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| 1 | The Chinese Society of Clinical Oncology(CSCO):Clinical guidelines for the diagnosis and treatment of gastric cancer,2021显示文摘There exist differences in the epidemiological characteristics,clinicopathological features,tumor biological characteristics,treatment patterns,and drug selections between gastric cancer patients from the Eastern and Western countries.The Chinese Society of Clinical Oncology(CSCO)has organized a panel of senior experts specializing in all sub-specialties of gastric cancer to compile a clinical guideline for the diagnosis and treatment of gastric cancer since 2016 and renews it annually.Taking into account regional differences,giving full consideration to the accessibility of diagnosis and treatment resources,these experts have conducted expert consensus judgment on relevant evidence and made various grades of recommendations for the clinical diagnosis and treatment of gastric cancer to reflect the value of cancer treatment and meeting health economic indexes in China.The 2021 CSCO Clinical Practice Guidelines for Gastric Cancer covers the diagnosis,treatment,follow-up,and screening of gastric cancer.Based on the 2020 version of the CSCO Chinese Gastric Cancer guidelines,this updated guideline integrates the results ofmajor clinical studies from China and overseas for the past year,focused on the inclusion of research data from the Chinese population for more personalized and clinically relevant recommendations.For the comprehensive treatment of non-metastatic gastric cancer,attentions were paid to neoadjuvant treatment.The value of perioperative chemotherapy is gradually becoming clearer and its recommendation level has been updated.For the comprehensive treatment of metastatic gastric cancer,recommendations for immunotherapy were included,and immune checkpoint inhibitors fromthird-line to the first-line of treatment for different patient groups with detailed notes are provided. | Feng-Hua Wang Xiao-Tian Zhang Yuan-Fang Li Lei Tang Xiu-Juan Qu Jie-Er Ying Jun Zhang Ling-Yu Sun Rong-Bo Lin Hong Qiu Chang Wang Miao-Zhen Qiu Mu-Yan Cai QiWu Hao Liu Wen-Long Guan Ai-Ping Zhou Yu-Jing Zhang Tian-Shu Liu Feng Bi Xiang-Lin Yuan Sheng-Xiang Rao Yan Xin Wei-Qi Sheng Hui-Mian Xu Guo-Xin Li Jia-Fu Ji Zhi-Wei Zhou Han Liang Yan-Qiao Zhang Jing Jin Lin Shen Jin Li Rui-Hua Xu | 2021 | Cancer Communications2021，41，8： | 97 |
| 2 | Mortality and Morbidity of Extremely Low Birth Weight Infants in the Mainland of China: A Multi-center Study显示文摘 | Hui-Jia Lin Li-Zhong Du Xiao-Lu Ma Li-Ping Shi Jia-Hua Pan Xiao-Mei Tong Qiu-Ping Li Jian-Guo Zhou Bing Yi Ling Liu Yun-Bing Chen Qiu-Fen Wei Hui-Qing Wu Mei Li Cui-Qing Li Xi-Rong Gao Shi-Wen Xia Wen-Bin Li Chao-Ying Ya Ling He Kun Liang Xiao-Yu Zhou Shu-Ping Han Qin Lyu Yin-Ping Qiu Wen Li Dong-Mei Chen Hong-Ru Lu Xiao-Hong Liu Hong Liu Zhen-Lang Lin Li Liu Jia-Jun Zhu Hong Xiong Shao-Jie Yue Si-Qi Zhuang | 2015 | Chinese Medical Journal2015，，20： | 49 |
| 3 | The trend, seasonal cycle, and sources of tropospheric NO_2 over China during 1997―2006 based on satellite measurement显示文摘The characteristics of spatial and temporal distribution of tropospheric NO2 column density concen-tration over China are presented,on the basis of measurements from the satellite instruments GOME and SCIAMACHY.From these observations,monthly averaged tropospheric NO2 variations are deter-mined for the period of 1997 to 2006.The trend and seasonal cycle are also investigated.The possible source of tropospheric NO2 over megacity area is discussed in this paper.The results show a large growth of tropospheric NO2 over eastern China,especially above the industrial areas with a fast eco-nomical growth,such as,Yangtze Rive Delta region and Pearl River Delta region because of the prominent anthropogenic activity.There is a rapid increase of