 20 years in the field of molecular genetics and structural genomics within the Rosoideae,comment on how the knowledge gained will improve the efficiency of cultivar development and discuss how these advances will enhance our understanding of the biological processes determining agronomically important traits in all Rosoideae species. | Sara Longhi Lara Giongo Matteo Buti Nada Surbanovski Roberto Viola Riccardo Velasco Judson AWard Daniel J Sargent | 2014 | Horticulture Research2014，1，1： | 7 |
| 10 | DESIS国际网络:可持续和社会创新的设计显示文摘2010年9月7-10日,Cumulus国际设计院校联盟大会将在上海召开,它在与DESIS国际联盟合作的基础上,将'可持续与社会创新设计'作为会议分主题之一。9月10日,DESIS国际论坛和DESIS-国际联盟会议将在世博会联合国馆举行。9月12日,DESIS国际研讨会'为地方发展的社会创新设计'将在江南大学设计学院举办。9月13-18日,意大利米兰理工大学与江南大学再次联手合作组织主题为'新农村、新城市、新生活'的食品网络设计工作坊。在九月份连续几个以'可持续与社会创新设计'为主题的国际论坛及工作坊即将开展的背景下,本刊编辑部约请了参会的Cumulus国际设计院校联盟以及DESIS国际联盟内的若干重量级嘉宾,为本刊第四期'可持续与社会创新设计'专题提供论文。本专题共8篇文章,分别从DESIS国际网络介绍,以及DESIS组织在中国、法国、中东、巴西等地区推广'可持续与社会创新设计'的具体项目出发,将'可持续与社会创新设计'从理论呼吁走向了设计实践探索,对中国当代可持续与社会创新设计的发展极具启发意义。 | Ezio Manzini Lara Penin Carla Cipolla Mugendi K.M'Rithaa Andrea Mendoza Francois Jegou Adital Ela 张桢 | 2010 | 创意与设计2010，，4： | 7 |
| 11 | Adjuvant therapies for colorectal cancer显示文摘The management of colon and rectal cancer has changed dramatically over the last 25 years. The use of adjuvant therapies has become standard practice in locally advanced (stage Ⅲ and selected stage Ⅱ) colorectal cancer. Improved surgical techniques, chemotherapeutics and radiotherapy are resulting in higher cure rates and the development of agents targeting proliferative and angiogenic pathways offer further promise. Here we explore risk factors for local and distant recurrence after resection of colon and rectal cancer, and the role of adjuvant treatments. Discussion will focus on the evidence base for adjuvant therapies utilised in colorectal cancer, and the treatment of sub-groups such as the elderly and stage Ⅱ disease. The role of adjuvant radiotherapy in rectal cancer in reduction of recurrence will be explored and the role and optimal methods for surveillance post-curative resection with or without adjuvant therapy will also be addressed. | Suzanne Kosmider Lara Lipton | 2007 | World Journal of Gastroenterology2007，13，28： | 7 |
| 12 | Is autoimmune hepatitis a frequent finding among HCV patients with intense interface hepatitis?显示文摘AIM:To evaluate the overlap of autoimmune hepatitis in hepatitis C virus(HCV)-infected patients with intense interface hepatitis.METHODS:Among 1759 patients with hepatitis C submitted to liver biopsy,92(5.2%) presented intense interface hepatitis.These patients were evaluated regarding the presence of antinuclear antibody(ANA),anti-smooth muscle antibody(SMA) and anti-liver/kidney microsomal antibody(LKM-1),levels of γ-globulin and histological findings related to autoimmune hepatitis(plasma cell infiltrate and presence of rosettes).RESULTS:Among patients with hepatitis C and intense interface hepatitis there was a low prevalence of autoantibodies(ANA=12%,SMA=5%,LKM-1=0%) and the median γ-globulin level was within the normal range.Typical histological findings of autoimmune disease were observed in only two cases(2%).After applying the score for diagnosis of autoimmune hepatitis,only one patient was classified with a definitive diagnosis of autoimmune hepatitis.Since overlap with autoimmune hepatitis was not the explanation for the intense necroinflammatory activity in patients with chronic hepatitis C we sought to identify the variables associated with this finding.The presence of intense interface hepatitis was associated with more advanced age,both at the time of infection and at the time of the biopsy,and higher prevalence of blood transfusion and alcohol abuse.CONCLUSION:Although possible,overlap with autoimmune hepatitis is a very rare association in HCV-infected patients with intense interface hepatitis,an unusual presentation which seems to be related to other host variables. | Rosilene G Badiani Vitória Becker Renata M Perez Carla AL Matos Lara B Lemos Valéria P Lanzoni Luis Eduardo C Andrade Alessandra Dellavance Antonio Eduardo B Silva Maria Lucia G Ferraz | 2010 | World Journal of Gastroenterology2010，16，29： | 7 |
