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| 1 | Impact of an acute hemodynamic response-guided protocol for primary prophylaxis of variceal bleeding显示文摘AIM To evaluate the long-term outcome of an acute hemodynamic response-guided protocol in which acute responders to intravenous propranolol received traditional nonselective beta-blockers(NSBBs) and acute nonresponders received carvedilol.METHODS Retrospective review of a protocol for primary prophylaxis of variceal bleeding guided by the acute hemodynamic response to intravenous propranolol. Fifty-two acute responders treated with traditional NSBB(i.e. propranolol or nadolol) were compared with 24 acute nonresponders receiving carvedilol. A second hemodynamic study was performed in 27 and 13 patients, respectively. The primary endpoint was development of first or further decompensation. Secondary endpoints included death from any cause, association between acute and chronic hemodynamic response, and baseline clinical and laboratory variables related to the acute hemodynamic response.RESULTS Acute responders and acute nonresponders presented similar 1, 2, and 3-year probabilities of first decompensation(NSBB: 0%, 13.7%, 26.1% vs carvedilol: 0%, 20%, 20%, P = 0.968) or further decompensation(21.2%, 26.1%, 40.9% vs 21.2%, 50.0%, 50.0%, P = 0.525). A previous episode of hepatic encephalopathy was the only independent predictor of decompensation [hazard ratio(95% confidence interval): 8.03(2.76-23.37)]. Mortality rates were similar in acute responders and acute nonresponders with compensated(P = 0.428) or decompensated cirrhosis(P = 0.429). No clinical, laboratory, endoscopic or hemodynamic parameter predicted the acute hemodynamic response. In patients receiving traditional NSBB, the acute and chronic changes of hepatic venous pressure gradient were correlated(r = 0.59, P = 0.001). Up to 69.2% of acute nonresponders gained chronic response with carvedilol.CONCLUSION Early identification and treatment with carvedilol of acute nonresponders to intravenous propranolol improves the clinical outcome of this high-risk group of patients, probably due to its greater effects for reducing portal pressure. | José Ignacio Fortea ángela Puente Patricia Ruiz Iranzu Ezcurra Javier Vaquero Antonio Cuadrado María Teresa Arias-Loste Joaquín Cabezas Susana Llerena Paula Iruzubieta Carlos Rodríguez-Lope Patricia Huelin Fernando Casafont Emilio Fábrega Javier Crespo | 2018 | World Journal of Clinical Cases2018，6，13： | 6 |
| 2 | Randomised clinical trials: linaclotide phase 3 studies in IBS ‐C – a prespecified further analysis based on European Medicines Agency‐specified endpoints显示文摘 | E. M. M. Quigley J. Tack W. D. Chey S. S. Rao J. Fortea M. Falques C. Diaz S. J. Shiff M. G. Currie J. M. Johnston | 2012 | Aliment Pharmacol Ther2012，，1： | 3 |
| 3 | Cerebrospinal fluid beta-amyloid and phospho-tau biomarker interactions affecting brain structure in preclinical Alzheimer disease显示文摘 | Fortea J Vilaplana E Alcolea D | 2014 | Ann Neurol2014，76，2： | 1 |
| 4 | Kinetic characterisation and thermal inactivation study of polyphenoloxidase and peroxidase from table grape 显示文摘 | FORTEA M I LOPEZ-MIRANDA S SERRANO-MARTNEZ A | 2009 | Food Chemistry2009，113，： | 1 |
| 5 | Early over expression of messenger RNA for multiple genes,including insulin,in the pancreatic lymph nodes of NOD mice is associated with islet autoimmunity显示文摘 | Regnault B Osorio Y Fortea J | 2009 | BMC Med Genomics2009，2，4： | 1 |
| 6 | Cognitively preserved subjects with transitional cerebrospinal fluid β-amyloid 1-42 values have thicker cortex in Alzheimer′s disease vulnerable areas显示文摘 | Fortea J Sala-Llonch R Bartres-Faz D | 2011 | Biol Psychiatry2011，70，2： | 1 |
| 7 | Hirschprung's disease in adults显示文摘 | Fortea Sanchis C Martinea Ramos D Rivadulla Serrano I | 2011 | Rey Esp Enferm Dig2011，103，3： | 1 |
| 8 | Effect of time and cerebrovascular symptoms on the prevalence of microembdic signals in patients with cervical carotid stenosis显示文摘 | Fortea A M Babikian VL Hyde C | 1996 | Stroke1996，27，： | 1 |
| 9 | Insight into the uncoupling mechanism of sarcoplasmic reticnlum ATPase using the phosphorylating substrate UTP显示文摘 | FORTEA M I SOLER F BELDA F F | 2000 | Biological Chemistry2000，275，12： | 1 |
| 10 | Randomised clinical trials: linaclotide phase 3 studies in IBS ‐C – a prespecified further analysis based on European Medicines Agency‐specified endpoints显示文摘 | E. M. M. Quigley J. Tack W. D. Chey S. S. Rao J. Fortea M. Falques C. Diaz S. J. Shiff M. G. Currie J. M. Johnston | 2012 | Aliment Pharmacol Ther2012，，1： | 1 |
| 11 | Novel potential targets for prevention of arterial restenosis:insights from the pre–clinical research显示文摘 | ForteA RinaldiB BerrinoL | 2014 | Clin Sci(Lond)2014，127，61： | 1 |
| 12 | Inguinal bernioplasty: the gold standard of hernia repair显示文摘 | ForteA D'UrsoA Palumbo P | 2003 | Hernia2003，7，1： | 1 |
| 13 | Product formation in the Prato reaction on Sc3N@D5h-C80:Preference for-bonds,and not pyracylenic bonds显示文摘 | Osuna S Rodriguez Fortea A Poblet J M | 2012 | Chemical Communications2012，48，： | 1 |
| 14 | Kinetic characterisation and thermal inactivation study of polyphenol oxidase and peroxidase from table grape (Crimson Seedless)显示文摘 | Fortea M I S Lopez-Miranda | 2009 | Food Chemistry2009，113，： | 1 |
| 15 | Cerebrospinal fluidbeta - amyloid and phospho - tau biomarker interactions af-fecting brain structure in preclinical Alzheimer disease 显示文摘 | Fortea J Vilaplana E Alcolea D | 2014 | Ann Neurol2014，，： | 1 |
| 16 | Laser cutting of high-vitrified ceramic materials:development of a method using a Nd∶YAG laser to avoid catastrophic breakdown显示文摘 | COSP J P RAMíREZ DEL VALLE A J FORTEA J G | 2002 | Materials Letters2002，55，4： | 1 |
| 17 | Kinetic characterisation and thermal inactivation study of polyphenol oxidase and peroxidase from table grape显示文摘 | Fortea M I Lopez-Miranda S Serrano-Martnez A | 2009 | Food Chemistry2009，113，： | 1 |
| 18 | Irritable bowel syndrome with constipation:a European-focused systematic literature review of disease burden显示文摘 | Fortea J Prior M | 2013 | J Med Econ2013，16，： | 1 |
| 19 | Encapsulation of Quercetin and Myricetin in Cyclodextrins at Acidic pH显示文摘 | LUCAS -ABELLAN CARMEN FORTEA ISABEL ABALDON JOSE ANTONIO | 2008 | Journal of Agricultural and Food Chemistry2008，56，1： | 1 |
| 20 | Follicular mucinosis secondary to captopril-induced photoallergy显示文摘 | P6rez-Ferriols A Martinez-Mench6n T Fortea JM | 2005 | ActasDermosifiliogr2005，96，3： | 1 |
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