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| 1 | Imaging biomarkers in Parkinson’s disease and Parkinsonian syndromes:current and emerging concepts显示文摘Two centuries ago in 1817,James Parkinson provided the first medical description of Parkinson’s disease,later refined by Jean-Martin Charcot in the mid-to-late 19th century to include the atypical parkinsonian variants(also termed,Parkinson-plus syndromes).Today,Parkinson’s disease represents the second most common neurodegenerative disorder with an estimated global prevalence of over 10 million.Conversely,atypical parkinsonian syndromes encompass a group of relatively heterogeneous disorders that may share some clinical features with Parkinson’s disease,but are uncommon distinct clinicopathological diseases.Decades of scientific advancements have vastly improved our understanding of these disorders,including improvements in in vivo imaging for biomarker identification.Multimodal imaging for the visualization of structural and functional brain changes is especially important,as it allows a‘window’into the underlying pathophysiological abnormalities.In this article,we first present an overview of the cardinal clinical and neuropathological features of,1)synucleinopathies:Parkinson’s disease and other Lewy body spectrum disorders,as well as multiple system atrophy,and 2)tauopathies:progressive supranuclear palsy,and corticobasal degeneration.A comprehensive presentation of wellestablished and emerging imaging biomarkers for each disorder are then discussed.Biomarkers for the following imaging modalities are reviewed:1)structural magnetic resonance imaging(MRI)using T1,T2,and susceptibilityweighted sequences for volumetric and voxel-based morphometric analyses,as well as MRI derived visual signatures,2)diffusion tensor MRI for the assessment of white matter tract injury and microstructural integrity,3)proton magnetic resonance spectroscopy for quantifying proton-containing brain metabolites,4)single photon emission computed tomography for the evaluation of nigrostriatal integrity(as assessed by presynaptic dopamine transporters and postsynaptic dopamine D2 receptors),and cerebral perfusion,5)positron emission tomography for gauging nigrostriatal functions,glucose metabolism,amyloid and tau molecular imaging,as well as neuroinflammation,6)myocardial scintigraphy for dysautonomia,and 7)transcranial sonography for measuring substantia nigra and lentiform nucleus echogenicity.Imaging biomarkers,using the‘multimodal approach’,may aid in making early,accurate and objective diagnostic decisions,highlight neuroanatomical and pathophysiological mechanisms,as well as assist in evaluating disease progression and therapeutic responses to drugs in clinical trials. | Usman Saeed Jordana Compagnone Richard I.Aviv Antonio P.Strafella Sandra E.Black Anthony E.Lang Mario Masellis | 2017 | Translational Neurodegeneration2017，6，1： | 13 |
| 2 | Role of immunosuppression and tumor differentiation in predicting recurrence after liver transplantation for hepatocellular carcinoma: A multicenter study of 412 patients显示文摘AIM: To assess pre-orthotopic liver transplantation (OLT) factors that could be evaluated pre-operatively or con- trolled post-operatively associated with hepatocellular carcinoma (HCC) recurrence and disease-free survival after liver transplantation (LT).METHODS: Four hundred and twelve patients trans- planted for HCC between 1988 and 1998 in 14 French centers, who survived the postoperative period were studied. Kaplan Meier estimates were calculated for 24 variables potentially associated with recurrence of HCC. Uni- and multivariate analyses were conducted to iden- tify independent predictors of recurrence. RESULTS: Overall 5-year disease-free survival was 57.1%. By univariate analysis, variables associated with disease-free survival were: presence of cirrhosis (P = 0.001), etiology of liver disease (P = 0.03), α fetoprotein level (< 200, 200 to 2000, or > 2000; P < 0.0001), γ-GT activity (N, N to 2N or > 2N; P = 0.02), the number of nodules (1, 2-3 or ≥ 4; P = 0.02), maximal diameter of the largest nodule (< 3 cm, 3 to 5 cm or > 5 cm; P < 0.0001), the sum of the diameter of the nodules (< 3 cm, 3 to 5 cm, 5 to 10 cm or >10 cm; P < 0.0001), bi- lobar location (P = 0.01), preoperative portal thrombosis (P < 0.0001), peri-operative treatment of the tumor (P = 0.002) and chemoembolization (P = 0.03), tumor differentiation (P = 0.01), initial type of calcineurin inhibitor (P = 0.003), the use of antilymphocyte antibodies (P = 0.02), rejection episodes (P = 0.003) and period of LT (P < 0.0001). By multivariate