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| 1 | Hepatocellular adenoma: An unsolved diagnostic enigma显示文摘Hepatocellular adenoma (HCA) is a rare benign liver tumour associated with the use of oral contraceptives or other steroid medications which occurs predominantly in young and middle-aged women. Unlike other benign liver tumours, an HCA may be complicated by bleeding and malignant transformation. HCAs have been divided into four subtypes based on molecular and pathological features: hepatocyte nuclear factor 1α-mutated HCA, inflammatory HCA,β-catenin-mutated HCA, and unclassified HCA.β-cateninmutated HCA has the highest risk of haemorrhage or malignant transformation. In the latest upgrade of the guidelines regarding the management of benign liver tumours published in 2016 by the European Association for the Study of the Liver, magnetic resonance imaging (MRI) was recognized to be superior to all other imaging modalities in detecting HCAs and in being able to subtype HCAs up to 80%, with positive identification of 1α-mutated HCA or inflammatory HCA achievable with > 90% specificity. This review analyzed the imaging features of HCA using MRI with hepato-specific contrast agents, focusing on the limitations in the HCA characterization. | Matteo Renzulli Alfredo Clemente Francesco Tovoli Salvatore Cappabianca Luigi Bolondi Rita Golfieri | 2019 | World Journal of Gastroenterology2019，25，20： | 12 |
| 2 | Radioembolization with Yttrium-90 microspheres in hepatocellular carcinoma:Role and perspectives显示文摘Transarterial radioembolization(TARE) is a form of brachytherapy in which intra-arterially injected yttrium-90-loaded microspheres serve as a source for internal radiation purposes.On the average,it produces disease control rates exceeding 80% and it is a consolidated therapy for hepatocellular carcinoma(HCC);however,current data are all based on retrospective series or non-controlled prospective studies since randomized controlled trials comparing it with the other liver-directed therapies for intermediate and locally advanced stage HCC are still underway.The data available show that TARE provides similar or even better survival rates when compared to transarterial chemoembolization(TACE).First-line TARE is best indicated for both intermediatestage patients(staged according to the barcelona clinic liver cancer staging classification) who have lesions which respond poorly to TACE due to multiple tumors or a large tumor burden,and for locally advanced-stage patients with solitary tumors,and segmental or lobar portal vein tumor thrombosis.In addition,emerging data have suggested the use of TARE in patients who are classified slightly beyond the Milan criteria regarding radical treatment for downstaging purposes.As a secondline treatment,TARE can also be applied in patients progressing to TACE or sorafenib;a large number of phase Ⅱ/Ⅲ trials are ongoing with the purpose of evaluating the best association with systemic therapies.Transarterial radioembolization is very well tolerated and has a low rate of complications which are mainly related to unintended non-target tissue irradiation,including the surrounding liver parenchyma.The complications can be additionally reduced by accurate patient selection and a strict pre-treatment evaluation including dosimetry and assessment of the vascular anatomy.Since a correct treatment algorithm for potential TARE candidates is not clear and standardized,this comprehensive review analyzes the best selection criteria for patients who really benefit from TARE and also the new advances of this therapy,which can be a very important weapon against HCC. | Cristina Mosconi Alberta Cappelli Cinzia Pettinato Rita Golfieri | 2015 | World Journal of Hepatology2015，7，5： | 10 |
