|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 5-羟色胺代谢动力学与功能性胃肠病的研究靶点显示文摘5-羟色胺(5-HT)是重要的生物活性物质,参与体内多种生理和病理生理过程,与摄食、精神情绪、神经内分泌、心血管活动等密切相关。人体约95%的5-HT源自胃肠道,对胃肠运动和内脏感觉有重要调节作用。功能性胃肠病(FGIDs)是一组消化道功能紊乱性疾病,其发生、发展与5-HT的代谢活动密切相关。色氨酸羟化酶(TpH)、5-HT再摄取转运体(SERT)、5-HT受体等是5-HT代谢的关键环节。本文从5-HT代谢动力学入手,对FGIDs的研究靶点作一综述。 | 景富春 张军 | 2014 | 胃肠病学2014，19，10： | 24 |
| 2 | 肠易激综合征的流行病学显示文摘肠易激综合征(irritable bowel syndrome,IBS)是一种常见的胃肠功能紊乱性疾病,主要表现为与排便频率和排便性状改变相关的腹痛或不适综合征,缺乏可解释症状的形态学改变和生化异常。文献报道,全球人群中有10%~20%的成人和青少年IBS症状,女性多于男性。IBS症状可反复发作,严重影响患者的生活质量,并占用了大量的医疗资源。近年来,随着对IBS认识的不断深入和发展,先后制定并出版了一系列共识标准, | 陈世耀 庄莉红 | 2007 | 现代消化及介入诊疗2007，12，2： | 21 |
| 3 | Irritable bowel syndrome: A microbiome-gut-brain axis disorder?显示文摘Irritable bowel syndrome(IBS) is an extremely prevalent but poorly understood gastrointestinal disorder. Consequently, there are no clear diagnostic markers to help diagnose the disorder and treatment options are limited to management of the symptoms. The concept of a dysregulated gut-brain axis has been adopted as a suitable model for the disorder. The gut microbiome may play an important role in the onset and exacerbation of symptoms in the disorder and has been extensively studied in this context. Although a causal role cannot yet be inferred from the clinical studies which have attempted to characterise the gut microbiota in IBS, they do confirm alterations in both community stability and diversity. Moreover, it has been reliably demonstrated that manipulation of the microbiota can influence the key symptoms, including abdominal pain and bowel habit, and other prominent features of IBS. A variety of strategies have been taken to study these interactions, including probiotics, antibiotics, faecal transplantations and the use of germ-free animals. There are clear mechanisms through which the microbiota can produce these effects, both humoral and neural. Taken together, these findings firmly establish the microbiota as a critical node in the gut-brain axis and one which is amenable to therapeutic interventions. | Paul J Kennedy John F Cryan Timothy G Dinan Gerard Clarke | 2014 | World Journal of Gastroenterology2014，20，39： | 20 |
| 4 | Neuropathophysiology of functional gastrointestinal disorders显示文摘The investigative evidence and emerging concepts in neurogastroenterology implicate dysfunctions at the levels of the enteric and central nervous systems as underlying causes of the prominent symptoms of many of the functional gastrointestinal disorders. Neurogastroenterological research aims for improved understanding of the physiology and pathophysiology of the digestive subsystems from which the arrays of functional symptoms emerge. The key subsystems for defecation-related symptoms and visceral hyper- sensitivity are the intestinal secretory glands, the musculature and the nervous system that controls and integrates their activity. Abdominal pain and discomfort arising from these systems adds the dimension of sensory neurophysiology. This review details current concepts for the underlying pathophysiology in terms of the physiology of intestinal secretion, motility, nervous control, sensing function, immuno-neural communication and the brain-gut axis. | Jackie D Wood | 2007 | World Journal of Gastroenterology2007，13，9： | 17 |
| 5 | 肠吉泰治疗腹泻型肠易激综合征的随机双盲安慰剂平行对照试验显示文摘目的观察中药验方肠吉泰治疗腹泻型肠易激综合征(肝郁脾虚型)的疗效和安全性。方法采用随机双盲、安慰剂平行对照的方法,将60例符合纳入标准的腹泻型肠易激综合征患者,以1:1比例按随机数字进入试验组或对照组(各30例),对受试者、干预措施实施者及结果测量者实施盲法;试验组予肠吉泰颗粒剂,对照组予安慰剂,两组临床试验疗程均为28天;实施干预措施前、干预结束后对受试者采用症状尺度量表(IBS-BSS)、大便性状量表(IBS-DSQ)观察临床症状变化及生活质量改善情况,疗程结束后评价临床疗效。结果试验组和对照组主要症状有效率符合方案集(PP)分别为83.33%、62.10%,全分析集(FAS)分别为83.33%、60.00%(P<0.05);试验组和对照组的次要症状有效率符合方案集(PP)分别为86.67%、58.62%,全分析集(FAS)分别为86.67%、56.67%。组间主要症状和次要症状有效率比较,各分析集差异均有统计学意义(P<0.05)。试验组治疗前后主要症状总积分及各单项症状积分差异均有统计学意义(P<0.05);对照组除腹胀症状外,主要症状总积分及其他各单项积分差异有统计学意义(P<0.05);组间治疗后比较,主要症状总积分及各单项积分差异均有统计学意义(P<0.05)。两组治疗前后自身比较,排便次数和10天内大便急迫天数积分差异有统计学意义(P<0.05);组间治疗后比较,10天内大便急迫天数积分差异有统计学意义(P<0.05)。两组治疗过程中均未发生不良事件。结论中药验方肠吉泰治疗腹泻型肠易激综合征(肝郁脾虚型)安全有效。 | 李熠萌 张亚楠 蔡淦 林江 | 2010 | 上海中医药杂志2010，44，12： | 6 |
| 6 | 针灸治疗便秘型肠易激综合征的研究概况显示文摘对近年来便秘型肠易激综合征的中医病因病机认识及针灸治疗概况进行了综述,同时对目前研究中存在的问题进行了分析,指出应进一步加强其发病机制研究和疗效评价的标准化。 | 赵继梦 施茵 吴焕淦 赵海音 | 2011 | 中华中医药学刊2011，29，12： | 6 |
您所在的机构暂未开通此部分的功能，请联系管理员