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| 1 | 欧洲新生儿呼吸窘迫综合征防治指南-2010版显示文摘呼吸窘迫综合征(RDS)是由于肺表面活性物质(PS)缺乏及肺结构发育不成熟所致,多见于早产儿,自然病程为生后当时或很快发病,并在生后2d内进行性恶化,如不及时治疗,因进行性缺氧和呼吸衰竭而死亡,存活者,在生后2—4d病情开始改善。胎龄越小,RDS发生率越高,2006年EuroNeoStat的数据显示:胎龄23~25周的早产儿RDS发生率为91%, | Sweet DG Carnielli V Greisen G Hallman M Ozek E Plavka R Saugstad OD Simeoni U Speer CP Halliday HL 袁琳(翻译) 陈超(审校) | 2011 | 中华儿科杂志2011，49，1： | 137 |
| 2 | The Open Quantum Materials Database (OQMD): assessing the accuracy of DFT formation energies显示文摘The Open Quantum Materials Database(OQMD)is a high-throughput database currently consisting of nearly 300,000 density functional theory(DFT)total energy calculations of compounds from the Inorganic Crystal Structure Database(ICSD)and decorations of commonly occurring crystal structures.To maximise the impact of these data,the entire database is being made available,without restrictions,at www.oqmd.org/download.In this paper,we outline the structure and contents of the database,and then use it to evaluate the accuracy of the calculations therein by comparing DFT predictions with experimental measurements for the stability of all elemental ground-state structures and 1,670 experimental formation energies of compounds.This represents the largest comparison between DFT and experimental formation energies to date.The apparent mean absolute error between experimental measurements and our calculations is 0.096 eV/atom.In order to estimate how much error to attribute to the DFT calculations,we also examine deviation between different experimental measurements themselves where multiple sources are available,and find a surprisingly large mean absolute error of 0.082 eV/atom.Hence,we suggest that a significant fraction of the error between DFT and experimental formation energies may be attributed to experimental uncertainties.Finally,we evaluate the stability of compounds in the OQMD(including compounds obtained from the ICSD as well as hypothetical structures),which allows us to predict the existence of~3,200 new compounds that have not been experimentally characterised and uncover trends in material discovery,based on historical data available within the ICSD. | Scott Kirklin James E Saal Bryce Meredig Alex Thompson Jeff W Doak Muratahan Aykol Stephan Rühl Chris Wolverton | 2015 | npj Computational Materials2015，，1： | 62 |
| 3 | 影响湖相沉积岩中有机碳分布的主要因素——以三水盆地为例显示文摘湖相沉积中的有机质含量随有机质堆积条件变化而发生波动。本文以三水盆地下第三系土布心组二段地层为例 ,对其作高分辨率岩芯取样并结合地球化学方法 ,分析生物学因素对有机碳分布的影响。在较干燥的气候条件下 ,水生浮游生物是有机质的主要来源 ,由于此时湖泊与海洋沟通 ,出现半咸水环境 ,硫酸盐还原作用显著 ,不利于有机质保存。所取岩芯段的中上部即是这种情况 ,以低TOC和高SRI值为特征。而当气候湿润时 ,植物繁荣 ,湖水淡化 ,陆源有机质丰富。缺氧条件下的有机质降解主要是效率极低的发酵作用。有利于有机质保存。这种情形出现于岩芯段的下部 。 | 刘春莲 杨建林 Hans-JoachimRhl Annette Schmid Rhl | 2001 | 沉积学报2001，19，1： | 37 |
| 4 | Matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-1 expression in fibrotic rat liver显示文摘INTRODUCTIONLiver fibrosis is an excessive deposition ofextracellular matrix(ECM)resulted from bothincreased synthesis and decreased degradation.Matrix metalloproteinases(MMPs)represent agroup of neutral proteinases with variable | Liu HL Li XH Wang DY Yang SP | 2000 | World Journal of Gastroenterology2000，6，6： | 31 |
