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| 1 | Thiazolidinedione treatment inhibits bile duct proliferation and fibrosis in a rat model of chronic cholestasis显示文摘AIM: To investigate the effects of troglitazone (TGZ), an anti-diabetic drug which activates peroxisome proliferatoractivated receptor-γ (PPAR-γ), for liver tissue repair, and the development of ductular reaction, following common bile duct ligation (BDL) in rats.METHODS: Rats were supplemented with TGZ (0.2% w/w in the pelleted food) for 1 wk before BDL or sham operation.Animals were killed at 1, 2, or 4 wk after surgery.RESULTS: The development of liver fibrosis was reduced in rats receiving TGZ, as indicated by significant decreases of procollagen type Ⅰ gene expression and liver hydroxyproline levels. Accumulation of α-smooth-muscle actin (SMA)-expressing cells surrounding newly formed bile ducts following BDL, as well as total hepatic levels of SMA were partially inhibited by TGZ treatment, indicating the presence of a reduced number and/or activation of hepatic stellate cells (HSC) and myofibroblasts. Development of the ductular reaction was inhibited by TGZ, as indicated by histochemical evaluation and hepatic activity of γ-glutamyltransferase (GGT).CONCLUSION: Treatment with thiazolidinedione reduces ductular proliferation and fibrosis in a model of chronic cholestasis, and suggests that limiting cholangiocyte proliferation may contribute to the lower development of scarring in this system. | Fabio Marra Raffaella DeFranco Gaia Robino Erica Novo Eva Efsen Sabrina Pastacaldi Elena Zamara Alessandro Vercelli Benedetta Lottini Carlo Spirli Mario Strazzabosco Massimo Pinzani Maurizio Parola | 2005 | World Journal of Gastroenterology2005，11，32： | 9 |
| 2 | Proangiogenic Cytokines as Hypoxia-Dependent Factors Stimulating Migration of Human Hepatic Stellate Cells显示文摘 | Erica Novo Stefania Cannito Elena Zamara Lorenzo Valfrè di Bonzo Alessandra Caligiuri Carlo Cravanzola Alessandra Compagnone Sebastiano Colombatto Fabio Marra Massimo Pinzani Maurizio Parola | 2007 | The American Journal of Pathology2007，，6： | 6 |
| 3 | Proangiogenic cytokines as hypoxia-dependent factors stimulating migration of human hepatic stellate cells 显示文摘 | Novo E Cannito S Zamara E | 2007 | Am JPathol2007，170，6： | 1 |
| 4 | Proangiogenic cytokines as hypoxia-dependent factors stimulating migration of human hepatic stellate cells显示文摘 | Novo E Cannito S Zamara E | 2007 | Am J Pathol2007，170，6： | 1 |
| 5 | Overexpression of Bcl- 2 by activated human hepatic stellate cells: Resistance to apoptosis as a mechanism of progressive hepatic fibrogenesisin humans显示文摘 | Novo E Marra F Zamara E | 2006 | Gut2006，55，8： | 1 |
| 6 | Over expression of bcl-2 by activated human hepatic stellate cells:resistance to apoptosis as a mechanism of progressive hepatic fibrogenesis in humans显示文摘 | Novo E Marra F Zamara E | 2006 | Gut2006，55，8： | 1 |
| 7 | Dose dependent and divergent effects of superoxide anion on cell death, pro liferation and migration of activated human hepatic stellate cells显示文摘 | Novo E Marra F Zamara E | 2006 | Gut2006，55，4： | 1 |
| 8 | Overexpression of Bcl-2 by activated human hepatic stellate cells:resistance to apoptosis as a mechanism of progressive hepatic fibrogensis in humans显示文摘 | NOVO E MARRA F ZAMARA E | 2006 | Gut2006，55，8： | 1 |
| 9 | Dose dependent and divergent effects of superoxide anion on cell death, proliferation, and migration of activated human hepatic stellate cells显示文摘 | Novo E Marra F Zamara E | 2006 | Gut2006，55，1： | 1 |
| 10 | Prevention of severe toxic liv- er injury, and oxidative stress in MCP-1-deficient mice显示文摘 | Zamara E Galastri S Aleffi S | 2007 | J Hepa- tol2007，46，2： | 1 |
| 11 | Overexpression of Bcl-2 by activated human hepatic stellate cells:resistance to apoptosis as a mechanism of progressive hepatic fibro- genesis in humans 显示文摘 | Novo E Marra F Zamara | 2006 | Gut2006，55，： | 1 |
| 12 | Dose dependent and divergent effects of superoxide anion on cell death,proliferation,and migration of activated human hepatic stellate cells显示文摘 | Novo E Marra F Zamara E | 2006 | Gut2006，55，1： | 1 |
| 13 | Meta-Disc: a software for Meta- analysis of test accuracy data显示文摘 | Zamara J Abraira V Muriel A | 2006 | BMC Med Res Methodol2006，6，： | 1 |
| 14 | Dose dependent and divergent effects of superoxide anion on cell death,proliferation,and migration of activated human hepatic stellate cells显示文摘 | Novo E Marra F Zamara E | 2006 | Gut2006，55，1： | 1 |
| 15 | 4-Hydroxynonenal as a selective pro-fibrogenic stimulus for activated human hepatic stellate cells显示文摘 | Zamara E Novo E Marra F | | 0，，： | 1 |
| 16 | Overexpression of Bcl-2 by activated human hepatic stellate cells: resistance to apoptosis as a mechanism of progressive hepatic fibrogenesis in humans显示文摘 | Novo E Marra F Zamara E | 2006 | Gut2006，55，8： | 1 |
| 17 | Overexpression of Bcl-2 by activ- ated human hepatic stellate ceils: resistance to apoptosis as a mech- anism of progressive hepatic fibrogenesis in human显示文摘 | E Novo F Marra E Zamara | 2006 | Gut2006，55，8： | 1 |
| 18 | Proangiogenic cytokines as hypoxia-dependent factors stimulating migration of human hepatic stellate cells 显示文摘 | Novo E Cannito S Zamara E | 2007 | Am J Pathol2007，170，6： | 1 |
| 19 | Overexpression of Bcl-2 by activated human hepatic humans stellate cells:resistance to apoptosis as a mechanism of progressive hepatic fibrogenesis in humans显示文摘 | Novo E Marra F Zamara E | 2006 | Gut2006，55，： | 1 |
| 20 | Proangiogenic cytokines as hypoxia-dependent Factors stimulating migration of human hepatic stellate cells显示文摘 | Novo Erica Cannito Stefania Zamara Elena | | 0，，06： | 1 |
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