tropospheric NO2 over megacities in China.For instance,Shanghai had a linear significant increase in NO2 columns of ~20% per year(ref-erence year 1997) in the period of 1997―2006,which is the rapidest increase among all the selected cities.The seasonal pattern of the NO2 concentration shows a difference between the east and west in China.In the eastern part of China,an expected winter maximum in seasonal cycle is found because of the prominent anthropogenic activity and meteorological conditions.In the western part this cycle shows a NO2 maximum in summer time,which is attributed to natural emissions,especially soil emissions and lightning.A quickly increasing vehicle population may contribute to the increase of tropo-spheric NO2 over megacities in China for the remarkable correlation for vehicle population with tropospheric NO2. | ZHANG XingYing ZHANG Peng ZHANG Yan LI XiaoJing QIU Hong | 2007 | Science China Earth Sciences2007，50，12： | 30 |
| 4 | Effect of hepatocyte apoptosis induced by TNF-α on acute severe hepatitis in mouse models显示文摘AIM To study the effect of hepatocyteapoptosis and necrosis induced by TNF-α on thepathogenesis of acute severe hepatitis(ASH).METHODS The model of ASH was prepared inD-galactosamine(GAIN)sensitized BALB/c miceby injection of either endotoxin(ET)or tumornecrosis factor-α(TNF-α).Morphologicalchanges of apoptotic hepatocytes were studiedby both light and electron microscope and in siteend labeling method(ISEL).Molecular biologicalchanges of DNA ladder were observed byelectrophoresis of extract from liver tissues.Biochemical changes were measured by alanineaminotransferase(ALT),asparticaminotransferase(AST)and TNF-α.The relationbetween apoptosis and necrosis was evaluatedsimultaneously.RESULTS The sequence of hepatocyteapoptosis,necrosis,and final death from ASHwas observed both in GAIN/ET and GAIN/TNF-agroup.Apoptosis was prominent at 3.5 h and 5 hafter injection of inducer,while necrosis becamedominant at 9 h after challenge.The appearanceof apoptosis was earlier in GAIN/TNF-α groupthan that in GAIN/ ET group.Pretreatment ofmice with antiTNF IgG1 may completely preventthe liver injury induced by GalN/ET.CONCLUSION TNF-α can cause liver damageby inducing hepatic apoptosis and necrosis inmice with endotoxemia. | Guo Qing Zang Xia Qiu Zhou Hong Yu Qing Xie Guo Ming Zhao Bin Wang Qing Guo Yue Qin Xiang Dan Liao Department of Infectious Diseases,Rujin Hospital,Shanghai Second Medical University,Shanghai 200025,China | 2000 | World Journal of Gastroenterology2000，6，5： | 30 |
| 5 | HIF-1α-induced expression of m6A reader YTHDF1 drives hypoxia-induced autophagy and malignancy of hepatocellular carcinoma by promoting ATG2A and ATG14 translation显示文摘N6-methyladenosine(m6A),and its reader protein YTHDF1,play a pivotal role in human tumorigenesis by affecting nearly everystage of RNA metabolism.Autophagy activation is one of the ways by which cancer cells survive hypoxia.However,the possibleinvolvement of m6A modification of mRNA in hypoxia-induced autophagy was unexplored in human hepatocellular carcinoma(HCO).In this study,specific variations in YTHDF1 expression were detected in YTHDF1-overexpressing,knockout,and-knockdownHCC cells,HCC organoids,and HCC patient-derived xenograft(PDX)murine models.YTHDF1 expression and hypoxia inducedautophagy were significantly correlated in vitro;signifhcant overexpression of YTHDF1 in HCC tissues was associated with poorprognosis,Multivariate cox regression analysis identihed YTHDF1 expression as an independent prognostic factor in patients withHCC.Multiple HC models conhrmed that YTHDF1 deficiency inhibited HCC autophagy,growth,and metastasis.Luciferase reporterassays and chromatin immunoprecipitation demonstrated that HlIF-1a regulated YTHDF1 transcription by directly binding to itspromoter region under hypoxia.The results of methylated RNA immunoprecipitation