| 5 | 欧洲早产儿呼吸窘迫综合征防治共识指南(2013版)显示文摘本次指南更新包括了自2010年以来Cochrane系统评价和医学文献中的最新证据,并采纳了一种新的证据评估分级系统(GRADE)。以往关于早期肺表面活性物质和持续气道正压通气治疗的推荐目前拥有了更坚定的循证依据。对产房复苏、稳定生命体征等内容进行了较大扩充。生命体征稳定后的氧疗目前仍存在一定的争议,但是在获得更多的证据之前,血氧饱和度的目标范围不应低于90%,支持治疗对于超早早产儿仍然极为重要。指南对其他注意事项进行了缩减。 | Sweet D Carnielli V Greisen G Hallman M Ozek E Plavka R Saugstad OD Simeoni U Speer CP Halliday HL 王敏婕 袁琳 陈超 | 2014 | 中华儿科杂志2014，52，10： | 34 |
| 6 | Increased expression of Toll-like receptor 4 on peripheral-blood mononuclear cells in patients with coronary arteriosclerosis disease显示文摘 | Geng HL Lu HQ Zhang LZ Zhang H Zhou L Wang H Zhong RQ | 2006 | 第二军医大学学报2006，27，5： | 20 |
| 7 | 替诺福韦可降低慢性HBV感染者发生肝细胞癌的风险显示文摘【据《Gastroenterology》2020 年1 月报道】题:在中国,替诺福韦与恩替卡韦相比,可降低慢性HBV 感染者发生肝细胞癌的风险(作者Yip TC 等)在慢性HBV 感染者中,用替诺福韦治疗与恩替卡韦治疗罹患肝细胞癌(HCC)风险的研究结果相互矛盾。 | 冯丽娜 金清龙 YIP TC WONG VW CHAN HL | 2020 | 临床肝胆病杂志2020，36，2： | 17 |
| 8 | Effects of endogenous beta-amyloid overproduction on tau phosphorylation in cell culture.显示文摘 | Wang ZF Li HL Li XC Zhang Q Tian Q Wang Q Xu H Wang JZ | 2006 | 中国生物学文摘2006，20，9： | 15 |
| 9 | Production of soybean isoflavone genistein in non-legume plants via genetically modified secondary metabolism pathway显示文摘 | Liu, RR Hu, YL Li, HL Lin, ZP | 2007 | 中国生物学文摘2007，21，10： | 15 |
| 10 | Five-year long-term outcomes of laparoscopic surgery for colon cancer显示文摘AIM:To perform a meta-analysis to answer whether long-term recurrence rates after laparoscopic-assisted surgery are comparable to those reported after open surgery.METHODS:A comprehensive literature search of the MEDLINE database,EMBASE database,and the Cochrane Central Register of Controlled Trials for the years 1991-2010 was performed.Prospective randomized clinical trials(RCTs)were eligible if they included patients with colon cancer treated by laparoscopic surgery vs open surgery and followed for more than five years.RESULTS:Three studies involving 2147 patients reported long-term outcomes based on five-year data and were included in the analysis.The overall mortality was similar in the two groups(24.9%,268/1075 in the laparoscopic group and 26.4%,283/1072 in open group).No significant differences between laparoscopic and open surgery were found in overall mortality during the follow-up period of these studies[OR(fixed) 0.92,95%confidence intervals(95%CI):0.76-1.12,P=0.41].No significant difference in the development of overall recurrence was found in colon cancer patients,when comparing laparoscopic and open surgery [2147 pts,19.3%vs 20.0%;OR(fixed)0.96,95% CI:0.78-1.19,P=0.71].CONCLUSION:This meta-analysis suggests that laparoscopic surgery was as efficacious and safe as open surgery for colon cancer,based on the five-year data of these included RCTs. | Bai HL Chen B Zhou Y Wu XT. | 2010 | World Journal of Gastroenterology2010，16，39： | 13 |