| 3 | Non-invasive tests for the prediction of primary hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC)is one of the most common malignancies in the world and it is one of the main complications of cirrhosis and portal hypertension.Even in the presence of a well-established follow-up protocol for cirrhotic patients,to date poor data are available on predictive markers for primary HCC occurrence in the setting of compensated advanced chronic liver disease patients(cACLD).The gold standard method to evaluate the prognosis of patients with cACLD,beyond liver fibrosis assessed with histology,is the measurement of the hepatic venous pressure gradient(HVPG).An HVPG≥10 mmHg has been related to an increased risk of HCC in cACLD patients.However,these methods are burdened by additional costs and risks for patients and are mostly available only in referral centers.In the last decade increasing research has focused on the evaluation of several,simple,non-invasive tests(NITs)as predictors of HCC development.We reviewed the currently available literature on biochemical and ultrasound-based scores developed for the noninvasive evaluation of liver fibrosis and portal hypertension in predicting primary HCC.We found that the most reliable methods to assess HCC risk were the liver stiffness measurement,the aspartate aminotransferase to platelet ratio index score and the fibrosis-4 index.Other promising NITs need further investigations and validation for different liver disease aetiologies. | Giovanni Marasco Antonio Colecchia Giovanni Silva Benedetta Rossini Leonardo Henry Eusebi Federico Ravaioli Elton Dajti Luigina Vanessa Alemanni Luigi Colecchia Matteo Renzulli Rita Golfieri Davide Festi | 2020 | World Journal of Gastroenterology2020，26，24： | 8 |
| 4 | Large regenerative nodules in a patient with Budd-Chiari syndrome after TIPS positioning while on the liver transplantation list diagnosed by Gd-EOB-DTPA MRI显示文摘BACKGROUND:Large regenerative nodules (LRNs) are hyperplastic benign nodules most commonly associated with Budd-Chiari syndrome (BCS),caused by outflow obstruction of the hepatic veins or vena cava.To our knowledge,no cases of LRNs arising in BCS after transjugular intrahepatic portosystemic shunt (TIPS) positioning and detected by GdEOB-DTPA MRI have been reported in the literature.METHODS:A 58-year-old woman with BCS,on the liver transplantation (LT) list,underwent a follow-up enhanced MRI.Two years earlier,a TIPS had been placed.In 2008,recurrent hepaticoencephalopathy resistant to medical treatment fulfilled the LT criteria for BCS treated with TIPS and the patient was therefore added to the LT list.CT performed before TIPS had not detected any hepatic lesions.CT performed six months after TIPS showed its complete patency but documented two indeterminate hypervascular liver lesions.RESULTS:MRI performed with Gd-EOB-DTPA revealed additional hypervascular lesions with uptake and retention of the medium in the hepatobiliary phase,thus reflecting a benign behavior of hepatocellular composition.These MRI features were related to LRNs as confirmed by histopathologic analysis.CONCLUSIONS:Gd-EOB-DTPA-enhanced MRI is potentially superior to standard imaging using gadolinium chelates or spiral CT,especially for the differential diagnosis of hypervascular lesions.Gd-EOB-DTPA MRI may become the imaging method of choice for evaluating LT list patients with BCS after TIPS placement. | Matteo Renzulli Vincenzo Lucidi Cristina Mosconi Chiara Quarneti Emanuela Giampalma Rita Golfieri | 2011 | Hepatobiliary & Pancreatic Diseases International2011，10，4： | 5 |
| 5 | Response rate and clinical outcome of HCC after first and repeated cTACE performed “on demand”显示文摘 | E. Terzi R. Golfieri F. Piscaglia M. Galassi A. Dazzi S. Leoni E. Giampalma M. Renzulli L. Bolondi | 2012 | Journal of Hepatology2012，，6： | 4 |