sequencing,proteomics,and polysomeprofling indicated that YTHDF1 contibuted to the translation of autophagy-related genes ATG2A and ATG14 by binding to m6A-modifhed ATG2A and ATG14 mRNA,thus facilitating autophagy and autophagy-related malignancy of HCC.Taken together,HlE-1d-induced YTHDF1 expression was associated with hypoxia-induced autophagy and autophagy-related HCC progression via promoting translation of autophagy-related genes ATG2A and ATG14 in a m6A-dependent manner.Our fndings suggest thatYTHDF1 is a potential prognostic biomarker and therapeutic target for patients with HCC. | Qing Li Yong Ni Liren Zhang Runqiu Jiang Jing Xu Hong Yang Yuanchang Hu Jiannan Qiu Liyong Pu Jinhai Tang Xuehao Wang | 2021 | Signal Transduction and Targeted Therapy2021，6，3： | 24 |
| 6 | Construction, expression and characterization of the engineered antibody against tumor surface antigen, p185^(c-erbB-2)显示文摘The c-erbB-2 proto-oncogene encodes a 185kDa protein p185, which belongs to epidermal growth factorreceptor family. Amplification of this gene has been shown to correlate with poor clinical prognosis forcertain cancer patients. The monoclonal antibody A21 which directed against p185 specifically inhibitsproliferation of tumor cells overexpressing p185, hence allows it to be a candidate for targeted therapy. Inorder to overcome several drawbacks of murine MAb, we cloned its VH and VL genes and constructed thesingle-chain Fv (scFv) through a peptide linker. The recombinant scFvA21 was expressed in Escherichiacoli and purified by the affinity column. Subsequently it was characterized by ELISA, Western blot, cellimmunohistochemistry and FACS. All these assays showed the binding activity to extracellular domain(ECD) of p185. Based on those properties of scFvA21, we further constructed the scFv-Fc fusion moleculewith a homodimer form and the recombinant product was expressed in mammalian cells. In a series ofsubsequent analysis this fusion protein showed identical antigen binding site and activity with the parentantibody. These anti-p185 engineered antibodies have promised to be further modified as a tumor targetingdrugs, with a view of application in the diagnosis and treatment of human breast cancer. | LIAN SHENG CHENG, AI PING LIU, JIA HONG YANG, YAN QIU DONG, LIANG WEI LI, JING WANG, CHAO CHEN WANG, JING LIUSchool of Life Science, University of Science and Technology of China, Hefei 230027, China | 2003 | Cell Research2003，13，1： | 24 |
| 7 | The protective effect of vitamin E against oxidative damage caused by formaldehyde in the testes of adult rats显示文摘瞄准:在成年老鼠的睾丸由 FA 对氧化损坏在睾丸和维生素E(VE ) 的保护的效果上调查甲醛(FA ) 的效果。方法:三十只老鼠随机被划分成三个组:(1 ) 控制;(2 ) FA 处理组织(脂肪) ;并且(3 ) 胖 + VE 组织。胖、胖的 + VE 组被吸入在 10 mg/m (3 ) 的集中暴露于 FA 2 个星期。另外,胖 + VE 组在 2 星期的 FA 处理期间是口头上地管理的 VE。在精子的处理,在睾丸的组织病理学说、生物化学的变化,以及数量和质量以后,被观察。结果:精子的阴囊的重量,数量和质量,超级氧化物歧化酶(草皮)的活动,而 malondialdehyde ( MDA )的水平显著地在控制组与那些相比在胖组在老鼠的睾丸被增加,谷胱甘肽过氧化物酶( GSH-Px )和谷胱甘肽( GSH )显著地被减少。VE 处理在胖 + VE 组恢复了这些参数。另外,有 hematoxylin 曙红的显微镜学(他) 染色证明细精管萎缩的、生精的上皮细胞瓦解了,在在胖组和 VE 处理的老鼠的 shed 显著地在胖 + VE 改进了阴囊的结构组。结论:在由导致氧化应力的成年老鼠的阴囊的结构和功能,和这损坏能部分是的 FA 破坏由 VE 逆行。 | Dang-Xia Zhou Shu-Dong Qiu Jie Zhang Hong Tian Hai-Xue Wang | 2006 | Asian Journal of Andrology2006，8，5： | 21 |
| 8 | Sevoflurane postconditioning protects against myocardial ischemia/reperfusion injury by restoring autophagic flux via an NO-dependent mechanism显示文摘Volatile anesthetics improve postischemic cardiac function and reduce infarction even when administered for only a brief-time at the onset of reperfusion.A recent study showed that sevoflurane postconditioning (SPC)attenuated myocardial reperfusion injury, but the underlying mechanisms remain unclear,in this study,we examined the effects of sevoflurane on nitric oxide (NO)release and autophagic flux during the myocardial ischemia/reperfusion (I/R)injury in rats in vivo and ex vivo.Male rats were subjected