| 11 | The performance characteristics of prostate-specific antigen and prostate-specific antigen density in Chinese men显示文摘我们在中国人调查了前列腺特定的抗原(PSA ) 和 PSA 密度(PSAD ) 的表演特征。经历了 transrectal 的所有中国人到 2013 的从 2000 年的指导超声的前列腺活体检视(TRUS-PB ) 被包括。为 PSA 和 PSAD 操作特征(巨鸟) 曲线的接收装置被分析。敏感,特性,积极预兆的价值(PPV ) 和在不同截止层次的否定预兆的价值(NPV ) 是计算的。2606 个中国人的一个总数被包括。为 ROC,在曲线下面的区域为 PSA 是 0.770 (P <0.001 ) 并且 0.823 为 PSAD (P <0.001 ) 。4.5 ng ml −1 的 PSA 94.4% 的有的敏感, 14.1% 的特性, 29.5% 的 PPV,和 86.9% 的 NPV;0.12 ng ml −1 cc −1 的 PSAD 有 94.5% 的敏感, 26.6% 的特性, 32.8% 的 PPV,和 92.7% 的 NPV。在逻辑回归分析的 multivariate 上,在 4.5 ng ml −1 截止的 PSA (或 1.61, 95% CI 1.05-2.45, P = 0.029 ) 并且在 0.12 ng ml −1 cc 截止的 PSAD −1( 或 6.22, 95% CI 4.20-9.22, P <0.001 ) 是为 TRUS-PB 上的前列腺癌症察觉的重要预言者。在结论,在在中国人的不同截止层次的 PSA 和 PSAD 的表演与在白种人的那些很不同。4.5 ng ml −1 的 PSA 和 0.12 ng ml −1 cc −1 的 PSAD 在 95% 敏感附近有并且是在中国人的前列腺癌症察觉的重要预言者。 | Jeremv YC Teoh Steffi KK Yuen James HL Tsu Charles KW Wong Brian SH Ho Ada TL Ng Wai-Kit Ma Kwan-Lun Ho Ming-Kwong Yiu | 2017 | Asian Journal of Andrology2017，19，1： | 13 |
| 12 | Overexpression of P-glycoprotein in hepatocellular carcinoma and its clinical implication显示文摘INTRODUCTIONMost advanced hepatocellular garcinoma (HCC) isinsensitive to most anticancer drugs which might berelated to the high frequency of expression of themultidrug resistance-1(MDR1) gene and itsproduct,P-glycoprotein (p-gp).p-gp expressionmay also be concerned with tumor progression anddifferentiation.In the present study。 | Kong XB Yang ZK Liang LJ Huang JF Lin HL | 2000 | World Journal of Gastroenterology2000，6，1： | 13 |
| 13 | 鼻腔鼻窦嗅神经母细胞瘤的手术径路探讨显示文摘目的 总结鼻腔鼻窦嗅神经母细胞瘤 (esthesioneuroblastoma,ENB)的临床经验。方法 对Fulda医院耳鼻咽喉 头颈及面部整形外科 1 988年 7月~ 2 0 0 1年 1 2月经治的 1 7例ENB的临床资料、手术治疗的径路、方法及预后进行回顾性分析。结果 据Morita等的临床分期标准 ,1 7例中A期1例 ,B期 6例 ,C期 9例 ,D期 1例。术后 8~ 1 63个月 (平均 44个月 )的随访观察结果表明 :2年既无复发、亦无转移的总生存率 90 90 % (1 0 / 1 1 ) ,其中A期为 1 / 1、B期为 6/ 6、C期为 3/ 3、D期为 0 / 1。所有经鼻内径路手术的 6例患者至今均存活 ,临床和影像学检查都无复发和转移迹象 ,存活最长者已达1 30个月 ;2例经额下径路手术的C期患者在随访的 8、2 7个月内均未发现复发和转移 ;经面正中掀翻径路手术的B、C期患者各 1例已分别存活 1 63个月和 82个月 ,均无复发和转移。 6例在此观察期间死于ENB :其中C期 5例、D期 1例 ;Ⅱ级 1例、Ⅲ级 1例、Ⅳ级 3例 (另 1例未行分级诊断 )。 1例 (C期/Ⅱ级 )于ENB术后 7年死于星形细胞瘤 ,此间一直无ENB复发。结论 联合应用手术和放射治疗ENB的效果最佳。前颅底恶性肿瘤的手术治疗径路选择应按照以下原则 :若病变组织没有浸润至颅内或眶内 ,采用鼻内径路 ; | 游学俊 Wolfgang Draf Ulrike Bockmühl | 2003 | 中华耳鼻咽喉科杂志2003，38，3： | 12 |
| 14 | Schisandrin B decreases the sensitivity of mitochondria to calcium ioninduced permeability transition and protects against ischemia-reperfusion injury in rat hearts显示文摘瞄准:为了阐明,位于 cardioprotection 下面的分子的机制由 schisandrin 负担得起 B (Sch B ) ,到刺激 Ca2+ 的渗透转变(磅) 的线粒体的敏感上的 Sch B 处理的效果在正常和 ischemia-reperfusion (红外) 条件下面在老鼠心被调查。结果:心肌的红外损害在线粒体的敏感引起了增加到刺激 Ca2+ 的磅在试管内。到 mitochondrial 磅的提高的敏感与 mitochondrial Ca2+ 内容以及反应氧化剂的程度的增加被联系种类生产在试管内和细胞色素 c 版本在活体内。Sch B 预告的处理对 I-R-induced 损害负担得起的 cardioprotection 是由在到刺激 Ca2+ 的磅的心肌的线粒体的敏感的减少的 paralleled,特别地在红外条件下面。结论:结果建议 Sch B 治疗增加心肌的线粒体的抵抗到刺激 Ca2+ 的磅并且免于 I-R-induced 组织损害。 | Po-yee CHIU Hoi-yan LEUNG Ada HL SIU Michel KTPOON Kam-ming KO | 2007 | Acta Pharmacologica Sinica2007，28，10： | 12 |
| 15 | 在有类型 2 糖尿病的病人的 nephropathy 的管理。 | Critchley JA Zhao HL Tomlinson B Leung W Thomas GN Chan JC Cockram CS | 2002 | Chinese Medical Journal2002，，1： | 12 |
