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| 1 | Platelets generated from human embryonic stem cells are functional in vitro and in the microcirculation of living mice显示文摘 | Shi-Jiang Lu Feng Li Hong Yin Qiang Feng Erin A Kimbrel Eunsil Hahm Jonathan N Thon Wei Wang Joseph E ltaliano Jaehyung Cho Robert Lanza | 2011 | Cell Research2011，21，3： | 14 |
| 2 | Angiomyolipoma of the kidney and lymph nodes显示文摘 | Thomas Fr?hlich Alexander Brands Walter F. Thon Hans-Peter Weskott Helmut Ostertag | 1999 | World Journal of Urology1999，，2： | 2 |
| 3 | Diabetes mellitus type?2 in childhood and adolescence in Germany and parts of Austria显示文摘 | Edith Schober Reinhard W. Holl Matthias Grabert Angelika Thon Birgit Rami Thomas Kapellen Ora Seewi Thomas Reinehr | 2005 | European Journal of Pediatrics2005，，11： | 2 |
| 4 | Herpes simplex virus colitis complicating ulcerative colitis: A case report and brief review on superinfections显示文摘 | Marco Oliver Schunter Thorsten Walles Peter Fritz Uta Meyding-Lamadé Klaus-Peter Thon Klaus Fellermann Eduard Friedrich Stange Wolfram Lamadé | 2007 | Journal of Crohn’s and Colitis2007，，： | 2 |
| 5 | Generation of flavour compounds in fermented sausages—the influence of curing ingredients, Staphylococcus starter culture and ripening time显示文摘 | Pelle Thonning Olesen Anne Strunge Meyer Louise Heller Stahnke | 2003 | Meat Science2003，，3： | 2 |
| 6 | Circulating miR-21-5p level has limited prognostic value in patients with hepatocellular carcinoma and is influenced by renal function显示文摘BACKGROUND MicroRNAs(miRNAs)have been suggested as biomarkers for malignant diseases including hepatocellular carcinoma(HCC).Specifically,hsa-miR-21-5p(miR-21)is among the most frequently deregulated miRNA in cancer.The diagnostic and prognostic value of miR-21 has been demonstrated in HCC tissue,mostly in the Asian population.Although the impact of various factors has been recently reported for circulating hsa-miR-122-5p(miR-122),at present only limited knowledge is available for miR-21.AIM To evaluate the value of miR-21 for the assessment of prognosis in HCC patients and to delineate the influence of clinical and preanalytical factors on miR-21 level in sera.METHODS Patients with confirmed HCC from our European cohort with predominantly alcohol-associated liver damage were included in the study.All subjects were characterized according to their clinical and laboratory work-up and overall survival data were obtained.Quantitative real-time polymerase chain reaction was performed for miR-21 and spiked-in cel-miR-39-3p.The results were compared to previously reported miR-122 data.RESULTS Survival of HCC patients was comparable between patients with low and high serum miR-21 concentration.No association was observed between miR-21 level in sera and Child-Pugh score,Barcelona Clinic Liver Cancer staging system,or etiology of HCC/liver disease.Age,gender,or pretreatment had no association with miR-21 level.A positive correlation was observed between miR-21 and aspartate aminotransferase(r=0.2854,P=0.0061),serum miR-122(r=0.2624,P=0.0120),and the International Normalized Ratio(r=0.2065,P=0.0496).Negative correlation of miR-21 with serum creatinine(r=-0.2215,P=0.0348)suggests renal function as a potential influencing factor in miR-21 biogenesis in blood.CONCLUSION The results from this work do not support clinically relevant prognostic value of circulating miR-21 in HCC patients in real-life settings.Following systematic evaluation,we identified renal function and aspartate aminotransferase as potential factors that may affect miR-21 concentration in blood.This knowledge should be considered in future miRNA-based biomarker studies not only for HCC but also for other diseases. | Martin Franck Cosima Thon Kerstin Schutte Peter Malfertheiner Alexander Link | 2020 | World Journal of Hepatology2020，12，11： | 2 |
| 7 | Presence of plu- ripotent CD133^+ cells correlates with malignancy of gliomas 显示文摘 | Thon N Damianoff K Hegermann J | 2010 | Mol Cell Neurosci2010，43，1： | 1 |
| 8 | Graphene plasmonics: A platform for strong light-matter interactions显示文摘 | Koppens F H L Chang D E Thon'grattanasiri S | 2011 | Optics & Photonics News2011，22，12： | 1 |
| 9 | Lymphatic mapping and sentinel node biopsy is the mehtod applicable to patients with colorectal and gastric cancer?显示文摘 | Magnus Thon | 2000 | Eur J Surg2000，166，7： | 1 |
| 10 | Improvement in health-related quality of life for children with juvenile idio- pathic arthritis after start of treatment with etanercept 显示文摘 | Klotsche J Minden K Thon A | 2014 | Arthritis Care Res (Hoboken)2014，66，2： | 1 |
| 11 | The dynamics of colo-ny organization in the primitively eusocial wasp Polistes dominulus(Christ)显示文摘 | THERAULAZ G GERVET J THON B | 1992 | Ethology1992，91，3： | 1 |
| 12 | Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses显示文摘 | O'Connell R J Thon M R Hacquard S et ol | 2012 | Nature Genetics2012，44，9： | 1 |
| 13 | Denovo urothelial carcinoma of the upper and lower urinary tract in kidney- -transplant patients with end-stage analgesic nephropathy 显示文摘 | Thon WF Kliem V Truss MC | 1995 | World J Urol1995，13，： | 1 |
| 14 | Prophylactic endovascular placement of internal iliac occlusion balloon catheters in parturients with placenta accreta:A retrospective case series显示文摘 | Thon S Mclintic A Wangner Y | | 0，，01： | 1 |
| 15 | The pl;lce of inter- stitial brachylherapy and radiosurgery for low grade gliomas 显示文摘 | Kreth FW Thon N Siefert A Tonn JC | 2010 | AdvTech Stand Neurosurg2010，35，： | 1 |
| 16 | stereotactic brachytherapy in recurrent high-grade gliomas 显示文摘 | Schwartz C Romagna A Thon N | 2015 | Acta Neurochir ( Wien )2015，157，10： | 1 |
| 17 | Role of the fission yeast SUMO E3 ligase Pli1p in centromere and telomere maintenance显示文摘 | Xhemalce B Seeler JS Thon G | 2004 | EMBO J2004，23，19： | 1 |
| 18 | A new horizon in primary prevention of cardiovascular disease, can we prevent heart attack by 'heart polypill' ?显示文摘 | Rastegarpanah M Malekzadeh F Thon as G N | 2008 | Archives of Iranian Medicine2008，11，30： | 1 |
| 19 | Exact focusing of extracorporeal shock wave therapy for calcifying tendinopathy显示文摘 | HAAKE M DEIKE B THON A | 2002 | Clin Orthop Relat Res2002，，397： | 1 |
| 20 | Persistently modified h-channels after complex febrile seizures convert the seizure-induced enhancement of inhibition to hyperexcitability显示文摘 | Chen K Aradi I Thon N | 2001 | Nat Med2001，7，3： | 1 |
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