to 30 min ischemia and 2 h reperfusion in the presence or absence of sevoflurane (1.0 minimum alveolar concentration)during the first 15 min of reperfusion.We found that SPC significantly improved hemodynamic performance after reperfusion,alleviated postischemic myocardial infarction,reduced nicotinamide adenine dinucleotide content loss,and cytochrome c.release in heart tissues.Furthermore,SPC significantly increased the phosphorylation of endothelial nitric oxide synthase (NOS)and neuronal nitric oxide synthase,and elevated myocardial NOS activity and NO production.All these effects were abolished by treatment with an NOS inhibitor NG-nitro-L-arginine methyl ester (L-NAME,10 mg/kg,i.v.).We also observed myocardial I/R-induced accumulation of autophagosomes in heart tissues,as evidenced by increased ratios of microtubule:associated protein 1 light chain 3 Ⅱ/Ⅰ,upregulation of Beclin 1 and P62,and reduced lysosome-assciated membrane protein-2 expression.SPC significantly attenuated I/R- impaired autophagic flux,which were blocked by L-NAME.Moreover,pretreatment with the autophagic flUX blocker chloroquine (10 mg/kg,i.p.)increased autophagosome accumulation in SPC-treated heart following I/R and blocked SPC-induced cardioprotection.The same results were also observed in a rat model of myocardial I/R injury ex vivo,suggesting that SPC protects rat hearts against myocardial reperfusion injury by restoring I/R-impaired autophagic flux yia an NO-dependent mechanism. | Shi-gang Qiao Ying Sun Bo Sun An Wang Jia Qiu Lei Hong Jian-zhong An Chen Wang Hui-ling Zhang | 2019 | Acta Pharmacologica Sinica2019，40，1： | 21 |
| 9 | Nickel-exposed Workers in China: A Cohort Study显示文摘There are more than 50 000 workers in Jinchuan Group Co,Ltd(JNMC).Since all staff in JNMC are eligible for a medical examination every two years,only 23 484 nickel-exposed subjects who participated in medical examination were included in this study.Their data,collected from June 22,2011 to September 28,2012,in a | BAI Ya Na YAGN Ai Min PU Hong Quan HE Jie CHENG Ning ZHENG Tong Zhang DAI Min ZHANG Ya Wei BASSING Bryan WANG Qiu Ying | 2014 | Biomedical and Environmental Sciences2014，27，3： | 20 |
| 10 | Concurrent chemoradiotherapy combined with enteral nutrition support:a radical treatment strategy for esophageal squamous cell carcinoma patients with malignant istulae显示文摘Background: Concurrent chemoradiotherapy(CCRT) significantly increases the survival rate of esophageal squa?mous cell carcinoma(ESCC) patients with malignant fistulae. Recent clinical evidence has shown the benefits of enteral nutrition for malnourished cancer patients. In this study, we aimed to validate that, with the support of enteral nutrition, ESCC patients who develop malignant fistulae might be able to complete CCRT and achieve long?term survival.Methods: We reviewed the medical records of 652 patients with ESCC who received definitive CCRT at Sun Yat?sen University Cancer Center between January 2010 and December 2012. Treatment outcome and toxicity were ret?rospectively evaluated in 40 ESCC patients with malignant fistulae. All the 40 patients were treated with CCRT and evaluated by clinical nutritionists using nutrition risk screening(NRS) before, during, and after treatment. Twenty?two patients received a nasogastric tube, and 18 underwent percutaneous endoscopic gastrostomy feeding. The median energy intake was 2166 kcal/day. Treatment response was evaluated at 3 months after the completion of CCRT.Results: With a median follow?up of 18 months(range, 3–39 months), patients' 1?year overall survival(OS) rate was 62.5%, and the estimated OS time was 25.5 months. Univariate analysis showed that the NRS score(P n NRS score(P se to treatment(P < 0.001) were sig= 0.003), increase i= 0.024), fistula closure(P = 0.011), and responnifi?cantly associated with OS. Multivariate analysis showed