| 16 | Endoscopic mucosal resection of colorectal polyps in typical UK hospitals显示文摘AIM:To evaluate the outcomes of endoscopic mucosal resection(EMR) for colorectal polyps,with particular regard to procedural complications and recurrence rate,in typical United Kingdom(UK) hospitals that perform an average of about 25 colonic EMRs per year.METHODS:A total of 239 colorectal polyps(≥ 10 mm) resected from 199 patients referred to Rochdale Infirmary,Salford Royal Hospital and Royal Oldham Hospital for EMR between January 2003 and January 2009 were studied.RESULTS:The mean size of polyps resected was 19.6 ± 12.4 mm(range 10-80 mm).The overall major complication rate was 2.1%.Complications were less frequent with non-adenomas compared with the other groups(Pearson's χ 2 test,P < 0.0001).Resections of largersized polyps were more likely to result in complications(unpaired t-test,P = 0.021).Recurrence was associated with histology,with carcinoma-in-situ more likely to recur compared with low-grade dysplasia [hazard ratio(HR) 186.7,95% confidence interval(95% CI):8.81-3953.02,P = 0.001].Distal lesions were also more likely to recur compared with right-sided and transverse colon lesions(HR 5.93,95% CI:1.35-26.18,P = 0.019).CONCLUSION:EMR for colorectal polyps can be performed safely and effectively in typical UK hospitals.Stricter follow-up is required for histologically advanced lesions due to increased recurrence risk. | Teegan R Lim Venkat Mahesh Salil Singh Benjamin HL Tan Mohamed Elsadig Nerukav Radhakrishnan Phil Conlong Chris Babbs Regi George | 2010 | World Journal of Gastroenterology2010，16，42： | 11 |
| 17 | Peroxynitrite induces Alzheimer-like tau modifications and accumulation in rat brain and its underlying mechanisms.显示文摘 | Zhang YJ Xu YF Liu YIH Yin J Li HL Wang Q Wang JZ. | 2006 | 中国生物学文摘2006，20，9： | 10 |
| 18 | Novel functional proteins interact with midkine in hepatic cancer cells显示文摘BACKGROUND: Midkine is a heparin-binding growth factor that promotes the proliferation, survival, migration and differentiation of various target cells. Midkine plays an important role in tumorigenesis and tumor progression, and is overexpressed in many human malignant tumors. Patients with high tumor midkine expression frequently have a worse prognosis than those with low expression. The present study was designed to investigate the interaction network of midkine in hepatic cancer cells, and to elucidate its role in hepatocellular carcinoma. METHODS: DNA encoding full-length midkine was cloned into pDBLeu vector to serve as bait in yeast two-hybrid screening to identify interacting proteins. Candidate proteins were examined on SC-Leu-Trp-His+3-AT (20 mmol/L) plates and assayed for X-gal activity, then sequenced and classified according to the GenBank. Finally, identified proteins were expressed by the in vitro expression system pCMVTnT, and protein interactions were confirmed by co-immunoprecipitation. RESULTS: Using the yeast two-hybrid system, we found 6 proteins that interacted with midkine: NK-kappa-B inhibitor alpha (I-κ-B-α), Dvl-binding protein naked cuticle 2, granulin, latent active TGF-β binding protein 3, latent active TGF-β binding protein 4, and phospholipid scramblase 1. In vitro co-immunoprecipitation demonstrated that all identified proteins directly interacted with midkine.CONCLUSION: The identification of midkine-interacting proteins in hepatic cancer cells indicates that midkine is a multifunctional factor that may participate in cell migration, differentiation, and proliferation, and is also associated with the multicellular response feedback during the development of hepatocellular carcinoma. | Qiang