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| 1 | Long-term alpha interferon and lamivudine combination therapy in non-responder patients with anti-HBe-positive chronic hepatitis B:Results of an open,controlled trial显示文摘AIM: To investigate the safety and efficacy of long-term combination therapy with alpha interferon and lamivudine in non-responsive patients with anti-HBe-positive chronic hepatitis B.METHODS: 34 patients received combination treatment (1 month lamivudine, 12 month lamivudine+interferon, 6month lamivudine), 24 received lamivudine (12 months),24 received interferon (12 months). Interferon was administered at 6 MU tiw and lamivudine at 100 mg orally once daily. Patients were followed up for 6 months after treatment.RESULTS: At the end of treatment, HBV DNA negativity rates were 88 % with lamivudine+interferon, 99 % with lamivudine and 55 % with interferon, (P=0.004, combination therapy vs. interferon, and P=0.001 lamivudine vs.interferon), and serum transaminase normalization rates were 84 %, 91% and 53 % (P=0.01 combination therapy vs. interferon, and P=0.012 lamivudine vs. interferon). Six months later, HBV DNA negativity rates were 44 % with lamivudine+interferon, 33 % with lamivudine and 25 % with interferon, and serum transaminase normalization rates were 61%, 42 % and 45 %, respectively, without statistical significance. No YMDD variants were observed with lamivudine+interferon (vs. 12 % with lamivudine). The combination therapy appeared to be safe. CONCLUSION: Although viral clearance and transaminase normalization are slower with long-term lamivudine+interferon than that with lamivudine alone, the combination regimen seems to provide more lasting benefits and to protect against the appearance of YMDD variants. Studies with other regimens regarding sequence and duration are needed. | M. Francesca Jaboli Carlo Fabbri Stefania Liva Francesco Azzaroli Giovanni Nigro Silvia Giovanelli Francesco Ferrara Anna Miracolo Sabrina Marchetto Marco Montagnani Antonio Colecchia Davide Festi Letizia Bacchi Reggiani Enrico Roda Giuseppe Mazzella | 2003 | World Journal of Gastroenterology2003，9，7： | 10 |
| 2 | 淋巴瘤中MYC蛋白的表达和MYC基因的重排情况显示文摘MYC易位是伯基特淋巴瘤( BL )和一组弥漫性大B细胞性淋巴瘤( DLBCL)的最典型特征,然而在淋巴瘤中仍未阐明MYC基因重排与临床关联,及其与MYC蛋白表达的相关性。采用组织微阵列技术,通过免疫组化法利用抗MYC单克隆抗体Y69和双重分离荧光原位杂交探针对1214个淋巴瘤进行MYC基因重排的检测。结果发现侵袭性B细胞淋巴瘤( BL和DLBCL)显示较高水平的MYC蛋白着色,大于50%的瘤细胞着色;很大一部分浆母细胞性淋巴瘤、B或T细胞淋巴母细胞性淋巴瘤和结外NK/T细胞性淋巴瘤显示大于50%的瘤细胞MYC蛋白着色,只有极少数的浆细胞骨髓瘤、套细胞淋巴瘤和经典的霍奇金淋巴瘤表现出较高水平的染色;当小B细胞性淋巴瘤中出现MYC蛋白着色时,小于50%的瘤细胞阳性。在侵袭性B细胞淋巴瘤中,MYC重排和MYC免疫组化显示较高的一致性,然而一些DLBCL和所有伴MYC蛋白表达的T细胞和NK细胞淋巴瘤却缺乏MYC基因的重排。本组结果指出MYC蛋白在淋巴瘤中的表达情况,并表明其表达并不特定于淋巴瘤亚型和细胞谱系,并与可预测的临床行为无关。另外,MYC蛋白的表达不一定与MYC基因重排有关,因此有必要高度谨慎说明MYC蛋白免疫组化在淋巴瘤鉴别诊断中的作用。 | Chisholm K M Bangs C D Bacchi C E 魏建国 刘勇 | 2015 | 临床与实验病理学杂志2015，31，5： | 8 |
| 3 | How to select elderly colorectal cancer patients for surgery: a pilot study in an Italian academic medical center显示文摘Objective: Cancer is one of the most common diagnoses in elderly patients. Of all types of abdominal cancer, colorectal cancer(CRC) is undoubtedly the most frequent. Median age at diagnosis is approximately 70 years old worldwide. Due to the multiple comorbidities affecting elderly people, frailty evaluation is very important in order to avoid over- or undertreatment. This pilot study was designed to investigate the variables capable of predicting the long-term risk of mortality and living situation after surgery for CRC.Methods: Patients with 70 years old and older undergoing elective surgery for CRC were prospectively enrolled in the study. The patients were preoperatively screened using 11 internationally-validated-frailty-assessment tests. The endpoints of the study were long-term mortality and living situation. The data were analyzed