| 13 | Institutional experience of PTH evaluation on fine-needle washing after aspiration biopsy to locate hyperfunctioning parathyroid tissue显示文摘Assaying parathyroid hormone(PTH) in the washing liquid after fine-needle aspiration biopsy(FNAB) seems to be a valid approach to locate parathyroid tissue.PTH-FNAB was evaluated in 47 patients with a clinical picture of primary hyper-parathyroidism(PHP) and ultrasonography(US) suggestive of parathyroid lesion.The patients were subdivided into two groups on the basis of the absence or presence of US thyroid alterations.The result of PTH-FNAB was compared with those of cytology,scintigraphy and,in 24 patients,surgical outcome.PTH-FNAB samples with a value higher than that recorded in the serum and higher than our institutional cut-off were deemed to be probable samples of parathyroid tissue.Cytology proved diagnostic for benign thyroid lesions,non-diagnostic for thyroid lesions,hyperplastic parathyroid tissue,undetermined or malignant thyroid lesions and other lesions in 45%,30%,17%,4%,and 4% of cases,respectively.In 47% of cases,PTH-FNAB indicated that the sample had been taken in parathyroid tissue.In patients without US alterations,the diagnostic accuracy of PTH-FNAB was greater than that of scintigraphy.After surgery,comparison between the results of PTH-FNAB and scintigraphy,in terms of positive predictive value(PPV),revealed the superiority of PTH-FNAB;PPV was 94% for FNAB and 71% for scintigraphy,while sensitivity was 83% and 69%,respectively.PTH-FNAB evaluation after FNAB appears to be more diagnostic than cytology and scintigraphy.Of all the procedures used,PTH-FNAB appears to be the method of choice when the target is US suggestive and reachable.PTH-FNAB appears to be a useful method of guiding surgical intervention. | Massimo GIUSTI Mara DOLCINO Lara VERA Carla GHIARA Francesca MASSARO Laura FAZZUOLI Diego FERONE Michele MUSSAP Francesco MINUTO | 2009 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2009，10，5： | 6 |
| 14 | Comment on “Chen et al., Fabrication and photovoltaic conversion enhancement...”,Electrochimica Acta,2014显示文摘In a recent article, Chen et al. [Electrochimica Acta, 2014, 130: 279] presented their fabrication and characterization results on a graphene/n-Si solar cell where the Au nanoparticles were inserted in graphene to increase its optical and electrical properties. The higher efficiency of the device was attributed to increased conductivity of graphene after doping with Au nanoparticles. However, the knowledge in the field of Schottky diode solar cells relates this to increased band bending at the junction. Also, to explain the instability behaviour, they concluded that the growth of silicon oxide on the Si surface or oxygen adsorption on the window layer resulted in the device performance increasing initially and decreasing in the end. However, this instability seems to be due to variation in series resistance reduced at the beginning because of slightly lowered Fermi level and increased at the end by the self-compensation by deep in-diffusion of Au nanoparticles into n-Si layer. We also propose that inserting a very thin p-type layer at the junction will enhance the carrier collection and performance of this device. | Lara Valentic Nima E.Gorji Department of Environment Sciences,University of Nova Gorica Department of Physics,Brown University | 2015 | Journal of Semiconductors2015，36，9： | 6 |
| 15 | Glutamine transporters as pharmacological targets: From function to drug design显示文摘Among the different targets of administered drugs,there are membrane transporters that play also a role in drug delivery and disposition.Moreover,drug-transporter interactions are responsible for off-target effects of drugs underlying their toxicity.The improvement of the drug design process is subjected to the identification of those membrane transporters mostly relevant for drug absorption,delivery and side effect production.A peculiar group of proteins with great relevance to pharmacology is constituted by the membrane transporters responsible for managing glutamine traffic in different body districts.The interest around glutamine metabolism lies in its physio-pathological role;glutamine is considered a conditionally essential amino acid because highly proliferative cells have an increased request of glutamine that cannot be satisfied only by endogenous synthesis.Then,glutamine transporters provide cells with this special