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| 1 | Bouveret's syndrome complicated by a distal gallstone ileus显示文摘AIM: Gastric outlet obstruction caused by duodenal impaction of a large gallstone migrated through a cholecystoduodenal fistula has been referred as Bouveret's syndrome. Endoscopic lithotomy is the first-step treatment,however, surgery is indicated in case of failure or complication during this procedure.METHODS: We report herein an 84-year-old woman presenting with features of gastric outlet obstruction due to impacted gallstone. She underwent an endoscopic retrieval which was unsuccessful and was further complicated by distal gallstone ileus. Physical examination was irrelevant.RESULTS: Endoscopy revealed multiple erosions around the cardia, a large stone in the second part of the duodenum causing complete obstruction, and wide ulceration in the duodenal wall where the stone was impacted. Several attempts of endoscopic extraction by using foreign body forceps failed and surgical intervention was mandatory. Preoperative ultrasound evidenced pneumobilia whilst computerized tomography showed a large stone, 5 cm×4 cm×3 cm, loggingat the proximal jejunum and another one, 2.5 cm×2 cm×2 cm,in the duodenal bulb causing a closed-loop syndrome. She underwent laparotomy and the jejunal stone was removed by enterotomy. Another stone reported as located in the duodenum preoperatively was found to be present in the gallbladder by intraoperative ultrasound. Therefore,cholecystoduodenal fistula was broken down, the stone was retrieved and cholecystectomy with duodenal repair was carried out. She was discharged after an uneventful postoperative course.CONCLUSION: As the simplest and the least morbid procedure, endoscopic stone retrieval should be attempted in the treatment of patients with Bouveret's syndrome.When it fails, surgical lithotomy consisting of simple enterotomy may solve the problem. Although cholecystectomy and cholecystoduodenal fistula breakdown is unnecessary in every case, conditions may urge the surgeon to perform such operations even though they carry high morbidity and mortality. | Rasim Gencosmanoglu Resit Inceoglu Caglar Baysal Sertac Akansel Nurdan Tozun | 2003 | World Journal of Gastroenterology2003，9，12： | 9 |
| 2 | Gastric polypoid lesions:Analysis of 150 endoscopic polypectomy specimens from 91 patients显示文摘AIM: To analyze gastric polypoid lesions in our patientpopulation with respect to histopathologic features and demographic, clinical, and endoscopic characteristics of patients.METHODS: Clinical records and histopathologic reports of patients with gastric polypoid lesions were analyzed retrospectively. All lesions had been totally removed by either endoscopic polypectomy or hot biopsy forceps. The histopathologic slides were re-evaluated by the same histopathologist.RESULTS: One-hundred and fifty gastric polypoid lesions were identified in 91 patients. There were 53 (58%) women and 38 (42%) men with a median age of 53 (range, 31 to 82) years. The most frequent presenting symptom was dyspepsia that was observed in 35 (38.5%) patients.Symptoms were mostly related to various associated gastric abnormalities such as chronic gastritis or H pylori infection rather than polypoid lesion itself. Polypoid lesions were commonly located in the antrum followed by cardia. Out of 150 lesions, 80 (53%) had the largest dimensions less than or equal to 5 mm and only 7 were pedunculated. The frequencies of hyperplastic polyps, foveolar hyperplasia, and