using univariate Cox proportional-hazard regression analysis to verify the predictive value of score indices in order to identify possible risk factors.Results: Forty-six patients were studied. The median follow-up time after surgery was 4.6 years(range, 2.9-5.7 years) and no patients were lost to follow-up. The overall mortality rate was 39%. Four of the patients who survived(4/28, 14%) lost their functional autonomy. The preoperative impaired Timed Up and Go(TUG), Eastern Cooperative Group Performance Status(ECOG PS), Instrumental Activities of Daily Living(IADLs), Vulnerable Elders Survey(VES-13) scoring systems were significantly associated with increased long term mortality risk.Conclusion: Simplified frailty-assessing tools should be routinely used in elderly cancer patients before treatment in order to stratify patient risk. The TUG, ECOG-PS, IADLs and VES-13 scoring systems are potentially able to predict long-term mortality and disability. Additional studies will be needed to confirm the preliminary data in order to improve management strategies for oncogeriatric surgical patients. | Giampaolo Ugolini Francesco Pasini Federico Ghignone Davide Zattoni Maria Letizia Bacchi Reggiani Daniele Parlanti Isacco Montroni | 2015 | Cancer Biology & Medicine2015，12，4： | 4 |
| 4 | Multielement determination in orange juice by ICP-MS associated with data mining for the classification of organic samples显示文摘The aim of this study was to discriminate organic from conventional orange juice based on chemical elements and data mining applications.A comprehensive sampling of organic and conventional oranges was carried out in Borborema,state of Sao Paulo,Brazil.The fruits of the variety Valencia(Citrus sinensis(L.)Osbeck)budded on Rangpur lime(Citrus limonia Osbeck)were analyzed.Eleven chemical elements were determined in 57 orange samples grown in organic and conventional systems.In order to classify these samples,data mining techniques(Support Vector Machine(SVM)and Multilayer Perceptron(MLP))were combined with feature selection(F-score and chi-squared).SVM with chi-squared had a better performance compared with the other techniques because it reached 93.00% accuracy using only seven chemical components(Cu,Cs,Zn,Al,Mn,Rb and Sr),and correctly classified 96.73% of the samples grown in an organic system. | Christian Turra Marcio Dias de Lima Elisabete A.De Nadai Fernandes Marcio Arruda Bacchi Fernando Barbosa Jr. Rommel Barbosa | 2017 | Information Processing in Agriculture2017，4，3： | 3 |
| 5 | Effect of a triage course on quality of rating triage codes in a group of university nursing students:a before-after observational study显示文摘BACKGROUND:Most current triage tools have been tested among hospital nurses groups but there are not similar studies in university setting.In this study we analyzed if a course on a new fourlevel triage model,triage emergency method(TEM),could improve the quality of rating in a group of nursing students.METHODS:This observational study was conducted with paper scenarios at the University of Parma,Italy.Fifty students were assigned a triage level to 105 paper scenarios before and after a course on triage and TEM.We used weighted kappa statistics to measure the inter-rater reliability of TEM and assessed its validity by comparing the students' predictions with the triage code rating of a reference standard(a panel of five experts in the new triage method).RESULTS:Inter-rater reliability was K=0.42(95%Cl:0.37-0.46) before the course on TEM,and K=0.61(95%CI:0.56-0.67) after.The accuracy of students' triage rating for the reference standard triage code was good:81%(95%Cl:71-90).After the TEM course,the proportion of cases assigned to each acuity triage level was similar for the student group and the panel of experts.CONCLUSION:Among the group of nursing students,a brief course on triage and on a new inhospital triage method seems to improve the quality of rating codes.The new triage method shows good inter-rater reliability for rating triage acuity and good accuracy in predicting the triage code rating of the reference standard. | Nicola Parenti Maria Letizia Bacchi Reggiani Diego Sangiorgi Vito Serventi Leopoldo Sarli | 2013 | World Journal of Emergency Medicine2013，4，1： | 3 |