that tumor response(P = 0.044) and increase in NRS score(P = 0.044) were independent predictors of OS. Grade 3 vomiting was observed in 8 patients(20.0%), grade 3 neutro?penia was observed in 11 patients(27.5%), and grade 3 cough was observed in 13 patients(32.5%); 2 patients(5.0%) died of massive bleeding during treatment.Conclusions: CCRT combined with enteral nutrition support is effective for ESCC patients with malignant fistulae. Patients have an increased potential to be cured, especially those who experience complete response and have an increase in NRS score. Careful observation and nutrition support are required for patients with advanced T?category ESCC who undergo CCRT. | Li Ma Guang-Yu Luo Yu-Feng Ren Bo Qiu Hong Yang Chun-Xia Xie Song-Ran Liu Shi-Liang Liu Zhao-Lin Chen Qun Li Jian-Hua Fu Meng-Zhong Liu Yong-Hong Hu Wen-Feng Ye Hui Liu | 2017 | Chinese Journal of Cancer2017，36，1： | 19 |
| 11 | Studies on the Situation of Soil Organic Carbon Storage in Croplands in Northeast of China显示文摘This paper aims to estimate the soil organic carbon (SOC) storage in Northeast of China, identify its balance situation and changing trends under current cropping systems, and finally put forward some strategies to keep the SOC in balance. A biogeochemical model (DNDC) for agro-ecosystem was employed to predict SOC dynamics in agricultural ecosystems at regional scale. Data on climate, soil properties, cropping systems, acreage, and management practices at county scale were collected from various sources and integrated into a GIS database to support the model runs at the regional scale. The model predicted results revealed that (1) Total SOC storage in agricultural lands in Heilongjiang, Jilin and Liaoning provinces in Northeast of China is about 1 243.48 × 106 t (0-30cm soil layer), respectively occupying 58.4, 25.5 and 16.1%; (2) Under the current cultivation systems, SOC is in a situation of net loss with carbon losing at a high rate of 31.22 × 106 t a-1 (respectively 59.3, 25.9 and 14.8% in Heilongjiang, Jilin and Liaoning provinces) and 2.05 t ha-1 a-1, the situation is more serious in Heilongjiang and Jilin provinces; and (3) Protective cultivations, such as manuring, returning more residue of crop to the field, adopting no-till, are very useful for the accumulation of SOC in these regions. | QIU Jian-jun WANG Li-gang TANG Hua-jun LI Hong Changsheng LI | 2005 | Agricultural Sciences in China2005，4，8： | 18 |
| 12 | Long-term outcomes and independent predictors of mortality in patients presenting to emergency departments with acute heart failure in Beijing:a multicenter cohort study with a 5-year follow-up显示文摘Background:Acute heart failure(AHF)is the most common disease in emergency departments(EDs).However,clinical data exploring the outcomes of patients presenting AHF in EDs are limited,especially the long-term outcomes.The purposes of this study were to describe the long-term outcomes of patients with AHF in the EDs and further analyze their prognostic factors.Methods:This prospective,multicenter,cohort study consecutively enrolled 3335 patients with AHF who were admitted to EDs of 14 hospitals from Beijing between January 1,2011 and September 23,2012.Kaplan-Meier and Cox regression analysis were adopted to evaluate 5-year outcomes and associated predictors.Results:The 5-year mortality and cardiovascular death rates were 55.4%and 49.6%,respectively.The median overall survival was 34 months.Independent predictors of 5-year mortality were patient age(hazard ratio[HR]:1.027,95 confidence interval[CI]:1.023-1.030),body mass index(BMI)(HR:0.971,95%CI:0.958-0.983),fatigue(HR:1.127,95%CI:1.009-1.258),ascites(HR:1.190,95%CI:1.057-1.340),hepatic jugular reflux(HR:1.339,95%CI:1.140-1.572),New York Heart Association(NYHA)class III to IV(HR:1.511,95%CI:1.291-1.769),heart rate(HR:1.003,95%CI:1.001-1.005),diastolic blood