fundic gland polyps were 46%, 18%, and 14% respectively.We also detected gastritis varioliformis in 12 specimens,lymphoid follicles in 9, 4 adenomatous polyps in 4, polypoid lesions with edematous mucosa in 4, inflammatory polyps in 3, and carcinoid tumor in 1. Adenomatous changes were observed within two hyperplastic polyps and low grade dysplasia in one adenoma. Histopathologic evaluation of the surrounding gastric mucosa demonstrated chronic gastritis in 72 (79%) patients and H pylori infection in 45 (49%).CONCLUSION: Hyperplastic polyps are the most frequently encountered subtype of gastric polypoid lesions. They are usually associated with chronic gastritis or H pylori gastritis. Contrary to the previous belief, they may harbour adenomatous changes or dysplastic foci.Therefore, endoscopic polypectomy seems as a safe and fast procedure for both diagnosis and treatment of gastric polypoid lesions at the same session. In addition,edematous mucosa may appear misleadingly as a polypoid lesion in some instances and it can be ruled out only by histopathologic examination. | Rasim Gencosmanoglu Ebru Sen-Oran Ozlem Kurtkaya-Yapicier Erol Avsar Aydin Sav Nurdan Tozun | 2003 | World Journal of Gastroenterology2003，9，10： | 8 |
| 3 | Adrenomedullin in cirrhotic and non-cirrhotic portal hypertension显示文摘AIM:Adrenomedullin (ADM) is a potent vasodilator peptide.ADM and nitric oxide (NO) are produced in vascular endothelial cells. Increased ADM level has been linked to hyperdynamic circulation and arterial vasodilatation in cirrhotic portal hypertension (CPH). The role of ADM in non-cirrhotic portal hypertension (NCPH) is unknown, plasma ADM levels were studied in patients with NCPH, compensated and decompensated cirrhosis in order to determine its contribution to portal hypertension (PH) in these groups.METHODS: There were 4 groups of subjects. Group 1consisted of 27 patients (F/M: 12/15) with NCPH due to portal and/or splenic vein thrombosis (mean age: 41±12years), group 2 consisted of 14 patients (F/M: 6/8) with compensated (Child-Pugh A) cirrhosis (mean age: 46±4),group 3 consisted of 16 patients (F/M: 6/10) with decompensated (Child-Pugh C) cirrhosis (mean age: 47±12).Fourteen healthy subjects (F/M: 6/8) (mean age: 44±8) were used as controls in Group 4. ADM level was measured by ELISA. NO was determined as nitrite/nitrate level by chemoluminescence.RESULTS: Adl level in Group 11 (236±61.4 pg/mL) was significantly higher than that in group 2 (108.4±28.3 pg/mL)and group 4 (84.1±31.5 pg/mL) (both P<0.0001) but was lower than that in Group3 (324±93.7 pg/mL) (P=0.002). NO level in group 1 (27±1.4 μmol/L) was significantly higher than that in group 2 (19.8±2.8 μmol/L) and group 4 (16.9±1.6μmol/L) but was lower than that in Group 3 (39±3.6 μmol/L)(for all three P<0.0001). A strong correlation was observed between ADM and NO levels (r=0.827, P<0.0001).CONCLUSION: Adrenomedullin and NO levels were high in both non-cirrhotic and cirrhotic portal hypertension and were closely correlated, Adrenomedullin and NO levels increased proportionally with the severity of cirrhosis, and were significantly higher than those in patients with NCPH.Portal hypertension plays an important role in the increase of ADM and NO. Parenchymal damage in cirrhosis may contribute to the increase in these parameters. | V Tahan E Avsar C Karaca E Uslu F Eren S Aydin H Uzun HO Hamzaoglu F Besisik C Kalayci A Okten N Tozun | 2003 | World Journal of Gastroenterology2003，9，10： | 5 |
