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| 1 | Thiazolidinedione treatment inhibits bile duct proliferation and fibrosis in a rat model of chronic cholestasis显示文摘AIM: To investigate the effects of troglitazone (TGZ), an anti-diabetic drug which activates peroxisome proliferatoractivated receptor-γ (PPAR-γ), for liver tissue repair, and the development of ductular reaction, following common bile duct ligation (BDL) in rats.METHODS: Rats were supplemented with TGZ (0.2% w/w in the pelleted food) for 1 wk before BDL or sham operation.Animals were killed at 1, 2, or 4 wk after surgery.RESULTS: The development of liver fibrosis was reduced in rats receiving TGZ, as indicated by significant decreases of procollagen type Ⅰ gene expression and liver hydroxyproline levels. Accumulation of α-smooth-muscle actin (SMA)-expressing cells surrounding newly formed bile ducts following BDL, as well as total hepatic levels of SMA were partially inhibited by TGZ treatment, indicating the presence of a reduced number and/or activation of hepatic stellate cells (HSC) and myofibroblasts. Development of the ductular reaction was inhibited by TGZ, as indicated by histochemical evaluation and hepatic activity of γ-glutamyltransferase (GGT).CONCLUSION: Treatment with thiazolidinedione reduces ductular proliferation and fibrosis in a model of chronic cholestasis, and suggests that limiting cholangiocyte proliferation may contribute to the lower development of scarring in this system. | Fabio Marra Raffaella DeFranco Gaia Robino Erica Novo Eva Efsen Sabrina Pastacaldi Elena Zamara Alessandro Vercelli Benedetta Lottini Carlo Spirli Mario Strazzabosco Massimo Pinzani Maurizio Parola | 2005 | World Journal of Gastroenterology2005，11，32： | 9 |
| 2 | Proangiogenic Cytokines as Hypoxia-Dependent Factors Stimulating Migration of Human Hepatic Stellate Cells显示文摘 | Erica Novo Stefania Cannito Elena Zamara Lorenzo Valfrè di Bonzo Alessandra Caligiuri Carlo Cravanzola Alessandra Compagnone Sebastiano Colombatto Fabio Marra Massimo Pinzani Maurizio Parola | 2007 | The American Journal of Pathology2007，，6： | 6 |
| 3 | Measurement of Spleen Stiffness to Evaluate Portal Hypertension and the Presence of Esophageal Varices in Patients With HCV-Related Cirrhosis显示文摘 | Antonio Colecchia Lucia Montrone Eleonora Scaioli Maria Letizia Bacchi–Reggiani Agostino Colli Giovanni Casazza Ramona Schiumerini Laura Turco Anna Rita Di Biase Giuseppe Mazzella Luca Marzi Umberto Arena Massimo Pinzani Davide Festi | 2012 | Gastroenterology2012，，3： | 3 |
| 4 | Liver fibrosis: consensus recommendations of the Asian Pacific Association for the Study of the Liver (APASL)显示文摘 | Gamal Shiha Shiv Kumar Sarin Alaa Eldin Ibrahim Masao Omata Ashish Kumar Laurentius A. Lesmana Nancy Leung Nurdan Tozun Saeed Hamid Wasim Jafri Hitoshi Maruyama Pierre Bedossa Massimo Pinzani Yogesh Chawla Gamal Esmat Wahed Doss Taher Elzanaty Puja Sakhuj | 2009 | Hepatology International2009，，2： | 2 |
| 5 | Serum markers detect the presence of liver fibrosis: A cohort study显示文摘 | William M.C. Rosenberg Michael Voelker Robert Thiel Michael Becka Alastair Burt Detlef Schuppan Stefan Hubscher Tania Roskams Massimo Pinzani Michael J.P. Arthur | 2004 | Gastroenterology2004，，6： | 2 |
| 6 | Non invasive evaluation of portal hypertension using transient elastography显示文摘 | Laurent Castera Massimo Pinzani Jaime Bosch | 2011 | Journal of Hepatology2011，，3： | 2 |
| 7 | Angiogenesis in liver disease显示文摘 | Mercedes Fernández David Semela Jordi Bruix Isabelle Colle Massimo Pinzani Jaume Bosch | 2009 | Journal of Hepatology2009，，3： | 2 |
| 8 | Fibrosis and Cirrhosis Reversibility: Clinical Features and Implications显示文摘 | Massimo Pinzani Francesco Vizzutti | 2008 | Clinics in Liver Disease2008，，4： | 2 |