nutrient.Among the glutamine transporters,SLC1A5,SLC6A14,SLC6A19,SLC7A5,SLC7A8 and some members of SLC38 family are the best characterized,so far,in both physiological and pathological conditions.Few 3D structures have been solved by CryoEM;other structural data on these transporters have been obtained by computational analysis.Interactions with drugs have been described for several transporters of this group.For some of them,the studies are at an advanced stage,for others,the studies are still in nuce and novel biochemical findings open intriguing perspectives. | Mariafrancesca Scalise Lorena Pochini Michele Galluccio Lara Console Cesare Indiveri | 2020 | Asian Journal of Pharmaceutical Sciences2020，15，2： | 5 |
| 16 | Right ventricular septal pacing: Safety and efficacy in a long term follow up显示文摘AIM: To evaluate the safety and efficacy of the permanent high interventricular septal pacing in a long term follow up, as alternative to right ventricular apical pacing. METHODS: We retrospectively evaluated:(1) 244 patients(74 ± 8 years; 169 men, 75 women) implanted with a single(132 pts) or dual chamber(112 pts) pacemaker(PM) with ventricular screw-in lead placed at the right ventricular high septal parahisian site(SEPTAL pacing);(2) 22 patients with permanent pacemaker and low percentage of pacing(< 20%)(NO pacing);(3) 33 patients with high percentage(> 80%) right ventricular apical pacing(RVA). All patients had a narrow spontaneous QRS(101 ± 14 ms). We evaluated New York Heart Association(NYHA) class, quality of life(Qo L), 6 min walking test(6MWT) and left ventricular function(end-diastolic volume, LV-EDV; end-systolic volume, LVESV; ejection fraction, LV-EF) with 2D-echocardiography. RESULTS: Pacing parameters were stable duringfollow up(21 mo/patient). In SEPTAL pacing group we observed an improvement in NYHA class, Qo L score and 6MWT. While LV-EDV didn't significantly increase(104 ± 40 m L vs 100 ± 37 m L; P = 0.35), LV-ESV slightly increased(55 ± 31 m L vs 49 ± 27 m L; P = 0.05) and LV-EF slightly decreased(49% ± 11% vs 53% ± 11%; P = 0.001) but never falling < 45%. In the RVA pacing control group we observed a worsening of NYHA class and an important reduction of LV-EF(from 56% ± 6% to 43% ± 9%, P < 0.0001).CONCLUSION: Right ventricular permanent high septal pacing is safe and effective in a long term follow up evaluation; it could be a good alternative to the conventional RVA pacing in order to avoid its deleterious effects. | Eraldo Occhetta Gianluca Quirino Lara Baduena Rosaria Nappo Chiara Cavallino Emanuela Facchini Paolo Pistelli Andrea Magnani Miriam Bortnik Gabriella Francalacci Gabriele Dell’Era Laura Plebani Paolo Marino | 2015 | World Journal of Cardiology2015，7，8： | 5 |
| 17 | 中国有壳变形虫Argynnia(Vucetich,1974)属的修订及若干环境重建问题探讨显示文摘有壳变形虫是一类具外壳的陆相淡水根足纲(Rhizopoda)原生动物,广泛栖息于湖泊、泥炭、沼泽、土壤等各种淡水潮湿环境,由于其壳体具有很好的抗腐蚀性而在沉积物中保存下来,近年来广泛应用于泥炭和湖泊湿地的古环境重建研究中。大部分有壳变形虫是世界广泛分布的,但是也有一些种类具有一定的地带性分布格局。形态学和分子生物学的研究均已表明阿吉尼亚虫属(Argynnia Vucetich,1974)与梨壳虫属(Nebela Leidy,1874)有较大差别,而我国传统的有壳变形虫分类系统仍将它们统一划为梨壳虫属(Nebela)。本文在对神农架大九湖泥炭湿地有壳变形虫标本形态学观察的基础上,结合前人研究资料,将阿吉尼亚虫属(Argynnia)从梨壳虫属(Nebela)中分离出来,修正了我国传统的分类系统,并讨论了其生物地理学意义,目前在我国发现该属的2个种,即具尾阿吉尼亚虫Argynnia caudata(Leidy,1876)和齿口阿吉尼亚虫Argynnia dentistoma(Penard,1890)。本文还探讨了因有壳变形虫分类标准的差异可能引起的生态学转换函数和古环境重建问题。 | 秦养民 张文静 李鸿凯 Edward A. D. Mitchell Enrique Lara 张千帆 朱荣 顾延生 | 2011 | 第四纪研究2011，31，6： | 5 |
| 18 | Renin-angiotensin system in the kidney: What is new?显示文摘The renin-angiotensin system(RAS)has been known for more than a century as a cascade that regulates body fluid balance and blood pressure.AngiotensinⅡ(AngⅡ)has many functions in different tissues;however it is on the kidney that this peptide exerts its main functions.New enzymes,alternative routes for AngⅡformation or even active AngⅡ-derived peptides have now been described acting on AngⅡAT1or AT2receptors,or in receptors which have recently been cloned,such as Mas and AT4.Another interesting observation was that old members of the RAS,such as angiotensin converting enzyme(ACE),renin and prorenin,well known by its enzymatic activity,can also activate intracellular signaling pathways,acting as an outside-in signal transduction molecule or on the renin/(Pro)renin receptor.Moreover,the endocrine RAS,now is also known to have paracrine,autocrine and intracrine action ondifferent tissues,expressing necessary components for local AngⅡformation.This in situ formation,especially in the kidney,increases AngⅡlevels to regulate blood pressure and renal functions.These discoveries,such as the ACE2/Ang-(1-7)/Mas axis and its antangonistic effect rather than classical deleterious AngⅡeffects,improves the development of new drugs for treating hypertension and cardiovascular diseases. | Fernanda M Ferr?o Lucienne S Lara Jennifer Lowe | 2014 | World Journal of Nephrology2014，3，3： | 5 |