pressure(DBP)(HR:0.996,95%CI:0.993-0.999),blood urea nitrogen(BUN)(HR:1.014,95%CI:1.008-1.020),B-type natriuretic peptide(BNP)/N-terminal pro-B-type natriuretic peptide(NT-proBNP)level in the third(HR:1.426,95%CI:1.220-1.668)or fourth quartile(HR:1.437,95%CI:1.223-1.690),serum sodium(HR:0.980,95%CI:0.972-0.988),serum albumin(HR:0.981,95%CI:0.971-0.992),ischemic heart diseases(HR:1.195,95%CI:1.073-1.331),primary cardiomyopathy(HR:1.382,95%CI:1.183-1.614),diabetes(HR:1.118,95%CI:1.010-1.237),stroke(HR:1.252,95%CI:1.121-1.397),and the use of diuretics(HR:0.714,95%CI:0.626-0.814),(3-blockers(HR:0.673,95%CI:0.588-0.769),angiotensin-converting enzyme inhibitors(ACEIs)(HR:0.714,95%CI:0.604-0.845),angiotensin-II receptor blockers(ARBs)(HR:0.790,95%CI:0.646-0.965),spironolactone(HR:0.814,95%CI:0.663-0.999),calcium antagonists(HR:0.624,95%CI:0.531-0.733),nitrates(HR:0.715,95%CI:0.631-0.811),and digoxin(HR:0.579,95%CI:0.465-0.721).Conclusions:The results of our study demonstrate poor 5-year outcomes of patients presenting to EDs with AHF.Age,BMI,fatigue,ascites,hepatic jugular reflux,NYHA class III to IV,heart rate,DBP,BUN,BNP/NT-proBNP level in the third or fourth quartile,serum sodium,serum albumin,ischemic heart diseases,primary cardiomyopathy,diabetes,stroke,and the use of diuretics,P-blockers,ACEIs,ARBs,spironolactone,calcium antagonists,nitrates,and digoxin were independently associated with 5-year all-cause mortality. | Yang Li Xiao-Lu Sun Hong Qiu Jian Qin Chun-Sheng Li Xue-Zhong Yu Guo-Xing Wang Yan Fu Ya-An Zheng Bin Zhao Dong-Ming Yu Si-Jia Wang Guo-Gan Wang | 2021 | Chinese Medical Journal2021，，15： | 18 |
| 13 | Sedimentary Evolution of the Holocene Subaqueous Clinoform off the Southern Shandong Peninsula in the Western South Yellow Sea显示文摘Based on the stratigraphic sequence formed since the last glaciation and revealed by 3000 km long high-resolution shallow seismic profiles and the core QDZ03 acquired recently off the southern Shandong Peninsula, we addressed the sedimentary characteristics of a Holocene subaqueous clinoform in this paper. Integrated analyses were made on the core QDZ03, including sedimentary facies, sediment grain sizes, clay minerals, geochemistry, micro paleontology, and AMS 14 C dating. The result indicates that there exists a Holocene subaqueous clinoform, whose bottom boundary generally lies at 15–40 m below the present sea level with its depth contours roughly parallel to the coast and getting deeper seawards. The maximum thickness of the clinoform is up to 22.5 m on the coast side, and the thickness contours generally spread in a banded way along the coastline and becomes thinner towards the sea. At the mouths of some bays along the coast, the clinoform stretches in the shape of a fan and its thickness is evidently larger than that of the surrounding sediments. This clinoform came into being in the early Holocene(about 11.2 cal kyr BP) and can be divided into the lower and upper depositional units(DU 2 and DU 1, respectively). The unit DU 2, being usually less than 3 m in thickness and formed under a low sedimentation rate, is located between the bottom boundary and the Holocene maximum flooding surface(MFS), and represents the sediment of a post-glacial transgressive systems tract; whereas the unit DU 1, the main body of the clinoform, sits on the MFS, belonging to the sediment of a highstand systems tract from middle Holocene(about 7–6 cal kyr BP) to the present. The provenance of the clinoform differs from that of the typical sediments of the Yellow River and can be considered as the results of the joint contribution from both the Yellow River and the proximal coastal sediments of the Shandong Peninsula, as evidenced by the sediment geochemistry of the core. As is controlled mainly by coactions of multiple factors such as the Holocene sea-level changes, sediment supplies and coastal dynamic conditions, the development of the clinoform is genetically related with the synchronous clinoform or subaqueous deltas around the northeastern Shandong Peninsula and in the northern South Yellow Sea in the spatial distribution and sediment provenance, as previously reported, with all of them being formed from the initial stage of the Holocene up to the present. | QIU Jiandong LIU Jian SAITO Yoshiki YANG Zigeng YUE Baojing WANG Hong KONG Xianghuai | 2014 | Journal of Ocean University of China2014，13，5： | 17 |
