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| 1 | Hypoxia,angiogenesis and liver fibrogenesis in the progression of chronic liver diseases显示文摘Angiogenesis is a dynamic,hypoxia-stimulated and growth factor-dependent process,and is currently referred to as the formation of new vessels from preexisting blood vessels.Experimental and clinical studies have unequivocally reported that hepatic angiogenesis,irrespective of aetiology,occurs in conditions of chronic liver diseases(CLDs) characterized by perpetuation of cell injury and death,inflammatory response and progressive fibrogenesis.Angiogenesis and related changes in liver vascular architecture,that in turn concur to increase vascular resistance and portal hypertension and to decrease parenchymal perfusion,have been proposed to favour fibrogenic progression of the disease towards the end-point of cirrhosis.Moreover,hepatic angiogenesis has also been proposed to modulate the genesis of portal-systemic shunts and increase splanchnic blood flow,thus potentially affecting complications of cirrhosis.Hepatic angiogenesis is also crucial for the growth and progression of hepatocellular carcinoma.Recent literature has identified a number of cellular and molecular mechanisms governing the cross-talk between angiogenesis and fibrogenesis,with a specifi c emphasis on the crucial role of hypoxic conditions and hepatic stellate cells,particularly when activated to the myofibroblast-like pro-fibrogenic.Experimental anti-angiogenic therapy has been proven to be effective in limiting the progression of CLDs in animal models.From a clinical point of view,anti-angiogenic therapy is currently emerging as a new pharmacologic intervention in patients with advanced fibrosis and cirrhosis. | Claudia Paternostro Ezio David Erica Novo Maurizio Parola | 2010 | World Journal of Gastroenterology2010，16，3： | 23 |
| 2 | Thiazolidinedione treatment inhibits bile duct proliferation and fibrosis in a rat model of chronic cholestasis显示文摘AIM: To investigate the effects of troglitazone (TGZ), an anti-diabetic drug which activates peroxisome proliferatoractivated receptor-γ (PPAR-γ), for liver tissue repair, and the development of ductular reaction, following common bile duct ligation (BDL) in rats.METHODS: Rats were supplemented with TGZ (0.2% w/w in the pelleted food) for 1 wk before BDL or sham operation.Animals were killed at 1, 2, or 4 wk after surgery.RESULTS: The development of liver fibrosis was reduced in rats receiving TGZ, as indicated by significant decreases of procollagen type Ⅰ gene expression and liver hydroxyproline levels. Accumulation of α-smooth-muscle actin (SMA)-expressing cells surrounding newly formed bile ducts following BDL, as well as total hepatic levels of SMA were partially inhibited by TGZ treatment, indicating the presence of a reduced number and/or activation of hepatic stellate cells (HSC) and myofibroblasts. Development of the ductular reaction was inhibited by TGZ, as indicated by histochemical evaluation and hepatic activity of γ-glutamyltransferase (GGT).CONCLUSION: Treatment with thiazolidinedione reduces ductular proliferation and fibrosis in a model of chronic cholestasis, and suggests that limiting cholangiocyte proliferation may contribute to the lower development of scarring in this system. | Fabio Marra Raffaella DeFranco Gaia Robino Erica Novo Eva Efsen Sabrina Pastacaldi Elena Zamara Alessandro Vercelli Benedetta Lottini Carlo Spirli Mario Strazzabosco Massimo Pinzani Maurizio Parola | 2005 | World Journal of Gastroenterology2005，11，32： | 9 |
| 3 | Proangiogenic Cytokines as Hypoxia-Dependent Factors Stimulating Migration of Human Hepatic Stellate Cells显示文摘 | Erica Novo Stefania Cannito Elena Zamara Lorenzo Valfrè di Bonzo Alessandra Caligiuri Carlo Cravanzola Alessandra Compagnone Sebastiano Colombatto Fabio Marra Massimo Pinzani Maurizio Parola | 2007 | The American Journal of Pathology2007，，6： | 6 |
| 4 | Cellular and molecular mechanisms in liver fibrogenesis显示文摘 | Erica Novo Stefania Cannito Claudia Paternostro Claudia Bocca Antonella Miglietta Maurizio Parola | 2013 | Archives of Biochemistry and Biophysics2013，，： | 2 |