| 6 | Percutaneous Intraductal Radiofrequency Ablation is a Safe Treatment for Malignant Biliary Obstruction: Feasibility and Early Results显示文摘 | Malkhaz Mizandari Madhava Pai Feng Xi Vlastimil Valek Andrasina Tomas Pietro Quaretti Rita Golfieri Cristina Mosconi Ao Guokun Charis Kyriakides Robert Dickinson Joanna Nicholls Nagy Habib | 2013 | CardioVascular and Interventional Radiology2013，，3： | 3 |
| 7 | Noncontrast-enhanced MRI-based Noninvasive Score for Portal Hypertension(CHESS1802):An International Multicenter Study显示文摘Background and Aims:This study aimed to determine the performance of the non-invasive score using noncontrastenhanced MRI(CHESS-DIS score)for detecting portal hy-pertension in cirrhosis.Methods:In this international multicenter,diagnostic study(ClinicalTrials.gov,NCT03766880),patients with cirrhosis who had hepatic venous pressure gradient(HVPG)measurement and noncontrast-enhanced MRI were prospectively recruited from four university hospitals in China(n=4)and Turkey(n=1)between December 2018 and April 2019.A cohort of patients was retrospectively recruited from a university hospital in Italy between March 2015 and November 2017.After segmentation of the liver on fat-suppressed T1-weighted MRI maps,CHESS-DIS score was calculated automatically by an in-house developed code based on the quantification of liver surface nodularity.Results:A total of 149 patients were included,of which 124 were from four Chinese hospitals(training cohort)and 25 were from two international hospitals(validation cohort).A positive correlation between CHESS-DIS score and HVPG was found with the correlation coefficients of 0.36(p<0.0001)and 0.55(p<0.01)for the training and validation cohorts,respectively.The area under the receiver operating characteristic curve of CHESS-DIS score in detection of clinically significant portal hypertension(CSPH)was 0.81 and 0.9 in the training and validation cohorts,respectively.The intra-class correlation coefficients for assessing the inter-and intra-observer agreement were 0.846 and 0.841,respectively.Conclusions:A non-invasive score using noncontrast-enhanced MRI was developed and proved to be significantly correlated with invasive HVPG.Besides,this score could be used to detect CSPH in patients with cirrhosis. | Yanna Liu Tianyu Tang NecatiÖrmeci Yifei Huang Jitao Wang Xiaoguo Li Zhiwei Li Weimin An Dengxiang Liu Chunqing Zhang Changchun Liu Jinqiang Liu Chuan Liu Guangchuan Wang Cristina Mosconi Alberta Cappelli Antonio Bruno Seray Akçalar EmrecanÇelebioğlu EvrenÜstüner Sadık Bilgiç Zeynep Ellik ÖzgünÖmer Asiller Lei Li Haijun Zhang Ning Kang Dan Xu Ruiling He Yan Wang Yang Bu Ye Gu Shenghong Ju Rita Golfieri Xiaolong Qi | 2021 | Journal of Clinical and Translational Hepatology2021，9，6： | 3 |
| 8 | Adherence to AASLD guidelines for the treatment of hepatocellular carcinoma in clinical practice: Experience of the Bologna Liver Oncology Group显示文摘 | Simona Leoni Fabio Piscaglia Ilaria Serio Eleonora Terzi Irene Pettinari Luca Croci Sara Marinelli Francesca Benevento Rita Golfieri Luigi Bolondi | 2014 | Digestive and Liver Disease2014，，： | 2 |
| 9 | Percutaneous Intraductal Radiofrequency Ablation for Clearance of Occluded Metal Stent in Malignant Biliary Obstruction: Feasibility and Early Results显示文摘 | Madhava Pai Vlastimil Valek Andrasina Tomas Attila Doros Pietro Quaretti Rita Golfieri Cristina Mosconi Nagy Habib | 2014 | CardioVascular and Interventional Radiology2014，，1： | 2 |
| 10 | Criteria for diagnosing benign portal vein thrombosis in the assessment of patients with cirrhosis and hepatocellular carcinoma for liver transplantation显示文摘 | Fabio Piscaglia Alice Gianstefani Matteo Ravaioli Rita Golfieri Alberta Cappelli Emanuela Giampalma Elisabetta Sagrini Grazia Imbriaco Antonio Daniele Pinna Luigi Bolondi | 2010 | Liver Transpl2010，，： | 2 |
| 11 | Indocyanine green retention test as a noninvasive marker of portal hypertension and esophageal varices in compensated liver cirrhosis显示文摘 | Andrea Lisotti Francesco Azzaroli Federica Buonfiglioli Marco Montagnani Paolo Cecinato Laura Turco Claudio Calvanese Patrizia Simoni Massimo Guardigli Rosario Arena Alessandro Cucchetti Antonio Colecchia Davide Festi Rita Golfieri Giuseppe Mazzella | 2014 | Hepatology2014，，2： | 2 |