| 14 | Fuzzy Control of LED Tunnel Lighting and Energy Conservation显示文摘Current highway tunnel lighting control systems are often manually controlled,resulting in significant energy waste.This article designs a fuzzy control algorithm for tunnel lighting energy control systems.The system uses LED (Light Emitting Diode) lighting,so the fuzzy control algorithm is designed for LED lights.The traffic and the natural illumination level are used as parameters in the intelligent lighting control algorithm.This system has been deployed in the Lengshui tunnel on the 49th provincial highway of Zhejiang province and operated for more than six months.The performance results show that the energy conservation system provides sufficient lighting levels for traffic safety with significant energy conservation. | Hong Zeng Jian Qiu Xingfa Shen Guojun Dai Peng Liu Shuping Le | 2011 | Tsinghua Science and Technology2011，16，6： | 17 |
| 15 | Celecoxib induces apoptosis and cell-cycle arrest in nasopharyngeal carcinoma cell lines via inhibition of STAT3 phosphorylation显示文摘瞄准: 调查在鼻咽的癌(NPC ) 上位于 celecoxib 的 anticancer 效果下面的机制。 | Dong-bo LIU Guang-yuan HU Guo-xian LONG Hong QIU Qi MEI Guo-qing HU | 2012 | Acta Pharmacologica Sinica2012，33，5： | 16 |
| 16 | Recurrent gain-of-function USP8 mutations in Cushing's disease显示文摘库欣的疾病,引起过量皮质醇生产的也已知的同样促肾上腺皮质的荷尔蒙(ACTH )-secreting 垂体腺瘤(舞步) ,占多达 85%corticotrophin 依赖的库欣的症候群盒子。然而,在这疾病的基因改变是不清楚的。这里,我们执行了从 12 秘密 ACTH 舞步导出并且匹配血样品的 DNA 定序的 whole-exome,它在候选人基因揭示了体的变化的三种类型, USP8 (编码 ubiquitin 特定的朊酶 8 ) ,专门在 exon 14 在 12 秘密 ACTH 舞步中的 8 个。我们进一步评估了体的 USP8 变化在另外由定序的 Sanger 的 258 舞步。进一步定序指向在 108 秘密 ACTH 舞步(62.04%) 中的 67 个识别了 USP8 变体的 17 种类型的一个总数。然而,任何一个都没在舞步的另外的类型这些变化被检测(n = 150 ) 。这些变化在 USP8 的 14-3-3 绑定主题以内聚集并且破坏在 USP8 和 14-3-3 蛋白质之间的相互作用,导致保护 EGFR 免受 lysosomal 降级的伤害的一个提高的能力。因此,有 EGFR 表示,提高的 EGFR 蛋白质丰富和 mRNA 表示的更高的发生 POMC 铺平的变异的 USP8 显示的舞步,它编码 ACTH 的先锋。有变异的 USP8 的舞步在尺寸是显著地更小的并且比野类型的舞步有更高的 ACTH 生产。在里面通过手术 resected 主要变异 USP8 的肿瘤房间, USP8 击倒或堵住的 EGFR 有效地稀释 ACTH 分泌物。一起拿,体的 gain-of-function USP8 变化是普通的并且在库欣的疾病贡献 ACTH 生产过剩。USP8 或 EGFR 的抑制为对待变异 USP8 的 corticotrophin 腺瘤是有希望的。我们的学习在库欣的疾病加亮潜在地功能的变异的基因并且提供卓见进这疾病的治疗学。 | Zeng-Yi Ma Zhi-Jian Song Jian-Hua Chen Yong-Fei Wang Shi-Qi Li Liang-Fu Zhou Ying Mao Yi-Ming Li Rong-Gui Hu Zhao-Yun Zhang Hong-Ying Ye Ming Shen Xue-Fei Shou Zhi-Qiang Li Hong Peng Qing-Zhong Wang Dai-Zhan Zhou Xiao-Lan Qin Jue Ji Jie Zheng Hong Chen Yin Wang Dao-Ying Geng Wei-Jun Tang Chao-Wei Fu Zhi-Feng Shi Yi-Chao Zhang Zhao Ye Wen-Qiang He Qi-Lin Zhang Qi-Sheng Tang Rong Xie Jia-Wei Shen Zu-Jia Wen Juan Zhou Tao Wang Shan Huang Hui-Jia Qiu Ni-Dan Qiao Yi Zhang Li Pan Wei-Min Bao Ying-Chao Liu Chuan-Xin Huang Yong-Yong Shi Yao Zhao | 2015 | Cell Research2015，25，3： | 16 |
| 17 | Carbon carry capacity and carbon sequestration potential in China based on an integrated analysis of mature forest biomass显示文摘Forests play an important role in acting as a carbon sink of terrestrial ecosystem.Although global forests have huge carbon carrying capacity(CCC)and carbon sequestration potential(CSP),there were few quantification reports on Chinese forests.We collected and compiled a forest biomass dataset of China,a total of 5841 sites,based on forest inventory and literature search results.From the dataset we extracted 338 sites with forests aged over 80 years,a threshold for defining mature forest,to establish the mature forest