Yan, Hui-Lian Huang, Xing Yao, Jing Li, Li-Qin Li, Jing Zhong, Li-Shan Min, Li-Cheng Dai and Shu-Sen Zheng Department of Hepatobiliary and Pancreatic Surgery, Huzhou Central Hospital (Yan Q and Yao X) Huzhou Key Laboratory of Molecular Medicine, Affiliated Central Hospital of Huzhou Teachers College (Huang HL, Li J, Li LQ, Zhong J, Min LS and Dai LC), Huzhou 313000, China Division of Hepatobiliary and Pancreatic Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China (Yan Q and Zheng SS) | 2012 | Hepatobiliary & Pancreatic Diseases International2012，11，3： | 7 |
| 19 | The initial elevation of palaeokarst and planation surfaces on Tibet Plateau显示文摘THE formation periods,properties and initial elevations of Tibetan planation surfaces are keysto the issues ot the plateau uplift.Li et al.believed that the study on planation surfaces hasfar-reaching significance.Yang et al.indicated that the summit level and the basin level | Cui, ZJ Gao, QZ Liu, GN Pan, BT Chen, HL | 1997 | Chinese Science Bulletin1997，42，11： | 7 |
| 20 | The relationship of Imp2 and DR3 genes with susceptibility to type Ⅰ diabetes mellitus in south China Han population显示文摘AIN To study the relationship of Imp2 and DR3genes with type Ⅰ diabetes mellitus.NETHODS Imp2 genotypes and DR3 wereidentified in 68 patients with type Ⅰ diabetesmellitus(Ⅰ-DM)and 71 healthy controls.Then,Ⅰ-DM patients and controls were respectivelyallocated into DR3-positive and DR3-negativegroups.The frequencies of Imp2 and DR3 genein random subjects,and Imp2 genotypes in DR3-matched subjects were compared between Ⅰ-DMpatients and controls.At the same time,Ⅰ-DMpatients were divided into 3 groups based on theonset age of diabetics:group A≤14 years,group B 15-30 years and group C≥31 years.RESULTS The frequency of DR3 in Ⅰ-DMpatients was significantly higher than that incontrols(47% vs 21%,P<0.005),and it wassignificantly higher in group A than that in groupB+C(70% vs 36%,x^2=7.07,P<0.01).Therewas a significant difference among groups withdifferent onset age of diabetics(x^2=8.19,rp=0.33,P<0.05).In random subjects,thefrequency of Imp2.R/R in Ⅰ-DM patients waslower(43% vs 61%,P<0.05)and Imp2.R/Hhigher(53% vs 28%,P<0.05)than that incontrols,and there was no significant differenceamong groups with different onset age ofdiabetics.In DR3-positive subjects,thefrequency of Imp2.R/R in Ⅰ-DM patients waslower(47% vs 87%,P<0.05)and Imp2-R/H higher(47% vs 13%,P<0.05)than that incontrols.In DR3-negative subjects,thefrequency of Imp2.R/H in Ⅰ-DM patients washigher than that in controls(58% vs 32%,P<0.01),but the frequency of Imp2-R/R and Imp2H/H was not significantly different betweenthese two groups.CONCLUSION DR3 gene may be one of thesusceptible genes of Ⅰ-DM,and significantlyrelated to the onset age of diabetics,and thepersons with DR3 may have an younger onsetage of diabeteS.The Imp2-R/R may be theprotective genotype of Ⅰ-DM,and Imp2-R/H thesusceptible genotype.These were not affectedby DR3 gene.Imp-2 genotypes were not relatedwith the onset age of diabetics. | Ding HL Cheng H Fu ZZ Deng QL Yan L Yan T | 2000 | World Journal of Gastroenterology2000，6，1： | 7 |
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