| 12 | Comparison of the survival and tolerability of radioembolization in elderly vs. younger patients with unresectable hepatocellular carcinoma<!-- Doctopic: CAN -->显示文摘 | Rita Golfieri Josè Ignacio Bilbao Livio Carpanese Roberto Cianni Daniele Gasparini Samer Ezziddin Philipp Marius Paprottka Francesco Fiore Alberta Cappelli Macarena Rodriguez Giuseppe Maria Ettorre Adelchi Saltarelli Onelio Geatti Hojjat Ahmadzadehfar Ale | 2013 | Journal of Hepatology2013，，： | 2 |
| 13 | Sustained complete response of advanced hepatocellular carcinoma with metronomic capecitabine: a report of three cases显示文摘Background:Hepatocellular carcinoma(HCC)is one of the most frequent causes of cancer-related death.Sorafenib,a multitarget angiogenesis inhibitor,is an approved frontline treatment for advanced HCC in Western countries,although a complete response(CR)to treatment is infrequently reported.Capecitabine,an oral fluoropyrimidine,has been shown to be effect in both treatment-naïve patients and those previously treated with sorafenib.To date,how-ever,only one case of sustained CR to metronomic capecitabine has been reported.Case presentation:We describe three cases of advanced HCC treated with metronomic capecitabine where a CR was obtained.In the first case,capecitabine was administered as first line therapy;in the second case,capecitabine was used after intolerance to sorafenib;while in the third case,capecitabine was administered after sorafenib failure.Conclusion:Capecitabine is a potentially important treatment option for patients with advanced HCC and may even represent a cure in certain cases. | Giovanni Brandi Michela Venturi Stefania De Lorenzo Francesca Garuti Giorgio Frega Andrea Palloni Ingrid Garajovà Francesca Abbati Gioconda Saccoccio Rita Golfieri Maria Abbondanza Pantaleo Maria Aurelia Barbera | 2018 | Cancer Communications2018，38，1： | 2 |
| 14 | Pulmonary complications of liver transplantation: radiological appearance and statistical evaluation of risk factors in 300 eases 显示文摘 | Golfieri R Giampalma E Morselli Labate A M | 2000 | Eur Radio2000，10，7： | 1 |
| 15 | Patterns of appearance and risk of misdiagnosis of intrahepatic cholangiocarcinoma in cirrhosis at contrast enhanced ultrasound显示文摘 | Marzia Galassi Massimo Iavarone Sandro Rossi Simona Bota Sara Vavassori Laura Rosa Simona Leoni Laura Venerandi Sara Marinelli Angelo Sangiovanni Letizia Veronese Mirella Fraquelli Alessandro Granito Rita Golfieri Massimo Colombo Luigi Bolondi Fabio Pisca | 2013 | Liver Int2013，，5： | 1 |
| 16 | The impact of vascular and nonvascular findings on the noninvasive diagnosis of small hepatocellular carcinoma based on the EASL and AASLD criteria 显示文摘 | Leoni S Piscaglia F Golfieri R | 2010 | Am J Gastroenterol2010，105，： | 1 |
| 17 | Contribution of the hepatobiliary phase of Gd-EOB DTPA enhanced MRI to Dynam- ic MRI in the detection of hypovaseular small (≤2 cm) HCC in cirrhosis显示文摘 | Golfieri R Renzulli M Lucidi V | 2011 | Eur Radiol2011，21，6： | 1 |
| 18 | The percutaneous treatment of uterine fibromas by means of transcatheter arterial emboliz-ation显示文摘 | Golfieri R Muzzi C De Iaco P | 2000 | Radiol Med (Torinl)2000，100，12： | 1 |
| 19 | Contribution of the hepatobil- iary phase of Gd-EOB-DTPA-enhanced MRI to Dynamic MRI in the detection of hypovascular small (2 cm) HCC in cirrhosis 显示文摘 | Golfieri R Renzulli M Lucidi V | 2011 | Eur Radio12011，21，： | 1 |
| 20 | Contribut~n of the hepatobiliary phase of Gd -EOB -DTPA-enhanced MRI to Dy- namic MRI in the detection of hypovascular small ( ~ 2 cm ) HCC in cirrhosis显示文摘 | GOLFIERI R RENZULLI M LUCIDI V | 2011 | Eur Radiol2011，21，6： | 1 |
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