| 4 | Prevalence of hypertension among individuals aged 50 years and over and its impact on health related quality of life in a semi-rural area of western TUrkey显示文摘背景高血压是普通的,特别在 40 年并且在上的个人,并且它试图 50 年并且在上在个人之中决定高血压的频率和风险因素的 60 年和 over.This 学习关于人口的一半影响,并且联系了生活( HRQOL )的质量在健康上检验它的效果 .Methods 这基于人口的代表性的研究在在3月1日和4月30,2007日 .A | Didem Arslantas Unal Ayranci Alaettin Unsal Mustafa Tozun | 2008 | Chinese Medical Journal2008，，16： | 3 |
| 5 | Liver fibrosis: consensus recommendations of the Asian Pacific Association for the Study of the Liver (APASL)显示文摘 | Gamal Shiha Shiv Kumar Sarin Alaa Eldin Ibrahim Masao Omata Ashish Kumar Laurentius A. Lesmana Nancy Leung Nurdan Tozun Saeed Hamid Wasim Jafri Hitoshi Maruyama Pierre Bedossa Massimo Pinzani Yogesh Chawla Gamal Esmat Wahed Doss Taher Elzanaty Puja Sakhuj | 2009 | Hepatology International2009，，2： | 2 |
| 6 | Femoral shortening and cementless ar- throplasty in high congenital dislocation of the hip 显示文摘 | Sener N Tozun TR Asik M | 2002 | J Arthroplas- ty2002，17，1： | 1 |
| 7 | Femoral shortening and ce- mentless arthroplasty in high congenital dislocation of the hip 显示文摘 | Sener N Tozun IR Asik M | 2002 | J Arthroplasty2002，17，1： | 1 |
| 8 | IgG ‐Based Elimination Diet in Migraine Plus Irritable Bowel Syndrome显示文摘 | Elif Ilgaz Aydinlar Pinar Yalinay Dikmen Arzu Tiftikci Murat Saruc Muge Aksu Hulya G. Gunsoy Nurdan Tozun | 2012 | Headache: The Journal of Head and Face Pain2012，，3： | 1 |
| 9 | Balanced operation of three-phase induction motor with asymmetrical stator windings connected to single-phase supply system 显示文摘 | TOZUNE A | 1991 | lEE Proceedings B: Electric Power Applications1991，138，4： | 1 |
| 10 | Mid-term result of ceramic bearings in total hip arthroplasty显示文摘 | Tozun IR Ozden VE Dikmen G | 2014 | Int Orthop2014，38，10： | 1 |
| 11 | Influence of the metabolic complications of liver cirrhosis on dietary intake显示文摘 | Tozun N | 2000 | Med Sci Monit2000，6，6： | 1 |
| 12 | Prevalence of dysmenor- rhea and its effect on quality of life among a group of female university students显示文摘 | Unsal A Ayranci U Tozun M | 2010 | Ups J Med Sci2010，115，2： | 1 |
| 13 | Balanced operation of three-phase induction motor with asymmetrical stator windings connected to single-phase supply system 显示文摘 | Tozune A DEng | 1991 | IEE PROCEEDINGS-B1991，138，4： | 1 |
| 14 | The prevalence of celiac disease in children with iron-deficiency anemia显示文摘 | Ertekin V Tozun MS Ktic tik N | 2013 | Turk J Gastroenterol2013，24，4： | 1 |
| 15 | Prevalence of urinary incontinence among women and its impact on quality of life in a semiruraX area of Western Turkey 显示文摘 | Tozun M Ayranci U Unsal A | 2009 | Gynecol Obstet Invest2009，67，4： | 1 |
| 16 | Kotz and Ganz osteotomies in the treatment of adult acetabular dysplasia显示文摘 | Sen C Asik M Tozun IR | 2003 | Int Orthop2003，27，2： | 1 |
| 17 | Femoral shortening and cementless arthroplasty in high congenital dislocation of the hip显示文摘 | Sener N TOzun I R Asik M | 2002 | J arthroplasty2002，17，1： | 1 |
| 18 | Prevalence of dysmenor-rhea and its effect on quality of life among a group of female u- niversity students 显示文摘 | Unsal A Ayranci U Tozun M | 2010 | Ups J Med Sci2010，115，2： | 1 |
| 19 | Femoral shortening and eementless arthroplasty in high congenital dislocation of the hip 显示文摘 | Sener N Tozun I Asik M | 2002 | J Arthroplasty2002，7，： | 1 |
| 20 | Influence of the metabolic complications of liver cirrhosis on dietary intake 显示文摘 | Tozun N | 2000 | Med Sci Monlt2000，6，6： | 1 |
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