biomass dataset.After analyzing the spatial pattern of the carbon density of Chinese mature forests and its controlling factors,we used carbon density of mature forests as the reference level,and conservatively estimated the CCC of the forests in China by interpolation methods of Regression Kriging,Inverse Distance Weighted and Partial Thin Plate Smoothing Spline.Combining with the sixth National Forest Resources Inventory,we also estimated the forest CSP.The results revealed positive relationships between carbon density of mature forests and temperature,precipitation and stand age,and the horizontal and elevational patterns of carbon density of mature forests can be well predicted by temperature and precipitation.The total CCC and CSP of the existing forests are 19.87 and 13.86 Pg C,respectively.Subtropical forests would have more CCC and CSP than other biomes.Consequently,relying on forests to uptake carbon by decreasing disturbance on forests would be an alternative approach for mitigating greenhouse gas concentration effects besides afforestation and reforestation. | LIU Ying Chun YU Gui Rui WANG Qiu Feng ZHANG Yang Jian XU Ze Hong | 2014 | Science China(Life Sciences)2014，57，12： | 15 |
| 18 | Combined Influence of Insulin Resistance and Inflammatory Biomarkers on Type 2 Diabetes:A Population-based Prospective Cohort Study of Inner Mongolians in China显示文摘This prospective study was designed to examine the combined influence of insulin resistance(IR)and inflammatory biomarker levels on type 2 diabetes mellitus(T2DM)among 1,903Inner Mongolians.During follow-up,205(10.77%)participants developed T2DM,and the incidence | QIU Qiao Yan ZHANG Bei Lei ZHANG Ming Zhi WU Jia Hui ZHOU Jing Wen LIANG Zhu ZHANG Yong Hong ZHANG Shao Yan | 2018 | Biomedical and Environmental Sciences2018，31，4： | 15 |
| 19 | IL-10 Gene Modified Dendritic Cells Inhibit T Helper Type 1-Mediated Alloimmune Responses and Promote Immunological Tolerance in Diabetes显示文摘Dendritic cells (DCs) have the potency to regulate the outcome of autoimmunity through the modulation of immune responses. The induction of antigen specific tolerance is critical for prevention and treatment of allograft rejection. In the present study,we transfected IL-10 gene into DCs and investigated their effect on inhibition of lymphocyte activity in vitro and induction of immune tolerance on islet allograft in mice. An IDDM C57BL/6 mouse model was induced by streptozotocin. The islet cells isolated from the BALB/c mice were transplanted into the kidney capules of the model mice followed by injection of IL-10 modified DCs (mDCs). The results showed that mDCs could significantly inhibit T lymphocyte proliferation mediated by allotype cells and induce its apoptosis,whereas,unmodified DCs (umDCs) could promote the murine lymphocyte proliferation markedly. The injection of mDCs could prolong the survival of allotype islet transplanted IDDM mice. The average plasma glucose (PG) level in mDCs treated mice returned to normal within 3 days and lasted for about 2 weeks. The rejection response in control mice occurred for 5 days after transplantation. The level of IFN-γ was lower while IL-4 was higher in mDCs treated mice than that in umDCs treated mice,which indicated that Th1/Th2 deviation occurred. Our studies suggest that IL-10 gene modified DCs can induce the immune tolerance to islet graft and prolong survival of the recipients by the inhibiting of T cell proliferation in allotype mice. | Huifen Zhu Wenhong Qiu Ping Lei Wei Zhou Xue Wen Fengrong He Li Li Hong Dai Guanxin Shen Feili Gong | 2008 | Cellular & Molecular Immunology2008，5，1： | 14 |
| 20 | Clinical Manifestations of Fibrosing Mediastinitis in Chinese Patients显示文摘 | Yan Hu Jian-Xing Qiu Ji-Ping Liao Hong Zhang Zhe Jin Guang-Fa Wang | 2016 | Chinese Medical Journal2016，，22： | 14 |
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