| 6 | Measurement of Spleen Stiffness to Evaluate Portal Hypertension and the Presence of Esophageal Varices in Patients With HCV-Related Cirrhosis显示文摘 | Antonio Colecchia Lucia Montrone Eleonora Scaioli Maria Letizia Bacchi–Reggiani Agostino Colli Giovanni Casazza Ramona Schiumerini Laura Turco Anna Rita Di Biase Giuseppe Mazzella Luca Marzi Umberto Arena Massimo Pinzani Davide Festi | 2012 | Gastroenterology2012，，3： | 3 |
| 7 | Detection of proliferating cell nuclear antigen in gliomas and adjacent resection margins显示文摘 | Kim DK Hoyt J Bacchi C | 1993 | Neurosurg1993，33，： | 2 |
| 8 | Frequent expression of CD99 in anaplastic large cell lymphoma: a clinicopathologic and immtmohistochemical study of 160 cases 显示文摘 | Buxton D Bacchi CE Gualco G | 2009 | Am J Clin Pathol2009，131，4： | 1 |
| 9 | Distribution and pattern of expression of villin,a gastrointestinal-associated cytoskeletal protein,in human carcinomas:a study employing paraffin-embedded tissue显示文摘 | Bacchi CE Gown AM | 1991 | Lab Invest1991，64，3： | 1 |
| 10 | The influence ofintraoperative central venous pressure on delayed graft function in renal transplantation:a single-center experience显示文摘 | Bacchi G Buscaroli A Fusari M | 2010 | Transplant Proc2010，42，9： | 1 |
| 11 | Risk of stroke in patients with high on-clopidogrel platelet reactivity to adenosine diphosphate after percutaneous coronary intervention显示文摘 | Taglieri N Bacchi Reggiani ML Palmerini T | 2014 | Am J Cardiol2014，113，11： | 1 |
| 12 | Invasion depth is the most important prognostic factor for transitional-cell carcinoma in a prospective trial of radical cystectomy and adjuvant chemotherapy 显示文摘 | Mazzucchelli L Bacchi M Studer U E | 1994 | Int J Cancer1994，57，1： | 1 |
| 13 | Five putative drug resistance parameters(MDR1/P-glycoprotein, MDR-associated protein, glutathione-S-transf erase, bcl-2 and topoisomerase Ⅱα) in 57 newly diagnosed acute myeloid le ukaemias显示文摘 | van Hille B Bacchi M | 1997 | Eur J Haematol1997，59，： | 1 |
| 14 | Fractal relation of mainstream length to catchment area in river networks显示文摘 | Rosso R Bacchi B Barbera P L | 1991 | Water Resour Res1991，27，3： | 1 |
| 15 | Antimicrobial and mutagenic properties of organotin (Ⅳ) complexes with isatin and N-alkylisatinbisthiocarbonohydrazones 显示文摘 | Bacchi A Carcelli M Pelagatti P | 2005 | Inorg Biochem2005，99，： | 1 |
| 16 | Matrix metalloproteinase-9 expression in pterygium显示文摘 | Schellini SA Hoyama E Oliveira DE Bacchi CE Padovani CR | 2005 | Arq Bras Oftalmol2005，69，2： | 1 |
| 17 | Eculizumab in severe Shiga toxin associated HUS 显示文摘 | Lapeyraque AL Malina M Fremeaux -Bacchi V | 2011 | N Engl J Med2011，364，26： | 1 |
| 18 | Prognostic significance of mean platelet volume on admission in an unselected cohort of patients with non ST-segment elevation acute coronary syndrome显示文摘 | Marrozzini C Bacchi Reggiani ML Palmeri T | 2011 | Thromb Haemost2011，106，1： | 1 |
| 19 | Ovarian theco- ma: clinicopathological analysis of 50 cases 显示文摘 | Nocito AL Sarancone S Bacchi C | 2008 | Ann Di- agn Pathol2008，12，1： | 1 |
| 20 | Relationship between cleaved L-selectin levels and the outcome of acute myeloid leukemia显示文摘 | EXTERMANN M BACCHI M MOANI N | 1998 | Blood1998，92，9： | 1 |
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