| 19 | Endogenous Hypoxia in Lateral Root Primordia Controls Root Architecture by Antagonizing Auxin Signaling in Arabidopsis显示文摘As non-photosynthesizing organs, roots are dependent on diffusion of oxygen from the external environment and, in some in stances, from the shoot for their aerobic metabolism . Establishment of hypoxic niches in the developing tissues of plants has been postulated as a consequence of insufficient diffusion of oxygen to satisfy the demands throughout development. Here, we report that such niches are established at specific stages of lateral root primordia development in Arabidopsis thaliana grown under aerobic conditions. Using gain- and loss-of-function mutants, we show that ERF-Ⅶ transcription factors, which mediate hypoxic responses, control root architecture by acting in cells with a high level of auxin signaling. ERF-Ⅶs repress the expression of the auxin-induced genes LBD16, LBD18, and PUCHI, which are essential for lateral root development, by binding to their promoters. Our results support a model in which the establishment of hypoxic n iches in the developing lateral root primordia con tributes to the shutting down of key auxin-induced genes and regulates the production of lateral roots. | Vinay Shukla Lara Lombardi Sergio lacopino Ales Pencik Ondrej Novak Pierdomenico Perata Beatrice Giuntoli Francesco Licausi | 2019 | Molecular Plant2019，12，4： | 4 |
| 20 | CO_(2)enrichment accelerates successional development of an understory plant community显示文摘Aims Rising concentrations of atmospheric carbon dioxide([CO_(2)])may influence forest successional development and species composition of understory plant communities by altering biomass production of plant species of functional groups.Here,we describe how elevated[CO_(2)](eCO_(2))affects aboveground biomass within the understory community of a temperate deciduous forest at the Oak Ridge National Laboratory sweetgum(Liquidambar styraciflua)free-air carbon dioxide enrichment(FACE)facility in eastern Tennessee,USA.We asked if(i)CO_(2)enrichment affected total understory biomass and(ii)whether total biomass responses could be explained by changes in understory species composition or changes in relative abundance of functional groups through time.Materials and methods The FACE experiment started in 1998 with three rings receiving ambient[CO_(2)](aCO_(2))and two rings receiving eCO_(2).From 2001 to 2003,we estimated species-specific,woody versus herbaceous and total aboveground biomass by harvesting four 130.5-m subplots within the established understory plant community in each FACE plot.In 2008,we estimated herbaceous biomass as previously but used allometric relationships to estimate woody biomass across two 535-m quadrats in each FACE plot.Important findings Across years,aboveground biomass of the understory community was on average 25%greater in eCO_(2)than in aCO_(2)plots.We could not detect differences in plant species composition between aCO_(2)and eCO_(2)treatments.However,we did observe shifts in the relative abundance of plant functional groups,which reflect important structural changes in the understory community.In 2001-03,little of the understory biomass was in woody species;herbaceous species made up 94%of the total understory biomass across[CO_(2)]treatments.Through time,woody species increased in importance,mostly in eCO_(2),and in 2008,the contribution of herbaceous species to total understory biomass was 61%in aCO_(2)and only 33%in eCO_(2)treatments.Our results suggest that rising atmospheric[CO_(2)]could accelerate successional development and have longer term impact on forest dynamics. | Lara Souza R.Travis Belote Paul Kardol Jake F.Weltzin Richard J.Norby | 2010 | Journal of Plant Ecology2010，3，1： | 4 |
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