| 9 | Small diameter H-graft porta-caval shunt performed at different stages of liver disease显示文摘BACKGROUND: Partial porto-systemic shunts have been popularized because of reported low rate of mortality and morbidity (especially encephalopathy, liver failure and oc- clusion). To further investigate these assumptions, we ret- rospectively reviewed the results of partial porta-caval shunts performed at different stages of liver disease. METHODS: Twenty-nine cirrhotic patients underwent a partial porta-caval shunt with a ringed polytetrafluoroethy- lene interposition prosthesis of 8-mm ( 20 patients) or 10- mm (9 patients) in diameter. Pre- and post-shunt porta- caval pressure was measured in all patients. Twelve patients (41.4%) belonged to Child A, 11 Child B (37.9%), and 6 Child C (20.7%). Eleven patients (37.9%) suffered from hepatic encephalopathy preoperatively. Twelve patients (41%) were operated on in emergency/urgency. RESULTS: Porta-caval pressure gradient, reduced signifi- cantly using either 8- or 10-mm prosthesis. The overall ear- ly mortality and morbidity were 13. 8% and 48% respec- tively. The early mortality and morbidity were different be- tween patients of Child A and B when compared to those of Child C (0 vs 66.6% and 34.8% vs 66.6% respectively). No patient re-bled early from varices. The overall late mor- tality and morbidity were 40% and 64% respectively. Shunt thrombosis and stenosis took place in 16% and 8% of the two groups of patients respectively; variceal re-bleeding oc- curred in 4 patients (16%). Encephalopathy occurred post- operatively in 5 patients (20%), acute in 3 patients (12%), and chronic in 2 (8%). The actuarial survival rate at 3 and 5 years was 92% and 75% for patients of Child A, 70% and 60% for patients of Child B, and 0% for patients of Child C. CONCLUSIONS: Our results indicate that partial porta-ca- val shunt with a small diameter interposition H-graft is an effective procedure for the treatment of variceal bleeding, as well as for the prevention of re-bleeding in patients of Child A and those of Child B, as an elective or emergency/ urgency procedure, with a low rate of complications and encephalopathy. This technique could be used safely in pa- tients with good liver function but they should be moni- tored closely because of the risk of shunt occlusion. | Giacomo Batignani Francesco Vizzutti Luigi Rega Michele Zuckermann Geri Fratini Massimo Pinzani Francesco Tonelli | 2004 | Hepatobiliary & Pancreatic Diseases International2004，3，4： | 1 |
| 10 | Tunnelling and Hydrogeological Issues: A Short Review of the Current State of the Art 显示文摘 | Massimo COLI Alice PINZANI | 2014 | Rock Mechanics and Rock Engineering2014，47，3： | 1 |
| 11 | Epithelial–mesenchymal transition in chronic liver disease: Fibrogenesis or escape from death?显示文摘 | Massimo Pinzani | 2011 | Journal of Hepatology2011，，2： | 1 |
| 12 | Serum markers detect the presence of liver fibrosis: A cohort study显示文摘 | William M.C. Rosenberg Michael Voelker Robert Thiel Michael Becka Alastair Burt Detlef Schuppan Stefan Hubscher Tania Roskams Massimo Pinzani Michael J.P. Arthur | 2004 | Gastroenterology2004，，6： | 1 |
| 13 | Anti-fibrotic therapy: Lost in translation?显示文摘 | Detlef Schuppan Massimo Pinzani | 2012 | Journal of Hepatology2012，，： | 1 |
| 14 | Fibrosis and Cirrhosis Reversibility: Clinical Features and Implications显示文摘 | Massimo Pinzani Francesco Vizzutti | 2008 | Clinics in Liver Disease2008，，4： | 1 |
| 15 | Spleen stiffness measurement can predict clinical complications in compensated HCV-related cirrhosis: a prospective study显示文摘 | Antonio Colecchia Agostino Colli Giovanni Casazza Daniele Mandolesi Ramona Schiumerini Letizia Bacchi Reggiani Giovanni Marasco Martina Taddia Andrea Lisotti Giuseppe Mazzella Anna Rita Di Biase Rita Golfieri Massimo Pinzani Davide Festi | 2014 | Journal of Hepatology2014，，： | 1 |
| 16 | Fibrosis and Cirrhosis Reversibility: Clinical Features and Implications显示文摘 | Massimo Pinzani Francesco Vizzutti | 2008 | Clinics in Liver Disease2008，，4： | 1 |
| 17 | Fibrosis in chronic liver diseases: diagnosis and management显示文摘 | Massimo Pinzani Krista Rombouts Stefano Colagrande | 2004 | Journal of Hepatology2004，，1： | 1 |
| 18 | Reversal of hepatic fibrosis: pathophysiological basis of antifibrotic therapies显示文摘 | Mona Ismail Massimo Pinzani | 2011 | Hepatic Medicine: Evidence and Research2011，，： | 1 |
| 19 | Hepatic fibrosis: Concept to treatment显示文摘 | Christian Trautwein Scott L. Friedman Detlef Schuppan Massimo Pinzani | 2015 | Journal of Hepatology2015，，1： | 1 |
| 20 | Expression of platelet-derived growth factor in newly formed cholangiocytes during experimental biliary fibrosis in rats显示文摘 | Cecilia Grappone Massimo Pinzani Maurizio Parola Giulia Pellegrini Alessandra Caligiuri Raffaella DeFranco Fabio Marra Hermann Herbst Gianfranco Alpini Stefano Milani | 1999 | Journal of Hepatology1999，，1： | 1 |
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