analysis, 6 variables were independently associated with HCC recurrence: maximal diameter of the largest nodule (P < 0.0001), time of LT (P < 0.0001), tumor differentiation (P < 0.0001), use of anti-lymphocyte antibody (ATG) or anti-CD3 antibody (OKT3) (P = 0.005), preoperative portal thrombosis (P = 0.06) and the number of nodules (P = 0.06). CONCLUSION: This study identif ies immunosuppression, through the use of ATG or OKT3, as a predictive factor of tumor recurrence, and confi rms the prognostic value of tumor differentiation. | Thomas Decaens Franoise Roudot-Thoraval Solange Bresson-Hadni Carole Meyer Jean Gugenheim Francois Durand Pierre-Henri Bernard Olivier Boillot Philippe Compagnon Yvon Calmus Jean Hardwigsen Christian Ducerf Georges Philippe Pageaux Sébastien Dharancy Olivier Chazouillères Daniel Cherqui Christophe Duvoux | 2006 | World Journal of Gastroenterology2006，12，45： | 10 |
| 3 | Proangiogenic Cytokines as Hypoxia-Dependent Factors Stimulating Migration of Human Hepatic Stellate Cells显示文摘 | Erica Novo Stefania Cannito Elena Zamara Lorenzo Valfrè di Bonzo Alessandra Caligiuri Carlo Cravanzola Alessandra Compagnone Sebastiano Colombatto Fabio Marra Massimo Pinzani Maurizio Parola | 2007 | The American Journal of Pathology2007，，6： | 6 |
| 4 | Transcriptional Regulation of P450scc Gene Expression in the Embryonic Rodent Nervous System 显示文摘 | Fabian H Nathalie A Compagnone | 2004 | Endocrinology2004，145，2： | 1 |
| 5 | The management of patients with intradural post-traumatic mass lesions: a multicenter survey of current approaches to surgical management in 729 patients coordinated by the European Brain Injury Consortium 显示文摘 | Compagnone C Murray GD Teasdale GM | 2007 | Neurosurgery2007，61，1： | 1 |
| 6 | Ischemic Preconditioning and Liver Tolerance to Warm or Cold Ischemia:Experimental Studies in Large Animals显示文摘 | Compagnon Philippe | 2005 | Transplantation2005，79，10： | 1 |
| 7 | Allelic mutant series reveal distinct functions for Arabidopsis cycloartenol synthase 1 in cell viability and plastid biogenesis 显示文摘 | Babiychuk E Bouvier-Nav6 P Compagnon V | 2008 | Proc Natl Acad Sci USA2008，105，8： | 1 |
| 8 | Albinism and cell viability in cycloartenol synthase deficient Arabidopsis 显示文摘 | Babiychuk E Bouvier-Nav6 P Compagnon V | 2008 | Plant Signal Behav2008，3，11： | 1 |
| 9 | Ischemic preconditioning and liver tolerance to warm or cold ischemia : experimental studies in large animals 显示文摘 | Compagnon P Lindell S Ametani MS | 2005 | Transplantation2005，79，10： | 1 |
| 10 | In vivo continues monitoring of L-lactate coupling subcutaneous microdialysis and an electrochemical biocell 显示文摘 | Volpe G Moscone D Compagnone D | 1995 | Sensors Actuators B1995，2425，： | 1 |
| 11 | Role of preop-erative optimization of the liver for resection in patients with hilar cholangiocarcinoma type Ⅲ显示文摘 | Grandadam S Compagnon P Amaud A | | 0，，12： | 1 |
| 12 | Metoclopramide stimulates catecholamine- and granin-derived peptide secretion from pheochromocytoma cells through activation of serotonin type 4 (5-HT4) receptors 显示文摘 | Guillemot J Compagnon P Cartier D | 2009 | Endocr Relat Cancer2009，16，： | 1 |
| 13 | Roland Barthes' s Novel 显示文摘 | ANTOINE COMPAGNON | 2005 | October2005，，112： | 1 |
| 14 | Detection of benzo(a)pyrene photodegradation products using DNA electrochemical sensors显示文摘 | M. Del Carlo M. Di Marcello M. Giuliani M. Sergi A. Pepe D. Compagnone | 2011 | Biosensors and Bioelectronics2011，，1： | 1 |
| 15 | Enantioselective Screen-Printed Amperometric Biosensor for the Determination of d-Amino Acids显示文摘 | Wcisl/o M Compagnone D Trojanowicz M | 2007 | Bioelectrochemistry2007，71，1： | 1 |
| 16 | Allelic mutant series reveal distinct functions for Arabidopsis cycloartenol synthase 1 in cell viability and plastid biogenesis显示文摘 | Babiychuk E Bouvier-Nave P Compagnon V | 2008 | Proc Natl Acad Sci USA2008，105，8： | 1 |
| 17 | Micro-solid phase extraction coupled with high-performance liquid chromatographytandem mass spectrometry for the determination of stimulants,hallucinogens,ketamine and phencyclidine in oral fluids显示文摘 | Sergi M Compagnone D Curini R | 2010 | Anal Chim Acta2010，675，2： | 1 |
| 18 | Biosynthesis and action of neurosteroids显示文摘 | Synthia H Mellon Lisa D Griffin Nathalie A Compagnone | 2001 | Brain Research Reviews2001，，1： | 1 |
| 19 | Amperometric glutathione electrodes 显示文摘 | Compagnone D Federici G Scarciglia L | 1993 | Biosensors & Bioelectronics1993，8，： | 1 |
| 20 | Recent advances in biosensor technology for food safety显示文摘 | CARLO M D COMPAGNONE D | 2008 | Food Safety2008，19，3： | 1 |
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