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| 1 | Irritable bowel syndrome: A microbiome-gut-brain axis disorder?显示文摘Irritable bowel syndrome(IBS) is an extremely prevalent but poorly understood gastrointestinal disorder. Consequently, there are no clear diagnostic markers to help diagnose the disorder and treatment options are limited to management of the symptoms. The concept of a dysregulated gut-brain axis has been adopted as a suitable model for the disorder. The gut microbiome may play an important role in the onset and exacerbation of symptoms in the disorder and has been extensively studied in this context. Although a causal role cannot yet be inferred from the clinical studies which have attempted to characterise the gut microbiota in IBS, they do confirm alterations in both community stability and diversity. Moreover, it has been reliably demonstrated that manipulation of the microbiota can influence the key symptoms, including abdominal pain and bowel habit, and other prominent features of IBS. A variety of strategies have been taken to study these interactions, including probiotics, antibiotics, faecal transplantations and the use of germ-free animals. There are clear mechanisms through which the microbiota can produce these effects, both humoral and neural. Taken together, these findings firmly establish the microbiota as a critical node in the gut-brain axis and one which is amenable to therapeutic interventions. | Paul J Kennedy John F Cryan Timothy G Dinan Gerard Clarke | 2014 | World Journal of Gastroenterology2014，20，39： | 20 |
| 2 | Early Life Stress Alters Behavior, Immunity, and Microbiota in Rats: Implications for Irritable Bowel Syndrome and Psychiatric Illnesses显示文摘 | Siobhain M. O’Mahony Julian R. Marchesi Paul Scully Caroline Codling Anne-Marie Ceolho Eamonn M.M. Quigley John F. Cryan Timothy G. Dinan | 2009 | Biological Psychiatry2009，，3： | 4 |
| 3 | 肠出血性大肠杆菌显示文摘肠出血性大肠杆菌自1982年北美首次描述以来,已经逐渐成为北美重要的肠道致病菌,并与特发性溶血尿毒综合征(HUS)的发生有关,暴发性感染中报道的死亡率可高达31%。本文综述有关肠出血性大肠杆菌感染的发病机理、实验室鉴定、流行病学和治疗。 | Cryan B 安平 | 1991 | 国外医学(微生物学分册)1991，14，3： | 3 |
| 4 | Gut memories: Towards a cognitive neurobiology of irritable bowel syndrome显示文摘 | Paul J. Kennedy Gerard Clarke Eamonn M.M. Quigley John A. Groeger Timothy G. Dinan John F. Cryan | 2011 | Neuroscience and Biobehavioral Reviews2011，，1： | 2 |
| 5 | Serotonin, tryptophan metabolism and the brain-gut-microbiome axis显示文摘 | S.M. O’Mahony G. Clarke Y.E. Borre T.G. Dinan J.F. Cryan | 2014 | Behavioural Brain Research2014，，： | 2 |
| 6 | Effects of the probiotic Bifidobacterium infantis in the maternal separation model of depression显示文摘 | L. Desbonnet L. Garrett G. Clarke B. Kiely J.F. Cryan T.G. Dinan | 2010 | Neuroscience2010，，4： | 2 |
| 7 | Alterations in the central CRF system of two different rat models of comorbid depression and functional gastrointestinal disorders显示文摘 | Javier A. Bravo Timothy G. Dinan John F. Cryan | 2010 | The International Journal of Neuropsychopharmacology2010，，5： | 2 |
| 8 | First detection of a class 2 integron among clinical isolates of Serratia marcescens 显示文摘 | Crowley D Cryan B Lucey B | 2008 | Br J Biomed Sci2008，65，2： | 1 |
| 9 | Mind-altering microorganisms:the impact of the gut microbiota on brain and behaviour显示文摘 | Cryan JF Dinan TG | | 0，，： | 1 |
| 10 | The ascent of mouse: advances inmodelling human depression and anxiety显示文摘 | CRYAN J F HOLMES A | 2005 | Nat Rev DrugDiscov2005，4，9： | 1 |
| 11 | Carrier-based strategies for targeting protein and peptlde drugs to the lungs 显示文摘 | Cryan S A | 2005 | AAPS J2005，7，1： | 1 |
| 12 | Interleukin-6 modulates colonic transepithelial ion transport in the stress-sensitive wistar kyoto rat 显示文摘 | O'Malley D Dinan T G Cryan J F | 2012 | Front Pharmacol2012，3，： | 1 |
| 13 | In search of a depressed mouse: utility of models for studying depression-related behavior in genetically modified mice显示文摘 | Cryan J F Momtereau C | 2004 | Mol Psychiatry2004，9，4： | 1 |
| 14 | Assessing substrates underlying the behavioral effects of antidepressants using the modified rat forced swimming test显示文摘 | Cryan JF Valentino RJ Lucki I | 2005 | Neurosci Biobehav Rev2005，29，45： | 1 |
| 15 | Assessing antidepressant activity in rodents:recent developments and future needs 显示文摘 | Cryan J F Markou A Lucki I | 2002 | Trends Pharmac01 Sci2002，，23： | 1 |
| 16 | Regulation of the stress response by the gutmicrobiota : implications for psychoneuroendocrinology 显示文摘 | Dinan TG Cryan JF | 2012 | Psycho- neuroendocrinology2012，37，： | 1 |
| 17 | Chitosan for gene delivery and orthopedic tissue engineering applications显示文摘 | Raftery R O'Bfien FJ Cryan SA | 2013 | Molecules2013，18，5： | 1 |
| 18 | Clinical multiplexed exome sequencing distinguishes adult oligodendroglial neoplasms from astrocytic and mixed lineage gliomas 显示文摘 | Cryan JB Haidar S Ramkissoon LA | 2014 | Oncotarget2014，5，18： | 1 |
| 19 | Inhalable siRNA : potential as a therapeutic agent in the lungs显示文摘 | Durcan N Murphy C Cryan SA | 2008 | Mol Pharm2008，5，4： | 1 |
| 20 | Secretory leucoprotease inhibitor binds to NF-kappaB binding sites in monocytes and inhibits p65 binding显示文摘 | Taggart CC Cryan SA Weldon S | 2005 | J Exp Med2005，202，12： | 1 |
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