| 5 | Partial oxidation of methane over SiO2 supported Ni and NiCe catalysts显示文摘Nickel and nickel-ceria catalysts supported on high surface area silica, with 6 wt% Ni and 20 wt% CeO2 were prepared by microwave assisted(co) precipitation method. The catalysts were investigated by XRD,TPR and XPS analyses and they were tested in partial oxidation of methane(CPO). The catalytic reaction was carried out at atmospheric pressure in a temperature range of 400–800℃ with a feed gas mixture containing methane and oxygen in a molecular ratio CH4/O2=2. The Ni catalyst exhibited 60% methane conversion with 60% selectivity to CO already at 500℃. On the contrary, the Ni–Ce catalyst was inert to CPO up to 700℃. Moreover, the former catalyst reproduced its activity at the descending temperatures maintaining a good stability at 600℃, over a reaction time of 80 h, whereas the latter one completely deactivated. Test of CH4 temperature programmed surface reaction(CH4-TPSR) revealed a higher methane activation temperature(> 100℃) for the Ni–Ce catalyst as compared to the Ni one. Noticeable improvement of the ceria containing catalyst occurred when the reaction test started at a temperature higher than the methane decomposition temperature. In this case, the sample achieved the same catalytic behavior of the Ni catalyst. As confirmed by XPS analyses, the distinct electronic state of the supported nickel was responsible for the differences in catalytic behavior. | A.Emamdoust V.La Parola G.Pantaleo M.L.Testa S.Farjami Shayesteh A.M.Venezia | 2020 | Journal of Energy Chemistry2020，29，8： | 2 |
| 6 | Hydrogenation of aromatics over Au-Pd/SiO2-Al2O3 catalysts: support acidity effect显示文摘 | Venezia A M Parola V L Pawelec B | 2004 | Appl Catal A2004，264，1： | 1 |
| 7 | Chikungunya: a paradigm of emergence and globalization of vector-borne diseases 显示文摘 | Simon F Savini H Parola P | 2008 | Med Clin North Am2008，92，6： | 1 |
| 8 | On the role of lipid peroxidation in the pathogenesis of liver damage induced by long-stalding cholestasis 显示文摘 | Parola M Leonaroluzzi G Robino G | 1996 | Free Radical Biol Med1996，20，3： | 1 |
| 9 | Hydrogenation of aromatics over Au-Pd/SiO2-Al2O3 catalysts; support acidity effect 显示文摘 | Venezia A M La Parola V Pawelec B | 2004 | Appl Catal A2004，264，： | 1 |
| 10 | Oxidative stress-related molecules and liver fibrosis显示文摘 | Maurizio Parola Gaia Robino | 2001 | Journal of Hepatology2001，，2： | 1 |
| 11 | Beta-site APP cleaving enzyme up-regulation induced by 4-hydroxynonenal is mediated by stress-activated protein kinases pathways显示文摘 | TAMAGNO E PAROLA M BARDINI P | 2005 | Journal of Neurochemistry2005，92，3： | 1 |
| 12 | Tick-borne rickettsioses around the world: emerging diseases challenging old concepts 显示文摘 | Parola P Paddock CD Raoult D | 2005 | Clin Microbiol Rev2005，18，4： | 1 |
| 13 | Hydrogenation of aromatics over Au-Pd/SiO2-Al2O3 catalysts: Support acidity effect显示文摘 | VENEZIA A M PAROLA V L PAWELEC B FIERRO J L G | 2004 | Appl Catal A2004，264，1： | 1 |
| 14 | Ticks and tick borne bacterial diseases in humans: an emerging infectious threat 显示文摘 | Parola P Raoult D | 2001 | Clin Infect Dis2001，32，15： | 1 |
| 15 | AuPd alloy formation in Au-Pd/Al2O3 catalysts and its role on aromatics hydrogenation显示文摘 | Pawelec B Venezia A M Parola V L | 2005 | Appl Surf Sci2005，242，： | 1 |
| 16 | AuPd alloy formation in Au-Pd/A1203 catalysts and its role on aromatics hydrogenation 显示文摘 | Pawelec B Venezia A M Parola V L | 2005 | Appl Surf Sci2005，242，： | 1 |
| 17 | Anion detection by fluorescent Zn ( Ⅱ ) complexes of functionalized polyamine ligands显示文摘 | Rodriguez L Lima J C Parola A J | 2008 | Inorg Chem2008，47，： | 1 |
| 18 | Acute generalized exanthematous pustulosis in cystic echinococcosis: immunological characterization显示文摘 | Cannistraci C Parola IL Rigan OR | 2003 | Br J Dermatol2003，148，6： | 1 |
| 19 | Effect of gold on the HDS activity of supported palladium catalysts 显示文摘 | Venezia A M La Parola V Nicoli V | 2002 | J Catal2002，212，： | 1 |
| 20 | Tick-borne rickettsioses a-round the word:emerging diseases challenging old concep ts显示文摘 | PAROLA P PADDOCK C D RAOULT D | 2005 | ClinMicrobiol Rev2005，18，4： | 1 |
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